Ischemic heart d modeling cardiovascular disease models cardiovascular. Medical search. Frequent questions

In Scotland, although mortality rates have declined steadily for decades (eg, coronary heart disease (CHD) mortality rates for men were 72% lower in 2009 than in 1950), in 2009, Scottish CHD mortality rates for men and women were 39% and 64% higher, respectively, than the average for Western Europe. (bmj.com)
This study is the first to show that among men with no previous history of coronary artery disease, gouty arthritis is a significant independent correlate of subsequent acute MI. (natap.org)
Coronary heart disease (CHD) events, ischaemic stroke events, and total mortality. (mja.com.au)
Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland coronary prevention study. (mja.com.au)
In this paper, we describe our coronary stent (INC-1) design and development, the way that we found the specific characteristics needed for our device including biophysics aspects, design, finite element testing, manufacturing, and mechanic trials, we submitted and animal models experiences. (scielo.org.mx)
We placed the coronary stent INC-1 on a rabbit and dog models so we can evaluate efficacy and security of the device in relationship to its biomechanical properties including navigation capacity, traceability, symmetric expansion, and safety, as well as endothelial attachment, thrombogenicity, and lack of involvement of secondary branches in these models. (scielo.org.mx)
Worldwide, 5.4 million new cases of cardiovascular diseases are diagnosed, most of them related to coronary artery atherosclerosis, and cause more than half a million deaths annually and an economic expenditure of billions of dollars 1 . (scielo.org.mx)
The role of coronary stents in the treatment of ischemic heart disease, both in its acute and chronic behavior, is now well established, and it is currently the most common modality for the performance of coronary artery bypass graft 3 , 4 . (scielo.org.mx)
Ischemic heart disease (or Coronary Artery Disease) is the most common cause of death in various countries, characterized by reduced blood supply to the heart. (ehu.eus)
During myocardial ischemia (lack of blood flow to the muscle tissue of the heart, commonly referred to as a "heart attack"), blood flow is interrupted because of damage to one or more of the coronary blood vessels that irrigate the heart. (prohealth.com)
It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)
Figure 2 illus- coronary heart disease and ischaemic trates the burden of these risk factors as stroke. (who.int)
High CAC scores are associated with a markedly increased risk of coronary heart disease (CHD) (4- to 10-fold higher) independent of other risk factors, and CAC has been shown to improve clinical reclassification of CHD and ASCVD risk. (medscape.com)
They evaluated 3281 subjects with paired scans performed over a larger interscan interval, 5.1 years, and with 7.8 years of follow-up after the second scan, resulting in 85 hard coronary, 161 hard cardiovascular, and 241 total cardiovascular events inclusive of revascularization. (medscape.com)

In addition, several studies have demonstrated the beneficial effects of empagliflozin on myocardial infarction (MI) in diabetic animal models 10 , 11 , prompting us to investigate the real-time ATP change in cardiac energy production in an ischemic-reperfusion model of MI. (nature.com)
The researchers focused on specific cardiovascular disease diagnoses: myocardial infarction (heart attack), chronic heart failure, stroke, and ischemic heart disease. (nyu.edu)
Cardioprotective effects of Hmox1 were demonstrated in experimental models of myocardial infarction (MI). (springer.com)
Clinically, beneficial effects of GLP-1 have also been demonstrated in patients with myocardial ischemia and heart failure. (biomedcentral.com)
While the heart is capable of utilizing a variety of available substrates to generate adenosine triphosphate, this metabolic flexibility is compromised under circumstances in which the heart is stressed, particularly by myocardial ischemia. (biomedcentral.com)
In the ischemic myocardium, an increase in glucose uptake and subsequent ATP generated through glycolysis helps to sustain myocardial electric and mechanical performance, maintains cellular ultrastructure, promotes myocardial recovery. (biomedcentral.com)
Heart failure and myocardial infarction are insulin-resistant states that are associated with a significant risk for either concurrently having or subsequently developing newly-onset diabetes [ 3 ]. (biomedcentral.com)
The injured myocardium develops an evolving dependence on glucose as its preferred metabolic substrate while development of myocardial insulin resistance is associated with the progression of heart failure and increased incidence as well as severity of the damaged hearts. (biomedcentral.com)
Most myocardial infarctions, commonly known as heart attacks, happen in people once they get older, and aging makes it more difficult to recover from this type of injury. (prohealth.com)
The authors carried out tests on an animal model to investigate the individual and combined effects of melatonin and NMN on myocardial function, mitochondrial activity, and oxidative stress status following ischemia/reperfusion injury in aged rat hearts. (prohealth.com)
Unchecked, this constant change can lead to advancement and disruption, culminating in ischemic heart disease and myocardial infarction. (medscape.com)

