AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Myocardial InfarctionCold IschemiaWarm IschemiaIschemiaMyocardial IschemiaTime FactorsInfarctionBrain IschemiaOrgan PreservationCerebral InfarctionElectrocardiographyDelayed Graft FunctionTreatment OutcomeAngioplasty, Balloon, CoronaryRisk FactorsThrombolytic TherapyTissue DonorsMyocardial ReperfusionGraft SurvivalCoronary AngiographyReperfusion InjuryNephrectomyAnterior Wall Myocardial InfarctionProspective StudiesKidney TransplantationDeathRetrospective StudiesLiver TransplantationMyocardiumVentricular RemodelingTissue and Organ HarvestingCreatine KinaseFollow-Up StudiesTissue and Organ ProcurementStreptokinaseCoronary DiseaseCadaverVentricular Function, LeftLiving DonorsMyocardial Reperfusion InjuryRisk AssessmentAngina PectorisCoronary Care UnitsFibrinolytic AgentsDisease Models, AnimalCoronary CirculationPrognosisBiliary TractOrgan Preservation SolutionsPredictive Value of TestsPlatelet Aggregation InhibitorsRaffinoseAngina, UnstableCoronary VesselsAcute DiseaseHeartStentsPostoperative ComplicationsRecurrenceEchocardiographyMyocardial RevascularizationCoronary Artery DiseasePercutaneous Coronary InterventionVentricular Dysfunction, LeftCoronary ThrombosisSurvival AnalysisStroke VolumeShock, CardiogenicHospital MortalityPancreas TransplantationBiological MarkersMultivariate AnalysisTransplantsSurvival RateInferior Wall Myocardial InfarctionChest PainLaparoscopyStrokeBrain DeathRoboticsChi-Square DistributionCoronary Artery BypassHeart VentriclesArrhythmias, CardiacHeart FailureKaplan-Meier EstimateAge FactorsHemodynamicsProportional Hazards ModelsIncidenceRats, Sprague-DawleyIschemic Attack, TransientRegistriesCardiotonic AgentsGraft RejectionAspirinTissue Plasminogen ActivatorAcute Coronary SyndromeCohort StudiesRats, Wistar
Hibernating myocardiumSTEMISymptomsSymptom onsetInfarctStrokeArrhythmiasFunction after myocardial infarctionNecrosisClinicalInferior myocardial infarctionDiagnosisRecurrentHypoxiaThrombolysisTransientRevascularizationUnstable anginaElevation myocardialArterialLeft ventricularHypertensionPatientsLesionsPercutaneousOxygenCondition characterizedClinicallyPrevalenceCerebralAnginaCoronary arteriesSevereInterventionOxidative stressHeart diseaseAnteriorAcute coronaryAsymptomaticDysfunctionAneurysmDistalOccur as a resultProtects the HeartReperfusion therapyChronicSuddenIncidenceTissue
Hibernating myocardium2
  • Chronic myocardial ischemia resulting from progressive coronary artery stenosis leads to hibernating myocardium (HIB), defined as myocardium that adapts to reduced oxygen availability by reducing metabolic activity, thereby preventing irreversible cardiomyocyte injury and infarction. (bvsalud.org)
  • OBJECTIVE: This study aimed to investigate whether or not the application of a stem cell-derived exosome-laden collagen patch (EXP) during coronary artery bypass grafting (CABG) can recover cardiac function by modulating mitochondrial bioenergetics and myocardial inflammation in hibernating myocardium (HIB), which is defined as myocardium with reduced blood flow and function that retains viability and variable contractile reserve. (bvsalud.org)
STEMI15
  • Acute MI includes both non-ST-segment-elevation myocardial infarction (NSTEMI) and ST-segment-elevation myocardial infarction (STEMI). (msdmanuals.com)
  • ST-segment elevation myocardial infraction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) showed 0.8 and 0.88, respectively, less expression of MIF mRNA with regard to CG. (hindawi.com)
  • ACS surrounds three clinical conditions that result from an acute imbalance between myocardial oxygen supply and demand: unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) [ 2 , 3 ]. (hindawi.com)
  • Several factors have been associated with an increased risk of developing ST elevation myocardial infarction (STEMI). (wikidoc.org)
  • Physical exertion, especially if the exertion is much more intense than the individual usually performs has been associated with the onset of STEMI. (wikidoc.org)
  • EMS is deeply involved in systems of care for time-sensitive conditions like major trauma, STEMI and cardiac arrest. (ems1.com)
  • At the start of this decade, there was a surge of interest in early recognition and treatment of ST-elevation myocardial infarction (STEMI). (ems1.com)
  • While these process changes made considerable reductions in D2B times, the top performing hospitals were utilizing EMS to declare STEMI alerts based on clinical presentation and the 12-lead ECG while the patient was still in the field. (ems1.com)
  • We and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known about the relationships between air pollution and specific subsets of myocardial infarction, such as ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI). (biomedcentral.com)
