Ischemic functional ischemia reperfusion. Medical search. Frequent questions

Both ischemic and reperfused rat myocardium can undergo apoptotic cell death, however the myocardium, which is subjected to ischemia followed by reperfusion, undergoes accelerated apoptosis [ 3 ]. (ac.ir)
In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)

Primary cortical neurons were subjected to glucose deprivation (GD), oxygen-glucose deprivation (OGD) or simulated ischemia-reperfusion (I/R). Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion. (scienceopen.com)
Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice. (scienceopen.com)
The purpose of this study is to establish and validate an animal model for research in the recovery and sequela stages of brain ischemia by testing brain infarction and sensorimotor function after middle cerebral artery occlusion/reperfusion (MCAO/R) after 1-90 days in rats. (jove.com)
Twelve rats were induced focal ischemic stroke by a 60 min middle cerebral artery occlusion/reperfusion surgery and then randomly divided into two group, control group (CG, n=6) and treadmill group (TG, n=6). (ijbbb.org)
Methods: Normoglycemic (n=30) and streptozocine-induced diabetic rats (n=82) were subjected to 30 minutes of sutureocclusion of the middle cerebral artery (MCAO) with 24 or 72 hours of reperfusion. (elsevierpure.com)
All the patients had occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging. (nih.gov)

Isolated ex vivo mice hearts were perfused in a constant pressure Langendorff mode, and exposed to 30min of global ischemia (GI) and 60min of reperfusion. (uib.no)
Under constant pressure perfusion, hearts were subjected to 15 min of control perfusion, 15 ("moderate injury") or 30 ("severe injury") min of global ischemia, followed by 30 min of reperfusion. (ox.ac.uk)
After an equilibration perfusion, isolated rat hearts were given 40 min of global ischemia followed by 30 min of reperfusion. (utmb.edu)
The functional recovery from 30-min global ischemia was studied in the isolated hearts perfused in-vitro. (nii.ac.jp)

Ischemic preconditioning, postconditioning, and remote conditioning trigger endogenous cardioprotective mechanisms that render the heart more resistant to lethal ischemic-reperfusion injury. (nih.gov)
Ischemia reperfusion injury and cardioprotection by conditioning have been shown to affect global myocardial gene expression profile at the transcript level. (nih.gov)
The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
This is called reperfusion injury. (justia.com)
Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. (uib.no)
Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)
In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. (mdpi.com)
The length and severity of hypo perfusion determine whether the colonic injury is predominantly ischemic or due to reperfusion. (heraldopenaccess.us)
In patient suffering an ischemic event, most of the myocardial damage incurred happens once blood flow is restored - a phenomena known as reperfusion injury. (sun.ac.za)
Mitochondrial ROS production is implicated as one of the major contributors to cell death in the reperfused heart and the importance of mitophagic processes (mitochondrial housekeeping) could be a potential therapeutic target to prevent ischemia/reperfusion injury (I/R-I). Aspalathus linearis (commonly known as rooibos) is an indigenous South African plant grown exclusively in the Western Cape fynbos region. (sun.ac.za)
Other compounds associated with MI are nitric oxide (NO) and its metabolites, which have been reported to protect the heart from ischemia/reperfusion (IR) injury and decrease MI in general [ 7 ]. (hindawi.com)
Atorvastatin has been shown to be cardioprotective in ischemia-reperfusion (I/R) injury. (ac.ir)
In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
These pleiotropic effects thus have a major role in protecting the myocardium against ischemic injury. (ac.ir)
In addition, it has been shown that atorvastatin can protect the isolated mouse heart against reperfusion-induced injury [ 6 ]. (ac.ir)
It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)
Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
Endothelin-1 increases susceptibility of isolated rat hearts to ischemia/reperfusion injury by reducing coronary flow. (ox.ac.uk)
Endothelin-1 (ET-1) is the most potent vasoconstrictor known to date, and it was proposed that this peptide plays a major role in myocardial ischemia/reperfusion injury. (ox.ac.uk)
The authors conclude that ET-1 increases the susceptibility of isolated hearts to ischemia/reperfusion injury via reduction of coronary flow. (ox.ac.uk)
In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)
Additionally, neuroprotectants could mitigate the ischemia/reperfusion injury, including edaravone and fingolimod, 3 but their clinical effects cannot achieve the desired condition, primarily due to the rigid blood-brain barrier (BBB) that limits drug delivery to the ischemic regions. (cbinsights.com)
4 On the other hand, a large number of neurons cause irreversible degeneration and necrosis in ischemic regions, which results from ischemia/reperfusion injury. (cbinsights.com)
The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model. (scienceopen.com)
Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. (kyobobook.co.kr)
Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. (kyobobook.co.kr)
In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)
Moreover, preliminary data identified a novel inhibitory effect of PKG on tubular cell necrosis and apoptosis following renal ischemia reperfusion (IR) induced acute kidney injury in young mice and an inhibitory effect of PKG on macrophage migration, suggesting a therapeutic potential of PKG for renal IR injury. (uky.edu)
We will determine whether genetically or pharmacologically increased PKG activity reduces the susceptibility of old animals to ischemia mediated acute kidney injury in Aim 1. (uky.edu)
We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
We hypothesized that overexpression of calpastatin, an endogenous calpain inhibitor, would attenuate the ischemia/reperfusion injury in the heart. (nii.ac.jp)
Adenovirus-mediated overexpression of calpastatin could be a novel biological storage to improve heart transplantation by minimizing ischemia/reperfusion injury. (nii.ac.jp)
dependent cytosolic cystein protease, is as an important key protease involved in the ischemic reperfusion injury such as cardiac stunning. (nii.ac.jp)
Time to rethink comorbidities in the reperfusion-injury phenomenon? (escardio.org)
This intervention limits neurologic injury associated with brain ischemia during a cardiac arrest and reperfusion injury associated with resuscitation. (medscape.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
In contrast, functional consequences of injury to the thalamus are poorly understood but may be crucially important. (cdc.gov)

