Loading...
  • hypoxia
  • This review summarizes the state-of-the-art of the complex kinase mTORC1 focusing in upstream and downstream pathways, their role in central nervous system and their relationship with autophagy, apoptosis and neuroprotection/neurodegeneration after ischemia/hypoxia. (frontiersin.org)
  • We will revise their connexion of mTORC1 with autophagy, apoptosis and neuroprotection/neurodegeneration, mostly focused on ischemia/hypoxia. (frontiersin.org)
  • If this was all initiated by hypertension, then managing the demand by treating the blood pressure and other physiologic variables such as pulmonary edema, hypoxia, etc. would result in resolution of the ischemia, and could be measured by resolving ST depression on the ECG. (blogspot.com)
  • induce
  • This is achieved by a midline laparotomy approach for the surgery with one incision allowing both a right nephrectomy that provides control tissue and clamping of the left renal pedicle to induce ischaemia of the left kidney. (jove.com)
  • Subsequently, various stimuli, in addition to short episodes of ischemia, have been shown to induce a preconditioning effect. (asahq.org)
  • brain
  • 4-7 Isoflurane, sevoflurane, and desflurane, currently used volatile anesthetics, have been shown to precondition the brain against ischemia in animal studies. (asahq.org)
  • Intense efforts are being undertaken to understand the pathophysiological mechanisms triggered after brain ischemia and to develop effective pharmacological treatments. (frontiersin.org)
  • Brain ischemia may be analyzed from two different perspectives: that of oxygen deprivation (hypoxic damage per se ) and that of deprivation of glucose/serum factors. (frontiersin.org)
  • 1 Although some of treatment regimens, primarily based on physical therapy, have partly improved the recovery of these patients, there are no drugs available that could effectively repair the brain tissue damage resulting from ischemia or mechanical injury. (asahq.org)
  • However, the effect of IL-1RA on blood-brain barrier disruption following ischemia-reperfusion has not been reported. (biomedcentral.com)
  • fluorescence
  • Total internal reflection fluorescence microscopy (TIRFM) is used for the first time to study the adsorption behavior of lipase onto the PBS crystal surface. (jove.com)
  • protein
  • Förderung durch die Deutsche Forschungsgemeinschaft (DFG): „C-reaktives Protein (CRP) als pathogenetischer Faktor bei Entzündung und Ischämie/Reperfusion: Therapeutische Implikationen" (EI 866/1-1) als Hauptantragsteller. (lexerklinik.de)
  • Using in vivo and neuronal OGD models, it was recently established that mTORC1 (mammalian Target of Rapamycin Complex-1), a protein complex downstream of PI3K-Akt pathway, is one of the players deregulated after ischemia and OGD. (frontiersin.org)
  • 14 have demonstrated that systemic delivery of neuroprotective protein Bcl-xL does not lead to protection after focal cerebral ischemia. (asahq.org)
  • various
  • In the present review, numerous phytochemicals and various feats in nanomedicine for the treatment of AD have been discussed mechanistically for the first time. (frontiersin.org)
  • novel
  • To enhance PI3K-Akt reactivation after cardiopulmonary resuscitation (CPR), we developed novel TAT-p85 fusion proteins designed to enter tissues rapidly during CPR and activate Akt (p-Akt). (ahajournals.org)
  • This approach uses a novel retroviral vector bearing a HIF-1-inducible "sensor" reporter gene (HSV1-tk/GFP fusion) and a constitutively expressed "beacon" reporter gene (DsRed2/XPRT). (aacrjournals.org)
  • cellular
  • Luxcel Biosciences' unique MitoXpress® Intra - Intracellular Oxygen Concentration Assay, allowing real-time quantitation of cellular oxygenation, and iii. (ddw-online.com)
  • study
  • Up until now, my wife and I have funded the PERFECT (Paced ECG Requiring Fast Emergent Coronary Therapy) study by making her the full time coordinator without pay. (blogspot.com)
  • treatment
  • The ICTM is a program which contains a team of professional doctors who have taken the time to scientifically research type 2 diabetes, the best treatment for the disease and ways to enhance healthy living. (pharmacologicalsciences.us)
  • possible
  • We are really excited about this innovative new tool for the ischemia reperfusion field, made possible by our recently reported MetaCell-TM collaboration, supported by the EU H2020 fast track to innovation initiative. (ddw-online.com)
  • 5) If the ischemia is refractory to maximal medical management, angiogram with possible PCI is indicated. (blogspot.com)
  • feature
  • If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. (cambridge.org)
  • minutes
  • They require a total incubation time of three hours and twenty minutes whereas the high sensitivity (HS and HSP) versions of the kits require a total incubation time of one hour and twenty minutes. (lifediagnostics.com)