Ischemia reduce ischemia reperfusion injury ischemic preconditioning. Medical search. Frequent questions

To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)
Additionally, GB treatment had an impact on the levels of oxidative stress and ferroptosis markers, including reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and Fe2+ in the cerebral environment during IR injury. (bvsalud.org)
Emerging data have revealed that complement and neutrophils contribute to hyperinflammation and oxidative stress in I/R induced acute kidney injury (AKI). (bvsalud.org)
oxidative stress that occurs during reperfusion injury has been shown to induce apoptosis, over and above that induced by ischemia. (latestfashiontips.com)
Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
Melatonin has been shown to reduce mitochondrial oxidative stress (37) and increase nitric oxide availability while reducing endothelin expression (38). (ectrx.org)
In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
Liang HW, Qiu SF, Shen J et al (2008) Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. (springer.com)
Conclusions: Fenofibrate protects TNF-alpha-induced dysfunctional ECs via up-regulated eNOS-NO, reduced oxidative stress and improved cell viability. (sun.ac.za)
Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)

Preconditioning, i.e., repeated exposure to short periods of ischemia, effectively reduces endothelial I/R injury. (artinis.com)
Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)

MATERIALS AND METHODS: Adult male Sprague-Dawley rats were exposed to transient middle cerebral artery occlusion (tMCAO) followed by reperfusion in order to trigger cerebral I/R injury. (bvsalud.org)
Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
2. Ren C, Yan Z, Wei D, Gao X, Chen X, Zhao H. Limb remote ischemic postconditioning protects against focal ischemia in rats. (ac.ir)
4. Ren C, Gao X, Niu G, Yan Z, Chen X, Zhao H. Delayed postconditioning protects against focal ischemic brain injury in rats. (ac.ir)
Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. (ac.ir)
Ischemic postconditioning may not influence early brain injury induced by focal cerebral ischemia/reperfusion in rats. (ac.ir)
10. Allahtavakoli M, Jarrott B. Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats. (ac.ir)
13. Zhang W, Miao Y, Zhou S, Jiang J, Luo Q, Qiu Y. Neuroprotective effects of ischemic postconditioning on global brain ischemia in rats through upregulation of hippocampal glutamine synthetase. (ac.ir)
16. Wang Q, Zhang X, Ding Q, Hu B, Xie Y, Li X, Yang Q, Xiong L. Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats. (ac.ir)
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
Rats in the EPCS-treated group had significantly reduced levels of blood urea nitrogen and serum creatinine at 24 hours after operation, compared to rats that in the IRI-operated group. (annalsoftransplantation.com)
Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
Ren C, Yan Z, Wei D et al (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. (springer.com)
Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)
Chen TY, Goyagi T, Toung TJ et al (2004) Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats. (springer.com)
Zhang Y, Chen ZW, Girwin M et al (2005) Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. (springer.com)
Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. (springer.com)
In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)

In rodents, Bbeta(15-42) inhibits proinflammatory cytokine release and is cardioprotective during ischemia-reperfusion injury. (bris.ac.uk)
However, clinical and preclinical results using various cardioprotective strategies to attenuate reperfusion injury have generally not been applicable for every day clinical practice. (eurekaselect.com)

Although the mechanisms of ischemic preconditioning and APC are thought to be similar, it is not known whether the beneficial effects of APC are also reduced in the aged myocardium. (asahq.org)
Given its similarities to IPC, it seems reasonable to hypothesize that the beneficial effects of APC may also be reduced in aged myocardium. (asahq.org)
Following myocardial I/R injury, the expression of miR‑133b‑5p was decreased in myocardium, while this decrease was restored by IPC. (spandidos-publications.com)
and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. (eurekaselect.com)

The major source of free radicals in post-ischemic tissue appears to be initiated by the formation of superoxide anion, formed by the action of xanthine oxidase. (lomr.org)
9. Allahtavakoli M, Moloudi R, Arababadi MK, Shamsizadeh A, Javanmardi K. Delayed post ischemic treatment with Rosiglitazone attenuates infarct volume, neurological deficits and neutrophilia after embolic stroke in rat. (ac.ir)
The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)

The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. (ectrx.org)
In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
DI-fusion Preconditioning of donors with interleukin-10 reduces hepatic. (ac.be)
Preconditioning of donors with interleukin-10 reduces hepatic ischemia-reperfusion injury after liver transplantation in pigs. (ac.be)

