Bone marrow transplaHSCTGraft versusOutcomesHematopoiesisDonorHematopoietic stemImmunosuppressiveImmunosuppressionAcuteSickle cell diPatientsThrombocytopeniaExperienceBloodAnemiaPlasmaManagementPatientTotal-body irradiGraft-versus-Autologous stem cell transHaematopoietic cellChemotherapyTreated with bone marrow transplaTransplantNonmyeloablativeTransfusion iron overloadSickle cell aDeferoxamineBoneSerum ferritinMyeloidComplicationsMyelodysplastic SyndromeChelation therapyAdults with sickle cell diChronicInduceBeta-thalassemiaMorbidityPretransplantationDysfunctionLiverSignificantly higherAbnormalitiesBloodCerebrovascularDisorderRoleMultipleMonthEffect
Bone marrow transpla5
- In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
- [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
- These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
- The patient was treated with corticosteroids for acute graft versus host disease following bone marrow transplantation for chronic myeloid leukemia. (medscape.com)
- Bone Marrow Transplantation, 2013. (nih.gov)
HSCT5
- Background: Pure red cell aplasia (PRCA) is one of the important complications in major ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
- No significant influence of PRCA on transplantation outcomes was observed.In conclusion, post-HSCT PRCA is a rare and less threatening complication in major ABO-incompatible HSCT. (bvsalud.org)
- Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
- Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
- There is a concern that labile plasma iron (LPI), the redox-active form of iron, can be involved in the occurrence of toxicity and other complications commonly observed in the early post-HSCT period. (karger.com)
Graft versus1
- In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
Outcomes3
- Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)
- Methods: We conducted a prospective nested case-control study to determine the prevalence, donor-related factors, and the outcomes of PRCA following major ABO-incompatible transplantation. (bvsalud.org)
- Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
Hematopoiesis1
- Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
Donor1
- With regard to predisposition through stem cell transplants, certain toll-like receptor (TLR) polymorphisms (eg, TLR 4 haplotype S4) in an unrelated stem cell donor can increase the risk of invasive aspergillosis in the transplant recipient. (medscape.com)
Hematopoietic stem2
- There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
- A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
Immunosuppressive1
- We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Immunosuppression1
- 1 Traditional factors used to gauge transplant risks include conditioning regimen intensity, 2 immunosuppression and HLA matching, 3 along with hematopoietic cell source, and graft cell yield. (haematologica.org)
Acute1
- the Cooperative Study of Sickle Cell Disease Acute chest syndrome (ACS) is an important cause of morbidity and mortality in sickle cell disease (SCD). (ashpublications.org)
Sickle cell di3
- Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
- In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
- Melanie Demers, PhD Sickle cell disease (SCD) is a genetic disorder caused by a missense mutation in the beta-globin gene [Glu6Val] resulting in the formation of HbS ( sickle hemoglobin). (ashpublications.org)
Patients2
- [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
- high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
Thrombocytopenia1
- Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
Experience1
- The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
Blood1
- In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
Anemia1
- Adult pure red cell aplasia (PRCA) is a rare syndrome characterized by a severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from bone marrow. (bvsalud.org)
Plasma1
- Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
Management1
- Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
Patient1
- Anti-erythropoietin antibody-mediated pure red cell aplasia (PRCA) has been associated with epoetin usage, and a PRCA incidence of 4.5 per 10,000 patient-years was observed for epoetin-α (Eprex) in 2002. (bvsalud.org)
Total-body irradi2
- 10. Results of hematopoietic stem cell transplantation after treatment with different high-dose total-body irradiation regimens in five Dutch centers. (nih.gov)
- Approximately one month later, the patient will be given two immune-suppressing drugs, Campath 1-H and Sirolimus, as well as a single low dose of total body irradiation and then the cells from the donor will be infused. (nih.gov)
Graft-versus-3