[ 11 ] Updated acute stroke guidelines now also recommend mechanical thrombectomy in selected patients with acute ischemic stroke within 6-16 hours of last known normal who have large vessel occlusion in the anterior circulation and meet other DAWN or DEFUSE 3 eligibility critieria and list mechanical thrombectomy as reasonable in selected patients known to be well 6-24 hours earlier. (medscape.com)
A cerebroprotectant (formerly known as a neuroprotectant) is a drug that is intended to protect the brain after the onset of acute ischemic stroke. (wikipedia.org)
It is also much lower than the relatively high success rate for devices to treat acute ischemic stroke, as there have been at least 5 different clot removal devices approved since 2015. (wikipedia.org)
70% of patients have ischemic stroke and the recurrence rate is as high as 17.7% ( 1 , 2 ). (spandidos-publications.com)
When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
Zhang G, Li Q, Tao W, Qin P, Chen J, Yang H, Chen J, Liu H, Dai Q, Zhen X. Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke. (thno.org)
It is known that alteration of the Sigma-1 receptor (Sig-1R) is involved in the pathological development of some neurological diseases, including ischemic stroke. (thno.org)
Our data provide the first evidence of the pivotal role of Sig-1R in macrophage/microglia-mediated efferocytosis and elucidate a novel mechanism for the neuroprotection of Sig-1R in ischemic stroke. (thno.org)
Ischemic stroke is a devastating disease, and effective therapeutics against its neurological consequences remain a challenge [ 1 ]. (thno.org)
Accumulating evidence indicates that immune cells, especially brain-resident microglia and infiltrated circulating macrophages, are intimately involved in the pathological development of ischemic stroke [ 2 , 3 ]. (thno.org)
Conclusion: The ginsenoside Rg1 nanoparticles may be an available blood-brain barrier penetrating agent for ischemic stroke. (cbinsights.com)
According to its etiology, a stroke can be divided into ischemic and hemorrhagic types, of which ischemic stroke accounts for about 60%-80% of stroke patients. (cbinsights.com)
1 Ischemic stroke represents the common form of cerebrovascular disease. (cbinsights.com)
Ischemic stroke leads to significant morbidity and mortality in the Western world. (scienceopen.com)
Abstract -Treadmill exercise has been a controversial method to help stroke rat with functional recovery and neuroprotection. (ijbbb.org)
In this study, we investigated the effect of treadmill exercise on focal brain ischemia stroke rat in subacute phase. (ijbbb.org)
Results illustrated that post-stroke treadmill exercise can facilitate the functional recovery and provide neuroprotection in focal ischemic stroke rat in the subacute phase. (ijbbb.org)
Trials of endovascular therapy for ischemic stroke have produced variable results. (nih.gov)
We randomly assigned patients with ischemic stroke who were receiving 0.9 mg of alteplase per kilogram of body weight less than 4.5 hours after the onset of ischemic stroke either to undergo endovascular thrombectomy with the Solitaire FR (Flow Restoration) stent retriever or to continue receiving alteplase alone. (nih.gov)
The coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (≥8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). (nih.gov)
In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome. (nih.gov)
Not only can both produce symptoms that mimic ischemic stroke, but they can also aggravate ongoing neuronal ischemia. (medscape.com)
In patients with transient ischemic attacks (TIAs), failure to recognize the potential for near- term stroke, failure to perform a timely assessment for stroke risk factors, and failure to initiate primary and secondary stroke prevention exposes the patient to undue risk of stroke and exposes clinicians to potential litigation. (medscape.com)
Current treatments for acute ischemic stroke include IV thrombolytic therapy with tissue-type plasminogen activator ( t-PA ) and endovascular therapies using stent retriever devices. (medscape.com)
[ 5 ] . A 2015 update of the American Heart Association/American Stroke Association guidelines for the early management of patients with acute ischemic stroke recommends that patients eligible for intravenous t-PA should receive intravenous t-PA even if endovascular treatments are being considered and that patients should receive endovascular therapy with a stent retriever if they meet criteria. (medscape.com)

