Iron status biomarkers. Medical search. Frequent questions

Assessment of iron status is challenging, and indices such as serum ferritin, soluble transferrin receptor, and zinc protoporphyrin have specific weaknesses. (ox.ac.uk)
The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 µg/dL (95% CI: 0.001⁻0.50) for iron, 1.54 ng/mL (0.56⁻2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40⁻1.22) for hemoglobin. (nih.gov)
The search incorporated terms for liver cancer (hepatocellular and cholangiocarcinoma) and for serum iron (iron, ferritin, and transferrin). (ncri.org.uk)
There was evidence of an association between high serum ferritin and primary liver cancer risk (6 studies, HR 1.49, 95% CI 1.13, 1.96) and high serum iron and primary liver cancer risk (3 studies, HR 2.47 95% CI 1.31, 4.63). (ncri.org.uk)
We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
In developed countries, individual iron prophylaxis guided by iron status (serum ferritin) has physiological advantages compared to general iron prophylaxis. (hindawi.com)
Associations between self-reported supplementation and duration of vegan diet with biomarkers of cobalamin (serum cobalamin, holotranscobalamin, homocysteine, folate) and iron status (serum ferritin, iron binding capacity, transferrin and saturation of transferrin) were assessed by cross-sectional analyses of medical data from a clinical nutrition center. (mdpi.com)
As a baseline set of blood tests, haemoglobin, haematocrit, mean cellular volume (MCV), mean cellular haemoglobin (MCH) and serum ferritin levels are the important parameters to monitor iron deficiency. (sems-journal.ch)
As an exception in adult elite sports, a ferritin value of 50µg/l should be attained in athletes prior to altitude training, as iron demands in these situations are increased. (sems-journal.ch)
A long-term daily oral iron intake or iv-supplementation in the presence of normal or even high ferritin values does not make sense and may be harmful. (sems-journal.ch)
Design-- In this community-based cluster survey, capillary blood was obtained from 680 children (aged 6-35 mo) for measurement of iron status by using ferritin, TfR, and ZP. (cdc.gov)
Positive predictive values of ID based on the other iron indicators in predicting ID based on the multiple- criteria model were highest for ferritin and TfR. (cdc.gov)
Another 30% is stored in ferritin, a protein found throughout the body (although this percentage can be significantly higher or lower in cases of iron overload or deficiency), and a few percent in myoglobin, a protein specifically utilized by muscle cells. (irondisorders.org)
When body iron stores increase above these relatively normal ratios, proportionally greater amounts of iron are stored in non-blood tissue in ferritin molecules or a complex called hemosiderin. (irondisorders.org)
Very low or very high ferritin in combination with low or high TS % can help a physician confirm a diagnosis of either iron deficiency or iron overload. (irondisorders.org)
Ferritin is a protein synthesized by the body that is mainly utilized to store iron for future use. (irondisorders.org)
Iron in excess of daily needs is stored in ferritin molecules, which hold up to 4,500 iron atoms each. (irondisorders.org)
It includes assessments of iron levels , ferritin, a complete blood count , and vitamin B12 and folate (vitamin B9) levels. (londonbloodtests.uk)
Ferritin is a blood protein responsible for storing iron. (londonbloodtests.uk)
Ferritin levels indicate the body's iron storage capacity and can assist in the diagnosis of anaemia and liver disease. (londonbloodtests.uk)

