SynthaseNitrogen OxidesNovel nitric oxideENOSSynthasesDonors2000InhibitionSubstancesAirwayRegulationVascularHydrogen peroxideReductionEnzymeExtractsPotentAsthmaPathwayCompoundsRespiratoryInflammatoryRenalActivationSeverityProteinCellsReactionReceptorsReleaseClinicalPotentialStudiesEarlyProductionSignalProjectStudyMedicineDisease
Synthase9
- The relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells was significantly higher in IANX rats compared to sham-operated and N-propyl-L-arginine (NPLA)-treated IANX rats. (iasp-pain.org)
- Long-term inhibition of nitric oxide synthase (NOS) in rats is known to cause systemic hypertension and renal parenchymal injury. (elsevierpure.com)
- It was hypothesized that black currant fruit extracts would cause activation of endothelial nitric oxide synthase (eNOS) through activation of redox-sensitive PI3 kinase/Akt signaling pathway. (nih.gov)
- 2. We measured neutrophil nitric oxide synthase activity in relation to the level of hepatic dysfunction in patients with liver disease of varying aetiology and severity. (portlandpress.com)
- Nitric oxide synthase activity was measured using the conversion of oxyhaemoglobin to methaemoglobin by nitric oxide and expressed in terms of cell protein. (portlandpress.com)
- Nitric oxide synthase activity increased with the degree of liver dysfunction ( P = 0.033) and was highest in patients with Child-Pugh score C. Systolic blood pressure correlated with nitric oxide synthase activity in patients with Child-Pugh score C ( P = 0.029). (portlandpress.com)
- 5. Our results show that nitric oxide synthase activity increases with increasing Child-Pugh score and is associated with the development of systemic hypotension. (portlandpress.com)
- We determined whether administration of a nitric oxide synthase (NOS) inhibitor alters optic nerve head blood flow (ONHBF) regulation during isometric exercise in healthy subjects. (arvojournals.org)
- Association of G84A and C276T polymorphism in neuronal nitric oxide synthase (nNOS) gene with herpes simplex encephalitis in eastern Indian population. (cdc.gov)
Nitrogen Oxides4
- NO can also be readily converted to higher nitrogen oxides such as N2O3 or ONOOH, which have very different chemical and biological properties. (bio5.org)
- As a whole, Dr. Miranda is interested in elucidating the fundamental molecular redox chemistry of NO and in developing compounds to deliver or scavenge NO and other nitrogen oxides. (bio5.org)
- First, she will work on the development and utilization of analytical techniques for detection and measurement of NO and other nitrogen oxides as well as the resultant chemistry of these species. (bio5.org)
- Second, she will synthesize potential donors or scavengers of NO and other nitrogen oxides. (bio5.org)
Novel nitric oxide2
- The relative functional importance of potassium channels and cGMP-dependent pathways in the relaxation of vascular smooth muscle to the novel nitric oxide donor, diethylamine NONOate (DEA NONOate), was investigated in a resistance artery. (ox.ac.uk)
- This project will exploit novel nitric oxide based therapies to improve the effectiveness of antibiotics against Pseudomonas aeruginosa biofilms. (southampton.ac.uk)
ENOS2
- Activation of Akt and eNOS was abolished by incubation with wortmannin, a PI3K inhibitor, supporting the involvement of PI3K/Akt. (nih.gov)
- A closer look revealed a reduction in the ability of the enzyme eNOS to produce nitric oxide (NO), a potent signal for blood vessels to dilate. (nih.gov)
Synthases2
- Nitric oxide (NO) is a short-lived radical generated by nitric oxide synthases (NOS). (researchgate.net)
- My PhD focussed on investigating the distributions and possible functions of nitric oxide/nitric oxide synthases in the physiology and pathology of a variety of tissues and organs and I was fortunate enough to publish some of the first papers on the involvement of these molecules in human diseases, notably in the cardiovascular system. (nottingham.ac.uk)
Donors1
- Fifth, she will identify of potential targets, such as enzymes, for treatment of disease through exposure to nitrogen oxide donors. (bio5.org)
20002
