Ischemic mouse brain. Medical search. Frequent questions

Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). (mdpi.com)
In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. (jneurosci.org)
Although steady-state conditions revealed no increase in primitive cell proliferation in p21-null mice, a significantly larger fraction of quiescent neural precursors was activated in the hippocampus and subventricular zone after brain ischemia. (rupress.org)
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. (greenmedinfo.com)
Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. (mpg.de)
Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Effects of hypothermia on focal cerebral ischemia in plasminogen knockout mice. (mpg.de)
Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Hypothermia strengths inhibitors of matrix degrading proteases following experimental focal cerebral ischemia in mice. (mpg.de)
Primary cortical neurons were either activated with TNF (10?ng/ml) … To help expand check out whether inhibition of TAK1 can be neuroprotective within an style of cerebral ischemia we subjected mice to middle cerebral artery occlusion (MCAO). (bioinf.org)
She studied novel treatment strategies to combat neonatal brain damage after hypoxia-ischemia. (umcutrecht.nl)
4:Braccioli L, Heijnen CJ, Coffer PJ, Nijboer CH. Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size and neuroinflammation in neonatal mice. (umcutrecht.nl)
Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses. (uni-due.de)
METHODS: Vehicle (dimethyl sulfoxide), a GPER agonist (G-1, 30 mug/kg), or a GPER antagonist (G-15, 300 mug/kg) were administered alone or in combination to young or aged male mice, or young intact or ovariectomized female mice, 1 hour before or 3 hours after cerebral ischemia-reperfusion. (monash.edu)
A model of global cerebral ischemia in C57 BL/6 mice. (riken.jp)
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. (duke.edu)
SUR2 may help protect the heart during ischemia, which occurs when tissues such as heart or brain experience a lack of oxygen due to an obstruction of blood flow. (warf.org)
Brief periods of ischemia can protect a tissue from subsequent, prolonged ischemia, a phenomenon known as ischemic preconditioning, or IPC. (warf.org)
the inventors found that mice in which SUR2 is disrupted suffered less damage following ischemia than wild-type mice without IPC. (warf.org)
Hypoxia-ischemia (HI) was induced in P9 and P30 mice using unilateral carotid artery ligation and exposure to 10% oxygen for 50min. (wisc.edu)
Microglia maturation is associated with changes in morphology and gene expression, and microglial responses to ischemia in the developing brain differ based on the age at which injury occurs. (wisc.edu)
The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion. (bvsalud.org)
Adenosine modulates vascular flow and exhibits neuroprotective effects , in which brain extracellular concentration of adenosine is dramatically increased during ischemic events and ischemia - reperfusion . (bvsalud.org)
Since the equilibrative nucleoside transporter -2 (Ent2) is important in regulating brain adenosine homeostasis , the present study aimed to investigate the role of Ent2 in mice with cerebral ischemia - reperfusion . (bvsalud.org)
Cerebral ischemia - reperfusion injury was examined in mice with transient middle cerebral artery occlusion (tMCAO) for 90 minutes, followed by 24-hour reperfusion . (bvsalud.org)
Ent2 deletion reduced the infarct volume, brain edema , and neuroinflammation in mice with cerebral ischemia - reperfusion . (bvsalud.org)
Ent2 plays a critical role in modulating cerebral collateral circulation and ameliorating pathological events of brain ischemia and reperfusion injury . (bvsalud.org)
Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)
Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
[ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