Hepcidin itself is regulated by a combination of signals derived from iron stores, inflammation, and erythropoietic expansion. (ox.ac.uk)
However, other factors besides iron deficiency can cause anemia, especially inflammation, which responds poorly to iron treatment, and inherited disorders of red blood cells, which are associated with accumulation of excess pathogenic iron. (ox.ac.uk)
Inflammation status. (cdc.gov)
CDC's Nutritional Biomarkers Branch (NBB) offers sets of value-assigned serum QC materials for biomarkers of nutritional status and inflammation. (cdc.gov)
We conducted a secondary analysis of 27 plasma biomarkers representing glucose metabolism, inflammation, adipokines, endothelial dysfunction, IGF axis, and iron store plus age and BMI at blood collection from an existing case-control study nested in the Nurses' Health Study (NHS), including 1,303 incident diabetes case subjects and 1,627 healthy women. (diabetesjournals.org)
EE can lead to malnutrition, anemia (iron-deficiency anemia and anemia of chronic inflammation), Stunted growth, impaired brain development, and impaired response to oral vaccinations. (wikipedia.org)
Associations between nutrient intake and biomarkers for nutrient status and nutrient status and growth are thus likely distorted in children with inflammation. (wikipedia.org)
We also measured haemoglobin and biomarkers of iron status and inflammation at the start and end of a malaria season. (ox.ac.uk)
2200C was similarly associated with reduced haemoglobin levels and trends towards iron deficiency, anaemia and iron deficiency anaemia at the end of the malaria season in models adjusted for age, sex, village, inflammation and malaria parasitaemia. (ox.ac.uk)
Exercise-induced inflammation impedes iron absorption in the digestive tract by upregulating the expression of the iron regulatory protein, hepcidin. (providence.org)
Total iron-binding capacity, total cholesterol, and albumin are markers of inflammation and nutrition status [5]. (lifespan.io)
Researchers speculated that heterogeneity regarding total iron-binding capacity, total cholesterol, and albumin within the centenarian population might reflect nutrition but not inflammation, as other markers of inflammation, liver function, and anemia didn't show differences within this population. (lifespan.io)
Iron status and inflammation in women of reproductive age: A population-based biomarker survey and clinical study. (disabilityresearchcenter.com)
We recommend further research into the causes of this subclinical inflammation as it could affect nutritional status and success of MAM treatment. (biomedcentral.com)

The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin. (ox.ac.uk)
Low levels of hepcidin allow iron absorption and effective iron incorporation into red blood cells. (ox.ac.uk)
here too, biomarkers including hepcidin may be useful to actively and beneficially manage iron status. (ox.ac.uk)
The main mechanisms by which sport leads to iron deficiency are an increased iron demand, an elevated iron loss and a blockage of iron absorption due to hepcidin bursts. (sems-journal.ch)
Ratios of sTfR:SF and hepcidin:EPO were calculated, and four categories of maternal iron and vitamin D status conceptualized. (ualberta.ca)
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. (mcmaster.ca)
Relatively recently, hepcidin, an endogenous antimicrobial peptide secreted by the liver, has been identified[2, 3, 4] as controlling the level of plasma iron by regulating the intestinal absorption of dietary iron, as well as the release of iron from macrophages and the transfer of iron stored in the hepatocytes. (medscape.com)

Transferrin saturation percentage (TS %) is calculated by dividing serum iron by TIBC, then multiplying by 100. (irondisorders.org)
Transferrin saturation represents the value obtained by dividing serum iron by the total iron-binding capacity of transferrin , providing insights into iron transport and availability. (londonbloodtests.uk)

In fully adjusted analyses, infants in the lowest tercile of soluble transferrin receptor (sTfR) (best iron status) achieved MSEL Cognitive Scores on average 1.9 points higher than infants in the highest sTfR tercile (p = 0.009, effect size = 0.48). (lboro.ac.uk)

Lindsay studies the prevalence, causes and consequences of micronutrient deficiencies, primarily in developing countries, using randomized, controlled human trials testing micronutrient supplements, food fortification, and food-based approaches to improve nutritional status, pregnancy outcome and child development. (kcl.ac.uk)
Her research emphasis is on iodine metabolism, including dietary requirements, status biomarkers, prevalence, causes and consequences of iodine deficiency and excess. (kcl.ac.uk)
In a global perspective, the most frequent nutritional insufficiency is definitely iron deficiency, which is encountered with a high prevalence in women of fertile age as well as in pregnant and postpartum women [ 1 ]. (hindawi.com)
In many developing countries, iron deficiency anemia (IDA) in pregnancy is more the rule than the exception with a prevalence of approximately 52% [ 2 ]. (hindawi.com)
As not much is known about the prevalence and predictors of nutritional deficiencies among vegans in the Czech Republic, we evaluated whether supplement use and duration of adherence to the vegan diet are associated with the risk of cobalamin and iron deficiencies. (mdpi.com)
Aim of this thesis was to investigate the prevalence and risk factors of ID and iron deficiency anemia (IDA) in children living in a high-income country. (dissertation.com)
In sports the rate of iron deficiency is distinctly higher up to 52% in female adolescent athletes [4,5,6] and occurs more often in endurance sports and in disciplines with a high prevalence of eating disorders. (sems-journal.ch)
Recent reports suggest that the prevalence of iron or vitamin D insufficiencies among pregnant people are underestimated. (ualberta.ca)

