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  • metabolism
  • IPC induced an increase in myocardial polyamines by regulating ODC and spermidine/spermine acetyltransferase (SSAT) in young rat hearts, but IPC did not affect polyamine metabolism in aged hearts. (hindawi.com)
  • 2) Determine if rIP influences the expression of genes known to influence substrate preference and thereby myocardial metabolism in patients undergoing heart surgery. (clinicaltrials.gov)
  • cardioprotection
  • Obestatin affords cardioprotection to the ischemic/reperfused isolated rat heart and inhibits apopto. (biomedsearch.com)
  • BACKGROUND: Although inotropic stimulation is considered harmful in the presence of myocardial ischaemia, both calcium sensitisers and phosphodiesterase inhibitors may offer cardioprotection. (biomedsearch.com)
  • tissue
  • Blood reperfusion of the ischemic tissue after stroke promotes increases in the inflammatory response as well as accumulation of unfolded/misfolded proteins in the cell, leading to endoplasmic reticul. (bioportfolio.com)
  • Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. (bioportfolio.com)
  • Molecular mechanism is not completely understood, but probably involves the released humoral mediators from ischemic tissue, including adenosine, bradykinin, and opioids, which react with the cell surface receptors and activate protein kinase cascades. (hindawi.com)
  • Effects of ischaemic conditioning on tissue oxygen saturation and heart rate variability: an observational study. (nih.gov)
  • protection
  • Exercise training inhibited the loss of preconditioning protection and restored the polyamine pool by activating ODC and inhibiting SSAT in aged hearts. (hindawi.com)
  • An ODC inhibitor, α -difluoromethylornithine, abolished the recovery of preconditioning protection mediated by exercise. (hindawi.com)
  • eNOS
  • Importantly, prolonged myocardial ischemia was associated with increased mortality in eNOS(-/-) mice, and the survival rate was higher in female eNOS(-/-) mice compared with male eNOS(-/-) mice. (biomedsearch.com)
  • effect
  • The aim of this study was to characterize the effect of increasing numbers of preconditioning cycles on the different branching patterns (bifurcation/trifurcation) of the coronary artery in the rabbit heart. (biomedsearch.com)
  • stimuli
  • Originally recognized in dog heart subjected to ischemic challenges, preconditioning has been demonstrated in multiple species, can be induced by various stimuli, and is applicable in different organ systems. (biomedsearch.com)
  • revascularization
  • Impact of European Society of Cardiology and European Association for Cardiothoracic Surgery Guidelines on Myocardial Revascularization on the activity of percutaneous coronary intervention and coronary artery bypass graft surgery for stable coronary artery disease. (nih.gov)