MyocardialTransientAssigned 362 patients wiPatientsPhase of ischemicOutcomeCoronary syndromeOcclusionMortalityIntravenousStrokesCerebrovascular eventThrombolytic treatmentTreatmentOutcomesAspirinVesselFound that acutePathophysiologyPulmonaryCerebralDiagnosisRandomized controRecanalizationFindingsNeurologicAnticoagulationBlockageHeart diseaseAssessmentPlacebo-controlled trialHemorrhagicComplicationsConclusionsCardiovascularIschemiaEfficacyColitis
Myocardial3
- Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. (bmj.com)
- [ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
- Ischemic heart disease and acute myocardial infarction mortality among police officers. (cdc.gov)
Transient10
- Recent trials have evaluated the use of aspirin to prevent stroke after an ischemic stroke or transient ischemic attack (TIA). (physiciansweekly.com)
- Although a decrease in serum potassium level has been suggested to be a fairly common observation in acute coronary syndrome (ACS), there have so far been no definitive reports directly demonstrating the transient potassium decrease (the potassium dip) during ischemic attack of ACS compared to stable phase in individual patients. (biomedcentral.com)
- We have clearly demonstrated that there is a transient decrease in serum potassium level during ischemic attack of ACS compared to stable phase. (biomedcentral.com)
- Moreover, there have so far been few studies directly demonstrating the transient relative decrease in K level during ischemic attack compared to stable phase in individual patients (rather than its absolute value on admission). (biomedcentral.com)
- To see this transient K decrease, "the potassium dip," during ischemic attack, it would be necessary to evaluate the fluctuation of K level in individuals by comparing the data during an attack to those during stable phase. (biomedcentral.com)
- Transient ischemic attacks (TIAs) cause similar symptoms, but the blockage of blood flow to the brain is temporary. (cdc.gov)
- From 2001 through 2011, the rate of emergency department visits for ischemic stroke or transient ischemic attack (TIA) decreased 35% for patients aged 18 and over and 51% for patients aged 55-74. (cdc.gov)
- The risk of stroke within 90 days of a transient ischemic attack (TIA) may be as high as 17%, with the greatest risk during the first week. (cdc.gov)
- A sudden, brief episode (symptoms lasting only minutes) of ischemia affecting the brain is called a transient ischemic attack (TIA), often called a mini-stroke. (wikipedia.org)
- Acute-onset amnesia: Transient global amnesia and other causes. (msdmanuals.com)
Assigned 362 patients wi1
- We randomly assigned 362 patients with acute ischemic stroke, within 4.5 hours after onset, to endovascular therapy (intraarterial thrombolysis with recombinant tissue plasminogen activator [t-PA], mechanical clot disruption or retrieval, or a combination of these approaches) or intravenous t-PA. (nih.gov)
Patients40
- In patients with ischemic stroke, endovascular treatment results in a higher rate of recanalization of the affected cerebral artery than systemic intravenous thrombolytic therapy. (nih.gov)
- The results of this trial in patients with acute ischemic stroke indicate that endovascular therapy is not superior to standard treatment with intravenous t-PA. (nih.gov)
- The use of an advanced imaging shortly after the onset of acute stroke failed to identify a subgroup of patients who could benefit from a clot-removal procedure, a study has found. (nih.gov)
- In patients with ischemic stroke (caused by a blockage in an artery), brain cells deprived of blood die within minutes to hours. (nih.gov)
- Organized systems of care should be implemented to ensure access to the optimal management of all acute stroke patients in stroke units. (nih.gov)
- Treatment of acute ischaemic stroke includes management of patients in stroke units. (nih.gov)
- The NINDS protocol and criteria show tPA is the first line treatment within 3 hours of the onset of symptoms for patients who have acute ischemic stroke. (cpraedcourse.com)
- The AHA guidelines recommend IV tPA administration for patients with acute ischemic stroke. (cpraedcourse.com)
- The relationship between blood pressure (BP) control and short and long term outcomes in patients with acute ischemic stroke (AIS) is highly complex and not well understood with conflicting data. (scirp.org)
- Identifying errors and safety considerations in patients undergoing thrombolysis for acute ischemic stroke. (ahrq.gov)
