Ischemia reperfusion model ischemia reperfusion. Medical search. Frequent questions

Coupled with the rapid increase in computing power, this has allowed the development of a mathematical model of cardiac metabolism in normal and ischaemic conditions. (ox.ac.uk)
Pre-existing models of cardiac cells such as Oxsoft HEART contain highly developed dynamic descriptions of cardiac electrical activity. (ox.ac.uk)
Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia-reperfusion. (ouhsc.edu)
Myocardial ischemia-reperfusion (I/R) injury is an important health concern in myocardial infarction and situations such as angioplasty and cardiac surgeries. (usask.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)
This is known as the "reperfusion" phase in cardiac IRI. (uwo.ca)
To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine model of ischemia/reperfusion, with serial cardiovascular magnetic resonance (CMR) imaging throughout one week using non-invasive pressure-volume loops. (lu.se)
CONCLUSION: Using non-invasive pressure-volume loops by CMR, we observed that mild hypothermia at reperfusion alleviates the heart's work after ischemia/reperfusion injuries during the first week and preserves short-term cardiac performance. (lu.se)
For the past several decades, the Society of Thoracic Surgeons (STS) has been leading the development of risk models and quality improvement monitoring with the STS National Cardiac Database. (medscape.com)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model. (unil.ch)
Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)
PLCA at 1 μM and metformin at 30 μM exerted similar effects on the improvement of cell viability and the alleviation of cell apoptosis in NRVM after H/R. PLCA promoted p-AMPK, p-AKT, and GLUT4 upregulation to induce a cardioprotective effect in both cell and animal model. (biomedcentral.com)

citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
Huang Y , Tan F , Zhuo Y , Liu J , He J , Duan D , Lu M , Hu Z , . Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α. (aging-us.com)

At 1 h before operation, 5.0 μg/kg dexmedetomidine and 5.0 μg/kg Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway agonist SC-39100 were intraperitoneally injected into experimental and control groups, respectively, while the same dose of normal saline was injected into sham and model groups. (ijpsonline.com)
To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)

Ischemia/reperfusion-induced renal failure in rats as a model for evaluating cell therapies. (wakehealth.edu)
To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)
Rats were randomly assigned into sham, model, experimental and control groups. (ijpsonline.com)
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
A total of thirty (30) Sprague-Dawley rats were randomly divided into sham, model and sevoflurane groups with 10 animals per group. (ajol.info)
Here, we determined the effects of CDDPs in Sprague-Dawley rats with the IR model. (bvsalud.org)
1991. Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. (cdc.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

METHODS: Five pigs were subjected to 60 min of focal kidney ischemia. (au.dk)
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
Histological studies were done and lactoferrin was measured in the autotransplanted kidney 72 hours after reperfusion. (unica.it)
To investigate the course of tubular cell senescence and expressions of p53, p21, and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb pathway on tubular cell senescence. (techscience.com)

abstract = "Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. (bris.ac.uk)
Abstract Compound Danshen Dripping Pills (CDDPs) have been used in clinical treatment to protect the heart from ischemia / reperfusion (IR) injury for many years. (bvsalud.org)

We show that Bbeta(15-42) robustly and reproducibly reduced infarct size in all models of ischemia-reperfusion. (bris.ac.uk)
This study attempted to determine whether neutrophil sequestration in reperfused myocardium can be inhibited and infarct size reduced by treatment with a chimeric, monoclonal IgG4 antibody (CLB54) directed against CD18 in a primate model of acute myocardial ischemia and reperfusion. (johnshopkins.edu)
Inhibition of neutrophil sequestration with CLB54 administered before reperfusion reduces infarct size, preserves ischemic zone microvascular perfusion and minimizes the decline of regional wall motion. (johnshopkins.edu)
BACKGROUND: Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. (lu.se)

During tourniquet ischaemia and subsequent reperfusion, changes in glutathione metabolism developed, indicating oxidative stress. (portlandpress.com)
In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)

