Involve nuclear kinase proteins nuclear proteins. Medical search. Frequent questions

In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)
Poly-L-lysine (PLL) of extracellular matrix proteins is a small natural homopolymer of the essential amino acid L-lysine that is used to coat culture substrates. (hindawi.com)
Extracellular signal-regulated kinase (ERK) is a serine/threonine protein kinase that functions as the major effector of the Ras protein, a small GTPase. (proteinkinase.biz)

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene. (wikipedia.org)
Further studies with pharmacological and genetic approaches revealed that TIGAR regulated the phosphorylation of ATM, a key protein in DDR, through Cdk5. (nature.com)
UVB-induced phosphorylation of c-Jun N-terminal kinase, p38 kinase and Akt was inhibited by delphinidin. (oregonstate.edu)
Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)
Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
These studies demonstrate a phosphorylation-dependent translocation of PIF7 when plants are in shade and a novel mechanism involving 14-3-3 proteins, mediated by the retention of PIF7 in the cytoplasm that suppresses the shade response. (elifesciences.org)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
found that RSV decreased the activity of PI3K/Akt phosphorylation, resulting in a decrease in BCL-2-associated X protein (BAX) and increases in BCL-2 and superoxide dismutase production in diabetic kidney [ 8 ]. (hindawi.com)
Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
EGCG significantly inhibited phosphorylation of the MAPKs p38 and c-Jun N-terminal kinase (JNK), and NFκB and AP-1 transcriptional activities. (molvis.org)
DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. (biolegend.com)
This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. (caslab.com)
Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications, including protein phosphorylation and acetylation. (wustl.edu)
Our results further suggest that the recycling supported by flotillin-positive endosomes provides a crucial contribution to T cell activation by regulating the nanoscale business of TCR at the immunological synapse and promoting phosphorylation of signaling proteins, and the nuclear import of transcription factors. (fabretp.org)

Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. (wikipedia.org)
Whereas the standard immunosuppressive agents foster development of PTLDs, the impact of novel immunosuppressive agents from the group of selective inhibitors of TOR serine/treonine kinase such as rapamycin and its derivatives including RAD remains undetermined. (upenn.edu)
DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470 kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. (biolegend.com)

Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in tumor suppressor genes such as LKB1, involved in AMPK activation, have been identified in certain cancers. (sigmaaldrich.com)
Mutations in the DPY19L2 gene result in a loss of functional DPY19L2 protein. (medlineplus.gov)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

Additionally, approximately 66% of melanomas harbour the BRAFV600E mutation, which represents a constitutive signal of the mitogen-activated protein kinase (MAPK) that is known to phosphorylate a range of substrates, resulting in the regulation involved in hyper-proliferation and survival of transformed cells. (bl.uk)
Thus far, no reports have shown that MAPK can influence VDR function however, it is known that MAPK can phosphorylate a subgroup of nuclear receptors, which VDR is a member of, and thereby alter their signalling. (bl.uk)
An abrogation of MAPK activity by the clinically applied BRAFV600E inhibitor vemurafenib (PLX4032) or MEK1/2 inhibitor PD98059 has shown to downregulate the overall VDR levels in BRAFV600E melanoma, in part by shortening the half-life of this protein involving proteasomal activity. (bl.uk)
We identified two potential MAPK acceptor sites on VDR protein, which are T175 and S177 on VDR isoform 1 and T225 and S227 on VDR isoform 2, both of which lie within the PEST region that is commonly associated with short-lived regulatory proteins mediated through the ubiquitinproteasome system. (bl.uk)
Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. (creativebiomart.net)

Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)

The activities of mitogen-activated protein kinase kinase (MAPKK) 4 and phosphatidylinositol-3 kinase (PI-3K) were inhibited markedly by delphinidin. (oregonstate.edu)
Function of RSV has been extensively explored for its powerful antioxidant capacity and specific effects on proteins and/or signaling cascades, such as Sirt1, adenosine monophosphate activated kinase, phosphatidylinositol-3 kinase (PI3K)/Akt, and JNK/nuclear factor-kappa B (NF- B) in DN both in vivo and in vitro [ 8 - 10 ]. (hindawi.com)

The common regulatory step in both of these cascades is activation of an IκB kinase ( IKK ) complex consisting of catalytic kinase subunits (IKKα and/or IKKβ) and the regulatory non-enzymatic scaffold protein NEMO (NF-κB essential modulator also known as IKKγ). (abcam.com)

