AnatomyOrganismsChemicals and DrugsPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
LactoferrinLactoglobulinsIon ChannelsTransferrinIronMilk, HumanIon TransportIon Channel GatingMuramidaseNeutrophilsHeavy IonsCattleTearsApoproteinsMilkEncyclopedias as TopicColostrumTransferrins
GlycoproteinMetal ionsSecretionsProteinHigh affinityMilkAntibacterialMoleculePolypeptide chainProteinsBindsConcentrationsAlpha lactalbumin2002LipopolysaccharideMoleculesNeutrophilsBacterialConcentrationBelongsImmune systemChelateLigandsBiofilmMacrophagesHumanMolecularPositivelyIronInhibitSepsisInfantsHumansBabiesZinc
Glycoprotein11
  • Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. (wikipedia.org)
  • Lactoferrin (Lf) is an 80-kDa glycoprotein that belongs to the transferrin family and is abundant in the colostrum and milk of mammals. (springer.com)
  • Lactoferrin is an 80kDa iron binding glycoprotein that is found as a major component of human milk, as well as in many other exocrine solutions. (massey.ac.nz)
  • Lactoferrin (Lf) is a cationic glycoprotein synthetized by exocrine glands and is present in all human secretions. (frontiersin.org)
  • This glycoprotein possesses antimicrobial activity due to its capability to chelate two ferric ions per molecule, as well as to interact with bacterial and viral anionic surface components. (frontiersin.org)
  • Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. (encyclopedia.pub)
  • Bovine and human milk contains a wide array of bioactive components, including the iron-binding glycoprotein known as lactoferrin (Lf). (encyclopedia.pub)
  • Lactoferrin Pro + C from Drasanvi is a food supplement made from lactoferrin, lactic acids and vitamin C. It is a glycoprotein present in milk, in colostrum and in several body fluids. (moremuscle.com)
  • Given the huge burden that Chikungunya and Zika fevers impose to public health in the affected countries and the lack of effective interventions against them, the aim of this work was to evaluate the antiviral potential of bovine lactoferrin (bLf) - an iron-binding glycoprotein with broad-spectrum antimicrobial properties - in both CHIKV and ZIKV infections. (ufg.br)
  • Lactoferrin (formerly known as lactotransferrin) is a glycoprotein, and a member of a transferrin family, thus belonging to those proteins capable of binding and transferring Fe3+ ions (Metz-Boutique et al. (chemicalbook.com)
  • The Lactoferrin is a glycoprotein mainly present in breast milk, but is present in many secretions such as tears and saliva with a strong chelating action of the iron. (mesoskinline.com)
Metal ions4
  • In this book, experts from a variety of disciplines describe the present knowledge of the structural features of lactoferrin, its carbohydrate side chains and its capacity to bind different metal ions and anions. (kisch-online.de)
  • Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. (ucdavis.edu)
  • It catches and then binds iron, making it difficult for bacteria to reach metal ions, which they need for multiplication and growth. (eliveragroup.com)
  • Prior to the addition of metal ions, divalent cations were removed by treatment with Chelex-100 (Sigma Aldrich). (mmp-signal.com)
Secretions3
Protein24
  • Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. (wikipedia.org)
  • Therefore, it was named lactoferrin in 1961, though the name lactotransferrin was used in some earlier publications, and later studies demonstrated that the protein is not restricted to milk. (wikipedia.org)
  • Similarity in the size of exons and their distribution in the domains of the protein molecule indicates that the evolutionary development of lactoferrin gene occurred by duplication. (wikipedia.org)
  • The degree of glycosylation of the protein may be different and therefore the molecular weight of lactoferrin varies between 76 and 80 kDa. (wikipedia.org)
  • The results of recently conducted clinical trials suggest that lactoferrin, an iron-binding protein that is abundant in mammalian colostrum and milk, may be an effective agent in preventing sepsis in newborns. (springer.com)
  • However, despite numerous basic studies on lactoferrin, very little is known about how metal saturation of this protein affects a host's health. (springer.com)
  • Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
  • Valuable protein fractions that are lost during ion exchange (lactoferrin), glycomacropeptides and peptide fragments are thus preserved. (sharkfitness.ch)
  • Lactoferrin is an intriguing protein with an interesting structure and several known or suggested biological activities. (kisch-online.de)
  • Although the structure of the iron-free form has not been determined, it appears that changes to the hinge region of the N-lobe of lactoferrin do not affect the iron-binding or structural characteristics of the protein. (massey.ac.nz)
  • A substantial body of evidence, primarily from in vitro studies, suggests that some milk proteins interfere with viral infections.Lactoferrin (LF) has been the protein most comprehensively studied for its antiviral effects. (immunecare.co.uk)
  • Milk lactoferrin is one multifunctional protein. (diabetesasia.org)