- This study compared error rates of alteplase administration in patients presenting with acute ischemic stroke at either a regional hospital or a Comprehensive Stroke Center (CSC) and found that community hospitals had over a 10 times greater number of errors leading to hemorrhage. (ahrq.gov)
- Occurrence of no-harm incidents and adverse events in hospitalized patients with ischemic stroke or TIA: a cohort study using trigger tool methodology. (ahrq.gov)
- The aim of this study was to systematically review the use of imaging biomarkers in randomized controlled trials in patients with acute ischemic stroke, exploring the purposes for which the imaging biomarkers were used. (ajnr.org)
- Treatment options for patients with acute ischemic stroke are limited. (ajnr.org)
- This study aimed to assess the time to treatment and outcomes among acute ischemic stroke patients who received thrombolytic treatment in the Chulalongkorn Stroke Network by 1. (springer.com)
- Acute ischemic stroke patients who received thrombolytic treatment during January 2016-December 2017 in the Chulalongkorn Stroke Network were studied. (springer.com)
- Despite the increasing number of patients receiving thrombolytic treatment, this figure is relatively low compared to the number of all ischemic stroke patients. (springer.com)
- There are no randomized clinical trials available on this specific group of non-ST elevation acute coronary syndrome patients not pretreated for the timing of the invasive strategy," he said. (the-hospitalist.org)
- Early treatment remains the cornerstone of acute stroke therapy and it is of paramount importance that patients arriving in stroke units who are eligible for thrombolysis should be treated without delay. (science20.com)
- This is a randomized, placebo-controlled, double-blind trial, including a total of 11,106 patients who had a mild-moderate acute ischemic stroke or TIA. (physiciansweekly.com)
- Ischemic stroke occurred in 345 (6.3%) patients in the aspirin group and 276 (5.0%) patients in the ticagrelor-aspirin. (physiciansweekly.com)
- The research concluded that the risk of stroke or death in ischemic stroke or TIA patients was lower with ticagrelor-aspirin than with aspirin alone. (physiciansweekly.com)
- 3. Relatively severe autonomic dysfunction is associated with lower variation of blood pressure in patients following acute ischaemic stroke. (hkmj.org)
- In patients with acute ischaemic stroke (AIS) intravenous thrombolysis with alteplase (t-PA) is the only effective treatment and it is approved within three or four and a half hours of symptom onset based on regulatory area. (bmj.com)
- The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations in a single document for clinicians caring for adult patients with acute arterial ischemic stroke. (guidelinecentral.com)
- BACKGROUND: Intravenous recombinant tissue plasminogen activator (rtPA) is approved in Europe for use in patients with acute ischaemic stroke who meet strictly defined criteria. (lancs.ac.uk)
- IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit. (lancs.ac.uk)
- and, provide the first large-scale randomised evidence on effects in patients over 80, an age group which had largely been excluded from previous acute stroke trials. (lancs.ac.uk)
- The secondary objectives include: 1) to compare the effectiveness of common treatment regimens, 2) to analyze the cost-effectiveness of different treatment regimens for AIS, 3) to analyze the incidence of adverse events and complications in enrolled patients with AIS, 4) to analyze the effect of Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification on the specific therapies during acute phase treatment period. (biomedcentral.com)
- Therefore, this study aimed to further confirm the efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke. (researchsquare.com)
- Methods: Patients with acute ischemic stroke were administered an intravenous infusion of 320 mg cinepazide maleate or placebo once daily for 14 days. (researchsquare.com)
- Results: In total, 937 patients with an acute ischemic stroke were included, with a mean (standard deviation, SD) National Institutes of Health Stroke Scale score of 8.8 (2.4) and a mean (SD) stroke onset of 30.9 (11.4) hours prior. (researchsquare.com)
- Conclusions: The results of this study show that cinepazide maleate injection is superior to placebo in improving neurological function and activities of daily living, reducing disability, and promoting functional recovery in patients with acute ischemic stroke. (researchsquare.com)
- Understanding clinicians' decisions to offer intravenous thrombolytic treatment to patients with acute ischaemic stroke: a protocol for a discrete choice experiment. (ox.ac.uk)
