Ion trap spectrometer uses electrospray ionization. Medical search. Frequent questions

Bruker 456 Gas Chromatograph with SCION Triple Quadrupole (TQ) Mass Spectrometer (GC/MS/MS) with positive ion electron impact (EI) and positive and negative ion and chemical ionization (CI) modes, Bruker 8400 autosampler, solvent programmable temperature injector. (dri.edu)
Waters Acquity I-class ultra-high performance liquid chromatography (UPLC) coupled with electrospray ionization (ESI) triple quadrupole tandem mass spectrometer (MS/MS) (Waters Xebo TQ-S MS). (dri.edu)
Shimadzu Prominence HPLC coupled with a triple-quadrupole mass spectrometer (AB Sciex API 3200 LC-MS/MS), equipped with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources. (dri.edu)
The SCIEX QTRAP 6500+ ( YouTube Video ) is a state-of-the-art hybrid triple quadrupole mass spectrometer with a linear ion trap as Q3. (ccrc-hauner.de)
Electrospray ionization mass spectrometry (ESI-MS) experiments were conducted on authentic standards using an ion trap mass spectrometer, while a triple-quadrupole (QqQ) mass spectrometer was used in the selective reaction monitoring (SRM) mode to record energy-resolved CID. (edu.au)
There are several options for the mass analyzer, the most common combinations being time-of-flight (TOF) connected to MALDI and triple quadrupole, quadrupole-TOF, or ion trap mass analyzer coupled to ESI. (ashwinnaik.com)
This sensitive and robust triple quadrupole mass spectrometer is used for analysis of low (ppb) levels of environmental compounds and biomarkers. (lu.se)
According to the company, the software provides efficient workflows to identify and confirm metabolites from data acquired on Applied Biosystems/MDS SCIEX's triple quadrupole and linear ion trap mass spectrometers. (spectroscopyonline.com)
To obtain structural information, common types of mass spectrometers are used, such as the triple quadrupole mass spectrometer (QqQ) and the (linear) ion trap mass spectrometer (ITMS) [5]. (betasciencepress-publishing.com)
It has Xevo TQS triple quadrupole UPLC-MS-MS, with Electrospray, APCI and APPI interfaces. (ncl.ac.uk)

For UHPLC/MS/MS2 analysis, aliquots are separated using ultrahigh performance liquid chromatography and LTQ mass spectrometer (consisting of an electrospray ionization source and linear ion-trap mass analyzer. (jax.org)
Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. (jax.org)
The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-pro- ducts by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. (scirp.org)
Analysis of urine and stone extracts by UPLC-MS We evaluated ultra-performance PAC-1 liquid chromatography (UPLC) coupled with atmospheric pressure chemical ionization ion trap mass spectrometer (APCI/ITMS) for separating CDME and its reduced derivative CysME spiked into control urine. (exposed-skin-care.net)
Rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry was also employed to identify a total of 41 chemical constituents in CRP [ 27 ] . (encyclopedia.pub)
The different mass filters like Time of Flight (TOF), Ion Trap, Single or Triple Quadruple, Magnetic Sector Mass Analyzers in single or multiple mass spectrometry coupled with High Performance Liquid Chromatography(HPLC) give their unique pattern of mass spectra which are not easy to compare with each other. (ijlst.org)
High-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight and ion-trap tandem mass spectrometry to identify phenolic compounds from a lemon verbena extract. (chemfaces.com)
High-performance liquid chromatography with diode array and electrospray ionization mass spectrometric detection was used to carry out the comprehensive characterization of a lemon verbena extract with demonstrated antioxidant and antiinflammatory activity. (chemfaces.com)

Waters UPLC coupled with electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) MS/MS, and Evaporative Light Scattering Detector (Waters Acquity UPLC/Quattro micro API/ELSD). (dri.edu)
Its Turbo V™ source can be used with electrospray ionization (ESI) as well as atmospheric pressure chemical ionization (APCI). (ccrc-hauner.de)
The collision induced dissociation of organic molecules by Atmospheric Pressure Chemical Ionization (APCI) or Electro-Spray Ionization (ESI) show the need of standardization of experimental conditions for building up a reference library. (ijlst.org)
Ionisation modes include electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI). (lu.se)
Example ionization methods include atmospheric pressure chemical ionization (APCI) , electron ionization (EI), electrospray ionization (ESI) , chemical ionization (CI) inductively coupled plasma (ICP) ionization, and matrix-assisted laser desorption/ionization (MALDI). (thermofisher.com)
It has Electrospray and APCI interfaces. (ncl.ac.uk)