With the increase in aging and cardiovascular risk factors, the morbidity and mortality of atherosclerotic cardiovascular disease (ASCVD), represented by ischemic heart disease and stroke, continue to rise in China. (biomedcentral.com)
Atherosclerotic cardiovascular disease (ASCVD), which mostly involves heart attacks and strokes caused by atherosclerosis, is one of the main causes of death worldwide [ 1 ]. (biomedcentral.com)
These properties also offer the allure of quantifying change in atherosclerosis to better pinpoint and personalize atherosclerotic cardiovascular disease (ASCVD) risk estimates. (medscape.com)

Main outcome measures Primary outcome measures, identified from registry data, were time to death from all causes (n=11 944) and cause specific cardiovascular disease (n=3862), ischaemic heart disease (n=1932), and stroke (n=1100). (bmj.com)
Compared with intakes between 600 and 1000 mg/day, intakes above 1400 mg/day were associated with higher death rates from all causes (hazard ratio 1.40, 95% confidence interval 1.17 to 1.67), cardiovascular disease (1 49, 1.09 to 2.02), and ischaemic heart disease (2.14, 1.48 to 3.09) but not from stroke (0.73, 0.33 to 1.65). (bmj.com)
Conclusion High intakes of calcium in women are associated with higher death rates from all causes and cardiovascular disease but not from stroke. (bmj.com)
6 7 Worryingly, three recent reanalyses of randomised trials in women have indicated a higher risk of both ischemic heart disease and stroke with calcium supplements, 8 9 10 a pattern not observed in a reanalysis of another randomised trial. (bmj.com)
Crude CHD, ischaemic stroke, and total mortality rates were higher in the presence of MetS in men and women. (mja.com.au)
In proportional hazards models that included conventional risk factors, but excluded variables used to define the presence of MetS, MetS was a significant predictor of CHD, stroke and total mortality. (mja.com.au)
The effects of BP-lowering treatment on a composite endpoint of major cardiovascular events (stroke, ischaemic heart disease or heart failure) according to AF status at baseline were estimated using fixed-effect one-stage IPD meta-analyses based on Cox proportional hazards models stratified by trial. (ox.ac.uk)

Centers for Disease Control and Prevention. (cdc.gov)

Design A state transition model was developed using the Scottish Heart Health Extended Cohort (SHHEC) linked to Scottish morbidity and death records. (bmj.com)
Cardiovascular morbidity and mortality associated with the metabolic syndrome. (mja.com.au)
Among the individuals aged 60 and over, NCDs account for more than 87% of the disease burden, with an higher age-related occurrence of chronic diseases, disabilities, morbidity and mortality [ 4-7 ]. (iospress.com)

BACKGROUND: Left ventricular hypertrophy is a common finding in patients with ischemic heart disease and is associated with mortality in patients with cardiovascular disease (CVD). (bvsalud.org)
Metformin, an antidiabetic drug, has been shown to reduce oxidative stress and left ventricular mass index (LVMI) in animal hypertrophy models. (bvsalud.org)

However, a new study by NYU College of Global Public Health and the University of Michigan finds that this 'obesity paradox' is not present among people with new cases of cardiovascular disease. (nyu.edu)

Conclusions Our model can be used to estimate the impact of primary prevention interventions on life expectancy and can assess the impact of interventions on inequalities. (bmj.com)
For better prevention and intervention, relevant guidelines recommend using predictive models for early detection of ASCVD high-risk groups. (biomedcentral.com)
The Multiple Risk Factor Intervention Trial (MRFIT), a randomized primary cardiovascular prevention trial conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with the MRFIT investigators, is one such study with the information on traditional and other confounding risk factors that has been unaccounted for in previous studies. (natap.org)
Pharmacological BP lowering for prevention of cardiovascular events should be recommended in patients with AF. (ox.ac.uk)
This report is submitted in response to Health Assembly resolution WHA69.6 (2016) and provides an update on the preparation for the third High-level Meeting of the General Assembly on the Prevention and Control of Non-communicable Diseases, to be held in 2018, including the responses to specific assignments given to the Secretariat. (who.int)
Development Goals (by 2030, reduce by one third premature mortality from noncommunicable diseases through prevention and treatment and promote mental health and well-being). (who.int)