  • Milk lactoferrin is one multifunctional protein to sell bacterial clearance. (diabetesasia.org)
  • 50 grams of 100% pure ion exchange whey protein isolate. (vitasprings.com)
  • Nature's Best Perfect Low Carb Isopure contains 50 grams of 100% Pure Ion Exchange Whey Protein Isolate. (vitasprings.com)
  • Our protein source is clearly identified as 100% Pure Ion Exchange Whey Protein Isolate. (vitasprings.com)
  • ISOFLEX uses a unique protein extraction technology called Hybrid-Ratio Ion-Filtration (HRI). (tsw.com.sg)
  • Lactoferrin is a bioactive protein that naturally occurs in body fluids. (eliveragroup.com)
  • Do not use to dissolve hot liquids, because lactoferrin as a protein is destroyed at high temperature. (eliveragroup.com)
  • bovine lactoferrin binds to the main zika protein that makes up the Zika virus tertiary amino lipid coating, regardless of pH, and locks these proteins into place, preventing the structural re-arangement changes required for the fusion step of infection. (ufg.br)
  • Due to the increase in its concentration during most inflammatory reactions and some viral in fections, several authors classify lactoferrin as an acute-phase protein (Kanyshkova et al. (chemicalbook.com)
  • Lactoferrin is a multifunctional protein of transferin family. (chemicalbook.com)
  • Lactoferrin is a protein found in cow milk and human milk. (chemicalbook.com)
  • Isopure's Major Protein Include: Beta-lactoglobulin 55 - 62% Alpha-lactalbumin 19 - 22% Immunoglobulin 9 - 10% Bovine Serum Albumin 6 - 8% Lactoferrin .5 - 1% In addition, Isopure is rich in branched-chain amino acids and glutamine. (jnknutrition.com)
High affinity2
  • Its ability to bind two Fe +3 ions with high affinity, in cooperation with two HCO 3 - ions, contributes to its major structure-functional properties, including antimicrobial activity. (ift.org)
  • Lactoferrin binds reversibly, and with high affinity, 2 Fe3+ ions with 2 synergistic C032- ions. (massey.ac.nz)
Milk10
Antibacterial6
  • Lactoferrin provides antibacterial activity to human infants. (wikipedia.org)
  • The antibacterial action of lactoferrin was also documented in 1961, and was associated with its ability to bind iron. (wikipedia.org)
  • Mucous gels exhibit non-specific antibacterial capabilities as they contain molecules such as lactoferrin, lysozyme, and immunoglobulins. (bmj.com)
  • Probably the principal physiological characteristic of lactoferrin as an antibacterial agent is binding to the iron, additionally, interplay with distinct cell receptors, maybe an amazing cause for the antimicrobial hobby. (diabetesasia.org)
  • The principal physiological characteristic of lactoferrin as an antibacterial agent is binding to the iron and or sequestering iron as an important requirement for maximum bacterial pathogens . (diabetesasia.org)
  • The antibacterial hobby is the primary organic characteristic of lactoferrin in the host pre-immune protection system. (diabetesasia.org)
Molecule2
Polypeptide chain3
  • X-ray diffraction reveals that lactoferrin is based on one polypeptide chain that contains about 700 amino acids and forms two homologous globular domains named N-and C-lobes. (wikipedia.org)
  • The crystal structure shows that the polypeptide chain is folded into two similar lobes, each binding one Fe3+ and CO32- ion. (massey.ac.nz)
  • The three-dimensional structure of lactoferrin, consists of a single polypeptide chain of 692 amino acids, is organized in two globular lobes joined by a alpha-helix. (mesoskinline.com)
Proteins7
  • Lactoferrin belongs to the basic proteins, its isoelectric point is 8.7. (wikipedia.org)
  • There was also no change in the production of tight junction proteins regardless of lactoferrin metal saturation status. (springer.com)
  • 4 The proteins that occur in the mucus, including lactoferrin, lysozyme, and secretory IgA, are part of this defence system. (bmj.com)
  • The production by Cross Flow Micro- filtration (micro- and subsequent ultrafiltration, no ion exchange) guarantees the highest possible preservation and concentration of the valuable, non-denatured whey proteins. (sharkfitness.ch)
  • After transfection of the pNUT vector into baby hamster kidney cells (BHK), the mutant proteins were expressed and purified from the culture medium using a CM-sephadex ion-exchange column. (massey.ac.nz)
  • It has 500 mg of colostrum in one capsule and provides various biologically active proteins that are responsible for the body's immunity, including lactoferrin, immunoglobins and other factors. (auroxhealth.com)
  • The extent of domain opening is the same as in the N-lobe of human lactoferrin, showing that it depends on internal constraints that are conserved in both proteins, and that it is unaffected by the presence or absence of the C-lobe. (rcsb.org)
Binds1
  • Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis. (rcsb.org)
Concentrations1
  • hemoglobin 5 μg mL−1 (Sigma Aldrich), hemin 50 μg mL−1 (Sigma Aldrich), and iron-loaded lactoferrin at the concentrations indicated. (mmp-signal.com)
Alpha lactalbumin1