  • We found a significant 18% increase in the risk of STEMI associated with each 7.1 μg/m 3 increase in PM 2.5 concentration in the previous hour prior to acute coronary syndrome onset, with smaller, non-significantly increased risks associated with increased fine particle concentrations in the previous 3, 12, and 24 hours. (biomedcentral.com)
  • Increased fine particle concentrations in the hour prior to acute coronary syndrome onset were associated with an increased risk of STEMI, but not NSTEMI. (biomedcentral.com)
  • Further investigation into mechanisms by which PM can preferentially trigger STEMI over NSTEMI within this rapid time scale is needed. (biomedcentral.com)
  • ST segment elevation myocardial infarction [STEMI], non-ST segment elevation myocardial infarction [NSTEMI], and unstable angina) to reflect the spectrum of pathophysiologic events occurring. (biomedcentral.com)
  • T he treatment of ST-elevation myocardial infarction (STEMI) has evolved substantially over the last 10 years in the United States. (thoracickey.com)
  • Smoking (73.5%) and hypertension (63.3%) were the most prevalent risk factors for patients with ST elevation myocardial infarction (STEMI) in contrast to dyslipidaemia (70.2%) and hypertension (68.1%) in patients with non-ST elevation myocardial infarction (NSTEMI). (bvsalud.org)
Symptoms10
  • Acute coronary syndrome (ACS) is a cardiovascular disease, which describes any condition characterized by signs and symptoms of sudden myocardial ischaemia and reduction in blood flow to the heart [ 1 ]. (hindawi.com)
  • The modest prognostic benefit of an opened infarct-related artery may be realized even when recanalization is induced only 6 hours or later after the onset of symptoms, that is, when the salvaging of substantial amounts of jeopardized ischemic myocardium is no longer likely. (medscape.com)
  • Sudden onset of heart failure symptoms and a new murmur should raise clinical suspicion. (ctsnet.org)
  • The diagnosis of ACS is based on the ischaemic symptoms, clinical findings and ECG changes. (unboundmedicine.com)
  • 3 hours after the onset of symptoms reduce mortality or cardiac arrest. (biomedcentral.com)
  • 3 hours after the onset of symptoms. (biomedcentral.com)
  • Angiographic studies performed in stroke patients within 8 hours of symptom onset have shown arterial occlusions corresponding to symptoms in more than 80% of cases (7) . (ajnr.org)
  • Silent ischemia - Patients with coronary artery disease (particularly patients with diabetes) may have ischemia without symptoms. (rxharun.com)
  • This focus is anticipated to shift even further to reduce the symptom onset to balloon (S2B) time interval - with a stronger effort placed on public recognition of the signs and symptoms of cardiac ischemia, minimizing delays associated with the psychological barriers that have patients denying the urgency of their situation. (ems1.com)
  • Ischemic stroke may be classified according to the duration of onset of symptoms and causative agent. (wikidoc.org)
Symptom onset9
  • Intravenous recombinant tissue plasminogen activator (rTPA) is now approved by the Food and Drug Administration (FDA) for the treatment of acute ischemic stroke within 3 hours of symptom onset (8) . (ajnr.org)
  • All patients presented within 6 hours of symptom onset. (ajnr.org)
  • Recently, using hospital admissions data (without symptom onset time data), we reported that myocardial infarction/PM 2.5 associations may be limited to transmural infarctions [ 6 ]. (biomedcentral.com)
  • However, unstable angina was not included in this study since symptom onset times were not available, and the diagnosis is typically based on clinical judgment without objective criteria. (biomedcentral.com)
  • As time from symptom onset (artery occlusion) to reperfusion increases, the myocardium available to salvage decreases, which raises the risk of mortality ( 1 , 2 , 3 , 4 and 5 ). (thoracickey.com)
  • 12 hours from the symptom onset are reconstructed according to the data of scintigraphic studies in patients with acute myocardial infarction. (thoracickey.com)
  • These include prehospital variables (symptom onset to first medical contact, prehospital transport, prehospital notification, EMS-administered therapies) and in-hospital factors (diagnosis time, patient variables, cath lab staffing, and procedural time). (thoracickey.com)
  • Symptom-onset-toballoon time and door-to-balloon time are significantly correlated with mortality following primary PCI ( 6 , 7 and 8 ). (thoracickey.com)
  • Almost 49.5% of patients arrived at hospital more than 6 h after symptom onset. (bvsalud.org)
Infarct7
