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  • complex
  • The experiments refuted the idea that chirality of the iron complex affects its recognition by FepA and demonstrated the necessity of an unsubstituted catecholate coordination center for binding to the outer membrane protein. (asm.org)
  • Its three identical catechol groups chelate Fe 3+ in a Δ- cis complex, creating a hexadentate iron center with a net charge of −3. (asm.org)
  • aqueous
  • In the wild, the low solubility of iron in aqueous, aerobic conditions further complicates its acquisition: the concentration of available Fe 3+ at neutrality is 10 −18 M ( 34 ), whereas bacteria require a minimum of 10 −8 M for growth and 10 −6 M for iron sufficiency ( 24 ). (asm.org)
  • molecule
  • Building on the properties of the Pittsburgh Compound B (PiB), an Aβ-binding molecule suitable to use as positron emission tomography (PET) imaging agent, and aiming at using a more clinically available modality (like magnetic ressonance imaging, MRI), PiB derivatives have been conjugated to the macrocyclic chelator 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DO3A) monoamide. (ntno.org)
  • proteins
  • However, the FepA and IroN proteins of S. typhimurium failed to efficiently function in E. coli . (asm.org)
  • Pathogenic and commensal bacteria alike obtain iron from human and animal hosts by competing for the metal with eucaryotic proteins, like transferrin, lactoferrin, and ferritin ( 11 , 25 , 49 , 54 ). (asm.org)
  • Proteins of Iron Metabolism , Grune and Stratton, New York (1977). (springer.com)
  • secondary
  • The other group of secondary metabolites of rosemary are polyphenolic compounds including the flavonoids (e.g., homoplantaginin, cirsimaritin, genkwanin, gallocatechin, nepetrin, hesperidin, and luteolin derivatives) and phenolic acid derivatives (e.g., rosmarinic acid) [ 27 - 29 ]. (hindawi.com)
  • contains
  • Enterobactin, the native siderophore of Escherichia coli and the most avid microbial iron chelator (K a = 10 52 [ 10 ]) contains three dihydroxybenzoyl serine groups linked in a macrocyclic lactone ring (Fig. 1 ). (asm.org)
  • formation
  • The contacting is carried out in first and second contacting zones, the first being a gas-solution mixture formation zone and the second comprising a plurality of contacting sections adapted to provide reaction of the H.sub.2 S in the sour gaseous stream with the iron in the contacting solution without plugging due to deposition of sulfur. (patents.com)
  • The multifunctional nature of the compounds from the general antioxidant-mediated neuronal protection to other specific mechanisms including brain inflammation and amyloid beta (A β ) formation, polymerisation, and pathologies is discussed. (hindawi.com)
  • With semipolar bonds chelate formation occurs, especially when binding metal ions. (springer.com)
  • problems
  • Both classes of drugs, the cross-link inhibitors and the cross-link breakers, have been found to offer remarkable benefits at the clinical level, although some of these compounds suffered from commercial problems. (antiaging-systems.com)
  • small
  • Over the last decade, several small organic Aβ-targeting compounds have been identified, including benzothiazoles, stilbenes [ 6 ] and thioflavin T derivatives, such as the Pittsburgh Compound B (PiB) [ 7 ]. (ntno.org)
  • conditions
  • Exposure of tryptophan hydroxylase (TPH), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, to dopamine under mild oxidizing conditions (iron + H 2 O 2 ) or in the presence of tyrosinase results in a concentration-dependent inactivation of the enzyme. (jneurosci.org)
  • Several
  • Several species of Enterobacteriaceae , including E. coli ( 37 , 46 ), Salmonella typhimurium , ( 42 ) and Klebsiella pneumoniae ( 40 ), produce enterobactin in response to iron stress. (asm.org)
  • supply
  • We characterized the ability of seven analogs of enterobactin to supply iron via FepA by quantitatively measuring the binding and transport of their 59 Fe complexes. (asm.org)
  • excited state
  • While in the Haber-Weiss reaction superoxide reduces iron, which is oxidized by H$\sb2$O$\sb2$ to produce OH$\cdot$, excited state reduced dyes appeared capable of reducing the iron, so that SOD was only partially inhibitory of OH$\cdot$ production. (rice.edu)
  • charge
  • agrobactin A) with alterations to the chelating groups and different net charge on the iron center neither adsorbed to nor transported through FepA. (asm.org)