Thirty Wistar rats were selected and divided into three groups (n = 10): acute ischemia-reperfusion (I/R) group, acute ischemia-reperfusion and treated with atorvastatin group and sham-operated group. (ac.ir)
Pretreating the rats with simvastatin 18 hour prior to the induction of ischemiareperfusion has been shown to reduce cardiac dysfunction and improve coronary flow [ 7 ]. (ac.ir)
Daily functional test results were recorded and all rats were sacrificed for TTC staining on the 7th day. (ijbbb.org)
The aim of present study was to investigate the neuroprotective effect of agmatine (AGM) on cerebral ischemic damage in diabetic rats. (elsevierpure.com)
Results: AGM posttreatment improved the neurobehavioral activity of diabetic MCAO rats at 24 and 72 hours after reperfusion. (elsevierpure.com)
It has been established that a decrease of the density of endothelial location in an early ischemic-reperfusion period in the control rats has a relative characterstipulated by edema of cells whereas on the 12-th day of observation an increase of the absolute density of cells takes place. (kiev.ua)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

Acute ischemic strokes start when there is reduced blood flow, often caused by an occlusion, to part of the brain. (wikipedia.org)

Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)
Apoptosis of the cardiomyocytes has been demonstrated in animal models with coronary artery occlusion [ 1 ], and experimental evidence suggests that myocardial cells are able to undergo apoptosis during ischemia followed by reperfusion [ 2 ]. (ac.ir)
As a molecular chaperone, HSP90 regulates the conformational maturation and functional stability of many signaling proteins in cells, serves important roles in cell growth, differentiation, apoptosis and tumor development and is an important antitumor target ( 8 , 9 ). (spandidos-publications.com)
At an early stage, blocking nutrition and oxygen supply in response to brain ischemia activates various cell death processes, including apoptosis, autophagy and necrosis [ 4 ]. (thno.org)
Ischaemia and reperfusion trigger cardiomyocyte death by necrosis and apoptosis. (mmu.ac.uk)

These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
Excessive neuroinflammation further promotes neuronal and glial cell damage and impairs brain repair and functional recovery. (thno.org)
Western blot and immunohistochemical analysis were performed to determine the expression of neuronal nitric oxide synthase (NOS) and inducible NOS in ischemic brain tissues. (elsevierpure.com)

It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)

Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of novel drug targets for cardioprotection is of great importance. (nih.gov)
The results imply that the cardioprotection of ischemic preconditioning cannot be explained solely by myocardial glycogen depletion. (utmb.edu)
Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. (kyobobook.co.kr)

Treatment with troglitazone or -tocopherol, but not rosiglitazone, reduced manifestation of cytokine mRNA and cytokine protein in ischemic-reperfused myocardium compared with the ischemic-reperfused myocardium from untreated pigs. (tam-receptor.com)
CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)

However, major cardiovascular co-morbidities such as hyperlipidemia, diabetes, and their co-medications interfere with these cardioprotective mechanisms thereby limiting the efficacy of cardioprotective ischemic conditioning maneuvers. (nih.gov)
Asimakis, GK 1996, ' Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart ', Journal of Molecular and Cellular Cardiology , vol. 28, no. 3, pp. 563-570. (utmb.edu)

Endpoints were infarct size and functional recovery. (uib.no)
Adoptive transfer of Sig-1R intact bone marrow-derived macrophages (BMDMs) to Sig-1R knockout mice restored the clearance activity of dead/dying neurons, reduced infarct area and neuroinflammation, and improved long-term functional recovery after cerebral ischemia. (thno.org)
Although intralipid inhibits the opening of the mitochondrial permeability transition pore as efficiently as cyclosporine-A, intralipid is more effective in reducing the infarct size and improving the cardiac functional recovery. (silverchair.com)