- Spontaneous motor activity (SMA) which is a motivated behaviour of rats was measured using photoactometer 5 and 30 m after injecting graded doses (1000 and 2000 mg/kg) of Nitric Oxide (NO) precursor, L - arginine. (elsevierpure.com)
- 2000. Exhaled nitric oxide as an indicator of severity of asthmatic inflammation. (cdc.gov)
Inhibition3
- The involvement of NO production in the inhibition of nitrogenase activity by nitrate was investigated using the NO donor sodium nitroprusside (SNP) and the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO). (elsevierpure.com)
- Kato, K , Kanahama, K & Kanayama, Y 2010, ' Involvement of nitric oxide in the inhibition of nitrogenase activity by nitrate in Lotus root nodules ', Journal of Plant Physiology , vol. 167, no. 3, pp. 238-241. (elsevierpure.com)
- These results suggest the likely involvement of RANTES and MCP-1 in the recruitment of M/M into the renal cortex of rats with chronic NOS inhibition. (elsevierpure.com)
Substances2
- The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1) and nitric oxide (NO) during early chronic CRPS1. (biomedcentral.com)
- The present study aimed to investigate the involvement of the vasoactive substances ET-1 and nitric oxide (NO) in intermediate/cold type CRPS1 in relation to inflammatory mediators. (biomedcentral.com)
Airway2
- A deficiency in airway nitric oxide (NO) could contribute to pulmonary vaso-occlusion in sickle cell disease (SCD). (nih.gov)
- Nitric oxide (NO) may play an essential role in regulating airway function and in the pathophysiology of inflammatory airway diseases [ 1 ]. (biomedcentral.com)
Regulation2
- Nitric oxide-mediated regulation of biofilm dispersal. (southampton.ac.uk)
- Nitric oxide has an important role in basal ONHBF regulation, but seems not to be involved in the autoregulatory response during an increase in OPP induced by isometric exercise. (arvojournals.org)
Vascular1
- instead the vasoprotective nitric oxide (NO ⋅ ), plays a critical role in vascular dysfunction under various pathophysiological conditions and in aging. (frontiersin.org)
Hydrogen peroxide1
- Using predicted physiological concentrations of nitric oxide (NO), superoxide and hydrogen peroxide (H2O2) on low numbers of CFU of B. bronchiseptica, all redox active species displayed dose-dependent antimicrobial activity. (bio5.org)
Reduction1
- A potential of about-0.8 (±0.2) V (at 1 M versus normal hydrogen electrode) for the reduction of nitric oxide (NO) to its one-electron reduced species, nitroxyl anion ( 3 NO - ) has been determined by a combination of quantum mechanical calculations, cyclic voltammetry measurements, and chemical reduction experiments. (bio5.org)
Enzyme1
- Nitric oxide reductase (NAD(P), nitrous oxide-forming) (EC 1.7.1.14, fungal nitric oxide reductase, cytochrome P450nor, NOR (ambiguous)) is an enzyme with systematic name nitrous oxide:NAD(P) oxidoreductase. (wikipedia.org)
Extracts1
- Blockers such as atropine (1 µM), phentolamine (1 µM), propranolol (1 µM), and Nω‑nitro‑l‑arginine methyl ester (100 µM) were preincubated before addition of extracts to check for involvement of muscarinic, α‑ and β‑adrenergic receptors (AR) as well as nitric oxide, respectively. (iium.edu.my)
Potent1
- 1. Nitric oxide is a potent vasodilator which plays a major role in the control of blood pressure. (portlandpress.com)
Asthma2
- Exhaled nitric oxide (ENO) is elevated in bronchial asthma patients, and inhaled corticosteroid therapy lowers the elevated ENO levels in such patients. (biomedcentral.com)
- Exhaled nitric oxide in asthma: from bench to bedside. (cdc.gov)
Pathway4
- Results: AESP and MESP caused significant vasorelaxations through nitric oxide pathway. (iium.edu.my)
- Conclusion: Vasorelaxation effect by AESP and MESP involved nitric oxide pathway which is possibly mediated by the autonomic receptors. (iium.edu.my)
- Nitric oxide (NO) is thought to be involved in E-LTP, but until now there has been no information about the role of the NO-signaling pathway in L-LTP. (jneurosci.org)
- Much additional work by our group and others' is now elucidating the nitric oxide and c-di-GMP-mediated signalling pathway, and its exploitation for biofilm control in medical and industrial contexts. (southampton.ac.uk)
Compounds2
- Treatment of biofilms with nitric oxide also reduced their resistance to antimicrobial compounds. (southampton.ac.uk)
