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  • axonal
  • Stoeckel K, Schwab ME, Thoenen H. Role of gangliosides in the uptake and retrograde axonal transport of cholera and tetanus toxin as compared to nerve growth factor and wheat germ agglutinin. (springer.com)
  • Notably, our results showed that immune complex formation and the activating Fc gamma receptors (FcγRs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this model. (jneurosci.org)
  • There are no systematic studies examining the role of Fc-gamma receptors (FcγRs) and macrophages in anti-ganglioside Ab-mediated nodal and axonal injury. (jneurosci.org)
  • synaptic
  • In these experiments with partially hemitransected rats it was also possible to demonstrate that chronic ganglioside GM1 treatment could increase the synaptic function of DA, since following a three week treatment the ipsilateral amphetamine induced rotational behaviour in these rats was partly counteracted (Agnati et al. (springer.com)
  • Agnati LF, Fuxe K, Calza L, Benfenati F, Cavicchioli L, Toffano G, Goldstein (1983) Gangliosides increase the survival of lesioned nigral dopamine neurons and favour the recovery of dopaminergic synaptic function in striatum of rats by collateral sprouting. (springer.com)
  • As a matter of fact, gangliosides are just located- the synaptic junctions-where a specialized physiological event takes place, and definitely synaptic membranes would be and would behave differently without gangliosides. (springer.com)
  • cells
  • Gangliosides are characteristic glycolipid components of the plasma membranes of mammalian cells. (springer.com)
  • Publications] Saito M: 'Interleukin-3-associated ganglioside GDla is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene' Glycoconjugate J.13. (nii.ac.jp)
  • chronic
  • In 1983 we were able to demonstrate for the first time that chronic ganglioside GM1 treatment in mechanically lesioned rats could partly counteract the retrograde cell body degeneration taking place in the central nervous system (CNS) following lesion. (springer.com)
  • nerve
  • These studies provide new evidence that the activating FcγRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS. (jneurosci.org)
  • human
  • The family of cytolethal distending toxins (CDTs) consists of a number of bacterial protein exotoxins expressed by a broad range of Gram-negative bacteria, with a potential involvement in the pathogenesis of a diverse range of human infections. (mdpi.com)
  • immune
  • It remains unclear whether macrophages interact with immune complexes, formed by anti-glycan Ab binding to gangliosides on nodal and internodal axolemma and, if so, which molecules on macrophages are involved in this interaction. (jneurosci.org)
  • evidence
  • Agnati LF, Fuxe K, Toffano G, Calza L, Benfenati F, Zini I, Battistini N, Goldstein M, Zoli M (1984a) Evidence for structural plasticity in the nigrostriatal dopamine neurons: Morphometrical and biochemical evidence for a trophic action of gangliosides on partially lesioned nigrostriatal dopamine neurons. (springer.com)
  • Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms. (semanticscholar.org)
  • Further evidence for involvement of gangliosides in nervous system function is indicated by the behavior of the neurotoxin of Clostridium tetani . (springer.com)
  • study
  • Studies in animal models suggest that a diet rich in MFGM exerts a protective effect against gastrointestinal leakiness and injury (2,10-12) A rat study highlighted the involvement of gangliosides in the maintenance of gut integrity by inhibiting the degradation of tight junction proteins during acute inflammation (10). (frieslandcampinainstitute.asia)
  • potential
  • The opportunistic oral pathogen Aggregatibatcer actinoycemetemcomitans , which is involved in the aggressive form of the disease, can regulate the molecular mechanisms of bone remodeling in a manner that favors bone resorption, with the potential involvement of its CDT. (mdpi.com)