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  • putative
  • The bovine lactoferrin (bLf) promoter contains many putative binding sites for inflammatory modulators, which suggests that the increases in lactoferrin seen during inflammation may be due to activation of lactoferrin gene transcription by these specifically-induced transcription factors. (massey.ac.nz)
  • lactoferrin
  • Lactoferrin is an iron-binding protein found in many bodily secretions and in the secondary granules of polymorphonuclear leukocytes. (massey.ac.nz)
  • While there are many proposed functions for the lactoferrin protein - e.g. for iron storage, antibacterial properties, or a role in inflammation, the specific function(s) of lactoferrin have yet to be elucidated. (massey.ac.nz)
  • 1976) where after the induction of bovine mammary infections, a significant increase in secreted lactoferrin protein was seen during the early phase of the infection. (massey.ac.nz)
  • As this increase was during the period of the acute phase response, this suggested that lactoferrin, as was the case with other proteins induced during this time, may have a role in the inflammatory response. (massey.ac.nz)
  • macrophages
  • The intracellular iron level exerts a negative feedback on transferrin receptor (TfR) expression in cells requiring iron for their proliferation, in contrast to the positive feedback observed in monocytes-macrophages. (epfl.ch)
  • Nramp1 codes for an integral membrane protein expressed in the lysosomal compartment of macrophages, and is recruited to the membrane of phagosomes soon after the completion of phagocytosis. (nih.gov)
  • pathogens
  • Mutations at the natural resistance-associated macrophage protein 1 (Nramp1) locus cause susceptibility to infection with antigenically unrelated intracellular pathogens. (nih.gov)
  • species
  • binding of the iron complex was either similar or higher in all the species. (aspetjournals.org)
  • In the context of the pharmacokinetic properties of deferasirox and Fe-[ICL2 , the data indicate the importance of plasma protein binding for their disposition and support a comparison of the pharmacokinetics of deferasirox and its iron complex across species. (aspetjournals.org)
  • The blood binding parameters of a drug can be critical for its pharmacokinetics and are needed for a comparison of pharmacokinetics across species. (aspetjournals.org)
  • Intense NRVS peaks due to vibrations of the N-Fe-N unit can be observed between 500 and 700 cm(-1) and are diagnostic indicators of the type of iron dinitrosyl species present. (pcom.edu)
  • NRVS spectra for four iron dinitrosyl model compounds are presented and used as benchmarks for the identification of species formed in the reaction of Pyrococcus furiosus ferredoxin D14C with nitric oxide. (pcom.edu)
  • chelator
  • Deferasirox (Exjade, ICL670) is an orally active iron chelator. (aspetjournals.org)
  • For many years, Desferal (deferoxamine mesylate) has been the only iron chelator approved for general use. (aspetjournals.org)
  • An orally active iron chelator would be expected to improve the compliance and, therefore, the clinical responses, will be usable in areas with less developed infrastructure, and can facilitate the treatment of other diseases, including nontransfusion-dependent thalassemias, anemias, and possibly hemochromatosis. (aspetjournals.org)
  • antibody
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • deferasirox
  • Two molecules of deferasirox can form a complex with ferric iron (Fe-[ICL2 ) that can be excreted, reducing body iron overload. (aspetjournals.org)
  • Competition binding experiments indicated that deferasirox at high concentrations displaced markers from the two main drug binding sites of human albumin, whereas Fe-[ICL2 displaced only warfarin. (aspetjournals.org)
  • accumulation
  • This contrasts with IRP-2, whose activation reflected the accumulation of stable IRP-2 protein by de novo synthesis. (epfl.ch)
  • intracellular
  • Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. (nih.gov)
  • structures
  • The paper contains several other findings and achievements, including characterization of the first ever protein structures containing transuranic elements and how use of the protein can sensitize the metal's luminescence, which could lead to potential medical and industrial applications. (lbl.gov)
  • These are the first protein structures containing thorium or the transuranic elements plutonium, americium, or curium," Abergel said. (lbl.gov)
  • Clusters
  • IscU is a highly conserved protein that serves as the scaffold for IscS-mediated assembly of iron-sulfur ([Fe-S]) clusters. (nih.gov)
  • Abstract
  • ABSTRACT: BACKGROUND: Iron involvement/imbalance is strongly suspected in multiple sclerosis (MS) etiopathogenesis, but its role is quite debated. (unimi.it)
  • zinc
  • Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. (uniprot.org)
  • repression
  • The activation of IRP-2 was also prevented by transcription inhibition with actinomycin D. Further analysis revealed that, while both IRPs are rapidly inactivated following iron treatment of iron-depleted cells, the repression of IRP-2 was again completely translation dependent. (epfl.ch)
  • albumin
  • Oral neutrophil numbers in gingival inflammation and resolution correlated moderately with salivary β-globin, thioredoxin, and albumin and strongly with collagen alpha-1 and G-protein coupled receptor 98. (frontiersin.org)
  • cells
  • The cells were grown in either standard or iron-supplemented culture. (epfl.ch)
  • Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells. (lbl.gov)
  • Research led by Berkeley Lab's Rebecca Abergel, working with the Fred Hutchinson Cancer Research Center in Seattle, has found that plutonium, americium, and other actinides can be transported into cells by an antibacterial protein called siderocalin, which is normally involved in sequestering iron. (lbl.gov)
  • We showed that this protein is capable of transporting plutonium inside cells," she said. (lbl.gov)
  • Microarray of frataxin-deficient Schwann cells demonstrated strong activations of inflammatory and cell death genes including interleukin-6 and Tumor Necrosis Factor which were confirmed at the mRNA and protein levels. (biomedsearch.com)
  • Both proteins are activated in Ltk- cells following iron chelation. (epfl.ch)
  • fractions
  • Iron binding by both the insoluble and soluble fractions decreased in the presence of citric acid and ascorbic acid, with no significant differences between the effects of the two acids. (massey.ac.nz)
  • functions
  • Functions as an antenna for photosystem I (PSI) under iron-limiting conditions, when phycobilisomes disappear. (cusabio.com)
  • recruitment
  • Increased oral neutrophil recruitment and salivary cytoprotective proteins increased progressively during inflammation and decreased in resolution. (frontiersin.org)
  • Our results indicate that changes in salivary cytoprotective proteins in gingivitis are associated with a similar trend in oral neutrophil recruitment and clinical parameters. (frontiersin.org)
  • specific
  • From the evidence, we propose a mechanism for its function as a specific magnetite nucleation protein and summaries the key features for this action: namely, self-assembly to display a charged surface for specific iron binding, with the curvature of the surfaces determining the particle size. (biochemsoctrans.org)
  • poorly
  • Poorly liganded iron is potentially both a contributor to, and consequence of, these complications. (plymouth.ac.uk)
  • modulation
  • In this study, we compared modulation of the RNA-binding activities of IRP-1 and IRP-2. (epfl.ch)
  • Immunoblot analysis suggests that iron modulation of IRP-1 activity is predominantly a posttranslational process. (epfl.ch)
  • dependent
  • Solubility of each protein was dependent on pH and it generally decreased with increase in iron concentration. (massey.ac.nz)
  • The solubilizing effect of these two acids was dependent on the protein source, pH and acid concentration. (massey.ac.nz)
  • role
  • We explored the role of common single nucleotide polymorphisms (SNPs) in the main iron homeostasis genes in MS patients. (unimi.it)