Eluting peptides were analyzed online by a Q-Exactive mass spectrometer (Thermo Scientific) with an electrospray ion source. (neb.com)
With new capabilities for multiplexed quantitative proteomics and native protein characterization, the Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. (thermofisher.com)
Thermo Fisher Scientific announces the launch of a new tissue-imaging platform, combining its Thermo Scientific MALDI LTQ XL™ mass spectrometer with ImageQuest™ software, designed for scientists to analyze whole tissue, biological, and polymer samples without extensive sample preparation. (spectroscopyonline.com)

The ever-increasing sensitivity of commercial mass spectrometry (MS) instrumentation has enabled it to detect analyte ions generated at atmospheric pressure farther from the vacuum interface. (chromatographyonline.com)
However, if the object is too large or cannot be moved immediately adjacent to the instrument, ions pulled through atmospheric pressure transfer tubing become subject to egregious losses as the distance increases from centimeters to meters. (chromatographyonline.com)
Many objects and surfaces are simply too large (or have other complicating circumstances) to be positioned immediately adjacent to the MS, necessitating some form of transfer between the atmospheric pressure desorption/ionization site and the instrument inlet. (chromatographyonline.com)
Regardless of the predictable signal loss at atmospheric pressure, directing analyte ions into a long, atmospheric pressure transfer tube (Figure 2a) is otherwise convenient, cheap, and "good enough" for some applications. (chromatographyonline.com)

The product ions formed are retained in the trapping field. (wikipedia.org)
The precursor ions then undergo fragmentation, resulting in product ions that are related to the molecular structure of the precursor ions. (betasciencepress-publishing.com)
Finally, the product ions are selected in the third quadrupole and monitored, providing structural information of the molecular ions [1, 4, 5]. (betasciencepress-publishing.com)

Varian Saturn 4000 Ion Trap MS system coupled to Varian CP-3800 GC-FID, with MS/MS and EI/CI capabilities equipped with Gerstel Thermal Desorption System (TDS). (dri.edu)
This peptide mixture can be used to test a Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer (TOF, Q-TOF or Ion Trap). (neb.com)
Electrospray ionization (ESI) as well as soft laser desorption techniques became key to the analysis of proteomes and genomes. (dgms.eu)
Matrix-assisted laser desorption/ionization (MALDI), developed by Franz Hillenkamp and Michael Karas in the late 1980s, presents another milestone of MS technology. (dgms.eu)
DART ionizes compounds by combining thermal desorption to vaporize the sample, and Penning ionization to generate an ionizing gas region that surrounds sample molecules. (labmanager.com)
Alternative models for direct, non-proximate sample analysis are neutral desorption and transfer of gas-phase analyte to an ion source/MS, condensed-phase extraction and transfer, and the extension of instrument vacuum to the sample. (chromatographyonline.com)
At the cost of orders of magnitude in signal reduction, the tubing conducted desorption electrospray ionization (DESI) analytes from sample surfaces 3 m distant (2). (chromatographyonline.com)
Desorption electrospray ionization mass spectrometry (DESI-MS) is a powerful method for generating ions at ambient conditions without the need for sample preparation or pretreatment. (nova.edu)
Mass spectrometry has become a widely used method in protein analysis since the invention of matrix-assisted laser-desorption ionization/time-of-flight (MALDI-TOF) and electrospray ionization (ESI) methods. (ashwinnaik.com)
Prosolia's Omni Spray Ion sources are a series of ionization sources based on desorption electrospray ionization (DESI). (spectroscopyonline.com)
Mass spectrometry(MS) methods, particularly with the development of softionization techniques, such as electrospray (ESI) and matrix- assisted laser desorption/ionization (MALDI), have played an important role in the characterization of isolated Roots of aconite were purchased from a drug store. (healthdrugpdf.com)
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful tool for the visualization of proteins in tissues and has demonstrated considerable diagnostic and prognostic value. (cipsm.de)
Bruker Ultraflextreme Matrix Assisted Laser Desorption/Ionization - Time-of-flight / Time-of-flight mass spectrometer (MALDI/Tof/Tof MS). (edu.hk)