The benefits achieved by improved nutrient intake on environmental enteropathy may thus be independent of nutritional status. (wikipedia.org)
she has led the Nutritional Biomarker Analysis team at the Medical Research Council (UKRI) Elsie Widdowson Laboratory in Cambridge. (kcl.ac.uk)
and 3) to evaluate the effect of changes in nutrition and public health policies including welfare reform legislation, food fortification policy, and child nutrition programs on the nutritional status of the U.S. population. (cdc.gov)
One mechanism by which iron availability in early infancy impacts brain development may be through effects on early attentional processing, which is rapidly developing and has substantial nutritional requirements during this period. (lboro.ac.uk)
Treatment of iron deficiency consists of nutritional counselling and oral iron supplementation or, in specific cases, by intravenous injection. (sems-journal.ch)
in relation to nutritional iron status and anaemia in Gambian children over a malaria season. (ox.ac.uk)
2) the important role of transition metals, particularly iron, as enhancers of oxidative stress and inflammatory pulmonary responses to SWCNT, 3) essential nutritional (vitamin E status) and genetic (expression of NADPH oxidase) factors contributing to [pulmonary toxicity and 4) the fact of delayed bacterial clearance after SWCNT exposure likely associated with increased susceptibility to lung infection in exposed populations. (cdc.gov)

Significant evidence indicates that the initiation and progression of several pathologies are "highlighted" by the presence of specific C-miRNAs, underlining their potential diagnostic relevance as clinical biomarkers. (degruyter.com)
Here we review the current literature on the possible use of this new class of molecules as clinical biomarkers of diseases. (degruyter.com)
2014 represents a randomized, double-blind, placebo-controlled clinical trial in zinc-deficient children with asthma and the effects of zinc supplementation on the health status of the patients. (europa.eu)
This well designed and adequately reported clinical trial revealed a positive effect of zinc supplementation on the clinical symptoms of children patients with zinc deficiency and supports the evidence of the important role of a balanced zinc supplementation and status for the health of patients. (europa.eu)
In what clinical context might this biomarker be most useful? (medscape.com)
Conclusion Breast cancer biomarker analysis with STRAT4 has the potential to reduce the required human and capital resources in subSaharan African laboratories, leading to improved treatment selection and better clinical outcomes. (bvsalud.org)

Low hemoglobin is widely used as an indicator of iron deficiency anemia in India and other low-and-middle income counties, but anemia need not accurately reflect iron deficiency. (ox.ac.uk)
We examined the relationship between hemoglobin and biomarkers of iron status in antenatal and postnatal period. (ox.ac.uk)
low hemoglobin alone is not be a useful marker of iron deficiency. (ox.ac.uk)
Most of the body's iron (about 60%) is contained in hemoglobin, which is the essential oxygen carrying protein of the blood. (irondisorders.org)
The body requires iron to make hemoglobin for blood and myoglobin for muscles. (irondisorders.org)

Depletion of OTUD3 results in a disorder of iron metabolism. (nature.com)
Iron is involved in oxygen transport, energy metabolism, immune response, and plays an important role in brain development. (dissertation.com)
Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). (medrxiv.org)
Future studies should explore the impact of iron metabolism and anemia and in the pathophysiology, prognosis, and treatment of COVID-19. (medrxiv.org)

Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort. (who.int)

