• Software and algorithms have been developed to locate more genes that are also responsive to iron concentration. (wikipedia.org)
  • The small hepatic peptide hormone hepcidin (Hamp, LEAP1) orchestrates these iron fluxes and controls the amount of available extracellular iron by interacting with the iron exporter ferroportin: binding of hepcidin induces ferroportin internalization and degradation, thus reducing the levels of iron in circulation. (embl.de)
  • The two leading theories describe how iron probably interacts to impact posttranslational control of transcription. (wikipedia.org)
  • Iron is essential for fundamental metabolic processes in cells and organisms. (embl.de)
  • All cells use some iron, and must get it from the circulating blood. (wikipedia.org)
  • Cells have advanced mechanisms for sensing their own need for iron. (wikipedia.org)
  • Aconitases are iron-sulfur proteins that require a 4Fe-4S cluster for their enzymatic activity, in which they catalyze conversion of citrate to isocitrate. (wikipedia.org)