Unwanted ions that can cause space charge problems in the FTMS can be ejected in the linear trap to improve the resolution, sensitivity, and dynamic range of the system, although the system parameters used to optimize such signal characteristics co-vary with one another. (wikipedia.org)
Overall, the SCIEX QTRAP 6500+ mass spectrometer provides enhanced sensitivity and selectivity for targeted small and large molecule quantitation from 5 to 2000 Da in triple quadrupol mode and 50 to 2000 Da in Linear Ion Trap mode. (ccrc-hauner.de)
Subsequently, PMA alone was routinely analyzed using an Agilent 1100 LC/MSD SL mass spectrometer system using selected ion monitoring (SIM) in the negative ion ESI LC/MS mode for maximum sensitivity. (cdc.gov)
Notwithstanding the analytical success and cost savings that can be had transferring ions through air, even the high sensitivity of contemporary commercial MS instruments will inevitably be challenged by greater distances. (chromatographyonline.com)
According to the company, this tissue-imaging solution provides researchers with high sensitivity and MS n spectral quality of linear ion trap technology as well as fast sample analysis, compared with the standard practice of homogenizing and extracting from tissue. (spectroscopyonline.com)

The RF voltage is adjusted and multi-frequency resonance ejection waveforms are applied to the trap to eliminate all but the desired ions in preparation for subsequent fragmentation and mass analysis. (wikipedia.org)
To support confident assignment of these two isomers by use of mass spectrometry alone, this study explores the fragmentation reactions of their [M + H]+ and [M - H]- ions using collision-induced dissociation (CID). (edu.au)
Multiple fragmentation techniques - CID and HCD with optional UVPD, ETD, PCTR - are available at any stage of MS, with subsequent mass analysis in either the ion trap or ultra-high resolution Orbitrap mass analyzer. (thermofisher.com)
This unique dataset was generated from 30 histologically normal adult tissues, fetal tissues and purified primary hematopoietic cells that were analyzed at high resolution in the MS mode and by HCD fragmentation in the MS/MS mode on LTQ-Orbitrap Velos/Elite mass spectrometers. (amritabioquest.org)
Fragmentation pathways of aconitine-type alkaloids were investigated by electrospray ionization/ion trap multistage tandem mass spectrometry. (healthdrugpdf.com)

Modern flight-capable mass spectrometers, in combination with various sample processing, separation, and ionization techniques enable sensitive detection of chemical biosignatures. (frontiersin.org)
These changes sequentially move ions from within the stability diagram to a position where they become unstable in the x-direction and leave the trapping field for detection. (wikipedia.org)
Thus GC-MS systems, mostly using electron ionization, are the most common portable MS systems for explosives detection in the field. (labmanager.com)
For the detection of unknown DCF-related metabolites formed in the plant upon uptake of the parent drug‚ a new workflow based on the use of HPLC coupled to drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry (DTIM QTOF-MS) was developed. (springer.com)
Generally, positive ion detection is used for molecules with functional groups that readily accept a proton (such as amines), and negative ion detection is used for molecules with functional groups that readily lose a proton (such as carboxylic acids). (betasciencepress-publishing.com)
Mass spectrometry has four essential functions, which are ionization, separation (filtering), detection and analysis. (thermofisher.com)
The most common currently used method of analyzing for the presence of sulfur mustard and its metabolites in biological and environmental samples is gas chromatography/mass spectrometry (GC/MS). Prior to 1987, however, thin-layer chromatography (TLC) with a colorimetric detection system and gas chromatography with either flame ionization detector (FID), electron capture detector (ECD), or flame photometric detector (FPD) were the most frequently used methods. (cdc.gov)

In 1989, Prestage, Dick, and Malecki described that ions could be trapped in the linear quadrupole trap system to enhance ion-molecule reactions, thus it can be used to study spectroscopy of stored ions. (wikipedia.org)
Recently, Hardman and Makarov have described the use of a linear quadrupole trap to store ions formed by ESI for injection into an orbitrap mass analyzer. (wikipedia.org)