Damage to Myelin and Oligodendrocytes: A Role in Chronic Outcomes Following Traumatic Brain Injury? (mdpi.com)
Neural precursor cells from adults have exceptional proliferative and differentiative capability in vitro yet respond minimally to in vivo brain injury due to constraining mechanisms that are poorly defined. (rupress.org)
The cyclin-dependent kinase inhibitor, p21 cip1/waf1 (p21), maintains hematopoietic stem cell quiescence, and we evaluated its role in the regenerative response of neural tissue after ischemic injury using the mice deficient in p21. (rupress.org)
Therefore, p21 is an intrinsic suppressor to neural regeneration after brain injury and may serve as a common molecular regulator restricting proliferation among stem cell pools from distinct tissue types. (rupress.org)
CCDC120 is downregulated after neonatal hypoxic-ischemic brain injury in rats. (wikipedia.org)
In this Research Topic, we summarized original research and review articles that examine the more recent progress in pharmacological and cell therapies for perinatal HI brain injury. (frontiersin.org)
Interestingly, they observed behavioral deficits and neuronal loss caused by HI brain injury in female adolescent offspring after SE ( Huang et al. ). (frontiersin.org)
These therapies should target the cellular mechanisms that underly HI brain injury, including early phase propagators of injury such as neuro-inflammation, cell death, mitochondrial dysfunction, oxidative stress, and excitotoxicity, and they should be safe for use in both term and preterm infants. (frontiersin.org)
presents a promising therapy that used inhibitors of the Src family kinases (SFKs) for neuroprotection in a preterm model of HI brain injury ( Qiu et al. ). (frontiersin.org)
They induced HI brain injury in postnatal 3-day Sprague-Dawley (SD) rats, which corresponds to 23-32 weeks of human gestation ( Mallard and Vexler, 2015 ). (frontiersin.org)
They found that the {4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole [3,4-d] pyrimidine} (PP2), an SFK inhibitor when given within 0.5 h from HI, ameliorated pathological changes and myelin deficits and improved neuro-behaviors in the preterm rats with exposure to HI brain injury. (frontiersin.org)
Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage. (greenmedinfo.com)
Mangiferin potentiates neuroprotection by isoflurane in neonatal hypoxic brain injury. (greenmedinfo.com)
Electrically stimulating certain regions of the brain is relatively simple, and it has long been pursued to enhance recovery after injury or stroke (when the blood supply to a brain region stops). (elifesciences.org)
Ischemic brain injury is associated with a high rate of mortality and disability with no effective therapeutic strategy. (hindawi.com)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Thus, MSCs were suggested as a promising candidate for ischemic brain injury patients[ 11 ]. (hindawi.com)
Acute renal injury has been found in mice with increased neuronal pyknosis and microgliosis in the brain. (medscape.com)
Acute renal injury led to both soluble and cellular inflammation in the brain, affecting the CA1 region of the hippocampus foremost. (medscape.com)
Acute renal injury leads to increase in brain microvascular leakage. (medscape.com)
Atorvastatin pretreatment alleviate the ischemic brain injury linked to peroxisome proliferator-activated receptor coactivator-1α and angiogenic factors in diabetic mice. (nel.edu)
The lack of oxygen and glucose in the area of ischemic injury initiates a pathological cascade leading to blood-brain barrier (BBB) breakdown, inflammation, and neuronal cell death, a process that may be intercepted to limit stroke progression. (lu.se)
Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female Mice. (harvard.edu)
Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury. (harvard.edu)
I am particularly interested in developing novel MRI methodologies for examining brain function, investigating the role of sex and steroid hormones in ischaemic stroke/cognitive decline and increasing the translational relevance of experimental models of CNS injury and disease. (nottingham.ac.uk)
We found that sublethal hypoxia, which elicits tolerance to subsequent lethal hypoxic/ischemic injury in a natural process known as ischemic preconditioning (IPC), induced a rapid release of neuronal tPA. (jci.org)
2: Van Tilborg E, de Theije CGM, van Hal M, Wagenaar N, de Vries LS, Benders M, Rowitch DH, Nijboer CH. Origin and dynamics of oligodendrocytes in the developing brain: implications for perinatal white matter injury. (umcutrecht.nl)
Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. (umcutrecht.nl)
2: WKZ Research Fund (2013): "A novel strategy to protect the preterm brain against perinatal white matter injury. (umcutrecht.nl)
3: Hersenstichting Nederland -Fellowship Stroke (2014): "Mesenchymal stem cell therapy to repair white matter injury in the preterm neonatal brain: boosting oligodendrocyte differentiation and myelination. (umcutrecht.nl)
5: EU, Marie Sklodowska-Curie CoFund - RESCUE program Utrecht RMSC (2018): "Development of novel protective and regenerative treatment strategies for brain injury in the preterm and fullterm neonate. (umcutrecht.nl)
6: Young scientist award (Prof. Acarin award) (2012), Hershey Conference for Developmental Brain Injury, London, UK. (umcutrecht.nl)
Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. (riken.jp)
Hypoxic-ischemic brain injury (HI) was induced by unilateral carotid artery ligation and subsequent exposure to 10% oxygen for 50 minutes in infant (P9) and juvenile (P30) mice. (wisc.edu)
At 2 days post-injury, brain sections were stained with Iba1 (microglial stain), and quantitative morphometrics were performed using Imaris software. (wisc.edu)
Neuroinflammation plays an important role in ischemic brain injury and recovery, however the interplay between brain development and the neuroinflammatory response is poorly understood. (wisc.edu)
By identifying MRI biomarkers in animal models of pediatric brain injury, Waisman investigator Peter Ferrazzano hopes to provide a means for selecting the patients most likely to benefit from a particular neuroprotective intervention in subsequent clinical trials. (wisc.edu)
Did early studies of human traumatic brain injury overlook concomitant oligodendrocyte pathology in injured white matter tracts? (lu.se)
Along with the observation that migraine mutants had an elevated minimum cerebral blood flow threshold required for tissue survival and developed larger infarcts, these findings directly support the hypothesis that brain tissue in migraineurs is more susceptible to ischemic injury. (medscape.com)
If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)

