Loading...
  • toxicity
  • An acute martial toxicity is the second reason of poisoning in children and is often due to excessive administration of supplements containing iron by relatives. (daphnelab.com)
  • The universal importance of iron, its high toxicity, and complex chemistry present a challenge to biological systems in general and to protected compartments in particular. (physiology.org)
  • mammals
  • Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. (pubmedcentralcanada.ca)
  • trace element
  • Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. (hu-berlin.de)
  • accumulation
  • The absence of clear treatment-dependent changes in branchial Fe accumulation and ferrireductase activity indicated that the gills do not have a major role in Fe metabolism. (biologists.org)
  • There also has been a substantial growth of knowledge regarding the iron metabolism of glia and their effects on iron accumulation and degeneration of DA neurons in PD in recent years. (frontiersin.org)
  • Here, we attempt to describe the role of iron metabolism of glia and the effect of glia on iron accumulation and degeneration of DA neurons in the substantia nigra of PD. (frontiersin.org)
  • essential nutrient
  • Like other organisms, insects must balance two properties of ionic iron, that of an essential nutrient and a potent toxin. (nih.gov)
  • Iron is an essential nutrient for almost all living organisms, but is not easily made available. (mdpi.com)
  • iron is an essential nutrient that is toxic in excess ( 18 ). (physiology.org)
  • liver
  • The purpose of this study has been to investigate the absorption of iron in various kinds of liver disease and to determine the influence of some of the factors which might affect absorption. (bl.uk)
  • The absorption of iron was studied in a total of 39 patients with liver disease. (bl.uk)
  • Seventeen patients with cirrhosis of the liver were studied using either labelled ferrous sulphate or labelled haemoglobin iron. (bl.uk)
  • An excess of iron is also toxic, as it facilitates the generation of free radicals that can attack the liver, heart and pancreas. (innovations-report.com)
  • Liver: is the main seat of iron storage with the reticulo-endothelial system. (daphnelab.com)
  • Iron, transferrin-bound, reaches the liver after being absorbed by the intestines. (daphnelab.com)
  • From the liver the iron can be re-transferred again to transferrin in case of need. (daphnelab.com)
  • However, two early studies using injected 59 Fe suggest the liver is the main storage pool for iron in fish (in tench, Tinca tinca L. (biologists.org)
  • hemoglobin
  • The iron, atomic weight 55.8, is present in the human body in the amount of 4-5 grams, three quarters of which used for the formation of hemoglobin, essential metal-protein for the transport of the oxygen to the tissues. (daphnelab.com)
  • The iron is deleted or lost through the normal turnover of hemoglobin in the urine, sweat, with flaking, with feces as unabsorbed and how much comes from small and unapparent continuous bleeding of the gastrointestinal tract, with menstruation. (daphnelab.com)
  • tissues
  • Most iron deficient cancer patients present with functional iron deficiency (FID), a status with adequate storage iron, but insufficient iron supply for erythroblasts and other iron dependent tissues. (springermedizin.at)
  • Iron is essential for life (used for the transport of oxygen in the blood, to keep it lodged in the muscles, for the cellular respiratory activity, for cell replication and to build the structure of tissues and organs). (daphnelab.com)
  • Rats
  • The present study was undertaken to investigate changes in the metabolism of iron and in antioxidant defences of diabetic STZ rats following treatment with vanadium. (hindawi.com)
  • Clinical
  • Indeed, bloodletting could cause an increase of non-transferrin bound iron (NTBI) particularly for its reactive form called labile plasma iron (LPI) This adverse physiopathological effect could have clinical consequences and could be linked with articular consequences which can be aggravated by the treatment. (clinicaltrials.gov)
  • Here we present a short review on the epidemiology, pathophysiology, diagnosis, clinical symptoms, and treatment of iron deficiency in cancer patients. (springermedizin.at)
  • organisms
  • Thus iron can be both toxic and beneficial to organisms, and iron status in the body must be carefully regulated to provide sufficient iron for biological functions, whilst avoiding excess Fe 2+ which can lead to oxidative stress. (biologists.org)
  • Iron is an essential micronutrient for almost all organisms and is used as a co-factor for many enzymes involved in redox-reactions. (pubmedcentralcanada.ca)
  • concentration
  • Iron administration did not influence haemoglobin concentration which was in the normal range at baseline and throughout the study in both iron‐treated and placebo‐treated patients. (uzh.ch)
  • reactive oxygen
  • Nitric oxide, reactive oxygen species, Krebs cycle metabolites succinate and fumarate, cobalt chloride (CoCl 2 ), and iron chelators such as desferrioxamine inhibit HIF PHDs in the presence of oxygen, resulting in increased EPO transcription. (nih.gov)
  • testis
  • Iron and other representative metal levels were determined by inductively coupled plasma-mass spectrometry in total testis extracts. (physiology.org)
  • In mammalian and fruit fly testis, components of the mitochondrial iron metabolism are expressed, but so far their function during spermatogenesis is unknown. (pubmedcentralcanada.ca)
  • muscular
  • The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. (clinicaltrials.gov)
  • The normal serum iron fluctuates between 0.6 and 1.5 mg / ml of serum, but is susceptible to physiological variations in relation to a variety of conditions: age, gender, pregnancy, muscular work, etc. (daphnelab.com)