A variety of mass spectrometer types, including magnetic sector, quadrupole, time-of-flight, and ion trap, have and will continue to deepen our understanding of the formation and evolution of exploration targets like the surfaces and atmospheres of planets and their moons. (frontiersin.org)
Agilent 1260 Binary High-performance liquid chromatograph (HPLC) coupled with Quadrupole Time of Flight Mass Spectrometer (Agilent 6545 QTOF MS). (dri.edu)
B) Matrix Assisted Laser Adsorption Ionization Time-Of-Flight MASS SPECTROMETER (MALDI-TOF MS). Applied Biosystems Voyager DE-STR MALDI-TOF. (nih.gov)
Two different MS techniques have been coupled to HPLC: on one hand, time-of-flight mass spectrometry, and on the other hand, tandem mass spectrometry on an ion-trap. (chemfaces.com)
The UV-visible spectrophotometry was used to delimit the class of phenolic compound and the accurate mass measurements on time-of-flight spectrometer enabled to identify the compounds present in the extract. (chemfaces.com)
Trapped ion mobility spectrometry (TIMS) combined with quadrupole time of flight mass spectrometry (Q-TOF). (lu.se)
Some examples of mass analyzers include quadrupoles , triple quadrupoles , ion traps , Orbitraps, Fourier transform, magnetic sectors and time-of-flight (TOF) instruments. (thermofisher.com)

LC conditions for chromatographic separation were coupled with electrospray "soft ionization" and mass spectrometry. (cdc.gov)
A mass spectrometer and method of mass spectrometry are disclosed wherein two separate samples are mass analysed and then the relative intensity, concentration or expression level of one or more components, molecules or analytes in a first sample is quantitated relative to the intensity, concentration or expression level of one or more components, molecules or analytes in a second sample. (gc.ca)
In this light, assembling and chelating properties of sodium bis(2-ethylhexyl)sulfosuccinate (AOTNa) towards divalent metal ion chlorides have been investigated in the gas phase by electrospray ionization mass spectrometry in negative ion mode, tandem mass spectrometry and energy-resolved mass spectrometry. (unipa.it)
These include mass-spectrometers, gas analyzers, and fluorescence/Raman spectrometry instruments. (nasa.gov)
Mass spectrometry is an analysis method that can be performed once using a single analyzer, or it can be performed in tandem between different mass analyzers (such as those found in hybrid or tribrid mass spectrometers). (thermofisher.com)
The practice of simultaneous MS is frequently termed tandem mass spectrometry (MS/MS or MS 2 ) and refers to two or more reaction steps being performed on selected ions. (thermofisher.com)
We use gas chromatography (GC) to resolve complex mixtures of gases, and volatile and semi-volatile compounds, coupled with mass spectrometry (GC-MS) and other detectors such as flame ionisation (FID) and electron capture (ECD). (ncl.ac.uk)

With a continuous source, such as one utilizing electrospray ionization (ESI), ions generated while the 3D trap is processing other ions are not used, thereby limiting the duty cycle. (wikipedia.org)
A TOF mass spectrometer can also have a low-duty cycle when coupled with a continuous ion source. (wikipedia.org)
The analyses of dyes were performed on a LC-MS with ProStar 410 autosampler, two 212-LC chromatography pumps, a ProStar 335 diode array detector and a 500-MS ion trap mass spectrometer with an electrospray ionization (ESI) ion source (Varian, Palo Alto, CA, USA). (mfa.org)
All while producing more with less instrument setup utilizing the Auto-Ready ion source for automated calibration, and pre-built, optimized method templates to maximize convenience and ease-of-use. (thermofisher.com)
An automated instrument calibration and dedicated Auto-Ready ion source hardware ensure the instrument is ready when you are for data acquisition. (thermofisher.com)
Spend less time on instrument set-up with the integrated Auto-Ready ion source. (thermofisher.com)
Rather than relying on GC to separate explosive residue components, IonSense uses its direct analysis in real time (DART) ambient ionization source to generate ions from samples with little or no sample preparation. (labmanager.com)
Although a remote ion source and simple tube can be used, a truly capable analytical system requires a robust signal. (chromatographyonline.com)
Although ambient sampling and ionization methods continue to diversify, most systems position the ion source, analyte, and MS inlet within centimeters or less of one another. (chromatographyonline.com)
Early successes in ambient ionization source design led the Cooks laboratory to test the limits of pulling ions through a stainless steel tube. (chromatographyonline.com)
A logical way to subvert this limitation is to desorb or ablate the analyte material from a distant surface without ionization, then transfer the neutral, gaseous material to an ion source proximate to the MS (Figure 2b). (chromatographyonline.com)
However, after the technology was commercialized by Waters, a solvent addition/ heated collision source was incorporated into the instrument vacuum interface to drive voltage-free inlet ionization of the remotely generated analyte aerosol (7). (chromatographyonline.com)
METHODS:Water/methanol solutions of AOTNa and chloride salts of nickel, magnesium, calcium and manganese, with different AOTNa/metal salt ratios, were infused into the electrospray source of a LCQ DECA ion trap mass spectrometer, operating in negative ion mode, at a flow rate of 5 mL/min. (unipa.it)
Mass spectrometers consist of the ion source, mass analyzer, ion detector, and data acquisition unit. (ashwinnaik.com)
First, molecules are ionized in the ion source. (ashwinnaik.com)
If MS2 reporter ions are used for quantification, the interfering peptides lead to a distortion of the measured ratios, as the source of reporter ions (red squares) cannot be distinguished. (biorxiv.org)
Traditionally, aconitines in crude aconite can be divided equipped with an electrospray source and capable of into two main types according to the substituent at position 8 analyzing ions up to m/z 2000. (healthdrugpdf.com)
These functions are coordinated by the following components: the ion source, mass analyzer, detector and software. (thermofisher.com)
In the first step of mass analysis, precursor ions are formed in the ion source and induced to fragment. (thermofisher.com)