- Third, it's necessary to describe chemical characterization of these compounds (spectroscopic features, kinetics, mechanisms and profiles of nitrogen oxide release, etc. (bio5.org)
Respiratory3
- You discuss entering the INNOVO Trial (a multicentre RCT of addition of inhaled nitric oxide (inNO) to babies with severe respiratory failure) with the parents, who agree and the baby is entered into the control (no addition of inNO) arm. (bestbets.org)
- Nitric oxide inhalation in infants with respiratory distress syndrome. (bestbets.org)
- Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. (bestbets.org)
Inflammatory2
- In this context, overproduction of nitric oxide (NO) attributable to inflammatory stimuli in diseases such as ulcerative colitis and Crohn's disease may contribute to colonic carcinogenesis. (aacrjournals.org)
- The pathophysiology of CRPS1 is not unravelled yet, but growing evidence indicates the involvement of an exaggerated inflammatory processes. (biomedcentral.com)
Renal3
- Renal involvement is a rare initial presentation of this disease. (medscape.com)
- Few articles on renal involvement as an initial presentation of sarcoidosis have been published in the literature. (medscape.com)
- Renal involvement is an uncommon feature of sarcoidosis and it is essential to establish a fast and correct diagnosis because early therapy avoids progression to terminal renal failure. (medscape.com)
Activation1
- Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity. (iasp-pain.org)
Severity1
- Katrina Miranda, PhD, claims nitric oxide (NO), which is synthesized in the body via enzymatic oxidation of L-arginine, is critical to numerous physiological functions, but also can contribute to the severity of diseases such as cancer or pathophysiological conditions such as stroke. (bio5.org)
Protein1
- Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
Cells2
- The present findings suggest that following IANX, satellite glial cells are activated via nitric oxide (NO) signaling from TG neurons. (iasp-pain.org)
- The researchers investigated the potential involvement of TH17 cells in the gut. (nih.gov)
Reaction1
- Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. (wikipedia.org)
Receptors1
- The involvement of autonomic receptors and nitric oxide will be elucidated using respective blockers. (iium.edu.my)
Release1
- In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
Clinical1
- Safeguarding informed parental involvement in clinical research involving newborn babies and infants. (bestbets.org)
Potential1
- The aim is to obtain better understanding of the involvement of different endogenous and environmental factors in the process of xylogenesis, to elucidate the potential of pharmaceutical treatments for manipulation the dimensions of xylem vessels and to use the information obtained from the in vitro studies for in planta improvement of the post-harvest quality of cut flowers. (europa.eu)
Studies1
- However, no studies examined involvement of H 2 S in Pb-induced hypertension. (hindawi.com)
Early1
- Open RCT of inhaled nitric oxide and early dexamethasone in high risk preterm infants. (bestbets.org)
Production1
- Nitric oxide (NO) production was detected at that time in nitrate-supplied root nodules using the NO-reactive fluorescent probe diaminofluorescein-2 diacetate. (elsevierpure.com)
Signal1
- We discovered that exogenous nitric oxide can act as a signal for the dispersal of bacterial biofilms. (southampton.ac.uk)
Project1
- My involvement in this project is from the synthetic angle, and I am currently directing and supervising the preparation of the required enediyne cyclisation precursors. (exeter.ac.uk)
Study1
- Nitric oxide and biopterin: a study in Chiaroscuro. (jci.org)
Medicine1
- My first postdoctoral position was held jointly between Imperial College and the Royal London Hospital School of Medicine and Dentistry (with Professor Francis Hughes) looking at the roles of the nitric oxide and prostaglandin pathways in bone biology, specifically the osteoblast. (nottingham.ac.uk)
Disease1
- These data may support the involvement of nitric oxide in the haemodynamic disturbances seen in liver disease. (portlandpress.com)