- BACKGROUND: Intravenous thrombolysis is an effective emergency treatment for acute ischaemic stroke for patients meeting specific criteria. (ox.ac.uk)
- METHODS/ANALYSIS: A discrete choice experiment (DCE) will be conducted to better understand how clinicians make decisions about whether or not to offer thrombolysis to patients with acute ischaemic stroke. (ox.ac.uk)
- The degree of the potassium dip during ischemic attack (as indicated by ΔK, ΔK = K at discharge − K on admission) was examined in 311 consecutive patients with ACS who required urgent hospitalization in our institution. (biomedcentral.com)
- To understand the pathophysiological significance of the potassium dip in ACS and to ensure that patients have an optimal serum K level during the acute phase of ischemic attack, we herein examined the changes in K level throughout ischemic attack and evaluated the clinical factors affecting it. (biomedcentral.com)
- From 2004 through 2011, the percentage of emergency department visits for ischemic stroke or TIA in which the patient arrived by ambulance decreased 41% for patients under 75. (cdc.gov)
- Studies show that patients with ischemic strokes who receive tPA are more likely to recover fully or have less disability than patients who do not receive the drug. (cdc.gov)
Phase of ischemic1
- This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets. (lu.se)
Outcome5
- The effect of vessel patency, following recombinant tissue plasminogen activator (rtPA) administration, on clinical outcome in acute ischemic stroke (AIS) has been controversial. (ajnr.org)
- Both are authors of the manuscript Structural integrity of white matter tracts as a predictor of acute ischemic stroke outcome published recently in IJS. (world-stroke.org)
- First results from ECASS 3 (European Cooperative Acute Stroke Study) were presented today at the 6th World Stroke Congress in Vienna, Austria, showing that treatment with Actilyse(R) (alteplase) between 3 and 4.5 hours after stroke onset can improve clinical outcome. (science20.com)
- 1. The severity of autonomic dysfunction as measured by Ewing battery test predicts poor functional outcome after acute ischaemic stroke. (hkmj.org)
- The Chinese Acute Ischemic Stroke Treatment Outcome Registry (CASTOR) is designed to evaluate the patterns and cost-effectiveness of current treatments for AIS in real-world settings in China. (biomedcentral.com)
Coronary syndrome1
- CHICAGO - Coronary angiography within 2 hours of a diagnosis of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) significantly reduced the risk of recurrent ischemic events as compared to angiography delayed for 12 hours or more, based on the results of the EARLY trial presented at the American Heart Association scientific sessions. (the-hospitalist.org)
Occlusion4
- The functional prognosis of mechanical thrombectomy (MT) for mild acute ischemic stroke (AIS) with large-vessel occlusion (LVO) is controversial. (karger.com)
- Management of acute ischemic stroke due to tandem occlusion: extracranial or intracranial revascularization first? (cns.org)
- High recanalization rates of tandem occlusion is possible using acute carotid artery stenting and mechanical thrombectomy concurrently. (cns.org)
- The thrombi may dislodge and may travel anywhere in the circulatory system, where they may lead to pulmonary embolus, an acute arterial occlusion causing the oxygen and blood supply distal to the embolus to decrease suddenly. (wikipedia.org)
Mortality3
- The effect of pulse pressure and interactions with type of antihypertensive therapy on mortality after acute ischemic stroke has not been previously evaluated. (scirp.org)
- A retrospective cohort study was conducted to evaluate the independent and interactive effects of pulse pressure and antihypertensive class (specifically angiotensin converting enzyme inhibitor/angiotensin type 1 receptor blocker, or beta blocker) on mortality following acute ischemic stroke. (scirp.org)
- Background: Ischemic stroke is a leading cause of morbidity and mortality. (researchsquare.com)
Intravenous2
- The Ministry of Public Health and the National Health Security Office (NHSO) had accepted the use of intravenous thrombolysis as the standard treatment of acute ischemic stroke in 2008. (springer.com)
- The recommended dose of t-PA for acute ischemic stroke is 0.9 mg/kg (maximum 90 mg) infused over 60 minutes with 10% of the total dose administered as an initial intravenous bolus over 1 minute (see t-PA dosing chart). (medscape.com)
Strokes2