Therefore, it is often necessary to use the negative ion mode, which can be advantageous since it sometimes generates less chemical background noise compared to positive ion mode [3]. (betasciencepress-publishing.com)

Because the orbitrap requires that ions be injected in very short pulses, kilovolt ion extraction potentials were applied to the exit aperture. (wikipedia.org)
Flight times of ions to the orbitrap were mass dependent, but for a given mass, ions were injected in bunches less than 100 nanoseconds wide (fwhm). (wikipedia.org)
The proven Tribrid architecture combines the best quadrupole, linear ion trap, and Orbitrap HRAM technologies to acquire the richest MS data for every sample run. (thermofisher.com)

In this mode, the molecular ion of interest (precursor ion) is selected in the first quadrupole and allowed to react with a collision gas in the collision cell. (betasciencepress-publishing.com)
Selection of both precursor and fragment ions, as well as their number during each step of the process, can vary depending on the goal of the analysis. (thermofisher.com)

LITs can be used as stand alone mass analyzers, and they can be combined with other mass analyzers, such as 3D Paul ion traps, TOF mass spectrometers, FTMS, and other kind of mass analyzers. (wikipedia.org)
Both 3D and linear traps have been combined with TOF mass analyzers. (wikipedia.org)
Different analyzers are also combined in hybrid and tribrid mass spectrometers. (thermofisher.com)
Learn more about how mass analyzers separate, select and even fragment ions based on their distinct masses and charges. (thermofisher.com)

In DESI-MS, a continuous stream of charged microdroplets impacts a surface containing a sample (cDESI-MS). Upon impact, analyte molecules are extracted from the surface into secondary microdroplets, from which gas-phase ions are eventually formed. (nova.edu)
DESI is a simple, sensitive, gentle, and versatile ionization method that allows for the direct and rapid sampling of surfaces without any sample preparation and under ambient temperature and pressure conditions. (spectroscopyonline.com)

Varian Saturn 2000 Ion Trap MS system coupled to Varian CP-3800 GC, with MS/MS and EI/CI capabilities with Lotus Ultra-Trace Toxics whole air preconcentration system for automated sample delivery from up to 15 canisters. (dri.edu)

Several state-of-the-art mass spectrometers combined with ultra-high-pressure liquid chromatographic allow high-throughput sample analysis of up to a thousand compounds per sample injection. (ccrc-hauner.de)
Where a GC separation might take 15 to 30 minutes, DART ionization takes a few seconds, and provides much more information-the mass peaks defined by the GC trace, plus additional compounds. (labmanager.com)

In the second approach peptides after in-gel digestion are fragmented in the mass spectrometer, yielding partial amino acid sequences from the peptides (sequence tags). (ashwinnaik.com)

the Linear Accelerator™ Trap as Q3 allows ion fragmentations up to MS3 and the IonDrive™ High Energy detector provides an increased linearity range at higher count rates compared to previous models. (ccrc-hauner.de)

