• Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
  • CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. (umassmed.edu)
  • Interleukin 8 receptor, alpha is a chemokine receptor. (wikipedia.org)
  • This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. (wikipedia.org)
  • Thus far nearly 20 chemokine receptors have been recognized (Balkwill 2004 Gilman 1987 Pierce Premont & Lefkowitz 2002 Viola & Luster 2008 The large number of chemokines compared to chemokine receptors indicates substantial redundancy in chemokine receptor relationships with multiple ligands binding to the same receptor and vice versa. (scienceexhibitions.org)
  • The chemokine receptor 4 (CXCR4) is unique in that it specifically interacts with the endogenous ligand CXCL12 (Oberlin et al. (scienceexhibitions.org)
  • 2013 Although CXCR4 is known to bind only CXCL12 in 2005 another chemokine receptor CXC receptor 7 (CXCR7 ACKR3 RDC1 CMKOR1 or GPR159) was founded like a receptor for CXCL12 (Balabanian et al. (scienceexhibitions.org)
  • This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
  • A study in our lab demonstrated that Duffy antigen/receptor for chemokines (DARC, also known as DBGP, the Duffy protein phenotype), led to the inhibition of tumorigenesis. (biomedcentral.com)
  • Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. (biomedcentral.com)
  • Chemokine CXC receptor 4 (CXCR4) belongs to the family of G protein-coupled receptors. (biomedcentral.com)
  • Recently, it has been found that both chemokine C-X-C motif ligand 12 (CXCL12) and its receptor CXCR4 were upregulated in spinal glial cells of mice with partial sciatic nerve ligation (pSNL)-induced neuropathic pain or chronic post-ischemia-induced inflammatory pain [ 5 ]. (biomedcentral.com)
  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
  • Ayoub MA, Zhang Y, Kelly RS, See HB, Johnstone EKM, McCall EA, Williams JH, Kelly DJ and Pfleger KDG (2015) Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease. (perkins.org.au)
  • Mustafa S, See HB, Seeber RM, Armstrong SP, White CW, Ventura S, Ayoub MA and Pfleger KDG (2012) Identification and profiling of a novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer. (perkins.org.au)
  • 1996 CXCR4 also known as "fusin " is one of the most well-studied chemokine receptors due to its AMG-47a earlier found role like a coreceptor for HIV access (Feng Broder AMG-47a Kennedy & Berger 1996 The chemokine stromal cell-derived element-1 right now renamed as CXCL12 was founded as the specific ligand for CXCR4 (Bleul Fuhlbrigge Casasnovas Aiuti & Springer 1996 Oberlin et al. (scienceexhibitions.org)
  • When stratified by specific clinical manifestation, patients with meningoradiculoneuritis had higher levels of B-cell chemoattractants CXC motif chemokine ligand (CXCL) 12 and CXCL13 and T-cell-associated mediators CXCL9, CXCL10, and interleukin 17, compared with those without radicular pain. (cdc.gov)
  • In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)
  • Chemokines and their corresponding receptors have been well-characterized in RA progression, but less so in OA pathogenesis. (researchsquare.com)
  • Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
  • Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
  • Gilman 1987 present on the prospective cells (Baggiolini 1998 Chemokine receptors are grouped into four different family members as CXC CX3C CC and XC based on the chemokines they primarily interact with for signaling. (scienceexhibitions.org)
  • Chemokine receptors are pertussis toxin-sensitive GTP-binding proteins of Gi type. (scienceexhibitions.org)
  • CC chemokines/CCL attract monocytes, eosinophils, basophils, dendritic and T cells and signal through chemokine receptors CCR1 to CCR10. (biomedcentral.com)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • Pancreatic acinar cell injury triggers the synthesis and release of pro-inflammatory cytokines and chemokines (32, 36, 39, 41, 82). (pancreapedia.org)
  • This review aims to describe the roles of key cytokines and chemokines in commonly used experimental models of pancreatitis and how the cytokine profile is affected by the choice of a specific model. (pancreapedia.org)
