• In recent two years, as for the drug procurement in 22 cities in China , there were six major varieties of contrast media, namely, iohexol, iopromide, gadopentetate dimeglumine, iopamidol, ioversol and meglumine diatrizoate, of which the former three varieties were listed among the best-selling 200 drugs. (prnewswire.com)
  • According to the procurement of contrast media from sampled hospitals in 16 cities, iohexol and iopromide rank first and second respectively, accounting for 43% and 32% of market shares of CT contrast media respectively in domestic market. (prnewswire.com)
  • For example, 2nd-generation, low-osmolal agents (eg, iohexol , iopamidol , ioxaglate) have an osmolality of about 500 to 850 mOsm/kg (or mmol/kg), which is still higher than blood osmolality. (msdmanuals.com)
  • The DC Bead LUMI IFU recommends using contrast agents Omnipaque 350 (Iohexol 350) and Iomeron 400 (Iomeprol 400). (bostonscientific.com)
  • Hossain MA , Costanzo E , Cosentino J , Contrast-induced nephropathy: pathophysiology, risk factors, and prevention . (avma.org)
  • Contrast nephropathy is worsening of renal function after IV administration of radiocontrast and is usually temporary. (msdmanuals.com)
  • Preventing contrast nephropathy involves avoiding contrast when possible (eg, not using CT to diagnose appendicitis) and, when contrast is necessary for patients with risk factors, using a nonionic agent with the lowest osmolality at a low dose. (msdmanuals.com)
  • Those concerns have largely focused on contrast-induced nephropathy (CIN), the commonest and most important complication of the use of iodinated radiocontrast material. (peterdsteinberg.com)
  • abstract: RATIONALE AND OBJECTIVES:Diabetic patients frequently suffer contrast media-induced nephropathy. (shengsci.com)
  • However, risk is lower with newer contrast agents, which are nonionic and have a lower osmolality than older agents, whose osmolality is about 1400 to 1800 mOsm/kg (or mmol/kg). (msdmanuals.com)
  • High-osmolality contrast media consist of a tri-iodinated benzene ring with 2 organic side chains and a carboxyl group. (medscape.com)
  • The osmolality is related to some of the adverse events of these contrast media. (medscape.com)
  • In recent years, concerns about nephrotoxicity associated with high-osmolality contrast media (HOCM) have led to more widespread use of low- and iso-osmolality contrast agents in diagnostic imaging procedures. (peterdsteinberg.com)
  • Since their introduction in the 1950s, organic radiographic iodinated contrast media (ICM) have been among the most commonly prescribed drugs in the history of modern medicine. (medscape.com)
  • A low-osmolar, ionic contrast medium used in various radiographic procedures. (nih.gov)
  • Non-ionic contrast media such as iopamidol and iohexol are used. (wikipedia.org)
  • Research and Markets ( http://www.researchandmarkets.com/research/9g868h/research_and ) has announced the addition of the "Research and Development Forecast of China Contrast Media (Contrast Agent) Market, 2014" report to their offering. (prnewswire.com)
  • With the mushroom growth of world diagnostic imaging equipments and apparatuses, as for X-CT contrast media, iodinated contrast media serving as the main one is witnessing unprecedented development. (prnewswire.com)
  • Iohexol is featured with great security, high contrast ratio, lower osmotic pressure and small toxicity for human bodies etc. has become the best-selling contrast media in international market. (prnewswire.com)
  • Recently, hospitals attached more importance to instrument testing, boosting the development of contrast media market. (prnewswire.com)
  • As for domestic MRI contrast media, gadopentetate dimeglumine still plays the leading role, accounting for 83% of market shares of MRI contrast media. (prnewswire.com)
  • At present, Bayer Health Care, GE, Shanghai Bracco Sine Pharmaceutical Corp. Ltd., Yangtze River Pharmaceutical Group, Jiangsu Hengrui Medicine Co., Ltd. and BEILU Pharmaceutical Co., Ltd. dominate domestic contrast media market, they account for over 80% of market shares totally. (prnewswire.com)
  • In recent two years, domestic hospitals with certain strength put their attention on testing and examining, so they increased investment in imaging equipments, resulting in bringing momentum for the growth of contrast media market. (prnewswire.com)
  • Competition in contrast media market is not too fierce, and overall the market is on the rising trend. (prnewswire.com)
  • With continuous input and perfection of inspection equipments in China's large-scale hospitals, contrast media market will continue go up. (prnewswire.com)
  • In addition, contrast media price is high in terms of retail sales with considerable profits, representing one of motivators for its rapid growth. (prnewswire.com)
  • A number of clinical practice guidelines are available regarding safe and effective practices for the use of iodinated contrast media. (medscape.com)
  • Osmotic effects of contrast media that are specific for the kidney include transient decreases in blood flow, filtration fraction, and glomerular filtration rate. (medscape.com)
  • and be prepared to promptly recognize and manage any reactions to the contrast media. (medscape.com)
  • CIN has been variably defined as a condition characterized by kidney dysfunction following exposure to radioiodinated contrast media when no other explanation such as hypotension or sepsis can be implicated. (peterdsteinberg.com)