The use of comorbidity models is crucial in cardioprotective drug development. (nih.gov)
Endogenous cardioprotective mechanisms against I/R are impaired in hyperlipidemic and hyperglycemic in vivo animal models. (nih.gov)
In rodents, Bbeta(15-42) inhibits proinflammatory cytokine release and is cardioprotective during ischemia-reperfusion injury. (bris.ac.uk)
Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion. (aspetjournals.org)
Thus, acidified NaNO2 exerts a significant protective action during ischemia and reperfusion injury, which suggests that endothelium-derived relaxing factor has a cardioprotective effect in MI. (aspetjournals.org)
Our current projects are focused on: 1) Rescue and Role of Complex I in Myocardial Ischemic Injury 2) Subcellular Regulation of Autophagy 3) Mitochondria and Stem Cells in Anthracycline-Induced Heart Failure 4) Development of Small-Molecular Cardioprotective Agents for Treatment of Reperfusion Injury and 5) Microbial Basis of Cardiovascular Disease. (pewtrusts.org)

Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion. (edu.sa)
After cerebral hypoxia-ischemia, endogenously produced brain lactate is largely increased, and the exogenous administration of more lactate can decrease lesion size and ameliorate the neurological outcome. (edu.sa)
Dive into the research topics of 'Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion. (edu.sa)
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. (nanostring.com)
This article describes the pathophysiology of, and treatment strategy for, cerebral ischemia. (nih.gov)
Reperfusion plays an important role in the pathophysiology of cerebral ischemia. (nih.gov)
Magnetic resonance imaging (MRI) and histological studies in rat focal ischemia models using transient middle cerebral artery (MCA) occlusion indicate that reperfusion after an ischemic episode of 2- to 3-hour duration does not result in reduction of the size of the infarct. (nih.gov)
Microglial cells are the first line immune cells that initiate inflammatory responses following cerebral ischemia/reperfusion(I/R) injury. (aging-us.com)
Taken together, these findings reveal that hypoxia-preconditioned OM-MSC inhibits pyroptotic and apoptotic death of microglial cell in response to cerebral ischemia/reperfusion insult by activating HIF-1α in vitro . (aging-us.com)
Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
[ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)

MATERIALS AND METHODS: We randomly divided 34 Macaca cynomolgus monkeys into groups 1 and 2, which received a renal autograft after 2 hours of cold ischemia, and groups 3 and 4, which received the autograft after 24 hours of cold ischemia. (unica.it)
Before cold ischemia all harvested kidneys were subjected to 30 to 45 minutes of warm ischemia. (unica.it)
Groups 1 and 3 monkeys were treated with an antileukocyte function associated antigen 1 mAb before cold ischemia and then for 3 days, while groups 2 and 4 monkeys received an IgG1 isotype control. (unica.it)
RESULTS: A decrease in renal function was shown after 2 hours of cold ischemia with tubular necrosis and mild cell infiltration, while after 24 hours of cold ischemia there was severe renal failure with tubular and glomerular necrosis, and leukocyte infiltration. (unica.it)
The protective effects of antileukocyte function associated antigen 1 mAb on renal injury was not as dramatic as in rodent models but a significant improvement in renal function was observed in treated animals after 2 hours of cold ischemia. (unica.it)
Methods MSC derived from human bone marrow were labeled by DiI and administered intravascularly or endobronchially to the lungs of donor pigs after a period of 3 hours warm and 3 hours cold ischemia. (uni-koeln.de)

We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)
Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)

Ischemia-reperfusion injury occurs when circulation is abruptly restored following prolonged ischemia and it is well-known that high levels of calcium and tissue neutrophil accumulation cause cellular damage and produce reactive oxygen species (ROS) during reperfusion and trigger IR injury [ 1 ]. (hindawi.com)
Once reperfusion occurs, these cellular products are returned to the systemic circulation, and are exposed to other organs. (wikipedia.org)
Ischemia/reperfusion (I/R) injury of the spinal cord is a dynamic process that frequently occurs during a variety of clinical situations such as thoracoabdominal aortic surgery or spinal cord injury [ 1 ]. (biomedcentral.com)
Acute compartment syndrome occurs when the tissue pressure within a closed muscle compartment exceeds the perfusion pressure and results in muscle and nerve ischemia. (medscape.com)
Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)