We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. (nih.gov)
2002). "Cadmium exposure in pregnancy and lactation in relation to iron status. (cdc.gov)
1997). "Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. (cdc.gov)
Measures of a biomarker of exposure are needed for improved exposure assessments. (cdc.gov)
Based on our studies of lipid peroxidation induced in the lung by SWCNT exposure, we initiated detailed mass-spectrometric studies of oxidized phospholipids as potential biomarkers. (cdc.gov)
Further, a battery of pro-inflammatory and anti-inflammatory cytokines as they relate to the transition from acute inflammatory response to its chronic pro-fibrotic stage can be also utilized as biomarkers of SWCNT exposure. (cdc.gov)
We characterized these effects on multipollutant personal exposure to diesel exhaust and underground ambient air concentrations in an underground iron ore mine. (lu.se)
Urine samples (27 workers) were collected after 8 h exposure and analyzed for PAH metabolites and effect biomarkers (8-oxodG for DNA oxidative damage, 4-HNE-MA for lipid peroxidation, 3-HPMA for acrolein). (lu.se)

We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. (nih.gov)
Dietary Intake and Status of Vitamin B12 in Slovenian Population. (nih.gov)
A Systematic Review of Vitamin D Status and Dietary Intake in Various Slovenian Populations. (nih.gov)
The researchers discovered that a vegetarian diet tends to result in the 'avoidance of nutrient-dense meats, which can decrease intake of cobalamin, iron, omega-3 fatty acids, selenium, and zinc, particularly in young women of childbearing age. (beefmagazine.com)
Danish women of fertile age have a mean dietary iron intake of 9 mg/day, that is, the majority of the women (more than 90%) have an iron intake which is definitely below the recommended intake of 15-18 mg/day in women of fertile age [ 14 ]. (hindawi.com)
Normally, dietary intake offsets daily loss iron loss (about 1 to 1.5 milligrams per day). (irondisorders.org)

Appetite may be reduced both by pro-inflammatory cytokines and leptin and low zinc status, and may be continuous in children with environmental enteropathy. (wikipedia.org)
Researchers analyzed twelve blood-based biomarkers involved in inflammatory (uric acid), metabolic (total cholesterol and glucose), liver (liver enzymes and proteins), and kidney (creatinine) functions. (lifespan.io)
The major toxicity mechanisms include inflammatory response synergistically enhanced by oxidative stress exacerbated by iron. (cdc.gov)
The apoptotic/necrotic target cell death ratio dependent on the SWCNT iron is also a regulator of SWCNT toxicity via production of anti-/pro-inflammatory cytokines, respectively. (cdc.gov)

Moreover, a diagnosis of iron deficiency or iron deficiency anemia is most useful if the diagnosis also leads to effective treatment. (ox.ac.uk)
Briefly, nested case-control or cohort studies were included if they recorded a measure of iron, prior to diagnosis, and contained liver cancer patients and controls. (ncri.org.uk)
B-type natriuretic peptide (BNP) is a circulating biomarker that is mainly applied in heart failure (HF) diagnosis and to monitor disease progression. (degruyter.com)
Furthermore, we aimed to analyze the value of different iron status biomarkers in the diagnosis of ID. (dissertation.com)
Measurements of non-heme, serum iron (Fe) are used in the diagnosis and treatment of diseases such as Fe deficiency anemia, Fe toxicity and acute or chronic hemochromatosis. (healthmatters.io)
Measurements of serum inorganic phosphorus (phosphate or PO4) are used in the diagnosis and treatment of disorders including parathyroid gland and kidney diseases, and vitamin D status. (healthmatters.io)
TIBC tests are used to evaluate iron status and absorption, aiding in the diagnosis of conditions such as anaemia and iron overload disorders like Haemochromatosis . (londonbloodtests.uk)
Findings We estimated that breast cancer diagnosis in Rwanda costs 138.29 United States dollars (US$) per patient when conducting biomarker analysis by immunohistochemistry. (bvsalud.org)

Recently, to diagnose UTI noninvasively, several studies have reported that some urinary biomarkers of acute kidney injury (AKI) may be associated with UTI. (e-cep.org)