Young adult male C57BL/6 J mice subjected to 30 min of middle cerebral artery occlusion (MCAO) were administered intranasal preparations of E2-GNPs, water soluble E2, or saline as control 1 h after reperfusion. (nih.gov)
Using single-cell RNA sequencing in a mouse model of permanent middle cerebral artery occlusion, we investigated the temporal differences in transcriptomic signatures in pericytes at 1, 12, and 24 h after stroke. (lu.se)
We also quantified sub-acute neuroinflammation in the post-stroke brain in a separate cohort of mice following a 60 min transient middle cerebral artery occlusion (tMCAo). (frontiersin.org)
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. (nottingham.ac.uk)
Bremer AM, Yamada K and West CR: Ischemic cerebral edema in primates: Effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. (spandidos-publications.com)
Infarct volume, brain edema , neuroinflammation , microvascular structure, regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (CMRO2), and the production of reactive oxygen species (ROS) were examined following the reperfusion . (bvsalud.org)

Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes. (uni-due.de)
O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. (duke.edu)

IP is a biphasic phenomenon, with an early short-lasting phase of protection that develops within minutes from the initial ischemic insult and lasts ∼2 hr. (jneurosci.org)
This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets. (lu.se)
Here, we have demonstrated that hippocampal areas of the mouse brain lacking tPA activity are more vulnerable to neuronal death following an ischemic insult. (jci.org)

We have developed a gelatin nanoparticle-mediated intranasal drug delivery system as an efficient, non-invasive method for delivering 17β-estradiol (E2) specifically to the brain, enhancing neuroprotection, and limiting systemic side effects. (nih.gov)
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs have been identified. (greenmedinfo.com)
Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage has been extensively explored for treating ischemic stroke. (springer.com)

Kelly, S, McCulloch, J & Horsburgh, K 2001, ' Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion ', Brain Research , vol. 914, pp. 185 - 195. (bris.ac.uk)

Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
We also found that IPC in vivo increased tPA activity in the cornu ammonis area 1 (CA1) layer and Akt phosphorylation in the hippocampus, as well as ischemic tolerance in wild-type but not tPA- or plasminogen-deficient mice. (jci.org)
Trunk blood and tissue samples from the periphery (liver, spleen, fat, and heart) and brain (hypothalamus, prefrontal cortex, and hippocampus) were collected. (peerj.com)
Ob/ob mice exhibited elevated cytokine gene expression in liver (TNF-α, TGF-β1), heart (TGF-β1), fat (TNF-α), and brain (hippocampus, hypothalamus, prefrontal cortex: IL-1β, TNF-α) compared with wild-type mice. (peerj.com)
Representative Imaris-processed images are shown in A and B from contralateral (CL) and ipsilateral (IL) hippocampus of P9 and P30 mice at 2 days post-HI. (wisc.edu)

Therefore, intervening the mechanistic steps that lead to excitotoxicity may protect the brain in a broad range of acute and chronic central nervous system pathologies. (nature.com)
According to previously established studies [ 8 ], the ischemic avalanche followed by a stroke is comprised of three phases, i.e., (i) acute phase, (ii) the subacute phase, and (iii) the chronic phase (Figure 1 ). (hindawi.com)
Taken together, these findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. (peerj.com)
Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

