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  • cardiac
  • We hypothesized pulmonary exposure to Ag core AgNP induces a measureable increase in circulating cytokines, expansion of cardiac ischemia-reperfusion (I/R) injury and is associated with depressed coronary constrictor and relaxation responses. (rti.org)
  • infarct size
  • Next, we found that naringin was able to cross the blood-brain barrier, and naringin decreased neurological deficit score, reduced infarct size, and attenuated apoptotic cell death in the ischemia-reperfused rat brains. (springer.com)
  • protective
  • Although we have shown that administration of rat AM plus human AMBP-1 at the beginning of reperfusion is protective, it remains unknown whether a combination of human AM and human AMBP-1 is also beneficial and, if so, whether delayed administration of AM/AMBP-1 (which is more clinically relevant) reduces gut I/R-induced mortality. (sbir.gov)
  • Protective effect of celastrol on myocardial ischemia-reperfusion injury. (bioportfolio.com)
  • necrosis
  • A-769662 also augmented endothelial nitric oxide synthase (eNOS) activation during ischemia, which partially attenuated myocardial stunning, but did not prevent necrosis. (nih.gov)
  • organs
  • The goal of this review is to summarize the role of the proteasome and pharmacological compounds that regulate the proteasome in protecting the organs from the ischemia-reperfusion injury. (mdpi.com)
  • The use of AMPK activators may represent a novel strategy to protect the heart and other solid organs against ischemia. (nih.gov)
  • C57Bl
  • C) Isolated C57Bl/6 hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min prior to global no-flow ischemia (25 min) and reperfusion (30 min). (nih.gov)
  • artery
  • A. Hossny, "Blunt popliteal artery injury with complete lower limb ischemia: is routine use of temporary intraluminal arterial shunt justified? (hindawi.com)
  • reactive
  • In particular, ischemia leads to depletion of cellular energy, accumulation of intracellular sodium, calcium, and reactive oxygen species (ROS), and activation of multiple enzyme systems leading to cell damage [ 3 ]. (hindawi.com)
  • subsequent
  • Isolated AMPK inactivated kinase dead (KD) hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min during baseline aerobic perfusion, prior to global no-flow ischemia (25 min) and subsequent reperfusion (30 min) without compound. (nih.gov)
  • surgical
  • Blood samples were drawn from all animals to evaluate plasma neutrophil gelatinase-associated lipocalin (NGAL) at the beginning, 15 minutes after ischemia, 15 minutes after reperfusion, and 6 hours after the surgical procedure (T0, T1, T2, and T3, respectively). (dovepress.com)
  • reduce
  • Even though numerous modalities and substances have been studied to reduce gut ischemia/reperfusion (I/R)-induced mortality, none have been entirely successful. (sbir.gov)
  • functional
  • 7 In parallel, angiogenic growth factors such as vascular endothelial growth factor, signaling via the phosphatidylinositol 3 (PI3)-kinase-AKT pathway, counteract I/R injury as early as 24 hours after ischemia, 8 well before functional neovascularization would occur. (ahajournals.org)