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  • gene
  • We determined that a 10-nucleotide oligomer of peptide nucleic acid (PNA) targeting the start codon region of an essential gene acpP is able to cause complete growth inhibition of E. amylovora . (frontiersin.org)
  • assays
  • These properties have led to a diverse set of applications for PNA, which includes antisense/antigene inhibition of gene expression, various DNA/RNA detection assays, nucleic acid labeling and purification technologies, and programmed assembly of nanoscale materials. (schoolbag.info)
  • The shift toward molecular techniques for bacterial identification, such as DNA sequencing, real-time polymerase chain reaction (PCR) assays, and peptide nucleic acid-fluorescent in situ hybridization (PNA-FISH), has led to improvements in turnaround time. (aacc.org)
  • Chemistry
  • Stuart J. Rowan 's research interests focus on the investigation and utilization of Supramolecular Chemistry (the chemistry of the non-covalent bond) in polymer chemistry. (nsti.org)
  • structure
  • Actually, most of the steps of replication, transcription, and translation of the genetic information, as well as DNA repair, RNA maturation, or building of nucleosomes or ribosomes require the specific recognition of a nucleic acid structure or base sequence by proteins. (springer.com)
  • Influence of Metal Ions on the Structure and Reactivity of Nucleic Acids. (nhbs.com)
  • bases
  • This mass is then used to determine the amplicon's nucleic acid base composition from a mathematical algorithm that incorporates the combination of masses of the four nucleic acid bases (A, C, T, and G), along with the reverse complement of the DNA strand, to predict the amplicon's composition. (aacc.org)
  • carbon nanotubes
  • Herein, we present the first systematic investigation of the cellular uptake mechanism and pathway for carbon nanotubes. (docme.ru)
  • Carbon nanotubes (CNTs) have been extensively studied for delivering drugs, proteins, peptides, and nucleic acids including plasmid DNA to cells and organs with varying degrees of success, but few of them have been applied to DNA vaccine for HCV. (usask.ca)
  • Therapy
  • Biomimetic peptides of BDNF have emerged as a promising therapy against neurodegenerative disorders. (mdpi.com)
  • Progress
  • Mass Spectrometry of Nucleosides and Nucleic Acids puts into perspective the progress in biotechnological research developed over the last few decades. (nhbs.com)
  • analysis
  • The laboratory Membrane Biophysics and NMR at the University of Strasbourg has an opening for a postdoctoral position with experience in using solid-state NMR for the analysis of peptides and proteins. (weizmann.ac.il)
  • dependent
  • Feasible patient-specific theranostic platforms in the personalized medicine are particularly dependent on efficient and clinically applicable peptide constructs. (medsci.org)
  • Di Maro, S. Investigation of the Stereochemical-Dependent DNA and RNA Binding of Arginine-Based Nucleopeptides. (mdpi.com)
  • Tomassi S, Montalban FF, Russo R, Novellino E, Messere A, Di Maro S. Investigation of the Stereochemical-Dependent DNA and RNA Binding of Arginine-Based Nucleopeptides. (mdpi.com)
  • Replacement of any of the tryptophans of [LysA with isoleucine resulted in suppression of the pore-forming activity of the peptide, the effect being significantly dependent on the position of tryptophans. (springer.com)
  • effect
  • We found that conjugation of cell penetrating peptide (CPP) to PNA is essential for the antimicrobial effect, with CPP1 [(KFF)3K] being the most effective against E. amylovora . (frontiersin.org)
  • The binding of Arg-and Lys-peptides to single-stranded polyribonucleotides and its effect on the polymer conformation. (springer.com)
  • properties
  • One goal of this investigation was to develop a polymer conjugated with multiple copies of peptide nucleic acid (PNA) and with pharmacokinetic properties suitable for applications in vivo. (umassmed.edu)
  • However, the physicochemical properties of nucleic acids render them liable to degradation and also restrict their cellular entrance and gene translation/inhibition at the correct cellular location. (mdpi.com)
  • The chemical properties of different formulation materials determine their special features for nucleic acid delivery, so understanding the property-function correlation of the formulation materials will inspire the development of next-generation gene delivery carriers. (mdpi.com)
  • Therefore, in this review, we focus on the chemical properties of different types of formulation materials and discuss how these formulation materials function as protectors and cellular pathfinders for nucleic acids, bringing them to their destination by overcoming different cellular barriers. (mdpi.com)
  • Distribution
  • 53 Blitz DM, Christie AE, Marder E, Nusbaum MP: Distribution and effects of tachykinin-like peptides in the reutesr nervous system of the crab, Cancer borealis. (fin-forex.com)
  • drugs
  • PEGylation has demonstrated effectiveness in extending the half-life of drugs, especially peptides and antibodies, thus contributing to the reduction of the frequency of administration from daily to weekly, even monthly in certain cases. (drug-dev.com)
  • Life
  • After the deciphering of the human genome and the genomes of many other organisms, the investigation of the function of gene products and their orchestral interplay is now one of the most important challenges in the life sciences. (springer.com)
  • Results
  • Even though the mechanisms of this enhancement await further investigation, the results of this thesis may have important implications in developing DNA vaccines for infectious diseases in general and for hepatitis C in particular. (usask.ca)