On page 583, line 7 of the abstract, the sentence "Our results indicate that the cytokine-inducing, fully reduced isoform of HMGB1 was released from the ischemic brain in the hyperacute phase of stroke in mice and patients. (jneurosci.org)

This blood swap lessens damage to your brain, and any neurological deficits from the stroke are nil. (news-medical.net)

The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. (lu.se)
Following the reperfusion , the rCBF of the wild-type (WT) mice was quickly restored to the baseline, whereas, in Ent2-/- mice , rCBF was slowly recovered initially, but was then higher than that in the WT mice at the later phase of reperfusion . (bvsalud.org)

Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
The results provide region-specific quantification of neural connectivity and neuroinflammation, which could be a critical tool for investigating mechanisms of not only stroke recovery, but also a wide variety of brain injuries or diseases. (frontiersin.org)
This method can be applied to the investigation of cellular and molecular mechanisms in many mouse models of skin pathologies, including atopic dermatitis. (jove.com)
An alternative surgical approach reduces variability following filament induction of experimental stroke in mice Disease Models & Mechanisms. (nottingham.ac.uk)

Ischemic stroke increases membrane-bound G protein-coupled estrogen receptor (GPER) distribution and expression in the brain of male but not female mice. (monash.edu)

However, despite increasing knowledge of the physiologic, mechanistic, and imaging characterizations of the ischemic penumbra, no effective neuroprotective therapy has been found. (springer.com)

Previous efforts to repair damaged brain tissue following ischemic events have been hindered by the relative isolation of the central nervous system. (nih.gov)
While there is no known single medication for stroke, the only FDA-approved treatment for ischemic strokes is tPA, or tissue plasminogen activator, which dissolves the clot and improves blood flow. (news-medical.net)
Neutrophils, a type of white blood cell that helps lead the immune system's response, play a role in increasing the levels of an enzyme called MMP-9, which can lead to blood-brain barrier leakage and degeneration in brain tissue. (news-medical.net)
Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)
The treatment of ischemic stroke is to administer tissue plasminogen activator (t-PA) within 4.5 h of stroke onset, and only 5-8% of patients qualify for this therapy (Liaw and Liebeskind 2020 ). (springer.com)
In cases of cerebrovascular disease and intractable epilepsy where such neurosurgery is essential for treatment, tissue (vascular and brain tissue) is obtained that is removed for treatment during surgery. (riken.jp)
The main conclusion of our results are that alarmins released from necrotic brain tissue induce a sterile inflammatory immune response via pattern-recognition receptors. (jneurosci.org)
Rapid onset of systemic insulin resistance and adipose tissue remodeling but initially increased insulin-stimulated glucose transport despite deteriorating insulin signaling with high fat feeding in mice. (lu.se)

Whole-brain volumetric microscopy techniques such as serial two-photon tomography (STPT) can provide detailed information on the roles of neuroinflammation and neuroplasticity throughout the whole brain post-stroke. (frontiersin.org)
Detailed quantification of post-stroke neural connectivity and neuroinflammation indicates a role for remote brain regions in stroke pathology and recovery. (frontiersin.org)

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. (greenmedinfo.com)
In the study, led by Xuefang 'Sophie' Ren, research assistant professor in the Department of Neuroscience, the team found that blood substitution therapy rescues the brains of mice from ischemic damage. (news-medical.net)
Replacing 20 percent of the blood in a mouse was enough to show a profound reduction in damage to the brain. (news-medical.net)
So the neutrophils go to the brain and try to clean up the damage that happens. (news-medical.net)
But there's too much in the brain and those same neutrophils release MMP-9, which then exacerbates the damage. (news-medical.net)
Blood indeed saves our brains and lives from stroke damage,' she said. (news-medical.net)
TIMP1 protects mouse brain from ischemic damage of the BBB. (mpg.de)
Neuronal apoptosis plays a part in ischemic brain damage and neurodegenerative disorders. (bioinf.org)
In keeping with our findings these results also Docetaxel (Taxotere) demonstrate that activation of TAK1 contributes to ischemic mind damage. (bioinf.org)
In an ischemic stroke, lack of blood flow to the brain causes damage, which rapidly leads to nerve cell loss that affects large parts of the the vast network of nerve cells in the brain. (lu.se)
Importantly, sensorimotor functions improved, even though the extent of the brain damage was not diminished. (lu.se)

