[ 9 ] Valinomycin, a potassium ionophore, exhibited activity against La Crosse virus in multiple cell types in a dose-dependent manner, suggesting a potential therapeutic target to disrupt virus replication. (medscape.com)
From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies. (nih.gov)
Nigericin2
The term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. (wikipedia.org)
This study shows that ionophore antibiotics, including valinomycin, salinomycin, and nigericin, inhibit FCoV proliferation in vitro in a dose-dependent manner. (nih.gov)
Antibiotic1
Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and chemically related to the enniatins. (fermentek.com)
Selective3
Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). (wikipedia.org)
Ionophores selective for cations and anions have found many applications in analysis. (wikipedia.org)
Ionophores can be selective to a particular ion but may not be exclusive to it. (wikipedia.org)
Ions11
In chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. (wikipedia.org)
Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. (wikipedia.org)
Ionophores modify the permeability of biological membranes toward certain ions to which they show affinity and selectivity. (wikipedia.org)
Ions are bound to the hydrophilic center and form an ionophore-ion complex. (wikipedia.org)
The carboxy-terminal segment of STs shares similarities with ionophores and, therefore, are expected to interact with metal ions. (medscape.com)
Ionophore antibiotics are compounds that form complexes with alkali ions to alter the endosomal pH conditions. (nih.gov)
Membrane2
Structurally, an ionophore contains a hydrophilic center and a hydrophobic portion that interacts with the membrane. (wikipedia.org)
Several chemical factors affect the ionophore activity. (wikipedia.org)
The activity of an ionophore-metal complex depends on its geometric configuration and the coordinating sites and atoms which create coordination environment surrounding the metal center. (wikipedia.org)