SteatosisLiversStellateNecrosisApoptosisHypoxia-reoxygenationHepatocellularOxidative stressCold ischemiaInjuryRegenerationIschemicAccumulationRatsMitochondriaManifestationResectionSinusoidsMechanismInsultMitochondrialMechanismsFibrosisAcuteCholestasisExamination of the liverTransplantationNeutrophilsSerumPeroxisomeModelInhibitsHighlyEffects
Steatosis4
- Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
- Steatosis, i.e., the accumulation of fat in hepatocytes, plays an important role in the progression of non-alcoholic fatty liver disease (NAFLD). (theiet.org)
- Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
- 5% of hepatocytes displaying steatosis in the absence of significant ethanol intake and metabolic disease or toxic injury. (medscape.com)
Livers5
- Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)
- Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [J].2017,216. (wanfangdata.com.cn)
- Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice [J].2011,141(6). (wanfangdata.com.cn)
- Open up in another window Physique 3 MAGL inactivation attenuates hepatic I/R-induced swelling and oxidative tension(A) Both pharmacological and hereditary blockade of MAGL causes substantial postponed infiltration of neutrophils as evaluated by MPO staining (brownish staining) of livers after 24 h of reperfusion pursuing induction of just one 1 h hepatic ischemia (I/R 24h). (thetechnoant.info)
- To determine the relative importance of hepatic CD4+ T cell versus iNKT cell deficiencies in protection from IRI, iNKT KO and CD4-depleted WT livers were transplanted into WT recipients. (cetp-signal.com)
Stellate4
- We are working on the site-specific delivery of oligonucleotides and microRNA to hepatocytes or hepatic stellate cells for treatment of hepatitis and liver fibrosis. (unmc.edu)
- We have previously shown that the conjugation of siRNA to mannose-6-phosphate- PEG (M6P-PEG) can significantly enhance its delivery to hepatic stellate cells and this M6P-PEG-siRNA has the potential to treat liver fibrosis by inhibiting excess of collagen synthesis (Zhu et al, Bioconjug Chem, 2010, 21: 2119-2127 ). (unmc.edu)
- In addition, perilipin 5 regulates the activation of hepatic stellate cell, implicated in fibrosis, which is the creation of new tissue to repair the one damaged. (wikipedia.org)
- These cytokines induce caspase-3 activation as an effector caspase that activates hepatic stellate cells (HSCs) and cause fibrogenesis [ 11 ]. (bsmiab.org)
Necrosis6
- Briefly, in this classification, sinusoidal congestion, hepatocyte necrosis, and ballooning degeneration have been graded from 0 to four. (lckinhibitor.com)
- hepatocyte necrosis , sterile inflammation , and hepatocyte regeneration . (zju.edu.cn)
- For instance, N -acetyl- p -benzoquinone imine (NAPQI) protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis , danger-associated molecular patterns (DAMPs) are released to elicit sterile inflammation , and certain growth factors contribute to liver regeneration. (zju.edu.cn)
- During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. (mdpi.com)
- The process of hepatic fibrogenesis is affected by the presence of oxidative stress that increases proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), interferon, and interleukin (IL). (bsmiab.org)
- Pharmacological or hereditary inactivation of MAGL also clogged I/R-induced severe early pro-inflammatory reactions in cytokines tumor necrosis element (TNF-) and interleukin 1 (IL-1), chemokines macrophage inflammatory proteins 1 and 2 (MIP-1/CCL3 and MIP-2/CXCL2), and in hepatic manifestation of intercellular adhesion molecule 1 (ICAM-1) (Figs. 3B, 3C, S4). (thetechnoant.info)
Apoptosis4
- It has also been reported that triiodothyronine (T3) alleviates oxidative stress, inflammation and apoptosis caused by hepatic ischemia-reperfusion injury, and its mechanism of action is associated with negative regulation of the NLRP3 signaling pathway ( 10 ). (spandidos-publications.com)
- Caspase-3 levels were assessed from the blood sample, while the apoptosis of hepatocytes was evaluated using histopathologic examination of the liver. (bsmiab.org)
- Similarly, the apoptosis of hepatocyte was significantly lower in the combination group compared to the UDCA or HuMSC-S alone. (bsmiab.org)
- Because of this, we aimed to study the effect of human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptosis of hepatocytes in a rat model with cholestasis after choledochal duct ligation receiving standard UDCA therapy. (bsmiab.org)
Hypoxia-reoxygenation2
