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  • cardiac
  • Evidence has recently emerged indicating that circadian clocks intrinsic to cardiac cells may contribute to time of day dependence of cardiovascular physiology. (ahajournals.org)
  • Recently ischemia modified albumin (IMA) has emerged as the earliest cardiac marker. (alliedacademies.org)
  • Further data from the Multiple Risk Factor Intervention Trial (MRFIT) and Lipid Research Clinic's Coronary Primary Prevention Trial (LRCPPT) demonstrated individuals with asymptomatic ischemia on exercise treadmill testing (ETT) in a population of patients without known CAD was predictive of a five-fold increase in risk for coronary events and cardiac death in long-term follow-up. (oncologynurseadvisor.com)
  • Further understanding of I/R tolerance rhythms will potentially provide novel insight regarding the etiology and treatment of ischemia-induced cardiac dysfunction. (ahajournals.org)
  • severe
  • Hypoxia-ischaemia around the time of birth is associated with approximately 1-3/1000 cases of moderate to severe encephalopathy and a high risk of death or disability [ 1 , 2 ]. (mdpi.com)
  • A physician should suspect this in any patient with rapid onset of severe abdominal pain, which is often out of proportion to the physical exam findings (lacking involuntary guarding or peritoneal signs although these may occur later in the course). (thecardiologyadvisor.com)
  • We conclude that venous limb ischemia/gangrene is explained in some cancer patients by profoundly disturbed procoagulant-anticoagulant balance, whereby warfarin fails to block cancer-associated hypercoagulability while nonetheless contributing to severe PC depletion, manifest as a characteristic supratherapeutic INR caused by parallel severe factor VII depletion. (bloodjournal.org)
  • insult
  • Hypoxia-ischaemia is characterized by progressive evolution of damage over days following the insult [ 3 , 4 ]. (mdpi.com)
  • tolerance
  • We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. (ahajournals.org)
  • circadian
  • The results of this study demonstrate for the first time in humans that myocardial infarct size and left ventricular function after STEMI have a circadian dependence on the time of day onset of ischemia. (ahajournals.org)
  • This time of day dependence mainly has been attributed to noncardiac factors such as changes in sympathetic tone 6 and circadian variation in coagulation factors. (ahajournals.org)
  • Genetic ablation of the cardiomyocyte circadian clock (termed cardiomyocyte-specific circadian clock mutant [CCM] mice) attenuated/abolished time-of-day variations in I/R outcomes observed in wild-type hearts. (ahajournals.org)
  • mice
  • A plot of GABA, Tau, and neuronal marker concentrations against the ratio of acetate/NAA allowed precise separation of mice whose ischemia onset lay within arbitrarily chosen time-windows. (epfl.ch)
  • Wild-type (WT) and CCM mice were housed under controlled conditions in a 12-hour light/12-hour dark cycle (lights on at zeitgeber time [ZT]0, lights off at ZT12). (ahajournals.org)
  • alterations
  • 5 This mechanism allows the cell to anticipate alterations in environmental stimuli, through time-of-day-dependent modulation of cellular responsiveness to extrinsic factors. (ahajournals.org)
  • MEASURES
  • Time domain measures of heart rate variability described by the Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (intechopen.com)
  • The four measures marked in grey were recommended for time domain heart rate variability assessment . (intechopen.com)
  • mechanisms
  • To appropriately manage mesenteric ischemia, physicians need to be aware of mesenteric vasculature anatomy, etiological mechanisms as well as the spectrum of presentations of this condition (detailed below). (thecardiologyadvisor.com)
  • results
  • [ 3 ] Time wasted attempting to arrange for imaging studies, laboratory testing, or other diagnostic procedures results in the loss of testicular tissue. (medscape.com)
  • When the twist is sufficient to obstruct arterial inflow, testicular ischemia results. (medscape.com)
  • In its early stages, the disease affects pancreatic exocrine function, which could be followed by impaired endocrine function that results in the onset of diabetes mellitus [ 5 , 6 ]. (hindawi.com)
  • function
  • Multiple clock proteins appear to be regulated in a time-dependent manner in cardiomyocytes that may have profound effects on myocardial metabolism, function, and response to injury. (ahajournals.org)
  • The lack of ATP during ischemia ceases function of the 3Na + -2K + ATPase, thereby exacerbating the intracellular Na + overload. (jci.org)