  • 1] However, recent observations have called into question the specificity of the diagnosis, as up to 20% of patients who are hospitalized with cardiac disease and who never receive contrast media may also have a spontaneous rise in SCr equal to that seen in patients diagnosed with CIN. (peterdsteinberg.com)
  • Recent studies suggest that very large doses of contrast media may increase the risk of CIN, and that there is likely a low dose that does not convey such a risk. (peterdsteinberg.com)
  • Glucose alters the susceptibility of mesangial cells to contrast media. (shengsci.com)
  • Other investigators were using more innocuous contrast agents. (ajnr.org)
  • Classification of iodinated contrast agents by their molecular structures. (medscape.com)
  • The nonionic monomers are the contrast agents of choice. (medscape.com)
  • Several experimental studies have demonstrated the medullary vasoconstriction that results from the administration of contrast agents. (peterdsteinberg.com)
  • While contrast agents may induce medullary ischemia in any subject, only certain individuals are at risk for CIN. (peterdsteinberg.com)
  • Other risk factors have been proposed including patient age, dose of contrast agent, poor cardiac function, multiple exposures to contrast agents over a brief duration, use of pharmacologic agents that tend to cause renal vasoconstriction, extracellular volume depletion, and certain diseases such as multiple myeloma. (peterdsteinberg.com)
  • Studies in patients at very advanced stages of CKD in whom contrast is administered to assess vascular access pre-dialysis have shown that kidney function for these high-risk patients does not decline if less than 20 ml of contrast agents are infused with the venography. (peterdsteinberg.com)
  • May 13, 2021 With the increasing application of iodinated contrast agents, the adverse reactions and risks caused by iodinated contrast agents have attracted much attention. (beilupharma.com)
  • At high-contrast boundaries (jump discontinuity in mathematical terms), the Fourier transform corresponds to an infinite number of frequencies. (radiopaedia.org)
  • Diagnosis is based on a progressive rise in serum creatinine 24 to 48 hours after contrast is given. (msdmanuals.com)
  • Iopamidol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Ventricular fibrillation in coronary angiography: what is the role of contrast medium? (umassmed.edu)
  • The following patient data were extracted by interview and from the hospital's radiology information system: height, weight, age, menstrual cycle, CT images of normal tissue and tumors with or without contrast medium, and the histopathological diagnosis of the aspiration biopsy. (scirp.org)
  • In all conditions, regardless of contrast medium, the CT values of tumor tissues were higher than those of normal breast tissue, indicating the effectiveness of dual-energy CT (DE-CT) in the diagnosis of breast cancer. (scirp.org)
  • A contrast agent is introduced, and after the procedure, a CT scan identifies leakage from the discs to identify any spinal disc herniation. (wikipedia.org)
  • Volume loading with isotonic saline before and after contrast administration may help in prevention. (msdmanuals.com)
  • Pantopaque, a new contrast medium, was introduced in 1944 by Ramsey and Strain (15) . (ajnr.org)
  • The present study aimed to investigate the possibility of using dual-energy computed tomography (CT) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without the need to use a contrast medium. (scirp.org)
  • Silva M, Milanese G, Cobelli R, Manna C, Rasciti E, Poggesi S, Sverzellati N. CT angiography for pulmonary embolism in the emergency department: investigation of a protocol by 20?ml of high-concentration contrast medium. (umassmed.edu)
  • Sheiman RG, Raptopoulos V. Delayed intravenous contrast medium washout from the small bowel in patients with pancreatic carcinoma and splanchnic venous invasion. (umassmed.edu)
  • This graph shows the total number of publications written about "Iopamidol" by people in this website by year, and whether "Iopamidol" was a major or minor topic of these publications. (umassmed.edu)
  • 2,3] Nonetheless, since SCr is the only currently available measure of renal function, clinicians must employ the standard of an unexplained rise in SCr following contrast administration as evidence of CIN. (peterdsteinberg.com)
  • DC Bead LUMI must be suspended in soluble iodinated contrast (a minimum of 20ml per vial) to achieve effective delivery through microcatheters and to aid visualization during administration. (bostonscientific.com)
  • This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography , where data is obtained and computed from individual sequential exposures. (lookformedical.com)
  • Konen E, Konen O, Katz M, Levy Y, Rozenman J, Hertz M. Are referring clinicians aware of patients at risk from intravenous injection of iodinated contrast media? (medscape.com)
  • Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media. (medscape.com)
  • Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. (nih.gov)
  • The use of iodinated contrast media (CM) for both diagnostic imaging and interventional studies continues to increase. (uscjournal.com)
  • Non-contrast-enhanced MR angiography is a type of MR angiography that does not use gadolinium contrast to image the blood vessels, unlike the contrast enhanced MR angiography . (radiopaedia.org)
  • The addition of gadolinium into the blood (as in contrast-enhanced MR angiography) will reduce the T1 relaxation time, thus increasing the signal of the slow-flowing blood 5 . (radiopaedia.org)