Intestinal ischemia is a life-threatening condition associated with a broad range of clinical conditions including atherosclerosis, thrombosis, hypotension, necrotizing enterocolitis, bowel transplantation, trauma and chronic inflammation. (uthscsa.edu)
Furthermore, we observed that treatment with ERK5 inhibitor reduces inflammation, coagulopathy, and mortality in LPS-treated mice, but conversely increases mortality and bacteremia in a cecal ligation and puncture model of sepsis. (ucsf.edu)
We will also investigate the role of NADA, and the other components of the endocannabinoid system, in vivo using mouse models of infectious and non-infectious inflammation. (ucsf.edu)

In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S. (biomedcentral.com)

citation needed] Tissue swelling and fasciotomy Following ischemia, reperfusion induces local tissue swelling. (wikipedia.org)
The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)

Modulation of the NO pathway during short or prolonged blood reperfusion following ischaemia in a heterotopic rat heart transplantation model. (ox.ac.uk)
Experiments were performed using a modified Lewis to Lewis heterotopic abdominal heart transplantation with a total ischemic time of 3 hours followed by 1 or 24 hours of blood reperfusion (n = 12). (ox.ac.uk)

In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)
Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)

The in vitro I/R model was established by the hypoxia/reoxygenation method using H9C2 cells. (spandidos-publications.com)
Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. (wikipedia.org)
Our results suggest that the protective effects of lactate after hypoxia-ischemia come rather from the metabolic effects of lactate than its signaling through HCAR1. (edu.sa)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)

it is defined as a severe systemic manifestation (eg, rhabdomyolysis) of trauma and ischemia involving soft tissues, principally skeletal muscle, as a result of prolonged severe crushing. (medscape.com)

Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)

Therefore, experimental small animal models are critical for understanding the pathophysiology of IR injury and the development of novel therapies. (uthscsa.edu)
Experimental models of unilateral renal IRI were used in p53(+/+) and p53(-/-) mice. (techscience.com)

The re-establishing of blood flow to an ischemic zone is called reperfusion [ 1 ]. (biomedcentral.com)

Ischemia was created by a tourniquet strictly wrapping the pedicle containing skin and muscle for 8 h. (hindawi.com)
After ischemia, the tourniquet was cut, and the musculocutaneous flap was reperfused. (hindawi.com)
Patients ( n =15) undergoing elective knee replacement surgery employing tourniquet ischaemia were studied. (portlandpress.com)
In addition the patients were randomized to receive either glucose or a mannitol infusion in the 24 h following tourniquet ischaemia. (portlandpress.com)

Therefore, this study examined the differential effects of repetitive magnetic stimulation (rMS) in an in vitro neuronal model of ischemia/reperfusion (I/R) injury, depending on low and high frequency. (elsevierpure.com)
Neuro-2a cells were differentiated with retinoic acid and established for in vitro neuronal model of I/R injury under a subsequent 3 h of oxygen and glucose deprivation/reoxygenation (OGD/R) condition. (elsevierpure.com)

As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)

Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)

1995. Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment. (cdc.gov)

Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. (nanostring.com)
Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
However, the function of Trim8 in hepatic ischaemia/reperfusion (I/R) injury remains largely unknown. (ijbs.com)
Trim8 gene knockout mice and primary hepatocytes were used to construct hepatic I/R models. (ijbs.com)

The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich compounds. (portlandpress.com)
Over the past three decades, clinical and pharmacological studies have accumulated a body of evidence that not only demonstrated these therapeutic effects, but also provided significant insights into the pharmacokinetic behavior, therapeutic profile, and mode of action of scutellarin in humans and animal models. (cdc.gov)
Of the various EVD animal models that have been developed, those using nonhuman primates (NHPs) appear to most closely reproduce the known features of lethal disease in humans. (cdc.gov)

During the reperfusion part of the study, no differences attributable to the infusion of mannitol or glucose were observed. (portlandpress.com)
A traditional oxygen-glucose deprivation/reperfusion (OGD/R) model, analogous to I/R, was established. (aging-us.com)

Acidified NaNO2 (12.5-50 mmol/kg/hr) was infused i.v., starting 30 min postocclusion followed by reperfusion 1 hr later, in cats subjected to MI by occlusion of the left anterior descending coronary artery. (aspetjournals.org)

Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. (mdpi.com)
Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo . (tocris.com)

However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)

We investigated the effects of a fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of ischemia-reperfusion at three different study centers (Universities of Dusseldorf and Vienna, TNO Biomedical Research). (bris.ac.uk)