On the other hand, iron is essential for the growth of bacteria, and is a pro-oxidant that can catalyze the formation of oxidative radicals that damage proteins, lipids and nucleic acids. (dissertation.com)
Because iron is a catalyst of oxidative stress, iron-containing SWCNT are likely more toxic than iron-free SWCNT. (cdc.gov)

Accumulating evidence suggests that circulating and dietary iron biomarkers among pregnant women are associated with GDM, but the results should be interpreted with caution due to the high heterogeneity of analyses. (nih.gov)

2004). "Comprehensive study of the effects of age, iron deficiency, diabetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium-exposed female Japanese farmers. (cdc.gov)

Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. (nature.com)
Iron is important for development of the fetal brain and cognitive abilities of the newborn. (hindawi.com)
Using data from the Brain Imaging for Global Health (BRIGHT) Study in Gambia (n = 179), we conducted mixed effects modelling to assess the relationship between iron status at 5 months of age and trajectories of cognitive development from 5 months- 5 years using (i) a standardised measure of cognitive development (Mullen Scales of Early Learning) and (ii) an eye-tracking assessment of attention processing (visual disengagement time). (lboro.ac.uk)

However, few have considered the interconnectivity of these biomarkers in the etiology of diabetes as well as the potential changes in the biomarker correlation network during diabetes development. (diabetesjournals.org)

Objectives: The first objective was to determine how maternal concentrations of iron and vitamin D biomarkers changed across pregnancy into postpartum and to assess the combined maternal status of iron and vitamin D during the 2nd trimester (mid-pregnancy). (ualberta.ca)
Conclusions: Iron and vitamin D biomarker concentrations were dynamic across gestation and into the postpartum period in generally healthy pregnant individuals. (ualberta.ca)

In infancy, ID is associated with adverse effects on cognitive, motor, and behavioral development that may persist later in life, despite iron supplementation. (dissertation.com)
Iron supplementation in iron-replete children may have adverse effects, e.g. increased risk of infections and impaired growth. (dissertation.com)

Shiota S, Matsunari O, Watada M, Yamaoka Y. Serum Helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries. (medscape.com)
At a realistic immunohistochemistry antibody utilization efficiency of 70%, biomarker analysis comprises 48.7% (US$ 67.33) of diagnostic costs and takes 33 min. (bvsalud.org)

2) Development of new biomarkers of pulmonary toxicity of SWCNT. (cdc.gov)

These results show plainly the connection between CAD severity and the lipid, glucose, coagulation, and immunologic status of CAD patients, and substantiate the importance of sufficient treatment in this group of patients - in particular, CAD patients suffering from type 2 diabetes mellitus. (dovepress.com)
Plasma levels of Nesfatin-1 increased with severity of depression in adolescents and may be useful as a biomarker of depression severity. (bvsalud.org)
Multinomial logistic regression was used to examine the association between severity of anemia and iron status. (ox.ac.uk)

Stepwise multiple regression analysis with backward elimination revealed diabetes status, sex, and fibrinogen Clauss as significant predictors of coronary score. (dovepress.com)

Hereditary hemochromatosis, a disease which causes iron overload, has been shown to increase liver cancer risk but the association between serum iron levels within non-hemochromatosis population and liver cancer risk is unclear. (ncri.org.uk)
Generally men have higher levels of serum iron than women. (irondisorders.org)
When laboratories measure serum iron they often also measure transferrin and calculate the percentage of transferrin molecules that are used to bind iron. (irondisorders.org)
Total iron binding capacity (TIBC) is often measured at the same time as serum iron. (irondisorders.org)
This measurement indicates the potential capacity of transferrin molecules to bind with serum iron. (irondisorders.org)
If that occurs in combination with a relatively high measure of serum iron, it is likely that the ability of transferrin to safely bind serum iron is impaired. (irondisorders.org)