In addition, IPC reduced LDH and CK‑MB release, attenuated myocardial infarct size, improved cardiac function following I/R, and inhibited the elevation of ROS and MDA and the decrease in activities of the antioxidant enzymes SOD, CAT and GPx. (spandidos-publications.com)
remote ischemic conditioning reduced infarct size in ST-elevation myocardial infarction (STEMI) patients when used in the ambulance or emergency department as an adjunct therapy to primary percutaneous coronary intervention (PCI), or when used with thrombolytic drugs. (wikipedia.org)
In seven trials comprising 2,372 STEMI patients, infarct size-a measure of damage to the heart-was reduced by 17-30% on average, and the reduction was greatest (~60%) in the largest infarcts. (wikipedia.org)
citation needed] Infarct size is a predictor of future cardiovascular events as well as mortality, and researchers doing long-term follow-up on STEMI patients treated with RIC found that the reduction in heart damage at the time of the heart attack resulted in clinical improvement four years later: MACCE (major adverse cardiovascular and cerebrovascular event) rates were reduced by 47% (13.5% vs. 25.6%, p=0.018). (wikipedia.org)
We show that Bbeta(15-42) robustly and reproducibly reduced infarct size in all models of ischemia-reperfusion. (bris.ac.uk)
RESULTS: Reduced infarct volume and enhanced neurological function were signs of dose-dependent protection from cerebral I/R injury by GB therapy. (bvsalud.org)
Ischemic preconditioning and anesthetic preconditioning (APC) are reported to decrease myocardial infarct size during ischemia-reperfusion injury. (asahq.org)
Creatine kinase and infarct sizes were significantly reduced and left ventricular developed pressure was improved with APC in the young adult and middle-aged groups but not the aged group. (asahq.org)
Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
MG53 KO mice lack IPC-mediated cardioprotection as evidenced by a failure of IPC to reduce IR-induced myocardial infarct size. (biomedcentral.com)
Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)

6. Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X, Zhang S. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. (ac.ir)

Ischaemic preconditioning describes the phenomenon where transient and brief ischaemia confers protection against a subsequent prolonged and injurious period of ischaemia. (medsci.org)
Delayed postconditionig initiates additive mechanism necessary for survival of selectively vulnerable neurons after transient ischemia in rat brain. (ac.ir)
IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)

IPC involves single or multiple brief periods of sublethal ischemia, which increase myocardial resistance to a greater subsequent insult. (spandidos-publications.com)
BRIEF periods of sublethal ischemia before prolonged ischemia help to protect the heart against extensive infarction. (asahq.org)

abstract = "Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. (bris.ac.uk)
Abstract Purpose To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model. (bvsalud.org)
Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. (bvsalud.org)

20. Zhao H. The protective effect of ischemic postconditioning against ischemic injury: from the heart to the brain. (ac.ir)

Ischemic preconditioning (IPC) is an important endogenous adaptive phenomenon first described by Murry et al ( 1 ) in 1986. (spandidos-publications.com)
1 demonstrated the phenomenon in dogs, ischemic preconditioning (IPC) has been shown to occur in every mammalian species in which it has been investigated. (asahq.org)
Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. (sun.ac.za)
Remote ischaemic preconditioning (RIPC) is the phenomenon whereby brief periods of ischaemia (reduced oxygen delivery) in one organ can have a protective effect against subsequent prolonged ischaemic insults in other organs. (researchforlife.org.nz)
Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)

Remote ischaemic preconditioning (RIPC) is known to minimise IRI in previous studies. (medsci.org)
Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
PURPOSE OF THE STUDY The purpose of this study was to minimize tourniquet-induced ischemia-reperfusion injury (IRI) in total knee arthroplasty (TKA) surgery using the remote ischemic preconditioning (RIPC) model, as well as to assess antioxidant balance with thioldisulfi de homeostasis (TDH). (bvsalud.org)
Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. (silverchair.com)
The authors hypothesized that limb RIPC would reduce lung injury in patients undergoing pulmonary resection. (silverchair.com)
Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff served as RIPC stimulus. (silverchair.com)