The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than (or along with) restoration of normal function. (wikipedia.org)
Objective To examine the impact of systemic inflammation and serum lipids on cardiovascular disease (CVD) in rheumatoid arthritis (RA). (bmj.com)
Cox models were used to examine the association of lipids and inflammation with the risk of CVD and mortality, adjusting for age, sex and year of RA incidence. (bmj.com)
5 , - , 7 However, the association between lipids and cardiovascular risk in RA appears to be more complex than in the general population, with systemic inflammation being a notable contributor to the lipid profile changes. (bmj.com)
11 13 , - , 15 The implications of these changes on cardiovascular risk are unclear, and the relative impact of systemic autoimmune inflammation and dyslipidaemia on cardiovascular risk in RA is not fully understood. (bmj.com)
Nevertheless, its importance in timely resolution of post-ischemic inflammation remains incompletely understood. (springer.com)

Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
Empagliflozin also enhanced cardiac robustness by maintaining intracellular ATP levels and the recovery capacity in the infarcted area during ischemic-reperfusion. (nature.com)
Changes in cardiac energy production play a critical role in the pathophysiology of heart failure. (nature.com)
In the present study, we crossed cytoATP-Tg or mitoATP-Tg mice with a mouse model of T2D and assessed the effects of empagliflozin on the cardiac energy status of those mice. (nature.com)
The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
However, mitigation strategies to preserve cardiac function after an ischemic event have often only focused on individual therapeutic agents, and the results have not been ideal. (prohealth.com)
For the study, the researchers performed tests to measure the condition of cardiac tissue before and after an ischemic event and after perfusion was re-established. (prohealth.com)

Therefore, this study aims to establish a population ASCVD prediction model in rural areas of Xinjiang using survival analysis. (biomedcentral.com)
Traditional ASCVD prediction models (Framingham and China-PAR models) were constructed in the test set. (biomedcentral.com)
Different models' discrimination and calibration degrees were compared to find the optimal prediction model for this population according to different genders and further analyze the risk factors of ASCVD. (biomedcentral.com)
By comparing the discrimination and calibration degrees of each model, the RSF showed the best prediction performance in males and females (male: Area Under Curve (AUC) 0.791 (95%CI 0.767,0.813), C statistic 0.780 (95%CI 0.730,0.829), Brier Score (BS):0.060, female: AUC 0.759 (95%CI 0.734,0.783) C statistic was 0.737 (95%CI 0.702,0.771), BS:0.110). (biomedcentral.com)
The performance of the ASCVD prediction model based on the RSF algorithm is better than that based on Cox regression, Lasso-Cox, and the traditional ASCVD prediction model in the rural population of Xinjiang. (biomedcentral.com)
Currently, the most commonly used survival analysis method is the Cox proportional hazards model, and most traditional ASCVD prediction models are constructed based on this model. (biomedcentral.com)
Does a diagnosis of the metabolic syndrome provide additional prediction of cardiovascular disease and total mortality in the elderly? (mja.com.au)
To assess whether a diagnosis of the metabolic syndrome (MetS) improves the prediction of cardiovascular disease or total mortality beyond that already provided by conventional risk factors. (mja.com.au)
Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. (mja.com.au)
To generate a prediction model of diabetic retinopathy (DR) severity stages based on retinal neurodegeneration and capillary nonperfusion area (NPA) detected using optical coherence tomography (OCT) and OCT angiography (OCTA). (mdfoundation.com.au)
[ 4 ] There has been growing interest in exploring whether repeat CAC scanning, thereby evaluating change in the CAC score, could enhance cardiovascular risk prediction. (medscape.com)