We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)

The in vivo administration of HCAR1 agonists at reperfusion did not appear to exert any relevant protective effect as seen with lactate administration. (edu.sa)
The objectives of this study were to 1) determine the extent to which ascorbate or catechin alone at levels which could be in blood after dietary supplementation, can protect myocardial tissue in the reperfusion phase of I/R injury, and 2) evaluate the possible cooperative or synergistic protective effect of ascorbate and catechin when given together. (usask.ca)

Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)

eNOS protein levels were significantly lower during short reperfusion compared to the basal value (P = .0077) or to prolonged reperfusion (P = .004), returning to the basal value after 24 hours of reflow. (ox.ac.uk)

A comparison of IR hearts with two controls, sham (perfused for a 15 min stabilization period) and continuous perfusion (perfused for 135 min), showed in most but not all measurements that this was a suitable model of IR injury. (usask.ca)
Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)

Intestinal ischemia-reperfusion (IR) injury is a consequence of acute mesenteric ischemia, caused by inadequate blood flow through the mesenteric vessels, resulting in intestinal damage. (uthscsa.edu)
Ischemia": an inadequate blood supply to an organ or part of the body. (wikipedia.org)

Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)

Here, we assessed the metabolic alterations following subclinical focal ischemia-reperfusion injury with hyperpolarized [1- 13 C]pyruvate MRI in a porcine model. (au.dk)

citation needed] "Reperfusion": the restoration of blood flow to an organ or tissue after having been blocked. (wikipedia.org)
citation needed] Systemic effects of IR injury During periods of ischemia, cellular break down products accumulate in the local tissue. (wikipedia.org)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)

Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. (unicatt.it)

The left anterior descending coronary artery was ligated to construct the model of myocardial ischemia-reperfusion. (ijpsonline.com)
A rat model of myocardial I/R injury was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with GRh2. (spandidos-publications.com)
With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)

Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. (musc.edu)
Ischemia-reperfusion injury plays a major role in graft dysfunction following transplantation. (ox.ac.uk)
This study provides a detailed immunohistochemical and stereological analysis of the localization and distribution of exogenous MSC in a pig model of lung transplantation after intravascular or endobronchial application. (uni-koeln.de)

The model possesses predictive power, as it aided the identification of electrophysiological effects of therapeutic interventions such as Na(+)-H+ block. (ox.ac.uk)
This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)
A therapeutic drug that targets ischemia reperfusion (I/R) injury is needed and has yet to be developed. (biomedcentral.com)
In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. (cdc.gov)

PURPOSE: We established a primate model to investigate the effects of the antileukocyte function associated antigen 1 (CD 11a) mAb odulimomab (Imtix-Sangstad, Lyon, France) for preventing renal ischemia-reperfusion injury. (unica.it)
This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. (cdc.gov)

It has beneficial effects in animal models of acute brain injuries and traumatic brain injury or subarachnoid hemorrhage patients. (edu.sa)

This temporarily decreases the amount of oxygen the heart receives and simulates a clinical transplant-like model. (uwo.ca)

In the present study, knee replacement surgery was used as a clinical model to elucidate this pattern of metabolic alterations. (portlandpress.com)

Anatomy13

Organisms9

Diseases21

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes20

Disciplines and Occupations1

Health Care1

Cardiac12

Apoptosis3

Mesenchymal stem2

Signaling pathway2

Rats8

Kidney4

Abstract2

Infarct size4

Oxidative4

Cardioprotective6

Cerebral13

Cold ischemia6

Brain Ischemia2

Occurs5

Inflammation3

Pretreatment1

Induces2

Heart transplantation2

Cardiomyocytes3

Hypoxia4

Skeletal muscle1

Serum1

Experimental2

Ischemic zone1

Tourniquet4

Vitro2

Cardiovascular1

Subsequent1

Toxicology1

Hepatic4

Humans3

Glucose2

Occlusion1

Retinal2

Myocardium1

Rodent models1

Neuronal1

Protective effect2

Chronic1

Significantly1

Perfusion2

Inadequate blood2

Inflammatory1

Porcine1

Tissue3

Complement1

Coronary3

Transplantation3

Therapeutic4

Primate2

Acute brain1

Oxygen1

Metabolic alterations1