Ischaemic reperfusion injury (IRI) after tourniquet release during total knee arthroplasty (TKR) is related to postoperative cerebral complications. (medsci.org)
ETHNOPHARMACOLOGICAL RELEVANCE: Cerebral ischemia/reperfusion (I/R) injury is a major cause of neuronal damage and death. (bvsalud.org)
AIM OF STUDY: The aim of study was to investigate the potential role of GB in protecting against cerebral I/R injury and explore the underlying mechanisms. (bvsalud.org)
CONCLUSION: Our findings suggest that GB may protect against cerebral I/R injury by inhibiting ferroptosis through disrupting NCOA4-FTH1 interaction. (bvsalud.org)
GB has potential therapeutic applications for cerebral I/R injury, and further investigation of the underlying mechanisms and clinical trials are warranted. (bvsalud.org)
Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the hippocampal CA1 region. (springer.com)
Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. (springer.com)
The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
Global cerebral ischemia was performed via 10 min of four-vessel occlusion. (springer.com)
We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)

Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? (southampton.ac.uk)
Genetic and pharmacological studies have identified aldose reductase, heme oxygenase-1 (HO-1), and Mn-superoxide dismutase (MnSOD) as critical mediators of the antioxidative stress effects of late preconditioning ( 8 - 10 ). (spandidos-publications.com)
In this report, a comprehensive analysis of those factors is provided, and the fundamental molecular inflammatory mediators present after liver ischemia and reperfusion are discussed. (ectrx.org)
Investigations involving animal models and human trials are reviewed, a summary of significant studies in human subjects is presented ( Table 1 ), and the pathways and mediators important in liver ischemia-reperfusion injury are described ( Figure 1 ). (ectrx.org)

Tourniquet release during the late period of TKR can induce ischaemic-reperfusion injury, eliciting the activation of neutrophils, circulating pro-inflammatory cytokines, and reactive oxygen species [ 2 , 3 ]. (medsci.org)
The major drawback of such strategies is that they can induce I/R injury to the residual liver parenchyma [4, 12]. (123dok.net)
This technique is most commonly applied by inflating a blood pressure tourniquet on the upper arm to induce three five-minute cycles of ischaemia, with intervening periods of reperfusion. (researchforlife.org.nz)
The goal of this proposal is to investigate a novel preservation method utilizing hydrogen sulfide (H2S) to induce a protective state of hibernation against I/R injury. (gotomydoctor.com)

Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
Another endogenous form of cardioprotection, similar to PC but applicable at the time of reperfusion, termed postconditioning (PostC), has been recently described. (eurekaselect.com)

Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. (ectrx.org)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
The protection associated with preconditioning is one of the most powerful mechanisms of protection known. (lomr.org)
The key mechanisms underlying myocardial I/R injury include increased intracellular calcium concentration, sudden generation of reactive oxygen species (ROS) and inflammatory cytokines, adenosine triphosphate (ATP) depletion, and development of metabolic acidosis. (researchsquare.com)

Zhou Y, Fathali N, Lekic T et al (2012) Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. (springer.com)

Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)
In a previous study using a microRNA (miRNA/miR) microarray assay, we demonstrated that miR-133b-5p was upregulated in response to hypoxic preconditioning (HPC). (spandidos-publications.com)
Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
In addition, inhaled hypoxic air preconditioning including intermittent hypoxia has been suggested a potential non-pharmacological therapeutic intervention to improve some cardiovascular diseases such as hypertension, myocardial infarction. (spandidos-publications.com)
Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
These therapeutic effects can be further enhanced by hypoxic preconditioning. (researchsquare.com)

Endothelial ischemia-reperfusion (I/R) injury importantly contributes to the poor prognosis during ischemic (myocardial) events. (artinis.com)
In the present study, we examined the hypothesis that exercise has preconditioning effects on endothelial I/R injury. (artinis.com)
Therefore, we studied whether an acute bout of endurance or interval exercise is able to protect against endothelial I/R injury. (artinis.com)
In conclusion, a single bout of lower limb interval exercise, but not moderate-intensity endurance exercise, effectively prevents brachial artery endothelial I/R injury. (artinis.com)

Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation, by triggering the body's natural protection against tissue injury. (wikipedia.org)
Considering that tourniquet application during TKR is related to ischaemic injury, the organ protective effect of ischaemic preconditioning can have a beneficial role after tourniquet release during TKR. (medsci.org)
However, it is not easy to apply ischaemic preconditioning in a clinical setting because brief organ ischaemia should be preceded after real ischaemic time [ 8 ]. (medsci.org)
In conclusion, on top of its harmful early impact on organ function, I/R injury is linked to increased tumor growth. (123dok.net)
Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)

