MyocardialReactive oxygenAlleviating hepatic steatosisApoptosisProtective effectsSteatosisIschemicMechanismsAcute kidneyGene knockout miceOxidativeDysfunctionLipid peroxidationPathwaysInflammationMiceRatsSuppressesCytokinesTraumaTransplantationGlutathioneGraftMicroRNACardiacFibrosisHemorrhagic shockMediatorsLung2016LiversTissueMechanismHippocampalAbstractRoleCerebralKidney injuryDamageTherapeuticSevereEffectsRenalLipidsSurgical proceduresPathologicalDiseasesEndothelialClinical
Myocardial4
- showed that EX527 could increase ROS production by inhibiting Sirt1 activity, which aggravates myocardial injuries caused by diabetes ( 15 ). (frontiersin.org)
- Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. (wanfangdata.com.cn)
- The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury [J].2015,78. (wanfangdata.com.cn)
- Cardiac surgery-associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. (silverchair.com)
Reactive oxygen5
- It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
- As liver ischemia ends and reperfusion begins, reactive oxygen species are one of the first elements formed (14). (ectrx.org)
- All reactive oxygen species respond in varying degrees at the initiation of reperfusion. (ectrx.org)
- After hypoxia and ischemia, the production of reactive oxygen species (ROS) rapidly accumulates and leads to mitochondrial dysfunction and delayed neuronal death. (frontiersin.org)
- Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
Alleviating hepatic steatosis1
- Previous studies showed that Sirt1 can regulate diabetes-induced cardiac dysfunction and brain ischemic reperfusion injuries by preventing mitochondrial dysfunction and alleviating hepatic steatosis ( 2 - 4 ). (frontiersin.org)
Apoptosis4
- In addition, the molecular mechanisms involved were investigated, particularly regarding oxidative stress and apoptosis. (spandidos-publications.com)
- Trim8 knockout relieved hepatocyte injury triggered by I/R. Silencing of Trim8 expression alleviated hepatic inflammation responses and inhibited apoptosis in vitro and in vivo . (ijbs.com)
- Oxidative stress-mediated mitochondrial damage has been shown to be involved in apoptosis. (frontiersin.org)
- Its pathophysiological mechanisms involve various biological events such as neuronal apoptosis, oxidative stress, endoplasmic reticulum stress and inflammatory cascade[ 2 - 5 ]. (ijpsonline.com)
Protective effects5
- Therefore, in the present study the protective effects of GP against I/R-induced hepatic injury in mice was studied. (spandidos-publications.com)
- Mechanistically, our study suggests that Trim8 deficiency may elicit hepatic protective effects by inhibiting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38/JNK signalling pathways. (ijbs.com)
- In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
- BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
- 9 There is extensive animal work showing that lipoic acid, by supporting glutathione levels, can exert signifi cant protective effects against oxidant damage related to ischemia-reperfusion injury. (theamericanchiropractor.com)
Steatosis3
- Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
- Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
- It has been shown that STAT3 activation is involved in a decrease of lipid accumulation while C/EBPβ is correlated with an increase of fat content and steatosis. (theiet.org)
Ischemic2
- Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
- In the early stage of ischemia and hypoxia, cells will increase the energy supply to the ischemic area, especially the functional area of the ischemic penumbra, by regulating glycolysis. (ijpsonline.com)
Mechanisms8
- Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
- Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. (ectrx.org)
- Hypoxic ischemia (HI) involves multiple mechanisms, but the detailed pathogenesis is still unclear. (frontiersin.org)
- Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
- Our goal is to determine the mechanisms and proteins involved in SOCE in neutrophils, then ask whether targeting these proteins will reverse inflammatory disease. (ucsf.edu)
- Molecular mechanisms may involve the migration of bacterial metabolites from the gut to the liver and activation of neutrophil extracellular traps (NETs). (researchsquare.com)
- This review of literature discusses kidney injury associated with the use of AAS and ADE, highlighting the mechanisms of acute and chronic renal lesion, such as direct renal toxicity, glomerular hyperfiltration and hypercalcemia. (revistanefrologia.com)
- We aimed to identify potential genes and reveal the underlying the molecular mechanisms involved in the precise regulation of liver size during the termination phase of LR. (jomh.org)
Acute kidney3
- We hypothesized that elevated levels of circulating inflammatory mediators are associated with IRI and/or acute kidney injury (AKI) after liver transplantation (LT). (atcmeetingabstracts.com)
- Mihaylov P, Li P, Skill J, Timsina L, Fridell J, Ekser B, Mangus R, Kubal C. Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators [abstract]. (atcmeetingabstracts.com)
- Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Gene knockout mice2
- Trim8 gene knockout mice and primary hepatocytes were used to construct hepatic I/R models. (ijbs.com)
- Using gene knockout mice we have found that genetic deficiency of calcium signaling pathways in neutrophils results in a profound block in neutrophil activation and protection from tissue injury during inflammation. (ucsf.edu)
Oxidative5
- In conclusion, the present study indicated that GP effectively protected against I/R-induced hepatic injury via its anti-oxidative and anti-apoptotic bioactivity. (spandidos-publications.com)
- Oxidative stress and nitric oxide (NO) seem to be involved in the IR injury. (bvsalud.org)
