• Background: Pure red cell aplasia (PRCA) is one of the important complications in major ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
  • No significant influence of PRCA on transplantation outcomes was observed.In conclusion, post-HSCT PRCA is a rare and less threatening complication in major ABO-incompatible HSCT. (bvsalud.org)
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • There is a concern that labile plasma iron (LPI), the redox-active form of iron, can be involved in the occurrence of toxicity and other complications commonly observed in the early post-HSCT period. (karger.com)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)
  • Methods: We conducted a prospective nested case-control study to determine the prevalence, donor-related factors, and the outcomes of PRCA following major ABO-incompatible transplantation. (bvsalud.org)
  • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • With regard to predisposition through stem cell transplants, certain toll-like receptor (TLR) polymorphisms (eg, TLR 4 haplotype S4) in an unrelated stem cell donor can increase the risk of invasive aspergillosis in the transplant recipient. (medscape.com)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • 1 Traditional factors used to gauge transplant risks include conditioning regimen intensity, 2 immunosuppression and HLA matching, 3 along with hematopoietic cell source, and graft cell yield. (haematologica.org)
  • the Cooperative Study of Sickle Cell Disease Acute chest syndrome (ACS) is an important cause of morbidity and mortality in sickle cell disease (SCD). (ashpublications.org)
  • Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
  • In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
  • Melanie Demers, PhD Sickle cell disease (SCD) is a genetic disorder caused by a missense mutation in the beta-globin gene [Glu6Val] resulting in the formation of HbS ( sickle hemoglobin). (ashpublications.org)
  • [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
  • The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
  • In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
  • Adult pure red cell aplasia (PRCA) is a rare syndrome characterized by a severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from bone marrow. (bvsalud.org)
  • Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • Anti-erythropoietin antibody-mediated pure red cell aplasia (PRCA) has been associated with epoetin usage, and a PRCA incidence of 4.5 per 10,000 patient-years was observed for epoetin-α (Eprex) in 2002. (bvsalud.org)
  • 10. Results of hematopoietic stem cell transplantation after treatment with different high-dose total-body irradiation regimens in five Dutch centers. (nih.gov)
  • Approximately one month later, the patient will be given two immune-suppressing drugs, Campath 1-H and Sirolimus, as well as a single low dose of total body irradiation and then the cells from the donor will be infused. (nih.gov)
  • Hepatic diseases are common complications of haematopoietic cell transplant. (nih.gov)
  • We divided the patients according to the use of TBI or myeloablative chemotherapy (MCHT) in the conditioning regimen. (oncotarget.com)
  • The patient was treated with salvage chemotherapy, orbital radiation and eventual bone marrow transplantation, with notable improvement in vision and regression of retinal and optic nerve findings. (bvsalud.org)
  • 6. Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. (nih.gov)
  • 12. High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors. (nih.gov)
  • The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
  • Transplant Cell Ther. (uci.edu)
  • Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. (uci.edu)
  • All patients with severe IO or moderate IO with a high risk of engraftment delay or transplantation-related complications underwent chelation therapy with deferoxamine (DFO) from the first day of conditioning to discharge. (oncotarget.com)
  • This event explains the presence of multiple derangements observed in the bone marrow that involve several cell lineages. (medscape.com)
  • As the affected cell lines continue to divide and to provide the marrow with dysplastic cells, bone marrow dysfunction becomes apparent. (medscape.com)
  • Bone Marrow Transplantation, 2013. (nih.gov)
  • Vertebral fractures and low lean mass in young men with sickle cell disease: Lack of association with bone mineral density and clinical characteristics. (amedeo.com)
  • Reticuloendothelial cells (macrophages in the bone marrow and spleen, Kupffer cells in the liver) and hepatocytes are two major areas of iron storage in humans. (ashpublications.org)
  • Liver complications in stem-cell transplantation]. (nih.gov)
  • The American Society of Hematology (ASH) has published evidence-based guidelines on the screening, diagnosis, and management of cardiopulmonary, renal, and cerebrovascular complications of sickle cell disease (SCD), as well as on management of SCD-related pain and transfusion support in SCD. (medscape.com)
  • In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
  • Provider prescription of hydroxyurea in youth and adults with sickle cell disease: A review of prescription barriers and facilitators. (amedeo.com)
  • Psychiatric comorbidities in adults with sickle cell disease: A narrative review. (amedeo.com)
  • The overall goal of the initiative is to focus on approaches to enable successful stem transplantation for hemoglobinopathies and minimize recipient morbidity and mortality. (nih.gov)
  • Such studies will undoubtedly improve the morbidity and mortality associated with marrow and stem cell transplantation for hemoglobinopathies. (nih.gov)
  • Untreated iron overload from transfusions is responsible for morbidity and mortality in patients with thalassemia major, 4 , 5 but clinical consequences have been reported also in nonthalassemic adults with anemias requiring regular transfusions. (ashpublications.org)
  • Ethical problems concerning transplantation can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretransplantation preparation regimens, donor selection, stem cell harvest procedure, the 2 transplantation phase (including hospitalization during marrow aplasia), and short-term and long-term follow-up care. (docksci.com)
  • A novel promoter of endothelial dysfunction in African Americans: Relevance to sickle cell anaemia. (amedeo.com)
  • We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)
  • The observation of cytogenetic abnormalities, most specifically monosomy 7 and neurofibromatosis type 1 (NF1) genetic mutations, support the theory that cell dysregulation occurs in a multi-hit fashion. (medscape.com)
  • STEM CELL TRANSPLANTATION TO ESTABLISH ALLOCHIMERISM Release Date: September 4, 1998 P.T. RFA: HL-98-022 National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: October 26, 1998 Application Receipt Date: November 24, 1998 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)
  • Flow cytometry of blood and marrow cells is useful for the diagnosis of MDS in those who have experience with this testing. (medscape.com)
  • Luspatercept is recommended after ESA failure in red blood cell transfusion-dependent MDS-RS (ring sideroblasts). (medscape.com)
  • Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
  • Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub-Saharan Africa (the BIOCADRE study). (amedeo.com)
  • For many people with CMML, supportive therapy to prevent the problems caused by low blood cell counts is an important part of treatment. (cancer.org)
  • Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia. (amedeo.com)
  • Cytoplasmic ferritin has ubiquitous distribution among living species and plays a key role in body iron metabolism through its dual functions of iron detoxification and iron reserve. (ashpublications.org)
  • Aberration occurs in a stem cell that can give rise to multiple lineages. (medscape.com)
  • then his or her stem cells will be collected and frozen one month prior to BMT. (nih.gov)
  • In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)