For the last ten years the NBA team were responsible for providing and reporting on blood and urine biomarker data for the UK National Diet and Nutrition Survey, and also in support of a wide range of nutrition studies and surveys in UK and worldwide. (kcl.ac.uk)
Only small amounts of iron are lost each day through urine and body, sweat or as skin cells slough off. (irondisorders.org)

Maria's research field is micronutrient malnutrition, with focus on iodine and iron nutrition. (kcl.ac.uk)
There were also biomarker tests related to malnutrition (albumin) and anemia (iron and iron-binding capacity). (lifespan.io)

A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. (nih.gov)
Thus, the therapeutic range of iron is small, and prevention of both ID and iron overload is essential for optimal development. (dissertation.com)
When the percentage is calculated to be less that about 17% or higher than 45%, a condition of either iron deficiency or iron overload is possible. (irondisorders.org)

However, for glucose, creatinine, uric acid, liver enzymes, and total iron-binding capacity, it was the opposite: lower levels of these biomarkers are correlated with higher chances of becoming a centenarian. (lifespan.io)

Oral Iron Prophylaxis in Pregnancy: Not Too Little and Not Too Much! (hindawi.com)
Iron deficiency and iron deficiency anemia (IDA) during pregnancy increase the risk of preterm birth and low birth weight. (hindawi.com)
The demand for absorbed iron increase steadily during pregnancy from 0.8 mg/day in the initial 10 weeks of gestation to 7.5 mg/day in the last 10 weeks of gestation as shown in Figure 1 . (hindawi.com)
Iron balance in normal pregnancy and delivery, approximate figures. (hindawi.com)
Background: Investigations that assess how maternal iron or vitamin D status biomarkers change across pregnancy and postpartum, and their relationships with maternal and offspring outcomes, in cohorts of healthy pregnant individuals from high-income countries are limited. (ualberta.ca)
Pregnant individuals that were vitamin D replete but low in iron (p=0.04) or low in iron and vitamin D (p=0.02) during mid-pregnancy had higher 3rd trimester EPDS scores compared to those that were replete in both micronutrients. (ualberta.ca)

Iron toxicity results when circulating iron exceeds the capacity of transferrin available to bind it. (irondisorders.org)
Our central hypothesis was that SWCNT are toxic to the lung and the toxicity is dependent on their content of iron. (cdc.gov)
UIBC tests help monitor iron toxicity treatment and assess iron-related conditions. (londonbloodtests.uk)

Serum biomarkers of iron status and risk of primary liver cancer: A systematic review and meta-analysis. (ncri.org.uk)

Numerous studies have investigated individual biomarkers in relation to risk of type 2 diabetes. (diabetesjournals.org)
Although pairwise biomarker correlations tended to have similar directions comparing diabetes case subjects to noncase subjects, most correlations were stronger in noncase than in case subjects, with the largest differences observed for the insulin/HbA 1c and leptin/adiponectin correlations. (diabetesjournals.org)
Additional independent anemia risk factors, including female sex, Asian race, diabetes, low albumin and low iron saturation, were observed, but did not alter the anemia-phosphorus association. (medscape.com)

Intracellular iron levels are elaborately balanced by iron efflux, uptake, and storage proteins that are regulated by iron regulatory proteins (IRPs, including IRP1 and IRP2) [ 16 ]. (nature.com)
Each of these proteins uses iron to supply oxygen and energy for everyday needs. (irondisorders.org)

More definitive studies are needed to investigate the effects of genetically influenced IFN-γ levels on the risk of iron deficiency and anaemia in children living in malaria-endemic areas. (ox.ac.uk)
No studies provided information on anemia or other biomarkers of interest. (medrxiv.org)
Iron studies comprise a set of blood tests that measure the amount of iron present in the blood and stored in the body's tissues. (londonbloodtests.uk)
By assessing iron levels and related markers, iron studies provide valuable insights into your iron status and help identify potential causes of anaemia or other related conditions. (londonbloodtests.uk)

However, interventions targeting iron deficiency have had mixed results on cognitive outcomes. (lboro.ac.uk)
This may be due to previous interventions focusing on the correction of iron deficiency anaemia in late infancy and early childhood, at which point long lasting neural impacts may already be established. (lboro.ac.uk)

