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  • nitric oxide
  • Involvement of the endothelin and nitric oxide systems in the pathogenesis of renal ischemic damage in an experimental diabetic model," Life Sciences , vol. 91, no. 13-14, pp. 669-675, 2012. (hindawi.com)
  • We recently demonstrated that exogenous nitric oxide (NO) acts as a trigger for preconditioning in the isolated rat heart model. (ovid.com)
  • acute
  • H. Shi, D. Patschan, T. Epstein, M. S. Goligorsky, and J. Winaver, "Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury," American Journal of Physiology-Renal Physiology , vol. 293, no. 5, pp. (hindawi.com)
  • Stroke
  • Post-operative ischemic events such as stroke, myocardial infarction, cardiac, renal and respiratory failure affect patient survival and quality of life, and represent a sizeable financial burden to health care. (clinicaltrials.gov)
  • After one year, cardiovascular death, non-fatal heart attack, stroke, or the need for subsequent surgery or angioplasty to clear blocked arteries occurred in 26.6 percent of the group receiving remote ischemic preconditioning and 27.7 percent of the control group, a difference with no statistical significance. (acc.org)
  • Intervention
  • Remote ischemic preconditioning is a simple, non-invasive, low-cost intervention that has no obvious downsides," said Derek Hausenloy, M.D., Ph.D., professor in cardiovascular medicine at University College London and at Duke-National University of Singapore, and the study's lead author. (acc.org)
  • cycles
  • Iliodromitis EK, Kremastinos D Th, Katritsis DG, Papadopoulos CC, Hearse DJ (1997) Multiple cycles of preconditioning cause loss of protection in open-chest rabbits. (springer.com)
  • Remote ischemic post-conditioning is performed by the inflating tourniquets to certain extents on bilateral arms with 5 cycles of 5min inflation and 5min relax alternation for the total of 30 consecutive days. (clinicaltrials.gov)
  • mechanisms
  • Vogt AM, Htun P, Arras M, Podzuweit T, Schaper W (1996) Intramyocardial infusion of tool drugs for the study of molecular mechanisms in ischemic preconditioning. (springer.com)
  • 13 14 This phenomenon has received widespread interest, because it may provide insight into endogenous protective mechanisms that could be harnessed to attenuate ischemic cell death. (ahajournals.org)
  • The mechanisms responsible for the 1st and 2nd window of protection following ischemic preconditioning (IPC) have been studied in detail. (ahajournals.org)
  • repetitive
  • Pretreatment with an NO synthase inhibitor, L-NNA, prevented the 2nd window of IPC as expected, since iNOS was elevated, but failed to prevent the ischemic protection following repetitive CS, where iNOS was not elevated. (ahajournals.org)
  • Methods and Results- To test this, chronically instrumented conscious pigs were subjected to either repetitive coronary stenosis (RCS) or a traditional protocol of second-window ischemic preconditioning (SWIPC). (ahajournals.org)
  • heart
  • Ischemic heart disease (IHD) is currently the leading cause of morbidity and mortality in the developed world, and is set to become the leading cause of death in the world by the year 2020, according to the World Health Organisation. (clinicaltrials.gov)