- These results suggested that partial liver I followed by global liver R induced liver, kidney, and lung injuries characterized by neutrophil sequestration and increased oxidative stress. (bvsalud.org)
- Pathophysiology of CSA-MOD involves numerous injurious pathways linked to the use of CPB including oxidative stress and formation of reactive iron species. (silverchair.com)
- NABQI depletes hepatic glutathione stores, placing an enormous oxidative stress on the liver, leading to liver failure. (theamericanchiropractor.com)
Dysfunction3
- Hepatic I/R is an important cause of liver damage and is also the underlying cause of graft dysfunction in marginal organs. (ijbs.com)
- Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. (wanfangdata.com.cn)
- This study aimed to investigate the therapeutic potential of Ser on cognitive dysfunction induced by transient global cerebral ischemia/reperfusion (tGI/R) and its mechanism of action. (cjphysiology.org)
Lipid peroxidation2
- Following hepatic I/R, the levels of hepatic lipid peroxidation and serum alanine aminotransferase increased, while the ratio of hepatic glutathione (GSH):oxidized GSH was reduced, which was effectively attenuated by pretreatment with GP. (spandidos-publications.com)
- Our aim was to investigate the effects of liver I/R on hepatic function and lipid peroxidation, leukocyte infiltration and NO synthase (NOS) immunostaining in the lung and the kidney. (bvsalud.org)
Pathways7
- Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
- In conclusion, our study demonstrates that Trim8 deficiency plays a protective role in hepatic I/R injury by inhibiting the activation of TAK1-dependent signalling pathways. (ijbs.com)
- I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
- Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)
- Investigations involving animal models and human trials are reviewed, a summary of significant studies in human subjects is presented ( Table 1 ), and the pathways and mediators important in liver ischemia-reperfusion injury are described ( Figure 1 ). (ectrx.org)
- Due to the significance of impaired autophagy in these diseases, there is increased interest in studying pathways and targets involved in maintaining efficient autophagic functions as potential therapeutic targets. (hindawi.com)
- Autophagy is a process that relies on lysosomal pathways for the degradation of cytoplasmic proteins and organelles and plays an important role in the pathology of brain injury such as hypoxia ischemia[ 3 ]. (ijpsonline.com)
Inflammation1
- CB2 receptor ligands have been shown to inhibit inflammation and edema formation, exhibit analgesic effects, and play a protective role in hepatic ischemia-reperfusion injury. (vediherbals.com)
Mice4
- In the present study, a hepatic I/R‑injury model was successfully established using C57BL/6 mice. (spandidos-publications.com)
- Furthermore, GP exhibits a therapeutic effect on chronic hepatic injury, fibrosis, as well as fatty liver disease, which were induced by a high fat, high cholesterol diet and alcohol in mice ( 5 , 8 ). (spandidos-publications.com)
- The results indicated that Trim8 was significantly upregulated in liver of mice subjected to hepatic I/R injury. (ijbs.com)
- Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice [J].2011,141(6). (wanfangdata.com.cn)
Rats1
- This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
Suppresses1
- It has also been studied that acute administration of CBD in-vivo suppresses ischemia-induced cardiac arrhythmias and reduces infarct size when administered at reperfusion. (vediherbals.com)
Cytokines2
- In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)
- Activation of Kupffer cells and neutrophils leads to release of inflammatory cytokines and free radicals, which further aggravate liver injury [ 4 , 5 ]. (ijbs.com)
Trauma4
- Several factors such as contact of blood with foreign surfaces, surgical trauma, ischemia reperfusion to the organs, and release of endotoxin have been widely documented to cause SIRS after CPB. (peertechzpublications.com)
- Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. (ectrx.org)
- injury may be confined to the abdomen or be accompanied by severe, multisystem trauma. (msdmanuals.com)
- Blunt trauma may involve a direct blow (eg, kick), impact with an object (eg, fall on bicycle handlebars), or sudden deceleration (eg, fall from a height, vehicle crash). (msdmanuals.com)
Transplantation6
- Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
- Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)
- In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
- Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. (nanostring.com)
- Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
- A-1: Magnetic resonance angiogram in a transplantation patient with hepatic artery thrombosis. (medscape.com)
Glutathione1
- a co-factor for glutathione S-transferases , enzymes which are involved in the detoxifi cation of xenobiotics , including carcinogens. (theamericanchiropractor.com)
Graft5
- Hepatic I/R injury can result in loss of viability of a liver graft, which is directly correlated with the recipient's survival [ 2 ]. (ijbs.com)
- Complications following LT occur commonly and may derive from pretransplant recipient condition, graft-specific factors (including preservation and ischemia-reperfusion injury), technical or intraoperative complications, the immunologic response to the graft, or infection. (musculoskeletalkey.com)
- Ultrasonography (US), CT, MRI, cholangiography, angiography and scintigraphy are the most common radiological modalities used to evaluate the hepatic graft. (medscape.com)
- C-1: Gortex hepatic artery graft thrombosis in a 59-year-old man (shown by arrow). (medscape.com)