- daily aspirin use decreased the severity of acute ischemic strokes (AIS), and 2. (neurology.org)
- About 87% of all strokes are ischemic strokes. (cdc.gov)
Cerebrovascular event1
- Ischemic stroke is an acute cerebrovascular event caused by decreased blood flow to the brain. (researchsquare.com)
Thrombolytic treatment1
- The national thrombolytic treatment for acute ischemic stroke rate has been increased from 0.38% in 2008 [ 1 ] to 4.36% in 2015 [ 6 ]. (springer.com)
Treatment10
- The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. (lu.se)
- Update of Acute Ischaemic Stroke Treatment Guidelines of the Spanish Neurological Society based on a critical review of the literature. (nih.gov)
- Greater effort to prospectively use consistent imaging biomarkers should help improve the development of novel treatment strategies in acute stroke and improve comparison between studies. (ajnr.org)
- Alteplase is the cornerstone of acute ischemic stroke pharmacological treatment, either alone or prior to mechanical thrombectomy. (eso-stroke.org)
- Acute tandem occlusions of intracranial large vessel and cervical internal carotid artery present treatment challenges. (cns.org)
- Technological advancements in surgical procedures along with increasing aging population, increased demand for minimally invasive procedures and extension in healthcare spending are the other prominent factors widening the growth of Asia-pacific Acute Ischemic Stroke diagnosis and treatment market and on the other side imprudent usage of medication for the treatment of ischemic stroke and high cost of surgical procedures are hindering the development of the market. (emailwire.com)
- Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. (nottingham.ac.uk)
- However, more current studies are helping to refine its role in the acute treatment and prevention of stroke. (medscape.com)
- It is widely used in the treatment of acute ischaemic stroke in Russia , Eastern Europe , China , and other Asian and post-Soviet countries. (bvsalud.org)
- SELECTION CRITERIA Randomised controlled trials (RCTs) comparing Cerebrolysin or Cerebrolysin-like agents started within 48 hours of stroke onset and continued for any length of time , with placebo or no treatment in people with acute ischaemic stroke . (bvsalud.org)
Outcomes1
- This study aimed to measure and model the involvement of WM tracts with respect to 24-hours post-stroke National Institutes of Health Stroke Scale (NIHSS) and have found that white matter tract integrity and lesion load are important predictors for clinical outcomes after acute ischemic stroke as measured by the NIHSS and should be integrated for predictive modelling. (world-stroke.org)
Aspirin1
- This objective of this study is to compare the effectiveness of aspirin versus aspirin and ticagrelor to prevent stroke or death after ischemic stroke or TIA. (physiciansweekly.com)
Vessel2
- Results: Overall, we found that acute post-stroke IA GTN had little effect on vessel dilatation after 15 min. (nottingham.ac.uk)
- Acute ischemic stroke is a neurological emergency typically caused by a blood clot blocking blood flow in a vessel in the brain. (wikipedia.org)
Found that acute1
- The authors found that acute ischemic stroke hospitalization between 15 and 44 include smoking, diabetes, and rates increased from 2003-2004 to 2011-2012 in all hypertension. (cdc.gov)
Pathophysiology1
- Imaging biomarkers are increasingly used to provide a better understanding of the pathophysiology of acute ischemic stroke. (ajnr.org)
Pulmonary1
- Several physical symptoms include shrinkage of one or both kidneys, renovascular hypertension, acute renal failure, progressive azotemia, and acute pulmonary edema. (wikipedia.org)
Cerebral1
- A number of studies considered the absolute value of the CBF ( 1 , 2 ), while others were based on the cerebrovascular autoregulation theory, proposing standards based on a combination of CBF and CBV values ( 1 - 5 , 11 , 12 ) to determine the presence of a cerebral infarction core and ischemic penumbra. (spandidos-publications.com)
Diagnosis3
- Several studies reported that plasma levels of TNF-α and IL-6 are associated with prognosis after ischemic stroke and our group showed that plasma levels of cytokines such as TNF-α, IL-1β are different in every diagnostic subtype of ischemic stroke, and how plasma levels of some immunoinflammatory markers and thrombotic-phybrinolitic markers are predictive of acute ischemic stroke diagnosis in the acute setting. (eurekaselect.com)