- 2. Elevated pretransplant ferritin is associated with a lower incidence of chronic graft-versus-host disease and inferior survival after myeloablative allogeneic haematopoietic stem cell transplantation. (nih.gov)
- The patient was treated with corticosteroids for acute graft versus host disease following bone marrow transplantation for chronic myeloid leukemia. (medscape.com)
- Characteristics of Graft-Versus-Host Disease (GvHD) After Post-Transplantation Cyclophosphamide Versus Conventional GvHD Prophylaxis. (uci.edu)
Autologous stem cell trans3
- 11. Higher infused CD34+ hematopoietic stem cell dose correlates with earlier lymphocyte recovery and better clinical outcome after autologous stem cell transplantation in non-Hodgkin's lymphoma. (nih.gov)
- 13. The impact of histologic grade on the outcome of high-dose therapy and autologous stem cell transplantation for follicular lymphoma. (nih.gov)
- Haematopoietic stem cell mobilisation followed by high-dose chemotherapy and autologous stem cell transplantation for patients with sickle cell disease and myeloma. (amedeo.com)
Haematopoietic cell1
- Hepatic diseases are common complications of haematopoietic cell transplant. (nih.gov)
Chemotherapy2
- We divided the patients according to the use of TBI or myeloablative chemotherapy (MCHT) in the conditioning regimen. (oncotarget.com)
- The patient was treated with salvage chemotherapy, orbital radiation and eventual bone marrow transplantation, with notable improvement in vision and regression of retinal and optic nerve findings. (bvsalud.org)
Treated with bone marrow transpla1
- Because of this risk, they are most commonly treated with bone marrow transplantation. (medscape.com)
Transplant5
- 6. Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. (nih.gov)
- 12. High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors. (nih.gov)
- The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
- Transplant Cell Ther. (uci.edu)
- Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. (uci.edu)
Nonmyeloablative2
- Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (nih.gov)
- 3. Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. (nih.gov)
Transfusion iron overload4
- In patients who have transfusion iron overload, iron chelation is strongly recommended in patients who are candidates for allo-SCT. (medscape.com)
- There may also be a benefit of chelation therapy in patients with transfusion iron overload undergoing allogeneic stem cell transplantation. (ashpublications.org)
- Deferoxamine and deferasirox are currently available for treatment of transfusion iron overload in patients with myelodysplastic syndrome. (ashpublications.org)
- 6 This article will examine the clinical relevance of anemia and transfusion iron overload in patients with myelodysplastic syndrome. (ashpublications.org)
Sickle cell a1
- People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). (nih.gov)
Deferoxamine1
- All patients with severe IO or moderate IO with a high risk of engraftment delay or transplantation-related complications underwent chelation therapy with deferoxamine (DFO) from the first day of conditioning to discharge. (oncotarget.com)
Bone5
- This event explains the presence of multiple derangements observed in the bone marrow that involve several cell lineages. (medscape.com)
- As the affected cell lines continue to divide and to provide the marrow with dysplastic cells, bone marrow dysfunction becomes apparent. (medscape.com)
- Bone Marrow Transplantation, 2013. (nih.gov)
- Vertebral fractures and low lean mass in young men with sickle cell disease: Lack of association with bone mineral density and clinical characteristics. (amedeo.com)
- Reticuloendothelial cells (macrophages in the bone marrow and spleen, Kupffer cells in the liver) and hepatocytes are two major areas of iron storage in humans. (ashpublications.org)
Serum ferritin2
- 8. The Prognostic Significance of Elevated Serum Ferritin Levels Prior to Transplantation in Patients With Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation (autoHSCT): Role of Iron Overload. (nih.gov)
- Body iron status is routinely assessed by serum ferritin and transferrin saturation, but there is a need of reliable tools for locating iron accumulation in patients. (ashpublications.org)
Myeloid2
- 7. Transfusion-associated iron overload as an adverse risk factor for transplantation outcome in patients undergoing reduced-intensity stem cell transplantation for myeloid malignancies. (nih.gov)
- MDS is a clonal disorder of myeloid stem cells. (medscape.com)
Complications2
- Liver complications in stem-cell transplantation]. (nih.gov)
- The American Society of Hematology (ASH) has published evidence-based guidelines on the screening, diagnosis, and management of cardiopulmonary, renal, and cerebrovascular complications of sickle cell disease (SCD), as well as on management of SCD-related pain and transfusion support in SCD. (medscape.com)