- between the cursors) of the hepatic graft. (medscape.com)
MicroRNA1
- We are working on the site-specific delivery of oligonucleotides and microRNA to hepatocytes or hepatic stellate cells for treatment of hepatitis and liver fibrosis. (unmc.edu)
Cardiac2
- The study was a multicenter, open-label, parallel-group, randomized controlled study of the avoidance of arterial hyperoxemia versus usual care in patients undergoing cardiac surgery involving CPB. (silverchair.com)
- Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. (bvsalud.org)
Fibrosis2
- Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
- We have previously shown that the conjugation of siRNA to mannose-6-phosphate- PEG (M6P-PEG) can significantly enhance its delivery to hepatic stellate cells and this M6P-PEG-siRNA has the potential to treat liver fibrosis by inhibiting excess of collagen synthesis (Zhu et al, Bioconjug Chem, 2010, 21: 2119-2127 ). (unmc.edu)
Hemorrhagic shock1
Mediators3
- The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. (ectrx.org)
- In this report, a comprehensive analysis of those factors is provided, and the fundamental molecular inflammatory mediators present after liver ischemia and reperfusion are discussed. (ectrx.org)
- Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
Lung2
- Lung ischemia reperfusion injury: A bench-to-bedside review [J].2013,17(1). (wanfangdata.com.cn)
- Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. (nanostring.com)
20161
- The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury [J].2016,100(2). (wanfangdata.com.cn)
Livers2
- Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)
- Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [J].2017,216. (wanfangdata.com.cn)
Tissue2
- As a result of this defective neutrophil function, stim1-/- chimeras are protected from tissue injury in the zymosan model of acute peritonitis and show significantly reduced tissue injury in a hepatic ischemia reperfusion model. (ucsf.edu)
- Uncontrolled activation of neutrophils is a major cause of tissue injury in inflammatory diseases such as arthritis, vasculitis and ischemia-reperfusion injury. (ucsf.edu)
Mechanism2
- To the best of our knowledge, the role of GP in hepatic I/R injury and the underlying molecular mechanism, have not yet been investigated. (spandidos-publications.com)
- The nature and severity of abdominal injuries vary widely depending on the mechanism and forces involved, thus generalizations about mortality and need for operative repair tend to be misleading. (msdmanuals.com)
Hippocampal1
- Here, we investigated the role of Sirt1 in the pathogenesis of brain injuries after modulating its activity in primary cultured hippocampal neurons. (frontiersin.org)
Abstract1
- Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
Role6
- The aim of this study is to explore the role of Trim8 in hepatic I/R injury. (ijbs.com)
- This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
- The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
- However, the role of Sirt1 in perinatal brain injuries is not completely understood. (frontiersin.org)
- A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury. (nih.gov)
- 29256408 ). N-Acetyltryptophan has also been shown to have a role in preventing hepatic ischemia-reperfusion injury. (hmdb.ca)
Cerebral1
- Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
Kidney injury2
- Future perspectives regarding evaluation and early diagnosis of kidney injury in these patients are also discussed. (revistanefrologia.com)
- Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
Damage2
- Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
- showed that damage was decreased significantly when NETs were depleted in the context of bacterial-induced liver injury 11 . (researchsquare.com)
Therapeutic2
- Therefore, developing effective preventive and therapeutic strategies for I/R-induced hepatic injury is required. (spandidos-publications.com)
- Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
Severe1
- Hepatic ischemia followed by reperfusion (IR) results in mild to severe remote organ injury. (bvsalud.org)
Effects2
- Adenoviral delivery of superoxide dismutase has been shown to produce beneficial effects in warm ischemia reperfusion (18), alcohol-induced liver injury (19), and reduced-size liver grafts (20). (ectrx.org)
- 21]Peralta,C.,Jiménez-Castro,M.B.,Gracia-Sancho,J.. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu [J].2013,59(5). (wanfangdata.com.cn)
Renal2
- Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. (atcmeetingabstracts.com)
- También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes. (revistanefrologia.com)
Lipids1
- The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)
Surgical procedures1
- the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
Pathological3
- The effect of Trim8 on hepatic I/R injury was analysed via pathological and molecular analyses. (ijbs.com)
- I/R is a common pathological disorder leading to acute liver injury, a potentially life-threatening clinical condition with high morbidity, mortality, and prolonged patient hospitalization. (ijbs.com)
- In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. (thermofisher.com)
Diseases1
- The complexity of the sphingolipidome is hard to imagine, but one hopes that, when partnered with other systems biology approaches, the causes and consequences of the complexity will explain how these intriguing compounds are involved in almost every aspect of cell behavior and the malfunctions of many diseases. (sphingolipidclub.com)
Endothelial1
- Hepatic I/R injury is characterized by endothelial and Kupffer cell swelling, vasoconstriction, leukocyte infiltration, and platelet aggregation in sinusoids [ 3 ]. (ijbs.com)
Clinical1
- Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)