- In keeping with this idea, we demonstrated that MAGL blockade by JZL184, however, not 2-AG, in isolated hepatocytes subjected to MK-1775 hypoxia-reoxygenation attenuated hepatocyte cell loss of life as dependant on decreased lactate dehydrogenase (LDH) and ALT launch (Fig. S8). (thetechnoant.info)
- Hypoxia associated with OSA leads to hypoxia-reoxygenation with ischemia- reperfusion injury . (medscape.com)
Hepatocellular2
- The ischemia insult triggered TIM-4 expression by stressed hepatocellular phosphatidylserine (PS) presentation, peaking at 6 hours of reperfusion, and coinciding with the maximal hepatocellular damage. (bioxcell.com)
- Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
Oxidative stress2
- Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
- In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
Cold ischemia1
- In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
Injury16
- Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
- This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
- Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
- Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. (wanfangdata.com.cn)
- The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury [J].2015,78. (wanfangdata.com.cn)
- The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury [J].2016,100(2). (wanfangdata.com.cn)
- Lung ischemia reperfusion injury: A bench-to-bedside review [J].2013,17(1). (wanfangdata.com.cn)
- Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. (wanfangdata.com.cn)
- 21]Peralta,C.,Jiménez-Castro,M.B.,Gracia-Sancho,J.. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu [J].2013,59(5). (wanfangdata.com.cn)
- Systemic hypoperfusion is associated with hepatic ischemia-reperfusion injury, which may be irreversible. (uky.edu)
- The biochemical analysis revealed that the ischemic liver injury following AHF significantly elevated the activity of alanine aminotransferase (ALT), aspartate amino-transferase (AST), and alkaline phosphatase (ALP) enzymes, the level of total and direct bilirubin, and the expression of hepatic mitogen-activated protein kinase (MAPK), dynamin-1-like protein (DNM1L), and hepatic miRNA-17. (uky.edu)
- 2014). "T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury" Hepatology 60(6): 2052-2064. (bioxcell.com)
- Hepatic ischemia-reperfusion injury (IRI), an innate immunity-driven inflammation response, occurs in multiple clinical settings including liver resection, transplantation, trauma, and shock. (bioxcell.com)
- APAP overdose can induce hepatic toxicity, known as acetaminophen -induced liver injury (AILI). (zju.edu.cn)
- Nevertheless, when the inflammatory cascade is normally turned on and oxidative harm takes place under hemorrhagic surprise and ischemia-reperfusion injury, improved is mainly controlled in the transcriptional level, independent of calcium (16). (bioinbrief.com)
- p 0.05 between vehicle-treated I/R group as well as the sham organizations, and #p 0.05 between JZL184 Rabbit Polyclonal to MRPL9 treated I/R groups and vehicle-treated I/R groups in (C). MAGL inactivation attenuates hepatic I/R-induced swelling and oxidative tension We following sought to research the pathophysiological systems behind the hepatoprotective aftereffect of MAGL inhibitors on I/R-induced liver organ injury. (thetechnoant.info)
Regeneration2
- Multiple studies have shown that Nos2 takes on LY2228820 an important part in hepatocytes regeneration. (bioinbrief.com)
- Secretome is a soluble molecule and exosome produced by HuMSC, which can support hepatic epithelial regeneration through hepatogenic differentiation. (bsmiab.org)
Ischemic2
- Our results indicated that the hepatoprotective effect of carvedilol in ameliorating hepatic ischemic damage could be attributed to its ability to target the mitochondrial dynamics-related proteins (Mtf2, DNM1L and PGC-1α), but also their epigenetic regulator miRNA-17. (uky.edu)
- Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
Accumulation1
- The high rates regarding hepatic biotransformation might be a possible explanation for the low severe accumulation regarding triclosan after Transfusion-transmissible infections mouth intake. (mglurpathway.com)
Rats3
- The rats had been sacrificed immediately after 4 or 24 h of reperfusion, and liver and serum samples were collected for evaluation.Measurement of H2S concentration and aminotransferase levels inside the plasmaThe rats were euthanized four h immediately after reperfusion. (lckinhibitor.com)
- Rats underwent 60 min of IL-17 Purity & Documentation ischemia followed by four or 24 h of reperfusion. (lckinhibitor.com)