  • Acute myocardial infarct (MI), commonly known as a heart attack, is a condition characterized by ischemic injury and necrosis of the cardiac muscle. (medscape.com)
  • A cardiac MRI was negative for myocardial ischemia or infarct as well as myocarditis. (ctsnet.org)
  • Systematic review and meta-analysis of the mechanical complications of ischemic heart disease: papillary muscle rupture, left ventricle rupture and post-infarct ventricular septal defect. (ctsnet.org)
  • Ischemic infarct may be categorized into two types depending on the area of the brain involved as focal ischemic stroke or global ischemic stroke. (wikidoc.org)
  • Compared with fibrinolytic therapy, primary PCI is able to achieve higher rates of TIMI grade 3 flow and infarct artery patency, and lower rates of reinfarction, recurrent ischemia, intracranial hemorrhage, and death in randomized clinical trials ( 5 ). (thoracickey.com)
  • Time-independent benefits of opening the artery have also been suggested to exist, and include improving infarct healing, electrical stability, and reducing in reinfarction. (thoracickey.com)
  • Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)
Stroke28
  • There was no reduction in ischemic burden on myocardial perfusion scintigraphy or in the safety endpoints of major bleeding, contrast-induced nephropathy, or stroke between the groups. (nih.gov)
  • There are increasing evidences that show that the prognosis of patients with acute ischemic stroke (AIS) is closely related to the inflammatory response. (hindawi.com)
  • Acute ischemic stroke (AIS) is the most common type of stroke, accounting for 87% of all strokes [ 3 ]. (hindawi.com)
  • There is growing evidence that ischemic stroke is related to the systemic inflammatory response, and diverse inflammatory cytokines are being investigated as potential predictors of cardiovascular and functional prognosis after AIS [ 4 , 5 ]. (hindawi.com)
  • Inflammation plays a crucial role in the pathogenesis of ischemic stroke, with mechanisms of action including atherosclerosis, plaque instability, and plaque rupture triggering [ 7 , 8 ]. (hindawi.com)
  • A study reports high levels of CRP associated with clinical prognosis in the time window between 12 and 72 hours after ischemic stroke [ 17 , 18 ]. (hindawi.com)
  • At 1 year, EMACCE (Sum of cardiovascular death, stroke, congestive cardiac failure, and limb, gut and myocardial ischemia) was significantly elevated in the High syntax group (P=0.022). (opencardiovascularmedicinejournal.com)
  • Since the approval of intravenous tissue plasminogen activator for acute ischemic stroke, great interest has been generated in cerebral fibrinolysis. (ajnr.org)
  • Our purpose was to assess long-term outcome and hemorrhagic risk in patients with anterior circulation ischemic stroke treated with intraarterial urokinase. (ajnr.org)
  • The role of thrombus in stroke, combined with the success of thrombolysis in acute myocardial infarction, has generated great interest in cerebral fibrinolysis. (ajnr.org)
  • We retrospectively studied 26 patients with ischemic stroke in the carotid territory treated at our institution with local intraarterial fibrinolysis. (ajnr.org)
  • Between January 1993 and January 1998, 26 patients with ischemic stroke in the distribution of the carotid artery were treated with intraarterial thrombolysis. (ajnr.org)
  • A head CT scan was obtained in all patients prior to angiography to exclude hemorrhage and other mimics of ischemic stroke. (ajnr.org)
  • Treatment of acute ischemic stroke (AIS) was historically primarily based on the use of thrombolytic drugs to dissolve clots that were causing obstruction of cerebral arteries. (ems1.com)
  • The major classification system of ischemic stroke include toast classification system, causative classification of stroke system (CCS),and sparkle classification of ischemic stroke. (wikidoc.org)
  • The pathophysiology of ischemic stroke may depend on the underlying cause of ischemia . (wikidoc.org)
  • Hemodynamic changes in ischemic stroke results from cerebral auto regulation dysfunction as brain tissue is highly sensitive to mild changes in oxygen levels. (wikidoc.org)
  • Some of the non modifiable risk factors include advanced age, male gender, family history of ischemic stroke, african-american and hispanic race, and genetic diseases such as sicke cell disease. (wikidoc.org)
  • Stroke can cause temporary or permanent complications based on the location and time to appropriate treatment. (wikidoc.org)
  • Delayed treatment or sever hemorrhagic or ischemic stroke can lead to death. (wikidoc.org)
  • In non-rheumatic atrial fibrillation, the rate of ischemic stroke is 5%, which is 2-7 times greater than for a person without atrial fibrillation⁴ ⁶. (gehealthcare.com)
