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  • pyrite
  • Negative δ56Fe at the bottom of the core represent incorporation of isotopically light iron in diagenetic minerals, including pyrite, with only minor mixing with sediment input. (uu.nl)
  • bulk
  • Here, we present bulk iron isotope measurements of rocks from the Middle Mapepe formation of the Fig-Tree group from the Barb 5 drill core, Barberton Greenstone Belt, South Africa. (uu.nl)
  • oceans
  • The iron cycle on the early earth was significantly different from today due to anoxic oceans and atmosphere. (uu.nl)
  • severely
  • One hundred severely anemic (hemoglobin 5-9.9 g/dL) Ugandan children 6-59 mos with clinical signs of malaria who present to the Pediatric Acute Care Ward of Mulago Hospital in Kampala, Uganda, will be randomized to start iron immediately after antimalarial treatment on Day 0 (immediate group) or 4 weeks later on Day 28 (delayed group). (clinicaltrials.gov)
  • The results of this study will establish a physiologically-based framework for the optimal timing of antimalarial treatment and iron therapy upon which future interventions aimed at improving iron status in malaria-endemic regions can be built, thus helping to reduce the morbidity and mortality and ensure the full neurobehavioral development of the millions of severely anemic children suffering from iron-deficiency and malaria. (clinicaltrials.gov)
  • distribution
  • The working hypothesis is that red cell iron incorporation will be greater at the time of initial supplement administration in children starting iron 4 weeks after antimalarial treatment (delayed group) compared to children starting iron concurrently with antimalarial treatment (immediate group), due to more complete parasite clearance and resolution of inflammation, permitting better iron uptake, distribution, and utilization. (clinicaltrials.gov)
  • deficiency
  • This severe anemia frequently results from coexisting iron deficiency and malaria infection, but the standard of care, concurrent iron therapy and antimalarial treatment, has proven ineffective at curing the profound anemia and has promoted proliferation of the parasite in some studies. (clinicaltrials.gov)
  • absorption
  • The pro-inflammatory immune response mounted against malaria down-regulates iron absorption in the gut, making provision of oral iron supplements during malarial infection of questionable utility. (clinicaltrials.gov)
  • The working hypothesis is that delayed iron treatment will be associated with greater hemoglobin and improved iron status at Day 56 compared to immediate treatment due to more complete parasite clearance and consequent improved iron absorption and use in the delayed group. (clinicaltrials.gov)