As liver ischemia ends and reperfusion begins, reactive oxygen species are one of the first elements formed (14). (ectrx.org)
All reactive oxygen species respond in varying degrees at the initiation of reperfusion. (ectrx.org)
It has been demonstrated that ozone, probably by means of an oxidative preconditioning (OP) mechanism, protected the liver against the damage mediated by reactive oxygen species. (lomr.org)

In addition to its function in skeletal muscle, MG53 has been shown to have protective effects on various forms of cardiac muscle injury. (biomedcentral.com)

7. Yuan Y, Guo Q, Ye Z, Pingping X, Wang N, Song Z. Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (ac.ir)
Zhang Y, Irwin MG, Wong TM (2004) Remifentanil preconditioning protects against ischemic injury in the intact rat heart. (springer.com)
Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)

Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. (ectrx.org)
Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)
The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)
Liver ischemia-reperfusion injury is ameliorated by treatment with various free radical scavengers, as shown in investigations of allopurinol, superoxide dismutase, catalase, and other antioxidant compounds. (ectrx.org)
Adenoviral delivery of superoxide dismutase has been shown to produce beneficial effects in warm ischemia reperfusion (18), alcohol-induced liver injury (19), and reduced-size liver grafts (20). (ectrx.org)
Recent evidence has shown that in cases of generalized ischemia after hemorrhagic shock, the effectiveness of melatonin in improving liver function depends on the melatonin receptor (40). (ectrx.org)
Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)
the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
Thus, liver surgeons have the option to apply vascular inflow control procedures and sometimes total vascular exclusion to reduce intraoperative bleeding. (123dok.net)
In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
Many studies (9-10) indicate that oxygen free-radical formation after reoxygenation of liver may initiate the cascade of hepatocellular injury. (lomr.org)
It has been demonstrated (17-18) that ozone, probably by means of an oxidative preconditioning mechanism, protected the liver against the damage produced by a chemical challenge mediated by ROS. (lomr.org)
Also, preconditioning has been demonstrated in intestine (24), brain (25) and liver (26). (lomr.org)
Although the mechanism of preconditioning is not yet known, it has been suggested that liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin and through the balance of adenosine and xanthine levels (24,27). (lomr.org)
Taking into account both protective effects, ischemic and ozone oxidative preconditioning, against liver injury by I/R, the aim of this study is to stablish a comparison between them, in a liver I/R model. (lomr.org)

Neonatal rat cardiomyocytes were isolated and subjected to hypoxia/reoxygenation (H/R) injury, with or without HPC. (spandidos-publications.com)
IPC suppressed IR-induced infarction in wild type (WT) mouse hearts whereas overexpression of GFP-MG53 fusion protein reduced hypoxia- or H 2 O 2 -induced cell death [ 8 ]. (biomedcentral.com)

At present, pharmacological PC and PostC are possible alternative methods that may substitute pharmaceutical treatments the short ischemic insults. (eurekaselect.com)

Surgical ACL reconstruction performed with a tourniquet induces compression and ischemic stress of the quadriceps femoris (QF) muscle which can accelerate postoperative weakness. (artinis.com)
Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)

Moreover, the peptide significantly reduced plasma levels of the cytokines interleukin 1beta, tumor necrosis factor alpha, and interleukin 6. (bris.ac.uk)

HPC protected neonatal rat cardiomyocytes against H/R injury by increasing cell viability, while reducing LDH release and cell apoptosis. (spandidos-publications.com)
However, the knockdown of miR‑133b‑5p in the cardiomyocytes blocked HPC‑mediated cardioprotection as reflected by the aggravation of cell injury and apoptosis. (spandidos-publications.com)

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. (ac.ir)

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)

IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)

8-11 Volatile anesthetics are now being investigated as pharmacologic agents to precondition the heart during coronary artery bypass surgery, with both positive 12-14 and negative 15 results. (asahq.org)
We performed the other study group pharmacologic preconditioning by infusional administration of 10 μg/kg/minute bradykinin intravenously. (bvsalud.org)
Conclusion Either ischeamic preconditioning or pharmacologic preconditioning made by bradykinin reduced the ischemia reperfusion injury at jejunum. (bvsalud.org)

