• MG53 KO mice lack IPC-mediated cardioprotection as evidenced by a failure of IPC to reduce IR-induced myocardial infarct size. (biomedcentral.com)
  • Ischemic preconditioning and anesthetic preconditioning (APC) are reported to decrease myocardial infarct size during ischemia-reperfusion injury. (asahq.org)
  • For the end point infarct size, estimated by biomarkers of myocardial necrosis, an overall pooled effect was SMD =−0.58, 95% CI: −0.96 to −0.19. (dovepress.com)
  • 2 Paradoxically, reperfusion itself can enlarge the infarct size, by complex mechanisms collectively termed ischemia/reperfusion injury. (dovepress.com)
  • 3 In 2003, Zhao and et all published experimental data demonstrating a considerable reduction of infarct size by a reperfusion procedure termed ischemic postconditioning (IPost), consisting of brief, repetitive cycles of reperfusion and reocclusion, followed by sustained reperfusion. (dovepress.com)
  • We studied infarct size (IS) in rat hearts subjected to global ischemia-reperfusion (I/R) in vitro and endothelial function in healthy volunteers subjected to I/R of the upper arm. (ox.ac.uk)
  • Hypothermic ischemic preconditioning with four cycles of 5-minute coronary occlusions resulted in a 94% reduction of infarct size but hypothermic ischemic preconditioning with one cycle resulted in no reduction of infarct size. (neuraxismed.com)
  • Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
  • Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)
  • Oxygen free radicals in ischemic acute renal failure in the rat. (razavihospital.ir)
  • And it's really insights from the VOYAGER-PAD trial telling us about the reduction in acute limb ischemia with Rivaroxaban versus placebo in peripheral artery disease after lower extremity revascularization. (libsyn.com)
  • and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
  • Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
  • During open heart surgery, the myocardium suffers from ischemia-reperfusion injury (IR) despite perioperative cardioprotection. (oroboros.at)
  • Slagsvold KH, Rognmo O, Hoydal M, Wisloeff U, Wahba A (2014) Remote ischemic preconditioning preserves mitochondrial function and influences myocardial microrna expression in atrial myocardium during coronary bypass surgery. (oroboros.at)
  • Based on the experimental and first clinical data on helium conditioning we hypothesized that helium induces pre- and/or postconditioning in human myocardium of patients undergoing CABG surgery, involving regulation of PKC, p38 MAPK, ERK 1/2 and HSP-27, and reducing postoperative troponin T release. (biomedcentral.com)
  • Although the mechanisms of ischemic preconditioning and APC are thought to be similar, it is not known whether the beneficial effects of APC are also reduced in the aged myocardium. (asahq.org)
  • 9. Sasayama S, Nonogi H , Fujita M, Sakurai T, Wakabayashi A, Kawai C, Eiho S, Kuwahara M: Changes in diastolic properties of the regional myocardium during pacing-induced ischemia in human subjects. (fiercecert.com)
  • We investigated whether long-term GTN treatment modifies the protection by RIC in the rat myocardium and human endothelium. (ox.ac.uk)
  • NEW & NOTEWORTHY Remote ischemic conditioning (RIC) and long-term glyceryl trinitrate (GTN) treatment protect against ischemia-reperfusion injury in both human endothelium and rat myocardium. (ox.ac.uk)
  • Stem cell transplantation is emerging as a promising strategy to regenerate the ischemic myocardium in such patients. (biomedcentral.com)
  • Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of novel drug targets for cardioprotection is of great importance. (nih.gov)
  • Ischemia reperfusion injury and cardioprotection by conditioning have been shown to affect global myocardial gene expression profile at the transcript level. (nih.gov)
  • Powers SK, Quindry JC, Kavazis AN (2008) Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. (oroboros.at)
  • Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. (biomedcentral.com)
  • Ischemic preconditioning, postconditioning, and remote conditioning trigger endogenous cardioprotective mechanisms that render the heart more resistant to lethal ischemic-reperfusion injury. (nih.gov)
  • However, major cardiovascular co-morbidities such as hyperlipidemia, diabetes, and their co-medications interfere with these cardioprotective mechanisms thereby limiting the efficacy of cardioprotective ischemic conditioning maneuvers. (nih.gov)
  • Research done in animals shows that treatment with NAD+ precursors like NMN have cardioprotective effects against ischemia/reperfusion injury (4). (prohealth.com)
  • Aim 1 will investigate the mechanisms by which EPO protects the heart from injury following ischemiaand reperfusion. (grantome.com)
  • Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? (southampton.ac.uk)
  • Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. (ox.ac.uk)