In rats with RF, brain levels of creatine phosphate, adenosine triphosphate (ATP), and glucose are increased, whereas levels of adenosine monophosphate (AMP), adenosine diphosphate (ADP), and lactate are decreased. (medscape.com)
An international study published recently in the journal Brain and led by a research team from Lund University in collaboration with University of Rome La Sapeinza and Washington University at St. Louis, shows promising results in mice and rats that were treated with a class of substances that inhibit the metabotropic glutamate receptor (mGluR5), a receptor that regulates communication in the brain's nerve cell network. (lu.se)

4: Hersenstichting Nederland - The Next Step (2017): "Intranasal growth factor treatment: a novel strategy to repair the injured preterm brain. (umcutrecht.nl)

These forms of circuit plasticity involve recruitment of homologous neuronal pathways, inhibition of aberrant electrical signaling, and formation of new connections through synaptogenesis and axonal sprouting throughout the brain and spinal cord ( Murphy and Corbett, 2009 ). (frontiersin.org)

D ) Chronic, daily stimulation of the somatosensory cortex that is contralateral to the stroke site (lightning bolt) impairs the local remapping of the forepaw area and interferes with the integration of the recovered cortex into functional brain networks. (elifesciences.org)
Ischemic stroke is attributed to a high disability rate with limited or no therapeutic options for functional recovery [ 1 - 3 ]. (hindawi.com)
Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)

An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)

8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)

Thus, avoiding maternal SE during pregnancy is important to protect the brain from perinatal brain injuries. (frontiersin.org)
3: Wagenaar N, de Theije CGM, de Vries LS, Groenendaal F, Benders MJNL, Nijboer CH. Promoting neuroregeneration after perinatal arterial ischemic stroke: Neurotrophic factors and mesenchymal stem cells. (umcutrecht.nl)

Pericytes located at the blood/brain interface are one of the first responders to hypoxia in stroke and therefore a potential target cell for early stroke interventions. (lu.se)

The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. (researchgate.net)

At later time points (one month), stimulation of the forepaw is once again able to activate the brain, this time in a forepaw representation that is shifted to a new site due to cortical plasticity. (elifesciences.org)
Following a stroke, the brain being able to exhibit plasticity - and therefore nearby cortical areas taking on the role of the damaged regions - is associated with recovery. (elifesciences.org)
Reactive astrocytes prevent maladaptive plasticity after ischemic stroke. (gu.se)

We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. (springer.com)

The study is believed to be the first to show that blood replacement therapy leads to improved stroke outcomes in mice, a potential next step for stroke therapy in humans. (news-medical.net)
Although the data are promising , much of the research has been conducted with mice or come from trials of short-term use in humans. (medscape.com)

Besides, systemic hypoperfusion is another major factor in the occurrence of ischemic stroke [ 4 ]. (hindawi.com)

Male C57BL/6j (lean) and ob/ob mice (leptin-deficient mice exhibiting obese phenotype) were subjected to SF or control conditions for 24 h using an automated SF chamber. (peerj.com)

XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. (duke.edu)

Globally, ischemic stroke is a leading cause of death and adult disability. (nih.gov)
At the appropriate time point after treatment, use 10 centimeter surgical scissors to carefully excise a 25 by 25 millimeter area of shaved flank skin from an adult eight to twelve-week-old female ND4 Swiss-Webster mouse. (jove.com)

Astrocytes are specialized glial cells ubiquitously distributed throughout the spinal cord and brain. (news-medical.net)
Time-course profile compares growth across brain regions and reveals cortical astrocytes have the fastest rate of growth. (news-medical.net)

We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
Impaired protein homeostasis induced by endoplasmic reticulum dysfunction is a key feature of a variety of age-related brain diseases including stroke. (duke.edu)

C57BL/6 mice were subjected to TAC or sham operation and then were orally gavaged with acetazolamide (20 mg/kg/day). (spandidos-publications.com)