- According to the report Asia-Pacific Acute Ischemic Stroke Diagnosis Market published by Market Data Forecast, the Asia-pacific market is projected to reach USD 447.55 million by 2021, at a CAGR of 7.9% from 2016 to 2021. (emailwire.com)
- Emergency departments play a critical role in the diagnosis and management of ischemic stroke and TIA. (cdc.gov)
Randomized contro1
- We performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. (ajnr.org)
Recanalization2
- The effect of arterial recanalization following thrombolytic therapy of acute ischemic stroke (AIS) is a complicated and controversial issue. (ajnr.org)
- Objective: To examine an alternative use of GTN as an acute therapy for ischemic stroke following successful recanalization. (nottingham.ac.uk)
Findings3
- Furthermore, the ECASS 3 data are complemented by similar findings from SITS-ISTR (Safe Implementation of Treatments in Stroke - International Stroke Thrombolysis Registry), an academic-driven acute stroke registry of thrombolysis for ischaemic stroke, which were published last week in The Lancet(7). (science20.com)
- Findings will be translated into continuing professional development activities and will support implementation of a computerised decision aid for thrombolysis (COMPASS) in acute stroke care. (ox.ac.uk)
- Methodology/Principal Findings: We have shown that anoxic or terminal depolarization, a spreading depolarization wave ignited in the ischemic core where neurons cannot repolarize, can be evoked in human slices from pediatric brains during simulated ischemia induced by oxygen/glucose deprivation or by exposure to ouabain. (openrepository.com)
Neurologic1
- Dx of ischemic stroke with neurologic deficit? (cpraedcourse.com)
Anticoagulation1
- Current data do not support routine use of anticoagulation for acute ischemic stroke. (medscape.com)
Blockage2
- Ischemic stroke which accounts for 85% of all stroke cases and is caused by blockage of an artery in the brain. (cpraedcourse.com)
- The blockage of blood flow to the large intestine (colon) is called ischemic colitis. (wikipedia.org)
Heart disease1
- In most Western countries, Ischemic heart disease is the most common cause of death in both men and women, and a major cause of hospital admissions. (wikipedia.org)
Assessment1
- Clinical assessment scores in acute ischemic stroke are only moderately correlated with lesion volume since lesion location is an important confounding factor. (world-stroke.org)
Placebo-controlled trial1
- ECASS 3 was a randomised, double-blind, multicentre, placebo-controlled trial of Actilyse(R) in acute ischaemic stroke where thrombolysis is initiated between 3 and 4.5 hours after stroke onset. (science20.com)
Hemorrhagic1
- The purpose of the CT scan is to differentiate between ischemic and hemorrhagic stroke. (cpraedcourse.com)
Complications1
- Cases of ASCVD - defined as coronary artery disease (CAD), ischemic stroke , or acute complications - were identified via hospital records and death registry. (medscape.com)
Conclusions1
- Conclusions: These results demonstrate that acute IA GTN is neuroprotective in experimental ischemic stroke and warrants further study as a potentially new stroke therapy. (nottingham.ac.uk)
Cardiovascular2
- Over 700,000 people suffer from acute stroke medical emergencies every year in the US and 1/6 cardiovascular deaths are stroke related. (cpraedcourse.com)
- Regarding the primary endpoint at 30 days, which is a composite of cardiovascular death and recurrent ischemic event, there is a fivefold lower rate of MACE [major adverse cardiovascular events] in the very-early [group as] compared to the control group," said Laurent Bonello, MD, PhD, of University Hospital North in Marseilles, France. (the-hospitalist.org)
Ischemia6
- Increasing prevalence of acute ischemia stroke cases are operating the global demand for surgical procedures in market. (emailwire.com)
- Paralysis is a very late sign of acute arterial ischemia and signals the death of nerves supplying the extremity. (wikipedia.org)
- Brain ischemia is insufficient blood flow to the brain, and can be acute or chronic. (wikipedia.org)
- Inadequate blood supply to a limb may result in acute limb ischemia or chronic limb threatening ischemia. (wikipedia.org)
- Venous problems like venous outflow obstruction and low-flow states can cause acute arterial ischemia. (wikipedia.org)
- An aneurysm is one of the most frequent causes of acute arterial ischemia. (wikipedia.org)
Efficacy1
- The completed Efficacy of Nitric Oxide in Stroke trial suggested that GTN has therapeutic benefit with acute (within 6 hours) transdermal systemic sustained release therapy. (nottingham.ac.uk)