In the EMPA-REG OUTCOME trial, a large randomized controlled clinical trial, the highly selective SGLT2 inhibitor empagliflozin significantly reduced the risk of three-point major adverse CV events, cardiovascular death, heart failure hospitalization and composite renal outcomes in patients with type 2 diabetes (T2D) with established cardiovascular disease 2 . (nature.com)
Sensitivity analyses under recessive and additive models for the two outcomes with adequate data (major adverse cardiovascular events and stent thrombosis) produced results in the same direction but with larger effect sizes than the dominant model. (ahrq.gov)
Furthermore, to assess whether the associations between the intensity of BP reduction and cardiovascular outcomes are similar in those with and without AF at baseline, we used a meta-regression. (ox.ac.uk)
Although various measures of CAC progression were independently associated with outcomes, none of the 10 CAC progression algorithms demonstrated an improvement in the C statistic or net reclassification of risk for hard CHD or hard ASCVD compared with models including risk factors and baseline CAC score. (medscape.com)
3 The assessment will be based on the outcomes of the WHO's global noncommunicable disease country capacity survey, which will be conducted during the first half of 2017. (who.int)

Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. (nature.com)
Background Randomised evidence on the efficacy of blood pressure (BP)-lowering treatment to reduce cardiovascular risk in patients with atrial fibrillation (AF) is limited. (ox.ac.uk)

Reperfusion of ischemic tissues is often associated with microvascular injury, particularly due to increased permeability of capillaries and arterioles that lead to an increase of diffusion and fluid filtration across the tissues. (wikipedia.org)
What Happens During a Heart Attack and Reperfusion Injury? (prohealth.com)
Reperfusion injury increases the damage done after events such as heart attacks. (prohealth.com)
In many cases, damage to heart tissue by reperfusion injury is greater than the damage done by the interruption of blood flow. (prohealth.com)

The relationship between increased short-term mortality rates after invasive pneumococcal disease (IPD) has been frequently studied. (cdc.gov)
However, studies on long-term mortality rates after IPD have been largely deficient, despite IPD being a reportable disease in Canada since 2000 ( 9 ). (cdc.gov)

The Global Burden of Disease Study 1 estimated that in 2010 cardiovascular disease (CVD), including rheumatic heart diseases, hypertensive diseases, ischaemic heart diseases, pulmonary heart disease, other forms of heart disease, cerebrovascular diseases (CBVDs), diseases of arteries and diseases of veins, was the cause of death in approximately 30% of all global deaths. (bmj.com)

The Whitehall cohort study and the London cohort of the WHO multinational study of vascular disease in diabetes. (bmj.com)
Towards renewed health economic simulation of type 2 diabetes: risk equations for first and second cardiovascular events from Swedish register data. (lu.se)
This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
Cardiovascular diseases (CVDs) account for most NCDs deaths (17.7 million people annually), followed by cancers (8.8 million), respiratory diseases (3.9 million) and diabetes (1.6 million) [ 1 ]. (iospress.com)
Several systemic diseases, such as diabetes mellitus, may increase the prevalence, incidence, or severity of gingivitis and periodontitis. (medscape.com)
Overweight and obesity can lead to metabolic changes and raise the risk of NCDs, including heart disease and type 2 diabetes. (who.int)
Over three quarters of those deaths were caused by cardiovascular disease, cancer, diabetes and chronic respiratory disease. (who.int)

A significant proportion of diabetic patients are known to develop diabetic cardiomyopathy, with a high incidence of congestive heart failure. (biomedcentral.com)
Although many therapeutic agents such as β-blockers and angiotensin-converting enzyme inhibitors are currently used to control cardiovascular diseases (CVD), there remains a substantially high incidence of CVD among diabetic patients, necessitating alternative strategies of targeted management [ 2 ]. (biomedcentral.com)

Gouty arthritis is associated with an excess risk of acute MI, and this is not explained by its well-known links with renal function, metabolic syndrome, diuretic use, and traditional cardiovascular risk factors. (natap.org)
These specific conditions in the oral cavity may create foci of infection that can affect many other vital systems, such as the cardiovascular and renal systems. (medscape.com)

An adverse lipid profile or dyslipidaemia is an important risk factor for cardiovascular disease (CVD) in the general population. (bmj.com)
If people categorized as normal weight have lost weight because of more severe disease, researchers will underestimate the adverse effects of being obese relative to normal weight. (nyu.edu)
Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
Smoking, which has an adverse effect on periodontal health, also affects this overall disease condition. (medscape.com)

Methods In a population-based RA incident cohort (1987 American College of Rheumatology criteria first met between 1988 and 2007), details were collected of serum lipid measures, erythrocyte sedimentation rates (ESRs), C-reactive protein (CRP) measures and cardiovascular events, including ischaemic heart disease and heart failure. (bmj.com)
We discuss implications of this model, including the potential utility of SSRIs as antihypertensives in this cohort. (psychiatrictimes.com)

