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  • duration
  • IR in general depressed LV contractility irrespective of ischemia duration. (biomedcentral.com)
  • Longer ischemia duration in IR injury gradually impairs SSMs in terms of respiratory chain function and Ca2+-homeostasis. (biomedcentral.com)
  • The purpose: to establish influence of a full ischemia of different duration and the subsequent reperfusionon pathology development in pancreas of rats by means of laser speckle-visualization and lifetime digital microscopy. (ssmj.ru)
  • The current allocation scheme for kidneys favors equality over utility and emphasizes duration of waiting time, minimization of HLA-DR mismatches, allocation to those with a history of HLA sensitization but a negative HLA cross-match with the donor, pediatric recipients and those willing to accept extended criteria donors (ECD) ( 2 ). (wiley.com)
  • Onset
  • However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). (epfl.ch)
  • A plot of GABA, Tau, and neuronal marker concentrations against the ratio of acetate/NAA allowed precise separation of mice whose ischemia onset lay within arbitrarily chosen time-windows. (epfl.ch)
  • We conclude that 1H-MRS has the potential to detect the clinically relevant time of onset of ischemic stroke. (epfl.ch)
  • This timed, controlled, ischaemic insult to the brain provides an ideal model in which to investigate how rapidly purines are released into the blood following the onset of ischaemia, and how quickly they return to baseline following resolution of the ischemic insult. (springer.com)
  • arterial
  • We performed a prospective observational study to test whether purine levels in arterial blood might correlate with brain ischaemia. (springer.com)
  • To address this issue, we have used a novel biosensor technology to examine the purine levels in sequential arterial blood samples taken before, during and after the mild and reversible brain ischaemia that is imposed during the cross-clamp phase of awake carotid endarterectomy. (springer.com)
  • Ischemic
  • Ischemic preconditioning delayed the increase of ROS during ischemia and protected against ΔΨ m loss. (ahajournals.org)
  • Given that the cardiomyocyte circadian clock influences myocardial physiology, 1,11 and that this mechanism becomes rapidly inactivated following an ischemic event, 12 we hypothesized that the cardiomyocyte circadian clock modulates I/R tolerance in a time-of-day-dependent manner. (ahajournals.org)
  • The treatments for ischemic stroke can only be administered in a narrow time-window. (epfl.ch)
  • We also analyzed differences in oxygen tension recovery in post-ischemic myocardium depending on ischemic time to investigate the correlation between recovery parameters for oxygen tension and the severity of IR injury. (rsc.org)
  • underwent
  • Importantly, there was a significant inverse correlation between the level of ROS accumulation during ischemia and the latency until which the cell underwent ΔΨ m loss (r=−0.89). (ahajournals.org)
  • kidney
  • The main outcome measure was renal ischemia time and maintenance of kidney function. (pagepressjournals.org)
  • We performed a retrospective cohort study examining US registry data between 1998 and 2013 of adult first-time kidney-only recipients of small pediatric kidneys from donors weighing 10 to 20 kg, stratified by CIT levels of 0 to 18 (n = 1413), 19 to 30 (n = 1116), and longer than 30 (n = 338) hours. (ovid.com)
  • Finally, the current trends in research involving the role of stem cells, renal hibernation and the role of the innate immune response are highlighted with the aim of exploiting these mechanisms to achieve reduced kidney damage during ischemia. (numonthly.com)
  • Stroke
  • Although a few studies have examined whether purine levels in blood increase during stroke [ 20 ] and brain ischaemia [ 21 ], this has not been widely studied. (springer.com)
  • significantly
  • In contrast, increasing length of ischemia time highly significantly promoted ETC uncoupling at complex I-V and II-IV in state 3 respiration, respectively. (biomedcentral.com)
  • 001). Multivariable analyses illustrated that compared with NDM, IDDM was associated with significantly higher risk of both major amputation and RAS events after any first-time intervention (hazard ratio, 2.0 [95% confidence interval, 1.1-4.and 1.4 [1.1-1. respectively). (eur.nl)
  • periods
  • During daylight saving time, the customary time system is advanced one hour to take advantage of the longer periods of daylight during the summer months. (thefreedictionary.com)
  • Prolonged graft ischemia time can predispose to conduction system injury in both early and late postoperative periods. (ahajournals.org)
  • mice
  • Wild-type (WT) and CCM mice were housed under controlled conditions in a 12-hour light/12-hour dark cycle (lights on at zeitgeber time [ZT]0, lights off at ZT12). (ahajournals.org)
  • injury
  • We suggest that these recovery parameters could be utilized as an index of tissue injury and severity of ischemia. (rsc.org)
  • 14. Menger M.D., Bonkhoff H., Vollmar B. Ischemia-reperfu-sion-induced pancreatic microvascular injury: An intravital fluorescence microscopic study. (ssmj.ru)
  • Imaging
  • Magnetic resonance imaging may detect variability of surgically induced ischemia before treatment and thus improve treatment effect evaluation. (ahajournals.org)
  • vitro
  • Despite significant elevations in lysophospholipids levels, their absolute quantities were very small (0.6% of total phospholipid P) and 15-fold smaller than that reported in vitro to simulate electrophysiological manifestation of ischemia. (ahajournals.org)
  • rapidly
  • Our results suggest that blood purines may be a sensitive real-time and rapidly produced indicator of brain ischaemia, even when there is no accompanying neurological obtundation. (springer.com)
  • As soon as the ischemia was initiated, oxygen tension rapidly declined to near zero levels. (rsc.org)
  • period
  • The period of rotation of the earth with respect to the sun (i.e., the interval between successive high noons) is the solar day, which is the basis for solar time solar time, time defined by the position of the sun. (thefreedictionary.com)
  • And generally by the nature of the operation you can assume they already have gone untreated for a prolonged period of time. (wordpress.com)
  • The molecular species of lysophospholipids remained unchanged throughout the period of ischemia studied. (ahajournals.org)
  • different
  • A local government may not use a system of time different from that adopted by its state legislature. (thefreedictionary.com)
  • Under the standard time zone system, the continental United States is divided into four different zones. (thefreedictionary.com)
  • The concept of time may be discussed on several different levels: physical, psychological, philosophical and scientific, and biological. (thefreedictionary.com)
  • phase
  • Importantly, the rate of ROS accumulation during the early phase of ischemia was variable from cell to cell, and irreversible ΔΨ m loss occurred in an all-or-none manner depending on cellular ROS level, with a clear cut-off value. (ahajournals.org)
  • Patient
  • You can chop that time down by having a $250 satellite communicator (and $15/month service plan) , but it's still going to take a while for folks to get to that patient and really this article is written towards the folks providing that medical care. (wordpress.com)
  • Role
  • This study was performed to determine the early and delayed metabolic effects of myocardial ischemia on the major membrane phospholipids and to reassess the potential role of lysophospholipids in the genesis of malignant dysrhythmias induced by ischemia. (ahajournals.org)
  • Methods
  • Methods: We reviewed all limbs undergoing first-time infrainguinal bypass grafting (BPG) or percutaneous transluminal angioplasty with or without stenting (PTA/S) for CLTI at our institution from 2005 to 2014. (eur.nl)
  • increase
  • As soon as ischemia started, ROS level of each cell began to increase, despite maintained ΔΨ m . (ahajournals.org)
  • After the termination of 20-minute full ischemia the increase in speed of a bloodflow did not occur, there were morphological and clinical signs of pancreatic necrosis. (ssmj.ru)
  • sympathetic
  • 2,3 These rhythms have been attributed primarily to time-of-day oscillations in neurohumoral influences, such as sympathetic or autonomic stimulation. (ahajournals.org)