  • Airborne pollutants and cigarette smoke can induce the bronchial epithelium to acquire a proinflammatory phenotype, characterized by an increased production of autacoids, cytokines, and chemokines [ 5 ]. (biomedcentral.com)
  • 1996 Although CXCL12 is the only known chemokine that binds CXCR4 recent studies suggest that extracellular ubiquitin also functions as an immune modulator through CXCR4-mediated signaling (Saini Marchese & Majetschak AMG-47a 2010 Tripathi et al. (scienceexhibitions.org)
  • Group of chemokines with paired cysteines separated by a different amino acid. (umassmed.edu)
  • Dubrac A, Quemener C, Lacazette E, Lopez F, Zanibellato C, Wu WG, Bikfalvi A, Prats H. (2010) Functional divergence between two chemokines is conferred by single amino acid change.Blood. (u-bordeaux.fr)
  • Chemokines have been classified by structure and function into four groups: CXC, CC, C and CX3C (9). (researchsquare.com)
  • Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
  • In contrast to CC chemokines, the CXC chemokines (CXCL) are divided into two classes depending on the presence of the glutamate-leucine-arginine motif (ELR) in the NH 2 -terminal domain. (biomedcentral.com)
  • This review provides a comprehensive overview of the biological involvement of CXCR4 in human being cancers the current status of CXCR4-centered therapeutic approaches as well as recent improvements in noninvasive imaging of CXCR4 manifestation. (scienceexhibitions.org)
  • Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. (umassmed.edu)
  • N-cadherin, AR splicing variants, PCGEM-1, ELR-CXC chemokine antagonist, dual inhibitor of MET and VEGF as an alternative options for prostate cancer has been discussed in Chapter 1. (benthambooks.com)
  • Chemokines are abundant in RA synovial fluid, while OA synovial fluid also reveals the presence of chondrocytes, synovial cells and other cells capable of both expressing and responding to chemokines (2-4). (researchsquare.com)
  • Chemokines are well-recognized for their ability to recruit different leukocytes (6) and for their involvement in the migration of circulating cells into or within tissue (7, 8). (researchsquare.com)
  • Involvement of Th2 T cells/NFĸB in minimal change disease (MCD) has been postulated. (scienceopen.com)
  • Thus, located at the boundary between the alveolar airspace and the interstitium, alveolar epithelial cells type II (AEC-II) are ideally situated to regulate the recruitment and activation of different types of leukocytes through the production of chemokines/cytokines in response to inflammatory stimulation from the alveolar space. (biomedcentral.com)
  • Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)
  • Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. (umassmed.edu)
  • Chemokines can be either homeostatic or inflammatory, or display both qualities simultaneously. (researchsquare.com)
  • Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. (umassmed.edu)
  • Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. (umassmed.edu)
  • Importantly, both antibody microarray assay on sera and RT-PCR on mRNA of PBL revealed expression of a CXC chemokine GRO-γ (growth-related oncogene) in all MCD patients as compared with one of 7 controls. (scienceopen.com)
  • Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)
  • After chemokine binding the heterotrimeric G protein is activated from the exchange of GDP for GTP and dissociates into the GTP-bound α and the βγ subunits (Goldsmith & Dhanasekaran 2007 Mellado Rodriguez-Frade Manes & Martinez 2001 The dissociated βγ subunit activates two major transmission transduction enzymes a phospholipase C-β (PLC-β) which is definitely specific for phosphatidylinositol and a phosphatidylinositol-3-OH kinase (PI3K). (scienceexhibitions.org)
  • To investigate the involvement of complement in I/R injury, we studied the activation and deposition of complement in a murine model of renal I/R injury. (maastrichtuniversity.nl)
  • They are classified into four subfamilies on the basis of the primary sequence of the first two of four invariant cysteine residues, and named according to the recommendation for new systematic nomenclature for human chemokines [ 11 ]. (biomedcentral.com)