  • Although there are common risk factors for acute ischemic stroke and myocardial infarction, simultaneous onset of both diseases is uncommon. (e-jnc.org)
  • Double primary acute ischemic stroke and myocardial infarction are rare but may be fatal due to the narrow therapeutic time window for both diseases. (e-jnc.org)
  • Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) are life-threatening conditions that may lead to permanent morbidity or disability. (e-jnc.org)
  • Is There an Optimal Management Regimen for Transient Ischemic Attack Patients to Best Prevent Stroke? (touchneurology.com)
  • Transient ischemic attacks (TIAs) are associated with a high risk of subsequent stroke and often pose a diagnostic and treatment challenge. (touchneurology.com)
  • The original TIA definition as "a cerebral dysfunction of ischemic nature lasting no longer than 24 hours with a tendency to recur" was based on pure clinical findings and was formulated in a time period in which neuroimaging was rudimental and acute stroke treatment missing. (touchneurology.com)
  • Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. (cdc.gov)
Arrhythmias4
  • Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. (biomedcentral.com)
  • Previous reports 1-3 have shown the efficacy of IABCP in the control of ventricular arrhythmias after myocardial infarction, yet the arrhythmia itself is rarely considered a primary indication for IABCP use. (bmj.com)
  • Fatal and nonfatal myocardial infarction, ventricular arrhythmias, and cardiac arrest have occurred following Lexiscan injection. (lexiscan.com)
  • β-adrenergic receptor blockers increase AV conduction time and increase AV nodal refractoriness, thereby helping to terminate nodal reentrant arrhythmias. (pharmacology2000.com)
Function after myocardial infarction1
  • These N-Vs vesicles not only improved cardiac function after myocardial infarction in rats, but also promoted blood vessel formation and reduced tissue damage. (nmn-bio.com)
Necrosis6
Clinical7
  • Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction. (clinconnect.io)
  • Other clinical manifestations of myocardial ischaemia include acute pulmonary oedema, loss of consciousness and sudden death. (unboundmedicine.com)
  • It is noteworthy to mention the fact that these protective agents have been used in the clinical setting for various purposes for a long time. (magiran.com)
  • These words aptly describe the basic clinical manifestations of angina pectoris , commonly called angina, the classic expression of ischemic heart disease. (rxharun.com)
  • To understand the pathophysiological significance of the potassium dip, we examined the changes in serum potassium level throughout ischemic attack and evaluated the clinical factors affecting it. (biomedcentral.com)
  • To understand the pathophysiological significance of the potassium dip in ACS and to ensure that patients have an optimal serum K level during the acute phase of ischemic attack, we herein examined the changes in K level throughout ischemic attack and evaluated the clinical factors affecting it. (biomedcentral.com)
  • Classification of atrial fibrillation starts with clinical presentation, either acute onset or chronic. (gehealthcare.com)
Inferior myocardial infarction2
Diagnosis1
  • Recent-onset chest pain of suspected cardiac origin: assessment and diagnosis. (bmj.com)
Recurrent3
  • The primary endpoint was a composite of all-cause death, recurrent myocardial infarction (MI), heart failure, and ischemia-driven revascularization within 12 months. (nih.gov)
  • Although cardiovascular death, myocardial infarction or severe recurrent ischaemia were not proven better with ronalazine, the individual component of recurrent ischaemia was significantly reduced by ranolazine - demonstrated as safe. (escardio.org)
  • New-onset or recurrent atrial fibrillation with rapid ventricular response and atrial flutter have been reported following Lexiscan injection. (lexiscan.com)
Hypoxia1
Thrombolysis3
Transient8
  • Causes attributable to fatal drowning were transient ischemic attacks and bathing after drinking alcohol. (medline.ru)
  • Silent ischemia sometimes manifests as transient asymptomatic ST-T abnormalities seen during stress testing or 24-h Holter monitoring. (rxharun.com)
  • Although a decrease in serum potassium level has been suggested to be a fairly common observation in acute coronary syndrome (ACS), there have so far been no definitive reports directly demonstrating the transient potassium decrease (the potassium dip) during ischemic attack of ACS compared to stable phase in individual patients. (biomedcentral.com)