The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
In a retrospective study, the relationships between the time of day the animals were sacrificed, pre-ischemic myocardial glycogen content, and post-ischemic functional recovery were assessed in non-conditioned and ischemically preconditioned hearts. (utmb.edu)
However, time of day did not correlate significantly with post-ischemic recovery of heart rate x developed pressure (HR x DP) or end-diastolic pressure (EDP) in either the non-conditioned or preconditioned hearts. (utmb.edu)
However, there were no significant differences between p.m. (n = 13) and a.m. (n = 9) non-conditioned hearts with respect to post-ischemic recovery of HR x DP (20.6 ± 4 v 12.0 ± 4% of baseline, respectively, P = N.S.). In contrast, preconditioned-p.m. (n = 6) and -a.m. (n = 7) had pre-ischemic glycogen contents of 49.6 ± 6 and 76.6 ± 5.0 nmol glucose/mg protein, respectively. (utmb.edu)

0.01) following a 35 min regional ischemia protocol. (sun.ac.za)
Cytokine protein content material in hearts of sham pigs (not subjected to ischemia-reperfusion) did not differ significantly from content material in nonischemic regions of hearts subjected to regional ischemia and reperfusion (data not demonstrated). (tam-receptor.com)

We also identified NLRP1 and NLRP3 inflammasome inhibition as a novel mechanism by which IVIg can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that target inflammasome assembly and activity. (scienceopen.com)
Finally, addition of exogenous recombinant Wisp1 partially rescued myofibroblast-induced collagen gel contraction following HuR inhibition, demonstrating that HuR-dependent Wisp1 expression plays a functional role in HuR-dependent MF activity downstream of TGFβ. (harvard.edu)

These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
This age-dependent increase in susceptibility to AKI is linked to a decreased renal functional recovery and even progression to advanced chronic kidney disease, a severe health problem worldwide. (uky.edu)
Preliminary studies demonstrated that nitric oxide (NO) and its downstream signaling pathway cGMP and cGMP-dependent protein kinase (PKG) was down-regulated in aging kidney, which was associated with aging-related renal functional changes. (uky.edu)

A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)

Ischemic colitis (IC), the most common type of gastrointestinal ischemia, results from either severely decreased colonic perfusion or subsequent reperfusion damage [1]. (heraldopenaccess.us)
Ischemic colitis manifests in two main ways: gangrenous (transmural colonic necrosis), which typically requires surgery and has poor prognoses, and transient (reversible lesions of hypo perfusion to mucosa or submucosa), which has fewer problems and typically responds well to medical treatment. (heraldopenaccess.us)
Additionally, resolving the distribution patterns of perfusion is crucial for gaining a full understanding of the long-term impacts of cardiovascular diseases that can lead to adverse remodelling, such as myocardial ischemia and heart failure. (cupidoproject.eu)
Finally, we demonstrate how the method is used to visualise perfusion patterns of a healthy and ischemic human left ventricle geometry. (cupidoproject.eu)

The mechanism of ischemic preconditioning remains unknown. (utmb.edu)
The role of glycogen depletion prior to prolonged ischemia was examined as a potential mechanism of ischemic preconditioning. (utmb.edu)

In both cardiac surgical and cardiological settings, clinical interventions used to reperfuse the ischemic heart are associated with myocardial damage that is likely to influence long-term functional recovery. (mmu.ac.uk)

Ginsenoside Rg1 composite nanoparticles were employed to induce the expression of several key epigenetic enzymes and then activate the VEGF and Notch pathways after the onset of ischemic brain lesions. (cbinsights.com)

HSP90β expression coincided with astrocyte markers in the ischemic penumbra area, while no expression was observed in microglia. (spandidos-publications.com)
Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx. (scienceopen.com)
Our findings shed light on the overlapping and distinct functional complexity and diversity of myeloid cells of the CNS and provide new insight into repopulating microglia function and dynamics in the mouse brain. (stanford.edu)

Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

Ischemic heart disease including myocardial infarction develops on the basis of several risk-factors and comorbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. (nih.gov)

For this reason, it is prudent to closely monitor for signs of bowel ischemia and infection in patients who undergo embolization to control lower GI bleeding. (pearls4peers.com)