  • Ischemic preconditioning, therefore, protects against subsequent ischemic injury. (biomedcentral.com)
  • We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
  • Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
  • In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
  • Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
  • Ischemia is characterized by deprivation of oxygen (hypoxia), metabolicsubstrates, and cytokines/survival factors, as well as accumulation of toxic metabolites. (grantome.com)
  • Despite the complexpathophysiology of ischemia, hypoxia alone is a sufficient stimulus to induce a variety of adaptive responsesthat protect against ischemia-reperfusion injury. (grantome.com)
  • H9c2 cells were subjected to 3‑h hypoxia, followed by 1‑h reperfusion. (spandidos-publications.com)
  • Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
  • At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
  • Primary percutaneous coronary intervention (PCI) is the preferred method of reperfusion if this can be performed within recommended time frames. (dovepress.com)
  • We previously demonstrated that remote ischemic preconditioning preserves mitochondrial function during cardiac surgery [2,3], and animal studies have shown that as little as a few bouts of endurance exercise can protect the heart from IR [4]. (oroboros.at)
  • Slagsvold KH, Moreira JBN, Rognmo O, Hoydal MA, Bye A, Wisloeff U, Wahba A (2014) Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: A randomized trial. (oroboros.at)
  • Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning. (ox.ac.uk)
  • It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
  • It is known that both, timing and repetition of the preconditioning stimulus, are central for producing the respective protection. (biomedcentral.com)
  • Ischemic tolerance or preconditioning is a phenomenon by which a sub-injurious stimulus is applied to a tissue such as the brain. (biomedcentral.com)
  • After a certain delay, the brain develops tolerance to ischemic injury caused by the injurious stimulus. (biomedcentral.com)
  • The authors carried out tests on an animal model to investigate the individual and combined effects of melatonin and NMN on myocardial function, mitochondrial activity, and oxidative stress status following ischemia/reperfusion injury in aged rat hearts. (prohealth.com)
  • Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
  • 14. Sun X, Fang B, Zhao X, Zhang G, Ma H. Preconditioning of mesenchymal stem cells by sevoflurane to improve their therapeutic potential. (sciendo.com)
  • Isolating the Long-Term Cardiovascular Effects on Adult Offspring of Human Clinically Relevant Doses of Antenatal Glucocorticoids. (ed.ac.uk)
  • The Journal of Thoracic and Cardiovascular Surgery, 1998Rabbit hearts underwent 45 minutes of regional ischemia, followed by 2 hours of reperfusion. (neuraxismed.com)
  • And the catalytic subunit of telomerase called telomerase reverse transcriptase or trt has protective functions in the cardiovascular system, particularly in regard to ischemia reperfusion injury. (libsyn.com)
  • Ischemic cardiovascular and cerebrovascular diseases continue to represent the most common cause of death in modern society. (biomedcentral.com)
  • When blood flow is re-established (reperfusion), a series of inflammatory responses take place because of the damage sustained by the tissues affected by the previous lack of blood. (prohealth.com)
  • Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
  • Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. (spandidos-publications.com)
  • miR‑132 was significantly upregulated and SIRT1 was markedly downregulated in I/R myocardial tissues. (spandidos-publications.com)
  • The study has indicated that the angiogenesis play an important role in the repair of cerebral ischemia, which may prevent the patients away from stroke [ 5 ]. (hindawi.com)
  • Ischaemic preconditioning describes the phenomenon where transient and brief ischaemia confers protection against a subsequent prolonged and injurious period of ischaemia. (medsci.org)
  • Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)
  • Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. (sun.ac.za)
  • However, it is not easy to apply ischaemic preconditioning in a clinical setting because brief organ ischaemia should be preceded after real ischaemic time [ 8 ]. (medsci.org)
  • The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
  • Moens AL, Claeys MJ, Timmermans JP and Vrints CJ: Myocardial ischemia/reperfusion-injury, a clinical view on a complex patho-physiological process. (spandidos-publications.com)
  • Up until now, exercise as preconditioning has not been studied in humans in a clinical setting. (oroboros.at)
  • Phosphodiesterase inhibitors (PDIs) have important vascular and myocardial protective effects and thus have shown therapeutic usefulness in the clinical settings for treatment of patients with heart failure, pulmonary hypertension, and coronary artery disease. (biomedjournal.com)
  • Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)
  • However, combined application of RIC and long-term GTN treatment abolishes the individual protective effects of RIC and GTN treatment on ischemia-reperfusion injury, suggesting an interaction of clinical importance. (ox.ac.uk)
  • Reperfusion treatment has a potential risk of worsening tissue damage after ischemia, which can accelerate the deterioration of cardiac function [ 2 ]. (hindawi.com)
  • miR-21 was found to be highly deregulated in mouse cardiac tissue after cardiac ischemic preconditioning [ 12 ]. (hindawi.com)
  • During myocardial ischemia (lack of blood flow to the muscle tissue of the heart, commonly referred to as a "heart attack"), blood flow is interrupted because of damage to one or more of the coronary blood vessels that irrigate the heart. (prohealth.com)
  • In many cases, damage to heart tissue by reperfusion injury is greater than the damage done by the interruption of blood flow. (prohealth.com)
  • For the study, the researchers performed tests to measure the condition of cardiac tissue before and after an ischemic event and after perfusion was re-established. (prohealth.com)
  • However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)
  • Taking into account both protective effects, ischemic and ozone oxidative preconditioning, against liver injury by I/R, the aim of this study is to stablish a comparison between them, in a liver I/R model. (lomr.org)
  • Reperfusion injury is a significant threat to myocardial function that arises with the reintroduction of blood flow to the heart following an ischemic episode. (wikipedia.org)
  • The mitochondria has been known to protect the heart from ischemic-reperfusion injury through the opening of the ATP-sensitive K+ channel. (wikipedia.org)
  • Most myocardial infarctions, commonly known as heart attacks, happen in people once they get older, and aging makes it more difficult to recover from this type of injury. (prohealth.com)
  • What Happens During a Heart Attack and Reperfusion Injury? (prohealth.com)
  • Reperfusion injury increases the damage done after events such as heart attacks. (prohealth.com)
  • IPC activates the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways to protect the heart against IR injury. (biomedcentral.com)
  • Buja LM and Entman ML: Modes of myocardial cell injury and cell death in ischemic heart disease. (spandidos-publications.com)
  • In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
  • Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
  • No effect was observed of helium preconditioning, postconditioning or the combination thereof on activation of p38 MAPK, ERK 1/2 or levels of HSP27 and PKC-ε in the human heart. (biomedcentral.com)
  • 8-11 Volatile anesthetics are now being investigated as pharmacologic agents to precondition the heart during coronary artery bypass surgery, with both positive 12-14 and negative 15 results. (asahq.org)
  • Optimizing stem cell function for the treatment of ischemic heart disease. (sciendo.com)
  • Because of overlapping mechanisms, this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. (ox.ac.uk)
  • However, stem cell-based transplantation therapy faces the problems of poor donor cell engraftment and survival in the ischemic heart. (biomedcentral.com)
  • These findings could help develop new treatments for diseases caused by a limited blood supply to human organs, such as a stroke or heart attack. (elifesciences.org)
  • The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
  • 15. Nakamura Y, Sasayama S, Nonogi H , Miyazaki S, Fujita M, Kihara Y, Konishi T, Kawai C: Effects of pacing-induced ischemia on early left ventricular filling and regional myocardial dynamics and their modification by nifedipine. (fiercecert.com)
  • The protection associated with preconditioning is one of the most powerful mechanisms of protection known. (lomr.org)
  • Rats and humans were randomized to 1) control, 2) RIC, 3) GTN, and 4) GTN + RIC. (ox.ac.uk)
  • In protocols 3 and 4, rats and humans underwent long-term GTN treatment for 7 consecutive days, applied subcutaneously or 2 h daily transdermally. (ox.ac.uk)
  • We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. (biomedcentral.com)
  • 6,7 The mechanism of volatile anesthetic preconditioning (APC), although not fully understood, is believed to share similarities with IPC by activation of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels, particularly in the mitochondria. (asahq.org)
  • Volatile anesthetic-induced cardiac preconditioning. (sciendo.com)
  • Normothermic ischemic preconditioning with one cycle had a 58% reduction and four cycles had a 95% reduction. (neuraxismed.com)
  • Baseline characteristics were similar between the treatment groups and randomization to icosapent ethyl was associated with a significant reduction in the primary endpoint, as well as in key secondary endpoint and in total ischemic events compared to placebo. (libsyn.com)