  • We have clearly demonstrated that there is a transient decrease in serum potassium level during ischemic attack of ACS compared to stable phase. (biomedcentral.com)
  • Moreover, there have so far been few studies directly demonstrating the transient relative decrease in K level during ischemic attack compared to stable phase in individual patients (rather than its absolute value on admission). (biomedcentral.com)
  • To see this transient K decrease, "the potassium dip," during ischemic attack, it would be necessary to evaluate the fluctuation of K level in individuals by comparing the data during an attack to those during stable phase. (biomedcentral.com)
  • In postmarketing experience, transient ischemic attacks, seizures and syncope have been observed. (lexiscan.com)
  • The classic definition of transient ischemic attacks (TIAs) based on focal neurological deficits most likely due to cerebrovascular diseases with full recovery within 24 hours dates back to the 1960s. (touchneurology.com)
Revascularization5
  • Complete revascularization was performed either at the time of P-PCI or before hospital discharge. (nih.gov)
  • This is distinct from myocardial infarction, as HIB has the potential for recovery with revascularization. (bvsalud.org)
  • This regenerative therapy can stimulate myocardial recovery that does not respond to revascularization alone. (bvsalud.org)
  • Cardiogenic shock may be prevented with early revascularization in patients with myocardial infarction (MI) and with required intervention in patients with structural heart disease. (medscape.com)
  • An early revascularization strategy with either PCI or CABG, in collaboration between cardiologists and surgeons, is recommended for appropriate patients with suspected cardiogenic shock related to acute coronary syndrome (eg, those with uncertain neurologic status, those who received previous fibrinolysis), regardless of the time delay from MI onset. (medscape.com)
Unstable angina1
  • This is a specific form of unstable angina that can occur at any time (no trigger event causes it to happen). (rxharun.com)
Elevation myocardial5
Arterial2
  • 2) Acute risk factor: A short-term physiological change, such as a surge in arterial pressure or heart rate, an increase in coagulability, or vasoconstriction, that follows a trigger and may result in disease onset. (wikidoc.org)
  • The majority of ischemic strokes are due to thromboembolic arterial occlusions (6) , with 75% in the distribution of the carotid artery (3) . (ajnr.org)
Left ventricular2
  • Apical left ventricular (LV) dyskinesis (ventricular aneurysm) after an anterior myocardial infarction. (medscape.com)
  • Although an underlying arrhythmogenic substrate is necessary, the arrhythmia itself will compromise an already impaired haemodynamic state, by increasing myocardial ischaemia or left ventricular wall distension, and so exacerbate the situation. (bmj.com)
Hypertension2
  • Data from a large cohort of 42,676 patients with hypertension, including 20,156 patients with CHD onset, were investigated from electronic health records (EHRs) 1-3 years prior to CHD onset (for CHD-positive cases) or during a disease-free follow-up period of more than 3 years (for CHD-negative cases). (jmir.org)
  • The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
Patients23
  • The MFI system can detect the onset of arrhythmic and ischemic diseases in a very early stage with high accuracy for both acute and asymptomatic patients. (wikipedia.org)
  • [ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
  • Patients with significant coronary artery disease (CAD) experience chronic ischemia, which puts them at risk for heart failure and sudden death. (bvsalud.org)
  • Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. (clinconnect.io)
  • Absence of coronary artery disease: Cardiac ischaemia with angina pectoris can exist in the absence of significant coronary artery disease, possibly due to microcoronary dysfunction (up to 10% of patients of which a majority of women). (escardio.org)
  • Patients treated with ranolazine had significantly better exercise duration - an ncrease by 115 seconds from baseline versus 91 seconds in placebo group - time to onset of angina, and fewer angina attacks. (escardio.org)
  • 3,162) Metabolic efficiency with ranolazine for less ischemia in Non-ST elevation acute coronary syndromes compared long-term treatment with extended-release ranolazine with placebo, on top of standard therapy, for acute and long-term treatment of patients with non-ST-elevation ACS. (escardio.org)
  • The Promus ELITE Everolimus-Eluting Platinum Chromium Coronary Stent System is indicated for improving luminal diameter in patients, including those with diabetes mellitus, with symptomatic heart disease or documented silent ischemia due to de novo lesions in native coronary arteries ≥2.25 mm to ≤4.00 mm in diameter in lesions ≤34 mm in length. (bostonscientific.com)