ET-1 could increase myocardial susceptibility to ischemia by two mechanisms: via coronary flow reduction and/or via direct, metabolic effects on the heart. (ox.ac.uk)
In this proposal, we will test the hypothesis that down-regulation of NO/cGMP/PKG signaling in the kidney contributes to increased susceptibility of older individuals to ischemia reperfusion mediated AKI. (uky.edu)

This study uses an established animal model to research the recovery and the sequelae stages of brain ischemia. (jove.com)

Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)

We have studied the influence of bilateral carotid ischemia-reperfusion on the indices of the functional and morphological condition of the vascular endothelium of the brain hypothalamolimbic complex. (kiev.ua)

Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)

In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)

Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. (scienceopen.com)

Ischemia-like conditions increased the levels of NLRP1 and NLRP3 inflammasome proteins, and IL-1 β and IL-18, in primary cortical neurons. (scienceopen.com)

Regarding cardiac and mitochondrial signaling, prior to ischemia HCD heart had a decreased dependence on insulin-dependent AMPK and increased inflammation via upregulated p38, whereas GRT treatment presented with decreased insulindependent PKB and AS160 signaling (together with increased FA OxPhos compared to carbohydrates, however showed more mitochondrial uncoupling, decreasing basal metabolic rate and thereby potentially less ROS production), inhibited GSK3β and conferred an anti-inflammatory effect by significantly reducing p38 activation. (sun.ac.za)
Background: Diabetes mellitus is a metabolic disorder associated with structural and functional alterations of various organ systems including the central nervous system. (elsevierpure.com)

One case report described signs of infection (including fever, abdominal tenderness and leukocytosis) 2 days after arterial embolization in a patient who was treated conservatively (3), while another described "sepsis" 6 days post procedure with bowel wall ischemia requiring surgical resection (1). (pearls4peers.com)

In some cases, ischemia of the bowel appears to be mild enough to be treated conservatively, while in other cases bowel infarction with surgical intervention has been necessary (1). (pearls4peers.com)
For non-ST-segment-elevation myocardial infarction, reperfusion is via percutaneous intervention or coronary artery bypass graft surgery. (msdmanuals.com)

In the control period, ET-1 reduced coronary flow, ventricular function, phosphocreatine and intracellular pH dose-dependently: during ischemia/reperfusion, coronary flow, functional recovery and high-energy phosphate metabolism were adversely affected by ET-1 in a dose-related manner. (ox.ac.uk)
To study effects of ET-1 not related to coronary flow reduction, additional hearts were perfused under constant flow conditions (ET-1 0 or 400 pmol) during 15 min of control, 15 min of ischemia and 30 min of reperfusion. (ox.ac.uk)
When coronary flow was held constant, functional and energetic parameters were similar for untreated and ET-1 treated hearts during the entire protocol, i.e. the adverse effects of ET-1 on function and energy metabolism during ischemia/reperfusion were completely abolished. (ox.ac.uk)

Ischemic colitis (IC) occurs when blood flow to part of the colon is temporarily reduced. (heraldopenaccess.us)

Preconditioned hearts received 5 min of ischemia followed by a 5-min recovery period prior to the 40-min ischemic period. (utmb.edu)
The recovery of left ventricular developed pressure, max dP/dt, and min dP/dt during 60-min reperfusion was significantly greater in the calpastatin transfected group than control group heart by gene transfer. (nii.ac.jp)

In less severe ischemia, patients may experience bloody diarrhea that is not accompanied by abdominal pain while in more severe cases abrupt extreme abdominal pain and tenderness (often out of proportion), fever, and leukocytosis are characteristic. (heraldopenaccess.us)
Furthermore, diabetic patients are particularly at risk for developing ischemic heart disease and strokes. (sun.ac.za)

Anatomy32

Organisms15

Diseases32

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes36

Disciplines and Occupations1

Health Care2

Subjected to ischemia followed by reperfusion2

Middle cerebr6

Global ischemia4

Injury54

Stroke25

Rats7

Acute1

Apoptosis5

Neuronal3

Role in myocardial1

Cardioprotection3

Myocardium2

Cardioprotective2

Infarct3

Post ischemic4

Regional ischemia2

Inhibition2

Renal3

MCAO1

Perfusion4

Preconditioning2

Long-term functional recovery1

Onset1

Microglia3

Cardiac arrest1

Hypercholesterolemia1

Undergo1

Susceptibility2

Sequelae1

Hypoxia1

Bilateral1

Significantly higher1

Cardiovascular1

Brain1

Neurons1

Metabolic2

Bowel wall1

Intervention2

Coronary flow3

Occurs1

Recovery2

Patients2