In both, electrospray ionization (ESI) is used to deliver the dimers to the gas phase as ions, where they are trapped in an ion cyclotron resonance (ICR) mass spectrometer. (chalmers.se)
Enoch Powell, Ted Heath and Tony Benn represent for height with David Bowie, Hilda Ogden and Margo Leadbetter, and is why a ion seen by ion potentially began to Margaret Thatcher for cyclotron. (cpkmfg.com)

Shimadzu's AXIMA Performance™ mass spectrometer is designed for high-energy MS/MS interrogation of proteomics and biological and organic samples, including peptides, polymers, oligonucleotides, SNPs, metabolites, and carbohydrates. (spectroscopyonline.com)

CONCLUSIONS: This study shed some light on the assembling and chelating properties of AOT- towards divalent metal ions to form negatively charged assemblies, some of them incorporating the metal counter ion of the inorganic salt used. (unipa.it)
Furthermore, molecular ionization processes can result in positively and negatively charged ions. (betasciencepress-publishing.com)

The impurity structures were confirmed by the direct hyphenation of a liquid chromatograph to an ion trap mass spectrometer with a heated electrospray ionization interface. (org.mk)
The Guardion-7 portable GC-MS system by Torion features a low-thermal-mass capillary gas chromatograph with ballistic temperature programming and a miniature torodial ion trap mass spectrometer with a mass range of 50 to 500 Da. (spectroscopyonline.com)

Stone material was extracted with water (1 mg/30 ��l) via homogenization and sonication and the extract analyzed on a Waters Aquity UPLC system operating in reverse phase (BEH C18 column and alkaline mobile phase) coupled to a Waters Q-Tof Premier mass spectrometer operating in electrospray ionization mode. (exposed-skin-care.net)

Linear traps can be used to improve the performance of FT-ICR (or FTMS) systems. (wikipedia.org)
As with 3D ion traps, the duty cycle can be increased to nearly 100% if ions are accumulated in a linear trap, while the FTMS performs other functions. (wikipedia.org)
Bruker Daltonics introduces the apex-ultra FTMS mass spectrometer, which reportedly features a wide dynamic range, high resolving power, high mass accuracy, and fast data acquisition. (spectroscopyonline.com)

This information is used for determining which condition the ions stem from and permits relative quantification of peptides. (biorxiv.org)

The general operation of mass spectrometers, including hybrid and tribrid mass spectrometers. (thermofisher.com)

Ions are accelerated into two high voltage dynodes where ions produce secondary electrons. (wikipedia.org)
In each case, the detectors multiply the signal produced by the incident ion using dynodes or photon multipliers. (thermofisher.com)

Secondary ion mass spectroscopy microscopes can provide 50-nm spatial resolution mapping of molecular masses, but because the specimen is eroded in the microscope, one can examine a microscopic feature only once. (nationalacademies.org)
Instrument Development Development of a high-resolution mass spectrometer meant for use in infrared-ultraviolet (IR-UV) ion-dip spectroscopy of gas-phase biomolecules began in 2018 at the Department of Physics, University of Gothenburg. (chalmers.se)

Airports, a venue where explosives are of tremen dous concern, use ion mobility instrumentation to screen for bombs. (labmanager.com)
The reverse is currently true-although MS instrumentation has become more adept at grasping ions at the atmosphere-to-vacuum transition using wide inlet orifices, ion lenses and guides, and ion funnels, less research has been devoted to reaching out to analytes on a surface at a distance from the MS instrument. (chromatographyonline.com)

IonSense has teamed with Waters, a leader in both LC and LC-MS, to produce ambient ionization-capable mass detectors which, according to Musselman, are "highly reliable, and about as small as you can get with high performance-that is, the ability to obtain the mass of an ion in seconds. (labmanager.com)
These results demonstrate that pDESI-MS offers the potential to transform current approaches for implementing spray-based ambient ionization techniques in chemical analysis and imaging. (nova.edu)

In 1989, Hans G. Dehmelt and Wolfgang Paul received the Noble Prize for the development of the linear quadrupole mass spectrometer and the quadrupole ion trap. (dgms.eu)

ESI is a soft ionization process that allows observation of intact molecules that are multiple or single charged. (betasciencepress-publishing.com)