  • Glucose-insulin-potassium (GIK) has long been advocated as an adjunctive treatment for patients with cardiac dysfunction during episodes of ischemia and reperfusion. (biomedcentral.com)
  • GIK has now been commonly applied in patients with acute coronary syndrome (ACS) as a metabolic support to ischemic myocardium. (biomedcentral.com)
  • A strong effort was made to quickly capture a 12-lead ECG in the ED on patients who presented with signs of cardiac ischemia. (ems1.com)
  • This review focuses on direct and indirect causes of myocardial injury in COVID-19 patients and highlights current knowledge, treatment strategies, and outstanding questions in the field. (springer.com)
  • Ischaemia events occurred in 14 patients (M/F=13/1) and caused four deaths. (bmj.com)
  • Among the patients with KD with coronary aneurysms, 10-year ischaemia event-free and aneurysm persistence probability was 87.5% and 20.6%, respectively. (bmj.com)
  • The degree of the potassium dip during ischemic attack (as indicated by ΔK, ΔK = K at discharge − K on admission) was examined in 311 consecutive patients with ACS who required urgent hospitalization in our institution. (biomedcentral.com)
  • A longer hospitalization period, higher incidence of myocardial infarction and higher peak creatine kinase level were observed in patients with a larger ΔK. (biomedcentral.com)
  • Lexiscan ® (regadenoson) injection is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. (lexiscan.com)
  • Holding a DOAC for longer periods of time may be required for patients with moderate-severe renal dysfunction, especially if using dabigatran. (acc.org)
  • Chest pain without established ischaemic heart disease in primary care patients: associated comorbidities and mortality. (bmj.com)
  • Prevalence of acute myocardial infarction and other serious diagnoses in patients presenting to an urban emergency department with chest pain. (bmj.com)
  • 9. Collinson PO, Premachandram S, Hashemi K. Prospective audit of incidence of prognostically important myocardial damage in patients discharged from emergency department. (bmj.com)
  • Data extracted recorded patient demographics, risk factors, timing of care, therapeutic interventions, follow up with cardiology and mortality of patients. (bvsalud.org)
  • Three (12.5%) patients received thrombolytic therapy within the recommended 30-min time frame. (bvsalud.org)
Lesions1
  • More than two thirds of myocardial infarctions occur in lesions that are less than 60% severe. (medscape.com)
Percutaneous3
Oxygen4
  • Imbalance between the myocardial oxygen need and the availability of oxygen, and consequently myocardial ischaemia may also be caused, in the absence of an acute coronary stenosis (plaque rupture), by tachycardia and bradycardia, coronary spasm, hypotension, anaemia, respiratory insufficiency or other severe disease. (unboundmedicine.com)
  • If angina is not relieved, unmet myocardial oxygen demand increases further, making MI more likely. (rxharun.com)
  • Prolonged ischemia decreases oxygen delivery to the cells causing anaerobic glycolysis and increased production of free oxygen and nitrate radicals which in turn causes cell membrane, DNA damage and cell death. (wikidoc.org)
  • Many modifying factors may influence the absolute time periods of salvage ability (collaterals, intermittent occlusion, myocardial oxygen consumption, ischemic preconditioning, persistence of residual blood flow, recruitment of collaterals, hibernating). (thoracickey.com)
Condition characterized1
  • Acute coronary syndrome (ACS) describes any condition characterized by myocardial ischaemia and reduction in blood flow. (hindawi.com)
Clinically2
  • Hepatic laboratory parameters including ALT, AST, and bilirubin should be obtained prior to starting maraviroc tablets and at other time points during treatment as clinically indicated. (drugs.com)
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
Prevalence1
  • This study in May 2002, part of the Jordan Department of Statistics national cross-sectional, multistage employment and unemployment survey, measured the prevalence of self-reported myocardial infarction (MI) and the association with modifiable risk factors among Jordanians aged 40+ years. (who.int)
Cerebral2
Angina4
  • UA is suggested by angina pain that occurs for the first time and is then experienced with increasing frequency or that is a known symptom of previously diagnosed stable angina which is rapidly worsening (over days - in less than 2 weeks). (unboundmedicine.com)