Accumulating evidence indicates that expression of anaplastic lymphoma kinase (ALK) defines a distinct type of T-cell lymphoma. (upenn.edu)
Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)

The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
Also, other proteins which involved in the same pathway with MAPK4 were listed below. (creativebiomart.net)
Another important pathway is the AMP-activated protein kinase (AMPK) pathway. (sigmaaldrich.com)

This disorder is now formally referred to as X-linked agammaglobulinemia (XLA), and the gene defect has been mapped to the gene that codes for Bruton tyrosine kinase (Btk) at band Xq21.3. (medscape.com)
The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
Bruton's tyrosine kinase (Btk) is a member of the Tec family of kinases. (medscape.com)
Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
The substrate specificities of the ERK1 and ERK2 protein kinases are very similar. (proteinkinase.biz)
Suitable as substrate for kinase activity assays and for western blot analyses. (proteinkinase.biz)
Gonzalez FA, Raden DL, Davis RJ (1991) "Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases" J. Biol. (proteinkinase.biz)
1996) "A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1" Mol Cell Biol. (proteinkinase.biz)

In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. (yeastgenome.org)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats. (nih.gov)
The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)
This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
Results T cell activation promotes T cell receptor complex subunit (TCR) but not Lck internalization Internalization of T cell receptors and associated signaling proteins has been measured predominantly Fonadelpar by flow cytometry, which involves bulk measurements and provides no access to the dynamics of vesicle generation or movement. (fabretp.org)
However, the structure-function mechanism of LRRC15 involving the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and their mode of interaction is largely unknown. (bvsalud.org)
However, further experimental validations are necessary for unravelling the unknown mechanism and distinctive features of this host receptor in the COVID-19 pandemic, involving both the transmembrane as well as cytoplasmic domain. (bvsalud.org)

In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. (novusbio.com)
The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. (novusbio.com)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. (genetex.com)
We speculate that BRAFV600E has altered VDR gene targeting by inducing VDR translocation into the cytosol and/or its association capacity with its target molecules that usually results in the abrogation of cell proliferation, including β-catenin for its cytosolic re-distribution and ubiquitin ligase FBXW7 with which VDR corporately induce the degradation of genes involves in cell cycle arrest like c-myc. (bl.uk)
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. (caslab.com)
These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The DPY19L2 gene provides instructions for making a protein that is found in developing sperm cells. (medlineplus.gov)
Researchers have described other characteristics of the abnormal sperm cells that make fertilization of an egg cell difficult, although it is not clear how changes in the DPY19L2 gene are involved in development of these characteristics. (medlineplus.gov)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)

In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. (yeastgenome.org)
The key to NF-kB regulation is the inhibitory kB IkB proteins which retain NF-kB in an inactive form in the cytoplasm. (dtic.mil)
NF-κB proteins are inhibited by IκB proteins present in the cytoplasm. (abcam.com)

Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
Activator protein-1 and nuclear factor-kappaB, crucial transcription factors involved in COX-2 expression, were activated by UVB and delphinidin abolished this activation. (oregonstate.edu)

In vitro , RSV attenuated high glucose-induced plasminogen activator inhibitor (PAI-1) expression and mesangial cell proliferation, as well as Akt and nuclear factor-kappa B (NF- κ B) activation. (hindawi.com)
The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. (avivasysbio.com)
therefore, p50 and p52 homodimers repress transcription unless they are bound to a protein containing a TAD, such as RelA, c-Rel or RelB or Bcl-3 (a related transcriptional co-activator). (abcam.com)

Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
They indicate that pathways involving STAT3, PI3K/AKT and, apparently, STAT5 are constitutively activated by this kinase. (upenn.edu)
MAPK4 involved in several pathways and played different roles in them. (creativebiomart.net)
One of the central anti-apoptotic pathways in cells is mediated by NF-kB nuclear factor kappa-B transcription factors. (dtic.mil)
Protein complexes, which are formed as a result of these interactions, consist of two or more components that associate along specific pathways - protein association pathways. (lu.se)

DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. (wikipedia.org)
These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)

Novel selective inhibitors of nuclear export (SINE) have achieved outstanding preclinical results and are currently in Phase I trials. (massgeneral.org)

ERK1 / 2 differentially phosphorylates a variety of nuclear (Elk-1, c-Myc), cytosolic (MNK1/2, Raf) and cytoskeletal (MAP2, Tau) targets. (proteinkinase.biz)