- In conclusion, addition of HuMSC-S to UDCA lowered caspase-3 levels and apoptotic cell count in rats with hepatic cholestasis after choledochal duct ligation. (bsmiab.org)
Mitochondria1
- Because of this, the actual work directed at looking into how these kinds of results about remote mitochondria mean the entire and intact hepatocyte. (mglurpathway.com)
Manifestation1
- It is considered the hepatic manifestation of metabolic syndrome, strongly linked to obesity and insulin resistance (IR), which further predisposes for diabetes and cardiovascular diseases [ 2 ]. (springer.com)
Resection1
- As human being life expectancy offers improved greatly, more and more seniors individuals with liver disease need partial hepatic resection. (bioinbrief.com)
Sinusoids1
- Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)
Mechanism3
- Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes [J].2008,47(5). (wanfangdata.com.cn)
- CONCLUSION: These findings document the importance of macrophage-specific TIM-4 activation in the mechanism of hepatic IRI. (bioxcell.com)
- However, a recent study showed the expression of can be LY2228820 controlled by calciummediated signaling in hepatocytes through a mechanism self-employed of calcineurin (17). (bioinbrief.com)
Insult1
- Ischemia preconditioning (IPC) consisted of ten min of ischemia and 10 min of reperfusion prior to the complete 60 min of ischemia insult. (lckinhibitor.com)
Mitochondrial1
- At the same time, it significantly reduced the serum albumin level, the activity of hepatic superoxide dismutase (SOD), and the expression of mitochondrial peroxisome proliferator-activated receptor-1α (PGC-1α), and mitofusin 2 (Mtf2). (uky.edu)
Mechanisms2
- Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
- Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
Fibrosis1
- [ 8 ] In adolescents with NAFLD, a direct relationship between the degree of hypoxemia and severity of hepatic fibrosis was noted. (medscape.com)
Acute3
- Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
- Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)
- Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. (mdpi.com)
Cholestasis1
- Thus, this study aims to determine the effect of Human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptotic hepatic cells in a rat model with cholestasis after choledochal duct ligation receiving urso deoxy cholic acid (UDCA). (bsmiab.org)
Examination of the liver1
- The histological examination of the liver tissue revealed degenerated hepatocytes. (uky.edu)
Transplantation3
- Geha JA, Geha JD, O'Mahony CA, Cotton RT, Galván TN, Rana A, Goss JA " Reconstruction of the Replaced Right Hepatic Artery Using Donor Iliac Arterial Y-Graft in Orthotopic Liver Transplantation . (bcm.edu)
- Hepatic ischemia-reperfusion (Recruit) harm is really a pathological problem started by simply disturbed hepatic circulation Biopsia líquida as well as high following reperfusion, which is one of the most lethal pitfalls in hard working liver transplantation along with other liver surgical treatments. (mglurpathway.com)
- This suggests that the Oxymatrine resident hepatic CD4+ T cells (but not iNKT cells) are predominant mediators of early IRI following prolonged cold preservation and liver transplantation. (cetp-signal.com)
Neutrophils1
- To research which cell types 2-AG indicators upon, we utilized circulation cytometry and qPCR to show that CB2 receptors are indicated mainly on Kupffer cells, endothelial cells and neutrophils, however, not on hepatocytes (Fig. S7). (thetechnoant.info)
Serum1
- TIM-4-deficient or wild-type WT mice treated with antagonistic TIM-4 monoclonal antibody (mAb) were resistant against liver IRI, evidenced by diminished serum alanine aminotransferase (sALT) levels and well-preserved hepatic architecture. (bioxcell.com)
Peroxisome1
- Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent. (wanfangdata.com.cn)
Model2
- This study focuses on the putative role of TIM-4 signaling in a model of liver warm ischemia (90 minutes) and reperfusion. (bioxcell.com)
- Rosuvastatin (80 mg) is shows to decrease infarct size and improve cardiac mechanical function after ischemia/reperfusion in animal model. (bioservuk.com)
Inhibits1
- 1] Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. (bioservuk.com)
Highly1
- The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. (hindawi.com)
Effects1
- We evaluated whether siRNA targeting maternal hepatic angiotensinogen (Agt) could ameliorate symptoms of preeclampsia without adverse placental or fetal effects in 2 rodent models. (jci.org)