In the Whitehall study, the prevalence of heart disease was higher in the lowest social group compared with the highest group, by 6% among non-diabetic people (P=0.0001) and by 14% among diabetic subjects (P=0.02). (bmj.com)
In the Whitehall study this gradient was similar in both diabetic and non-diabetic subjects, and it persisted for mortality from cardiovascular disease and from ischaemic heart disease. (bmj.com)
We confirm the existence of an inverse socioeconomic mortality gradient in diabetic people and suggest that this is largely due to conventional cardiovascular risk factors. (bmj.com)
Metabolic syndrome: connecting and reconciling cardiovascular and diabetic worlds. (mja.com.au)

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. (mja.com.au)
The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. (mja.com.au)
Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. (mja.com.au)
The continuous requirement for high-energy phosphates to perform mechanical work burdens the heart as metabolic requirements not shared by other organ system. (biomedcentral.com)

At the beginning of this century, the World Health Organization (WHO) found that the so-called non-communicable diseases (NCDs), also known as chronic diseases, are responsible for the death of forty million people every year, equivalent to 70% of all deaths globally. (iospress.com)
Globally, premature mortality from these four main noncommunicable diseases declined by 15% between 2000 and 2012. (who.int)

A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)

En esta publicación se describen el diseño y el desarrollo de un stent coronario (INC-1), la forma en que se determinaron las características biofísicas deseadas, el diseño y las pruebas computacionales por elemento finito, su fabricación, así como las pruebas mecánicas a las que se sometió el prototipo y por último las primeras experiencias en modelos animales. (scielo.org.mx)

During events such as heart attacks or strokes, blood flow is interrupted and the tissue that is affected by this lack of blood becomes injured. (prohealth.com)
Scientists have studied the events that occur after a heart attack to search for ways to enhance the recovery process of the damaged tissues. (prohealth.com)
Over 4.5 years of median follow-up, a 5-mm Hg systolic BP (SBP) reduction lowered the risk of major cardiovascular events both in patients with AF (hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.83 to 1.00) and in patients without AF at baseline (HR 0.91, 95% CI 0.88 to 0.93), with no difference between subgroups. (ox.ac.uk)
Conclusions In this meta-analysis, we found that BP-lowering treatment reduces the risk of major cardiovascular events similarly in individuals with and without AF. (ox.ac.uk)
See the question and answer document available at http://www.who.int/nmh/events/2015/technical-note-qa-en.pdf?ua=1 (accessed 10 October 2016). (who.int)
1 Availab le at http://www.who.int/nmh/events/2015/technical-note-en.pdf?ua=1 (accessed 10 October 2016). (who.int)
3 See http://www.who.int/nmh/events/2015/bloomberg-data-for-health/en/ (accessed 10 October 2016). (who.int)

SUMMARY Noncommunicable diseases (NCDs) are a major disease burden in the Region. (who.int)

The qAF approach could serve as a method of early differential diagnosis and may help to identify appropriate disease targets as therapeutics become available to treat inherited retinal disease. (mdfoundation.com.au)
A new study published in the Journal of Cardiovascular Pharmacology and Therapeutics shows the benefits of using this combined-therapy approach (5). (prohealth.com)

Periodontal disease permits organisms to enter deep systemic tissues, such as the carotid atheroma. (medscape.com)

The majority of studies were conducted in populations with ischemic heart disease. (ahrq.gov)

We used Cox proportional hazards modeling, and the primary outcome was time to all-cause deaths. (cdc.gov)

Find out how these and other findings confirm berry polyphenols' unrivalled capacity to blunt free radical damage and thwart degenerative disease. (lifeextension.com)
Most prior work examines people with more longstanding disease, where disease-related factors can bias findings towards the observation of a paradox. (nyu.edu)
Among those with prevalent disease, the researchers observed a strong and significant obesity paradox, replicating earlier findings. (nyu.edu)

This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach. (biomedcentral.com)

Taking a competing risk approach, the cause-specific hazards of a first event are modelled using parametric survival analysis. (bmj.com)

Meta-regression analysis was used to assess the association of heart failure (HF), metformin dose, and duration with the SMCC. (bvsalud.org)
These cardioprotective effects may be involved in the beneficial effects on heart failure seen in clinical trials. (nature.com)