  • Generally, these techniques are time-consuming as compared with contrast-enhanced MR angiography . (radiopaedia.org)
  • 4. Navot B, Hecht E, Lim R, Edelman R, Koktzoglou I. MR Angiography Series: Fundamentals of Non-Contrast-Enhanced MR Angiography. (radiopaedia.org)
  • 5. Wheaton A & Miyazaki M. Non-Contrast Enhanced MR Angiography: Physical Principles. (radiopaedia.org)
  • Iopamidol injection is a commonly used iodine-containing contrast agent in the radiology department, mainly used for neurointervention, coronary angiography, CT enhancement, and angiography. (stanfordchem.com)
  • Images taken after administration of water-soluble contrast agents highlight the kidneys and urinary collecting system. (merckmanuals.com)
  • Iopamidol is a non-ionic water-soluble contrast agent, which is a drug for imaging diagnosis. (stanfordchem.com)
  • The use of iodinated and gadolinium contrast media during pregnancy and lactation. (nih.gov)
  • Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. (handwiki.org)
  • Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives an iodine-containing contrast medium. (nih.gov)
  • An iodinated radiographic contrast medium used as acetrizoate sodium in HYSTEROSALPINGOGRAPHY. (bvsalud.org)
  • When iopamidol was dissolved in river water spiked with chlorine or chloramine, high levels of iodoacetic acid and iodo-trihalomethanes were produced in a dose-dependent manner. (nih.gov)
  • Gadopentetic acid , sold under the brand name Magnevist , is a gadolinium -based MRI contrast agent . (handwiki.org)
  • Approximately half of all CT examinations are performed using contrast agents. (axisimagingnews.com)
  • Abdominal x-rays without radiopaque contrast agents may be done to check for positioning of ureteral stents or to monitor position and growth of kidney stones. (merckmanuals.com)
  • Most contrast agents are iodine based. (merckmanuals.com)
  • Faced with considerable opportunities in both the contrast agents business and all its other segments, Hovione decided to focus on its CDMO business, on its off-patent business supplying highly specialised APIs and to exit the large volume business of contrast media. (manufacturingchemist.com)
  • 1 - 4 ] However, because there is no published experience with iopamidol during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. (nih.gov)
  • Compared to other gadolinium-based MRI contrast agents, Gadopentetate dimeglumine (Gd-DTPA2-) chelates allow delayed Gadolinium-enhanced Magnetic Resonance of Cartilage (dGEMRIC). (handwiki.org)
  • It features low pressure, low viscosity, good contrast, stable injection, very little deiodine in vivo, suitable for myelography and patients with high-risk factors of contrast agent reaction. (stanfordchem.com)
  • Prefilled contrast media syringes simplify the tasks associated with contrast injection. (axisimagingnews.com)
  • This alters their MRI properties and enables contrast enhancement to be achieved. (handwiki.org)
  • Patients in emergency rooms with trauma, respiratory symptoms, and acute sepsis syndrome are also being sent for contrast-enhanced imaging. (uscjournal.com)
  • Iodinated X-ray contrast media (ICM), used medically to highlight soft tissues, are considered generally safe, and patients excrete 95% of the dose within 24 hours, making them a valuable tool in medical imaging. (nih.gov)
  • The contrast-enhanced CT examinations of 401 patients were studied. (axisimagingnews.com)
  • More patients with chronic conditions, such as atherosclerotic cardiovascular disease, renal insufficiency, and congestive heart failure, are becoming candidates for contrast studies. (uscjournal.com)
  • A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. (medscape.com)
  • contrast media (iodinated) increases levels of metformin by decreasing renal clearance. (medscape.com)
  • Supplies used for manual filling of contrast media syringes: empty syringe cartridge, transfer tubing, transfer straw, contrast bottle, and hand-control syringe. (axisimagingnews.com)
  • The bottle-filled cartridge method involves tearing the seal off of a vial of contrast medium, drawing the contrast into a syringe compatible with a power injector, labeling the syringe according to departmental guidelines, and disposing of the used supplies. (axisimagingnews.com)
  • The sale of iMAX Diagnostic Imaging for Hovione marks the end of a 24 years history of reliable and uninterrupted supply of iopamidol and iohexol to the generic industry globally. (manufacturingchemist.com)
  • 16. Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner. (nih.gov)
  • 8. Multiple CEST contrast imaging of nose-to-brain drug delivery using iohexol liposomes at 3T MRI. (nih.gov)
  • 9. Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH. (nih.gov)
  • In comparison, no iodo-DBPs formed in the absence of iopamidol in river water containing the two disinfectants. (nih.gov)
  • While there is no 'safe' amount of CM, the greater the volume of administered contrast, the greater the risk of CIN. (uscjournal.com)
  • Independent observers from a company specializing in time-and-motion evaluations monitored and recorded the time necessary to perform the steps of contrast-enhanced CT examinations. (axisimagingnews.com)
  • Among the changes brought about by spiral CT technology is a re-examination of contrast-media dosing protocols. (axisimagingnews.com)
  • The combination of increased speed and potentially reduced contrast dose makes this technology very attractive. (axisimagingnews.com)