We investigated the effects of a fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of ischemia-reperfusion at three different study centers (Universities of Dusseldorf and Vienna, TNO Biomedical Research). (bris.ac.uk)
Ginkgolide B (GB) has been shown to exhibit neuroprotective effects in various brain injury models. (bvsalud.org)
However, the beneficial effects of ischemic preconditioning have been shown to decrease with advancing age. (asahq.org)
Taking into account that ischemic preconditioning (IschP) is also a protective mechanism, a comparative study between both preconditioning effects, with the aim to study the effectiveness of both protective procedures, was performed. (lomr.org)
Alkan T (2009) Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning. (springer.com)
BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
Some effects of H2S protection require the continued presence of H2S, such as ROS scavenging during ischemia. (gotomydoctor.com)
[ 16 ] Early identification of pre-DIC and treatment with heparin may reduce mortality and duration of hospitalization, as heparin has combined antithrombin and anti-inflammatory effects. (medscape.com)

Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)

A total of 187 animals were used, and the peptide was compared with the free radical scavenger Tempol, CD18 antibody, alpha-C5 antibody, and the golden standard, ischemic preconditioning. (bris.ac.uk)
Antibody-mediated blockade of NETs can also significantly ameliorate renal tubular injury and inflammation. (bvsalud.org)

The degree of apoptotic cell death following ischemia/reperfusion may be reduced by the use of caspase inhibitors, antioxidants, and ischemic preconditioning. (latestfashiontips.com)

This "conditioning" activates the body's natural protective physiology against reperfusion injury and the tissue damage caused by low oxygen levels-a protection present in many mammals. (wikipedia.org)
Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)

Knockout of C3aR restores NETs release and improves renal function after I/R injury. (bvsalud.org)
At 72 hours after reperfusion, renal function and morphology showed significant improvements in the EPCs-treated group. (annalsoftransplantation.com)

an early phase occurring instantly and continuing for 3-4 h and a late (or delayed) phase occurring ~12 h after the preconditioning stimulus that may persist to 72 h ( 2 , 3 ). (spandidos-publications.com)

citation needed] In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
Other researchers confirmed this remote effect and found that performing the preconditioning protocol on kidney or gastrointestinal tissue also provided protection to the heart. (wikipedia.org)
This indicates the presence of a remote preconditioning effect of exercise, which is selectively present after short-term interval but not continuous exercise in healthy young subjects. (artinis.com)

Cellular injury was evaluated by detecting cell viability, lactate dehydrogenase (LDH) activity and apoptotic rate. (spandidos-publications.com)
This is an important feature of apoptotic cell death/removal that occurs during development and cellular injury. (latestfashiontips.com)

The benefits of APC are significantly reduced with advanced age in an isolated rat heart model. (asahq.org)

Since cardiomyocytes are terminally differentiated cells with limited self-renewal capacity, and membrane rupture is a major cause of cardiomyocyte cell death following injury, membrane repair is a necessary process for preserving cardiomyocyte viability [ 6 ]. (biomedcentral.com)

Ischemic preconditioning (IPC) was first reported in 1986 by Murry et al. (biomedcentral.com)

Anatomy30

Organisms14

Diseases39

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes37

Disciplines and Occupations1

Information Science1

Health Care4

Oxidative stress11

Short periods of ischemia2

Rats23

Cardioprotective2

Myocardium5

Post-ischemic3

Hepatic7

Infarct11

Focal cerebral ischemia1

Transient3

Periods of sublethal ischemia2

Abstract3

Effect of ischemic1

Phenomenon5

RIPC7

Cerebral10

Mediators4

Induce4

Endogenous2

Mechanisms4

Limb ischemic1

Hypoxic6

Endothelial4

Organ8

Reactive3

Cardiac1

Protects3

Liver15

Hypoxia2

Insults1

Induces2

Cytokines1

Apoptosis2

Myocardial injury1

Cause of acute kidney3

Acute kidney1

Pharmacologic3

Effects8

Clinical1

Antibody2

Caspase1

Tissue damage2

Renal function2

Stimulus1

Remote3

Apoptotic2

Significantly reduced1

Cardiomyocytes1

Murry1