Simultaneously, mass spectrometers (MSs) and gas chromatographs (GCs) have undergone democratization through miniaturization, simplification, enhanced user-friendliness, and applicability to specific tasks. (labmanager.com)

The energy of the selected ions is increased by application of a supplemental resonance excitation voltage applied to all segments of two rods located on the X-axis. (wikipedia.org)
Scanning the contents of the trap to produce a mass spectrum is accomplished by linearly increasing the RF voltage applied to all sections of the trap and utilizing a supplemental resonance ejection voltage. (wikipedia.org)
This heads Paper II in a ebook of quadrupoles where we like adjacent voltage Fundamental Confinement spectrometer legible special sports that increasingly have the tree of a idr research and anthony of small sales shed by an total first guide. (cpkmfg.com)
The spray voltage was of the norditerpenoid skeleton: diester-diterpenoid aconi- 4.5 kV in the positive ion mode. (healthdrugpdf.com)

The data generated revealed kinetically-controlled fragmentations involving participation of neighboring amino groups in the positive ion mode. (edu.au)
Although most molecules will be initially ionized in the positive ion mode, successful analysis cannot always be accomplished using the positive ion mode. (betasciencepress-publishing.com)

All experiments were performed using an LCQ ion trap All aconitines share a common C19-norditerpenoid skele- mass spectrometer (ThertmoFinnigan, San Jose, CA, USA) ton. (healthdrugpdf.com)

Mass Spectrometers: A) ThermoFinnigan ProteomeX HPLC/ELECTROSPRAY IONIZATION MASS SPECTROMETER (HPLC/ESI/MS) system consisting of a Surveyor Capillary HPLC interfaced to a LCQ Deca XP Plus ion trap ESI Mass spectrometer. (nih.gov)

Derivatized samples for GC/MS are separated on a 5% phenyldimethyl silicone column with helium as the carrier gas and a temperature ramp from 60°C to 340°C and analyzed on a Thermo-Finnigan Trace DSQ MS operated at unit mass resolving power with electron impact ionization and a 50-750 atomic mass unit scan range. (jax.org)

The first non-proximate analysis method to examine organic molecules in complex samples, REIMS was originally conceived as generating ions from tissue vaporization in electrosurgery before transporting the ions through heated, flexible PTFE tubing to an MS instrument (6). (chromatographyonline.com)
RATIONALE: Investigation of fundamental aspects driving surfactant self-assembling and of the capability of including guest molecules or ions in their micellar aggregates is an exciting research field for theoretical and technological reasons. (unipa.it)
In addition, the ability to produce multiple charged molecular ions makes it possible to observe very large molecules (e.g., a large variety of polymers, proteins, and DNA fragments) using an instrument with a relatively small mass range. (betasciencepress-publishing.com)
Atoms and molecules must first be ionized before they can be accelerated through the mass spectrometer and detected. (thermofisher.com)

This is because mass spectrometers separate particles by calculating their different mass-to-charge ratios (m/z). (thermofisher.com)

3D ion trap (or Paul trap) mass spectrometers are widely used but have limitations. (wikipedia.org)
An alternative approach is quantification by complementary ions, which allows accurate and precise multiplexed quantification at the MS2 level and is compatible with the most widely distributed instruments. (biorxiv.org)

The linear ion trap (LIT) is a type of ion trap mass spectrometer. (wikipedia.org)
One of the first LITs was constructed in 1969, by Dierdre A. Church, who bent linear quadrupoles into closed circle and racetrack geometries and demonstrated storage of 3He+ and H+ ions for several minutes. (wikipedia.org)
Combining a linear trap with a 3D trap can help overcome these limitations. (wikipedia.org)
Oosterink JE, Schierbeek H. Quadrupole versus linear iontrap for determination of tracers with LC/MS. J Appl Bioanal 1(4), 109-111 (2015). (betasciencepress-publishing.com)

The Xevo TQ MS System from Waters is an advanced tandem quadrupole mass spectrometer that uses IntelliStart™ and ScanWave™ technologies to deliver advanced quantitative capability to a broad range of scientists. (spectroscopyonline.com)

Organisms7

Diseases1

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Phenomena and Processes52

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena4

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Detection7

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Spectrometry7

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Orbitrap3

Precursor2

Analyzers4

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20001

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Detector1

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