  • WPC contains biological compounds, like lactoferrin, alpha lactalbumin, immunoglobins and beta lactoglobins, affecting everything from your immune system to nitrogen balance to fat loss. (simplyshredded.com)
20021
  • Thus, lactoferrin has a wide variety of biological functions, many of which do not appear to be connected with its iron binding ability (Brock, 2002). (chemicalbook.com)
Lipopolysaccharide2
  • However, the various lactoferrin forms did effectively inhibit the pro-inflammatory response in macrophages that were activated with lipopolysaccharide with the most potent effect observed for apolactoferrin. (springer.com)
  • Lactoferrin that was not bound to its cognate receptor was able to bind and neutralize lipopolysaccharide. (springer.com)
Molecules1
  • 2009). Lactoferrin consequences towards Gram-advantageous microorganisms are binding to anionic molecules, including lipoteichoic acid , and saving you the attachment of that microorganism to the host mobile surfaces ( Queiroz et al. (diabetesasia.org)
Neutrophils2
  • Neutrophils after degranulation were obser ved to be the main source of lactoferrin in blood plasma (Iyer and Lonnerdal, 1993). (chemicalbook.com)
  • As regards the ability anti-inflammatory of the Lactoferrin, significant traces have been noticed in the circulation during the inflammatory phase, resulting from activated neutrophils. (mesoskinline.com)
Bacterial2
  • Several of the possible physiological functions of lactoferrin are described in detail, including the role of lactoferrin in bacterial killing, its involvement in growth and proliferation, in immune function and in iron absorption. (kisch-online.de)
  • Lactoferrin is used for treating stomach and intestinal ulcers, diarrhea, and hepatitis C. It is also used as an antioxidant and to protect against bacterial and viral infections. (chemicalbook.com)
Concentration1
  • Humans, through secretion of lactoferrin, maintain an iron concentration of 10^(-18) M within macrophages, and the bacterium has evolved the siderophores mycobactin T and exomycobactin T (formerly exochelin) to cope with this shortage. (reactome.org)
Belongs2
Immune system2
  • You can trust the reinforcement that Lactoferrin Pro + C from Drasanvi can give your immune system. (moremuscle.com)
  • Lactoferrin is one of the most important elements of the immune system. (eliveragroup.com)
Chelate1
Ligands1
  • Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands. (wikipedia.org)
Biofilm3
  • According to research, iron withholding ability of lactoferrin affects the activation of immune cells and inhibit biofilm formation of pathogenic microorganism . (diabetesasia.org)
  • Bacteriostatic characteristic of lactoferrin is because of bind the Fe3 + ion and proscribing Fe3 + for microorganism increase and their virulence on the contamination web page, motility and biofilm formation of pathogenic microorganism could be inhibited (Gonzalez-Chavez et al. (diabetesasia.org)
  • N-acetylcysteine and lactoferrin also may cause biofilm degradation. (supremenutritionproducts.com)
Macrophages1
  • Therefore, the main objective of this study was to elucidate how iron-depleted, iron-saturated, and manganese-saturated forms of lactoferrin regulate intestinal barrier function via interactions with epithelial cells and macrophages. (springer.com)
Human6
  • Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin. (expasy.org)
  • The N-terminal half of human lactoferrin (LfN) has been constructed, expressed and the crystal structure determined. (massey.ac.nz)
  • Oligonucleotide site-directed mutagenesis has been used to construct mutants in the cDNA encoding for human lactoferrin using the M13 bacteriophage. (massey.ac.nz)
  • Jiang R, Lonnerdal B. Transcriptomic profiling of intestinal epithelial cells in response to human, bovine and commercial bovine lactoferrins. (ucdavis.edu)
  • Human lactoferrin that is made from specially processed rice appears to be safe for up to 14 days. (chemicalbook.com)
  • It is believed that this is the only system for integrating the iron in every cell of the human body and the use of Lactoferrin permitting its introduction in much lower dosages than those used up to now, since it increases the bioavailability and then absorption. (mesoskinline.com)
Molecular1
  • Aspects of the molecular biology of lactoferrin and its specific interactions with different cell types are also included. (kisch-online.de)
Positively2
Iron5
Inhibit1
  • This evidence suggests that the Lactoferrin put into circulation acts in such a way as to inhibit the excessive production of cytokines and preventing the excessive recruitment and activation of leukocytes in the inflamed areas. (mesoskinline.com)
Sepsis2
Infants1
Humans1
Babies2
  • Lactoferrin Pro + C from Drasanvi is a food supplement that will provide you with an effective combination of lactoferrin, lactic acid and vitamin C. It ensures an invaluable improvement in your body's defenses and also strengthens bones and promotes good development in babies. (moremuscle.com)
  • Lactoferrin Pro + C from Drasanvi is essential for the development of defenses in babies. (moremuscle.com)
Zinc1
  • Combines the Action of Natural Enzymes, an Abrasive Silicone System and Zinc Ions. (farmacianovadamaia.pt)