Like the endogenous HPK1, both wild-type HPK1 and its kinase-dead mutant, HPK1-M46, overexpressed in Panc-1 cells, were also targeted by proteasome-mediated degradation. (aacrjournals.org)
Several IkB kinases IKKs which trigger IkB degradation and NF-kB activation were discovered in 1997-2000 Zandi et al. (dtic.mil)

The protein is proposed to be involved in the regulation of nuclear functions. (wikipedia.org)
Involved in regulation of mitotic cell cycle. (nih.gov)
and negative regulation of meiotic nuclear division. (nih.gov)
Recently, the sterol regulatory element binding protein SrbA was found to be essential for adaptation to iron starvation, thereby linking regulation of iron metabolism, ergosterol biosynthesis, azole drug resistance, and hypoxia adaptation. (frontiersin.org)
The identification and functional characterization of 24 genes that are involved in iron homeostasis in A. fumigatus and/or Aspergillus nidulans , respectively, revealed significant insights into iron metabolism and its regulation (Table 1 ). (frontiersin.org)
Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. (genetex.com)
Upon investigation on the regulation of VDR expression and function in the context of BRAFV600E vs. BRAFWT melanoma, we show for the first time that VDR mRNA and protein expression, independently, acquire dependency on BRAFV600E signalling. (bl.uk)
There is also a dysregulated response to the ensuing redox assault, as the master regulator of oxidative stress, nuclear factor erythroid 2-related factor-2 (Nrf2), demonstrates marked down-regulation. (curefa.org)
The diversity of disorders involving the GI tract speaks to the differing forms of immune regulation along the length of the intestine, and the varying nature of the challenge (ie, food antigens in the small bowel and commensal flora in the colon). (medscape.com)

The protein level of key genes was detected using Western blot. (bvsalud.org)

Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. (aacrjournals.org)
The released NF-kB factors then translocate to the nucleus and activate kB-responsive genes involved in cell growth, apoptosis, and metastasis. (dtic.mil)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Our studies concentrate on identification of downstream effector molecules triggered by the NPM/ALK kinase. (upenn.edu)

Its substrates include MKS1 and probably MAP65-1.The MAP65-1 interaction is involved in mediating cortical microtuble organization. (creativebiomart.net)

Epirubicin was reported to block DNA replication either through direct DNA damage or indirectly through inhibition of replication proteins such as topoisomerase. (nature.com)
Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. (oregonstate.edu)

In Aspergillus fumigatus , iron starvation causes extensive transcriptional remodeling involving two central transcription factors, which are interconnected in a negative transcriptional feed-back loop: the GATA-factor SreA and the bZip-factor HapX. (frontiersin.org)
In vitro, we show that 1,25D3 to modestly increase the expression of E-cadherin mRNA and protein in SK-MEL-28, but remained absent in A375, a cell line that expresses relatively higher levels of EMT transcription factors including SNAI1 and ZEB1. (bl.uk)
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (avivasysbio.com)

Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)

Acetylproteome analysis highlighted acetylation on key nuclear proteins involved in the DNA damage response and revealed cross-talk between cytoplasmic and mitochondrial acetylation and metabolism. (wustl.edu)

However, the over production of oxygen free radicals in sperm membrane decreases the antioxidant defense activity thereby leading to low sperm motility and viability, DNA fragmentation and protein denaturation. (scialert.net)
Introduction The plasma membrane is usually a highly dynamic Fonadelpar environment, which constantly exchanges lipids and proteins with intracellular compartments through exocytic and endocytic processes. (fabretp.org)
The membrane organizing protein Rabbit Polyclonal to VAV1 flotillins have been reported to define Fonadelpar a clathrin-independent endocytic route22,23 and support the recycling of cell surface proteins24C26. (fabretp.org)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)

We have established a principal four step mechanism for this, which involves an activation step through master mitotic kinases that set the cue, a transport step involving a previously unknown cellular complex, a tethering step to mitotic chromatin, and a deactivation step, once cell division occurred. (europa.eu)