Iron deficiency and iron deficiency anemia are common and important conditions that can be treated with iron preparations. (ox.ac.uk)

Anaemia is a common health problem especially in developing countries [ 14 ], with iron deficiency as one of the main causes [ 14 ]. (biomedcentral.com)
Data from a general Swiss population show frequencies for iron deficiency for menstruating females of 22.7%, for male military recruits of 7.2% and for iron deficiency anaemia of 2.2% (females) and 0.1% (males) [2,3]. (sems-journal.ch)
Low iron levels may indicate anaemia, while high levels could be indicative of liver disease or other underlying health issues. (londonbloodtests.uk)
Transferrin tests assess iron status and can be helpful in diagnosing anaemia. (londonbloodtests.uk)

They found that except for two biomarkers (liver enzyme ALAT and albumin), all of the measured biomarkers were associated with the likelihood of becoming a centenarian. (lifespan.io)
The differences between groups were mostly not statistically significant, with the exception of total iron-binding capacity, total cholesterol, and albumin. (lifespan.io)

les cliniciens exerçant en milieu peu équipé peuvent donc sans équivoque suivre les recommandations sur la prise en charge des tumeurs classées BIRADS2 et BIRADS3 à l'échographie, bien que sa performance en ce qui concerne le diagnostic différentiel de ces tumeurs soit moindre. (bvsalud.org)

The best 'biomarker' to guide treatment may therefore be the physiological 'determinant' of iron utilization. (ox.ac.uk)
We previously showed that decreased IRP2 levels were observed in 1-methyl-4-phenylpyridinium (MPP + )-treated dopaminergic cells [ 25 ], supporting the physiological role of IRP2 in the control of iron balance. (nature.com)

All infants were iron sufficient at 1 month of age. (lboro.ac.uk)
At 5 and 12 months of age 30% and 55% of infants were iron deficient respectively. (lboro.ac.uk)
Infants are at risk of iron deficiency in early infancy. (lboro.ac.uk)

Iron deficiency is frequent among athletes. (sems-journal.ch)
Iron deficiency among athletes, in males and more often in females, is a commonly encountered condition for the sports medicine physician. (sems-journal.ch)

Each molecule of transferrin can transport two molecules of iron to areas of the body that need this element. (irondisorders.org)
When TIBC is at or below the low end of a laboratory range, it is an indication that there is limited capacity for transferrin molecules to accept additional iron. (irondisorders.org)
Generally, with minor variances based on blood PH, when 40% or less of transferrin molecules are used, iron is considered safely bound. (irondisorders.org)
Some of the iron will then bind to other molecules not have transferrin's ability to protect its host from iron catalyzed lipid peroxidation and the formation of reactive oxygen species. (irondisorders.org)

The Danish National Board of Health has since 1992 recommended prophylactic oral iron supplements to all pregnant women and the currently advocated dose is 40-50 mg ferrous iron taken between meals from 10 weeks gestation to delivery. (hindawi.com)
An adequate body iron status is, among other factors, a prerequisite for a normal and healthy gestation, a normal development of the fetus and a healthy newborn baby. (hindawi.com)
In gestation, the total demands for absorbed iron are approximately 1240 mg (Table 1 ). (hindawi.com)
During the entire gestation period, the average demand for absorbed iron is 4.4 mg/day [ 11 - 13 ]. (hindawi.com)

In conclusion, we found some evidence that increased iron levels was associated with primary liver cancer. (ncri.org.uk)
The likelihood of becoming centenarians was higher for people who displayed increased levels of total cholesterol and iron. (lifespan.io)
In these conditions, there is primarily a decreased availability of iron, relatively decreased levels of erythropoietin, and a mild decrease in the lifespan of RBCs to 70-80 days (normally 120 days). (medscape.com)
By examining blood cells, iron levels, and vitamin status, this test aims to uncover the underlying factors contributing to your fatigue and tiredness. (londonbloodtests.uk)
Adequate iron levels are crucial for maintaining healthy muscles, bone marrow function, and organ health. (londonbloodtests.uk)
Measuring iron levels provides valuable information about the iron content in your blood. (londonbloodtests.uk)