  • 1 Another description of angina states that it is a "discomfort in the chest or adjacent areas caused by myocardial ischemia. (rxharun.com)
  • Silent ischemia and angina pectoris may coexist, occurring at different times. (rxharun.com)
  • These increases may be the cause of rest angina or the result of ischemia induced by plaque rupture and thrombus formation. (rxharun.com)
Coronary arteries1
  • However, transmural and non-transmural myocardial infarction are estimations of assumed injury to the myocardium, whereas acute coronary syndromes attempt to describe the spectrum of physiologic events occurring in coronary arteries during an acute ischemic event. (biomedcentral.com)
Severe1
  • The standard surgical intervention for severe CAD is coronary artery bypass graft surgery (CABG), but it has been shown to be an imperfect therapy, yet no adjunctive therapies exist to recover myocytes adapted to chronic ischemia. (bvsalud.org)
Intervention2
  • Ventricular septal rupture carries a high risk of mortality with surgical intervention ranging from 60 percent with early intervention and decreasing with time from presentation (3). (ctsnet.org)
  • For example, treatment of hyperthyroidism may be the only intervention necessary to resolve an associated acute onset of atrial fibrillation. (gehealthcare.com)
Oxidative stress3
  • However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
  • oxidative stress that occurs during reperfusion injury has been shown to induce apoptosis, over and above that induced by ischemia. (latestfashiontips.com)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Heart disease6
  • The onset of this heart disease, which leads to the death of heart muscle cells, is one of the causes. (nmn-bio.com)
  • Complications of acute ischemic heart disease include ventricular septal rupture resulting in a defect and sudden left to right shunt. (ctsnet.org)
  • Ischaemic heart disease (IHD) - reduced blood supply to the heart usually caused by coronary artery disease - is the leading cause of death and morbidity in America and Europe and is expected to be so by the year 2020 in emerging countries as well (1-3). (escardio.org)
  • Oral anticoagulation plus P2Y 12 antiplatelet combination is recommended for the first 6-12 months (potentially switching P2Y 12 to aspirin for months 6-12 if PCI for stable ischemic heart disease), followed by anticoagulation monotherapy after 12 months. (acc.org)
  • For PCI with stable ischemic heart disease or acute coronary syndrome, use of oral anticoagulant plus a P2Y 12 inhibitor for no more than 12 months is recommended, followed by oral anticoagulation alone. (acc.org)
  • Acute myocardial infarction (AMI) following ischaemic heart disease (IHD) is associated with increased morbidity and mortality. (bvsalud.org)
Anterior1
  • We have previously shown that distal anterior wall ischemia/reperfusion induces gene expression changes in the proximal anterior myocardial area, involving genes responsible for cardiac remodeling. (oncotarget.com)
Acute coronary1
  • Therefore, in order to better understand the relationship between the acute pathophysiologic process of myocardial infarction and increased air pollutant concentrations, we sought to study acute coronary syndromes (i.e. (biomedcentral.com)
Asymptomatic1
Dysfunction1
  • However, questions remain as to whether apoptosis is a critical event in the transition from compensated to decompensated cardiac hypertrophy and the onset of ventricular dysfunction. (latestfashiontips.com)
Aneurysm2
  • Main outcome measures The acute coronary severities and late outcomes (survival free of coronary aneurysm persistence and ischaemia) were assessed. (bmj.com)
  • The only independent risk factor for aneurysm persistence or ischaemia events was aneurysm severity 1 month after Kawasaki disease onset. (bmj.com)
Distal1
Occur as a result1
Protects the Heart1
  • Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)
Reperfusion therapy2
Chronic1
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
Sudden1
  • Similar to what has been reported with respect to the onset of MI, there was no increase in the risk of sudden death with heavy exertion among those nurses who exercised more than 2 hours per week. (wikidoc.org)
Incidence1
  • Another study investigating time trends in the incidence and survival of GCA over a 50-year period in Olmsted County, Minnesota, found the age- and sex-adjusted annual incidence rate of giant cell arteritis was 18.8 (95% CI, 15.9-21.6) per 100,000 persons aged 50 years and older. (rheumatologyadvisor.com)
Tissue2
  • Ischemic injury occurs when the blood supply is insufficient to meet the tissue demand for metabolism. (medscape.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)