Western Blot: ROR alpha/NR1F1 Antibody [NBP1-52813] - Western blot analysis of RORa expression in NP tissues isolated from three rats showed positive expression of the protein. (novusbio.com)
We found that loss of HPK1 protein expression correlated significantly with the progression of pancreatic intraepithelial neoplasias ( P = 0.001) and development of invasive PDA. (aacrjournals.org)
Treatment of Panc-1 cells with a proteasome inhibitor, MG132, increased the HPK1 protein levels in a dose-dependent manner, suggesting that alteration in proteasome activity contributes to the loss of HPK1 protein expression in pancreatic cancer. (aacrjournals.org)
After MG132 withdrawal, wild-type HPK1 protein expression was markedly decreased within 24 hours, but kinase-dead HPK1 mutant protein expression was sustained for up to 96 hours. (aacrjournals.org)
Furthermore, restoring wild-type HPK1 protein in PDA cells led to the increase in p21 and p27 protein expression and cell cycle arrest. (aacrjournals.org)
Neuronal injury in the hippocampal dentate gyrus and ribosomal protein L6 (RPL6) expression in the brain tissues were detected using H&E staining, Nissl staining, and Western blot. (bvsalud.org)
Considering FA, which is due to the decreased expression of the mitochondrial protein, frataxin, this iron accumulation does not occur within protective storage proteins such as mitochondrial ferritin. (curefa.org)

Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). (yeastgenome.org)

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (nature.com)

SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
Investigations into how papillomaviruses exploit host cell division to gain access to the nuclear space for infection have identified cellular targets that are hijacked for this purpose. (europa.eu)
The most surprising finding of our research has probably been that by learning about a mechanism, we observed that the interactions of a viral protein with cellular proteins to achieve nuclear delivery can lead to misrouting of the cellular proteins. (europa.eu)
Changing the location of the cellular proteins, in turn, apparently changes the physiological function with dire consequences for cell division and subsequent cell fate. (europa.eu)
In activated T cells, polarized endocytic recycling is the result of a sequence of cellular events starting with kinase-mediated signaling8 and ending with the translocation of the microtubule-organization center (MTOC) and associated endosomes to the immunological synapse9. (fabretp.org)

Moreover, we have identified on the viral side a peptide in a crucial viral protein that mediates these interactions, Besides a more thorough understanding of viral infection, we found that the presence of the viral peptide concentration-dependently allows to stall mitosis and eventually induce cell death, so that this may provide an avenue for anti.cancer treatments. (europa.eu)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)

The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK4 itself. (creativebiomart.net)
We selected most functions MAPK4 had, and list some proteins which have the same functions with MAPK4. (creativebiomart.net)
Protein performs its biological functions by interacting with other proteins. (lu.se)

However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. (creativebiomart.net)
Collectively, frataxin depletion results in multiple, complex responses that lead to detrimental redox effects that could contribute to the mechanisms involved in the pathogenesis of FA. (curefa.org)

Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)

One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)

Its pathophysiology is likely to involve insulin resistance at the level of both skeletal muscle and visceral adipose tissue and altered fluxes of metabolic substrates between these tissues that in turn impair liver metabolism. (erudit.org)

They require cell division in order to deliver their genome in a replication competent form into the nuclei of cells, as during cell division the nuclear envelope, a protective border to the cytosol, is removed during cell division giving these viruses access to the nuclear lumen. (europa.eu)

Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
S. cerevisiae hypothetical proteins YBR129c and YHR155w. (embl.de)

Phosphoproteomics profiles uncovered novel associations between tumor suppressor loss and targetable kinases. (wustl.edu)

These protein kinases are currently seen as a target of choice to specifically inhibit NF- kB activity. (dtic.mil)

and (3) inhibited nuclear translocation of Nrf2. (curefa.org)

Biotinylated protein is not phosphorylated and activated by MKKs. (proteinkinase.biz)

Anatomy17

Organisms9

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes53

Disciplines and Occupations1

Information Science3

Extracellular3

Phosphorylation15

Serine3

Mutations9

MAPK5

Isoform1

Phosphatidylinositol-3 kina2

Catalytic1

Anaplastic lympho2

Pathway5

Tyrosine kinase4

Substrate6

Receptor9

Gene15

Differentiation1

Cytoplasm3

Factor-kappaB2

Activator3

Pathways5

Localization2

Inhibitors1

Erk11

Degradation2

Regulation10

Detected using Wester1

Apoptosis2

Effector2

Interaction1

Inhibition2

Transcription3

Proliferation1

Acetylation1

Membrane4

Mitotic1

Expression7

Checkpoint1

Mitochondrial uncoupl1

Cellular5

Mediates1

Accumulation1

Cytoskeletal1

Functions6

Responses2

Occur1

Interact1

Substrates1

Replication1

Cerevisiae3

Tumor1

Activity1

Translocation1

Phosphorylated and activated1