Guanidinosuccinic acid, methylguanidine, guanidine, and creatinine inhibited responses to GABA and glycine (inhibitory amino acids) in cultured mouse neurons. (medscape.com)
Two weeks post-stroke, mice received intramuscular injections of pseudorabies virus (PRV-152), a trans-synaptic retrograde herpes virus driving expression of green fluorescent protein (GFP), into the affected contralesional forelimb to label neurons in descending tracts to the forelimb musculature. (frontiersin.org)
mice pass away at E9.5-E10.5 17 18 we used a conditional approach to delete TAK1 in neurons. (bioinf.org)
Tatti R , Bhaukaurally K, Gschwend O , Seal RP , Edwards RH , Rodriguez I , Carleton A . A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb. (neurotree.org)
Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo (1) H-MR spectroscopy at 9.4 T. (lu.se)

Most strokes (ischemic) occur when the blood supply to the brain is interrupted, usually by a blockage of the arteries leading to the brain. (news-medical.net)

Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets has been observed. (greenmedinfo.com)

However, it is also found in structures of the brain that are highly vulnerable to hypoxia-induced cell death, where its association with neuronal survival is poorly understood. (jci.org)

We focus on the characterization of the central nervous system (CNS) immunologic response to VSBV-1 by IHC analyses of immune cells in the brain of all patients, as well as by examination of cerebrospinal fluid (CSF) reactions over time during the disease. (cdc.gov)
Researchers can map out areas of the brain affected by Alzheimer's disease , for example, by assessing where patients' glucose uptake drops. (medscape.com)

SF significantly increased IL-1β and TNF-α gene expression in fat and TGF-β1 expression in spleen relative to controls, but only in wild-type mice. (peerj.com)
Microglia were isolated from P2, P9, P30 and P60 mice, and expression of markers of classical and alternative microglial activation was assessed, as well as transforming growth factor beta (TGF-β) receptor, Serpine1, Mer Tyrosine Kinase (MerTK), and the suppressor of cytokine signaling (SOCS3). (wisc.edu)
HI resulted in a significant decrease in branching morphology only in the P9 mice, and expression of TGF-β receptor, Serpine1, MerTK, and SOCS3 were elevated in P30 mice compared to P9 post-HI. (wisc.edu)
Acetazolamide also reduced the expression of α-SMA, collagen I, TGF-β1 and p-Smad2 in the TAC mice. (spandidos-publications.com)
tMCAO-induced disruption of brain microvessels was ameliorated in Ent2-/- mice , with a reduced expression of matrix metalloproteinases -9 and aquaporin -4 proteins . (bvsalud.org)
Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. (cdc.gov)

At present, 301 clinical trials are registered to explore the impact of brain stimulation on stroke patients, examining outcomes ranging from upper or lower limb function to the ability to reflect on one's thinking. (elifesciences.org)
Bloom syndrome patients and mice display accelerated epigenetic aging. (cdc.gov)

One of the common things that happen during aging is that tissues - such as of the heart, brain, and muscle - lose the ability to metabolize glucose effectively. (medscape.com)

In mice, stimulating cortical areas in the undamaged hemisphere of a brain affected by stroke impairs recovery. (elifesciences.org)
The recovery of mouse IL-23 spiked to three levels throughout the range of the assay was evaluated. (rndsystems.com)

Anatomy57

Organisms16

Diseases32

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology9

Phenomena and Processes45

Disciplines and Occupations4

Technology, Industry, Agriculture1

Humanities2

Information Science10

Health Care4

Ischemia34

Injury40

Cerebral6

Post-ischemic2

Insult3

Neuroprotection3

Neuronal damage1

Hippocampus5

Acute5

Abstract1

Deficits1

Reperfusion2

Mechanisms4

Male but Not Female Mice1

Neuroprotective therapy1

Tissue8

Neuroinflammation2

Damage11

Rats2

20171

Inhibition1

Functional3

Oxidative stress1

Blood-brain b1

Perinatal2

Pericytes1

Neurotrophic1

Plasticity3

Decreases1

Humans2

Occurrence1

Deficient1

Impairment1

Adult2

Astrocytes2

Diseases2

C57BL1

Neurons5

Strokes1

Newborn1

Hypoxia1

Disease2

Expression6

Patients2

Glucose1

Recovery2