Hyperuricemia was an independent risk factor for acute MI in the multivariable regression models, with an odds ratio (OR) of 1.11 (95% confidence interval [95% CI] 1.08-1.15, P (natap.org)

We have shown a change in serotypes and associated potential increases in severity of disease among IPD patients in Alberta, Canada ( 13 ). (cdc.gov)
3 4 The evidence for an excess cardiovascular risk in patients with rheumatoid arthritis (RA) is convincing. (bmj.com)

A study published by Hosseini and colleagues brings us a step closer to addressing this detrimental disease by testing a pair of compounds that may have protective effects against heart damage in older people. (prohealth.com)

Survival following a first non-fatal event is also modelled parametrically. (bmj.com)
A Cox regression, Lasso-Cox regression, and random survival forest (RSF) model were established in the training set. (biomedcentral.com)
Although obesity is a well-known risk factor for getting cardiovascular disease, a controversial body of research suggests that obesity may actually be associated with improved survival among people who have cardiovascular disease. (nyu.edu)
Given that many diseases result in wasting at the end of life, the notion that extra catabolic reserve can prolong survival makes intuitive sense. (nyu.edu)

However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)

Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)

Moreover, the simultaneous usage of different types of drugs for the treatment of various chronic diseases makes the patient health status even weaker [ 4 ]. (iospress.com)

The Framingham risk score is a robust algorithm to predict cardiovascular disease (CVD) risk based on demographic and clinical factors among European Americans. (cdc.gov)

In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

Objective To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease. (bmj.com)

Empagliflozin treatment significantly increased cytosolic and mitochondrial ATP levels in the hearts of db/db mice. (nature.com)
Although PROM1-macular dystrophy (Stargardt disease 4) can exhibit phenotypic overlap with recessive Stargardt disease, significantly increased SW-AF levels were not detected. (mdfoundation.com.au)
Gulf Cooperation Council, where rapid in- piratory diseases is rising significantly in creases in obesity are being recorded, pri- the Eastern Mediterranean Region. (who.int)

Two mathematical models are present: An infinite dimensional, partial differential equation (PDE), production level modeling is present and a finite dimensional system for a coupled dynamic pricing, production rate and inventory level ordinary differential equations (ODE), integrating a proper Lyapunov stability analysis of the dynamical system and simulations. (preprints.org)

An important role of this protein was also demonstrated in different experimental studies on heart damage. (springer.com)
The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. (biomedcentral.com)
Objectives: We evaluated the effects of CM-352 (MMP-fibrinolysis inhibitor) in an experimental ICH model associated with oral anticoagulants as compared with clinically used prothrombin complex concentrate (PCC). (unav.edu)

Physical inactivity, low fruit and vegetable intake, high fast food consumption and high cholesterol are predominant causes of cardiovascular disease and some cancers. (who.int)

When a local or systemic disease process or concomitant use of medications alters this overall pattern, atypical organisms begin to predominate and some normal organisms with a benign nature, such as Candida albicans, become pathogenic. (medscape.com)
Increasing evidence indicates that oral microbiota participate in various systemic diseases. (medscape.com)

Of all deaths among persons under the age of 70, commonly referred to as premature deaths, WHO estimates that 52% were due to noncommunicable diseases in 2012. (who.int)

This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)

A combination model of capillary NPA and mGCIPL thickness may be a novel biomarker for predicting DR severity. (mdfoundation.com.au)
The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)

In this study, we introduce a cardiovascular disease (CVD) policy model which can be used to model remaining life expectancy including a measure of socioeconomic deprivation as an independent risk factor for CVD. (bmj.com)
We investigated associations between long term dietary and supplemental intake of calcium with all cause mortality as well as with cardiovascular mortality in a large population based prospective study of Swedish women. (bmj.com)
In this study, the researchers examined the association between obesity and mortality among people with cardiovascular disease, comparing incident and prevalent disease cases in the same dataset. (nyu.edu)

We show in exercised mice that the expression of CITED4, a transcriptional co-regulator necessary for cardioprotection, is regionally heterogenous in the heart with preferential significant increases in the lateral wall compared with sedentary mice. (researchgate.net)
We hypothesised that long term intake of low or high calcium increases the risk of cardiovascular mortality. (bmj.com)

Anatomy21

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