  • Dynamics of endothelial progenitor cells following sevoflurane preconditioning. (sciendo.com)
  • MicroRNA (miRNA) dysfunction has been confirmed as a key event of ischemic stroke appearance. (hindawi.com)
  • Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner [J].2016,23(2). (wanfangdata.com.cn)
  • Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
  • SNAI2, an angiogenesis-related factor, was highly expressed under the high glucose condition and also led to viability and migration of human brain microvascular endothelial cells (HBMECs) [ 13 ]. (hindawi.com)
  • Furthermore, the secreted factor in the macrophage-conditioned tradition medium of Mg-Al LDH group was more suitable for the bone differentiation of rat bone marrow stem cells (rBMSCs) and the Ned 19 angiogenic behavior of human being umbilical vein endothelial cells (HUVECs). (arcillaresearch.com)
  • Taking into account that ischemic preconditioning (IschP) is also a protective mechanism, a comparative study between both preconditioning effects, with the aim to study the effectiveness of both protective procedures, was performed. (lomr.org)
  • These therapeutic effects can be further enhanced by hypoxic preconditioning. (researchsquare.com)
  • However, the beneficial effects of ischemic preconditioning have been shown to decrease with advancing age. (asahq.org)
  • 10. Sasayama S, Nonogi H , Asanoi H, Yamanishi K, Kawai C: Effects of nifedipine on pacing-induced ischemia:modification of regional myocardial function and coronary hemodynamics. (fiercecert.com)
  • Some effects of H2S protection require the continued presence of H2S, such as ROS scavenging during ischemia. (gotomydoctor.com)
  • CAV -1 is an integral membrane protein found in caveolae, omega-shaped invaginations of the plasma membrane that form a subdomain of cholesterol- and sphingolipid-rich lipid rafts.Cav1 gene is localized to locus D7S522 of human chromosome 7q31.1In vivo, two isoforms of Cav1 are known to exist: α-caveolin that contains residues 1-178 and β-caveolin that contains residues 32-178. (diff.org)
  • Murine models of Matrigel plug and hindlimb ischemia were employed as in vivo angiogenic assays. (biomedcentral.com)
  • In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)
  • Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
  • More than 70% of stroke can contribute as ischemic type, and nearly 30% patients were related with primary hemorrhage [ 3 ]. (hindawi.com)
  • Angiogenesis is a complicated and sequential process, which occurs in the ischemic penumbra within hours after stroke and lasts for weeks. (hindawi.com)
  • Patients with higher blood vessel density showed better functional recovery after ischemic stroke impact. (hindawi.com)
  • Therefore, improving the angiogenesis of patients has been increasingly recognized as a promising therapeutic strategy for the treatment of ischemic stroke. (hindawi.com)
  • Della-Morte, D. Polyphenols and Ischemic Stroke. (encyclopedia.pub)
  • Polyphenols and Ischemic Stroke" Encyclopedia , https://encyclopedia.pub/entry/11184 (accessed December 07, 2023). (encyclopedia.pub)
  • Two main types of stroke exist: ischemic stroke (due to clot-mediated blood vessel occlusion), which accounts for about 85% of all stroke cases, and hemorrhagic stroke (caused by blood vessel rupture), which accounts for 15% of total cases. (encyclopedia.pub)
  • Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population. (biovendor.com)
  • Because of the high mortality and prevalence, HPV-associated cancers have got remained as a substantial medical condition in human culture, making an immediate have to develop a highly effective healing vaccine against them. (arcillaresearch.com)
  • Reperfusion triggers an inflammatory response and often results in oxidative damage. (wikipedia.org)
  • Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. (sciendo.com)
  • Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)
  • Ischemia decreases intracellular pH and increases intracellular Na and intracellular Ca in all age groups. (asahq.org)
  • Hypothermia during the preconditioning period increases the threshold for eliciting the infarct limitation of ischemic preconditioning. (neuraxismed.com)
  • Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
  • Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
  • Quality Controls are human serum based. (biovendor.com)
  • APC decreased intracellular Na and intracellular Ca accumulation during ischemia in young adult and middle-aged hearts. (asahq.org)
  • We hypothesized that TLRs other than TLR-4 may mediate preconditioning against cerebral ischemic injury in the developing brain. (biomedcentral.com)
  • However, mitigation strategies to preserve cardiac function after an ischemic event have often only focused on individual therapeutic agents, and the results have not been ideal. (prohealth.com)