Myelodysplastic Syndrome2
- Most patients with myelodysplastic syndrome eventually become dependent on regular red cell transfusions. (ashpublications.org)
- Clinical consequences of parenchymal iron overload have been reported not only in thalassemia major, but also in patients with myelodysplastic syndrome. (ashpublications.org)
Chelation therapy1
- Transfusion-dependent patients with isolated erythroid dysplasia and low risk of leukemic evolution are more likely to develop parenchymal iron overload and its toxicity, and therefore may benefit from chelation therapy. (ashpublications.org)
Adults with sickle cell di3
- In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
- Provider prescription of hydroxyurea in youth and adults with sickle cell disease: A review of prescription barriers and facilitators. (amedeo.com)
- Psychiatric comorbidities in adults with sickle cell disease: A narrative review. (amedeo.com)
Chronic1
- In addition, however, transfusion dependency may involve clinical consequences of chronic anemia and iron overload. (ashpublications.org)
Induce1
- 15. Allogeneic stem cell transplantation is able to induce long-term remissions in angioimmunoblastic T-cell lymphoma: a retrospective study from the lymphoma working party of the European group for blood and marrow transplantation. (nih.gov)
Beta-thalassemia1
- Pseudo-Gaucher cells in a splenectomised Beta-Thalassemia patient. (amedeo.com)
Morbidity3
- The overall goal of the initiative is to focus on approaches to enable successful stem transplantation for hemoglobinopathies and minimize recipient morbidity and mortality. (nih.gov)
- Such studies will undoubtedly improve the morbidity and mortality associated with marrow and stem cell transplantation for hemoglobinopathies. (nih.gov)
- Untreated iron overload from transfusions is responsible for morbidity and mortality in patients with thalassemia major, 4 , 5 but clinical consequences have been reported also in nonthalassemic adults with anemias requiring regular transfusions. (ashpublications.org)
Pretransplantation1
- Ethical problems concerning transplantation can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretransplantation preparation regimens, donor selection, stem cell harvest procedure, the 2 transplantation phase (including hospitalization during marrow aplasia), and short-term and long-term follow-up care. (docksci.com)
Dysfunction1
- A novel promoter of endothelial dysfunction in African Americans: Relevance to sickle cell anaemia. (amedeo.com)
Liver1
- Magnetic resonance imaging T2* provides a non-invasive method for detecting and quantifying both liver and myocardial iron overload. (ashpublications.org)
Significantly higher1
- We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)
Abnormalities1
- The observation of cytogenetic abnormalities, most specifically monosomy 7 and neurofibromatosis type 1 (NF1) genetic mutations, support the theory that cell dysregulation occurs in a multi-hit fashion. (medscape.com)
Blood6
- STEM CELL TRANSPLANTATION TO ESTABLISH ALLOCHIMERISM Release Date: September 4, 1998 P.T. RFA: HL-98-022 National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: October 26, 1998 Application Receipt Date: November 24, 1998 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. (nih.gov)
- Flow cytometry of blood and marrow cells is useful for the diagnosis of MDS in those who have experience with this testing. (medscape.com)
- Luspatercept is recommended after ESA failure in red blood cell transfusion-dependent MDS-RS (ring sideroblasts). (medscape.com)
- Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
- Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub-Saharan Africa (the BIOCADRE study). (amedeo.com)
- For many people with CMML, supportive therapy to prevent the problems caused by low blood cell counts is an important part of treatment. (cancer.org)
Cerebrovascular1
- Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia. (amedeo.com)
Disorder1
- 1 More than 500 million persons throughout the world have iron deficiency, 2 while hereditary hemochromatosis is the most common genetic disorder among Caucasians. (ashpublications.org)
Role1
- Cytoplasmic ferritin has ubiquitous distribution among living species and plays a key role in body iron metabolism through its dual functions of iron detoxification and iron reserve. (ashpublications.org)
Multiple1
- Aberration occurs in a stem cell that can give rise to multiple lineages. (medscape.com)
Month1
- then his or her stem cells will be collected and frozen one month prior to BMT. (nih.gov)
Effect1
- In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)