Iron contained in blood serum (or plasma) is normally bound to the protein transferrin. (irondisorders.org)
The body routinely looses greater amounts of iron as a result of trauma or other conditions resulting in blood loss or through menstruation. (irondisorders.org)
Serum elements are used to assess the status of key elements and electrolytes such as calcium, sodium, potassium and iron that have important functions in the extracellular fluid compartment of blood. (healthmatters.io)
By examining different blood cell types, this test provides crucial information about your hematological status. (londonbloodtests.uk)
Iron is a mineral essential for the production of red blood cells , which are responsible for carrying oxygen in the blood. (londonbloodtests.uk)
Total Iron Binding Capacity (TIBC) refers to the maximum amount of iron that can be transported in the blood. (londonbloodtests.uk)
Transferrin plays a key role in the transportation of iron, facilitating oxygen transport in the blood. (londonbloodtests.uk)
Iron is vital for oxygen transport in the blood. (londonbloodtests.uk)
It facilitates the transport of iron, which is essential for oxygen delivery in the blood. (londonbloodtests.uk)
Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort. (who.int)

Routinely available pre-transplant biomarkers independently risk-stratify for transplant-related mortality and survival. (haematologica.org)

1. Linked to socioeconomic status and social health maintenance organizations, which inequality. (who.int)
Oral Oncol, Retinoblastoma-independent antiproliferative activity socioeconomic status: a cross-sectional study. (who.int)

Furthermore, untreated iron deficiency and IDA in the third trimester strongly predisposes to postpartum iron deficiency and IDA [ 8 ], which are associated with decreased physical abilities and psychic disturbances including emotional instability, depression, stress, and reduced cognitive performance tests [ 9 , 10 ]. (hindawi.com)
The complex relationship between iron status and anemia in pregnant and postpartum women in India: Analysis of two Indian study cohorts of uncomplicated pregnancies. (ox.ac.uk)

Leptin and soluble leptin receptor were two hubs of the network, with large numbers of different correlations with other biomarkers in case versus noncase subjects. (diabetesjournals.org)
We performed a cost-minimization analysis to compare the cost of biomarker analysis for estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 status with immunohistochemistry versus STRAT4. (bvsalud.org)

Maternal Iron and Vitamin D Status During. (ualberta.ca)
Further, evidence supporting associations between maternal iron and vitamin D status and prospective maternal and child health outcomes is mixed, and the possible combined impact of both micronutrients is poorly described. (ualberta.ca)

11 Million Americans or more have the genes that can result in too much iron. (irondisorders.org)

Laboratories engaged in public health work assessing micronutrient status in populations. (cdc.gov)
Iron deficiency (ID) is the most common micronutrient deficiency in the world. (dissertation.com)

Anatomy11

Organisms3

Diseases27

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Psychiatry and Psychology7

Phenomena and Processes49

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture15

Information Science3

Named Groups7

Health Care46

Geographicals13

Ferritin20

Inflammation14

Hepcidin7

Transferrin saturation2

Soluble transferrin receptor1

Prevalence8

Nutritional7

Clinical6

Hemoglobin5

Metabolism4

Adipokines1

Exposure8

Intake6

Inflammatory4

Diagnosis8

Urinary1

Oxidative2

Dietary iron1

Absorption1

Brain3

Etiology1

Concentrations2

Supplementation2

Antibody2

Pulmonary1

Severity3

Predictors1

Serum iron6

Urine2

Malnutrition2

Overload3

Glucose1

Pregnancy6

Toxicity3

Meta-Analysis1

Diabetes3

Proteins2

Studies4

Interventions2

Deficiency and iron defici1

Anaemia4

Albumin2

Diagnostic1

Physiological2

Infants3

Athletes2

Molecules4

Gestation4

Levels6

Blood10

Routinely1

Socioeconomic status2

Postpartum2

Versus2

Vitamin D Status2

Genes1

Micronutrient2