Investigate synaptic setting the membrane potential. Medical search. Frequent questions

In his first postdoctoral period (1996-1998), he joined the laboratory of Prof. Roger Nicoll at the University of California San Francisco (UCSF) to investigate synaptic transmission and plasticity in the hippocampus. (wikipedia.org)
Among most sensitive to PCBD are pathways with key roles in synaptic plasticity. (nature.com)
Mild, acute stress often enhances hippocampal function by augmenting synaptic plasticity, reflecting the adaptive importance of remembering threatening or dangerous circumstances 2 . (nature.com)
In addition, it has also been proved that drugs too can be used as a model to explore potential plasticity in sensory systems. (intechopen.com)
Furthermore, it was explored in mice, how the application of drugs (serotonin and ketamine) modulates potential plasticity within the visual system. (intechopen.com)
Dopamine-dependent plasticity is a potential cellular mechanism underlying reinforcement learning in the striatum. (oist.jp)
We previously showed that corticostriatal synapses exhibit dopamine dependent plasticity according to a "three factor rule" for synaptic modification. (oist.jp)
Our current projects examine the importance of timing of afferent synaptic activity on synaptic plasticity. (oist.jp)
Sensitivity analysis over several parameters of the model has provided results that may help clarify the dynamics of synaptic transmission, while experiments with the model of the complete synapse seem worth explaining short-term plasticity mechanisms. (biomedcentral.com)
In the long term, we are interested, in particular, in addressing models of synaptic plasticity, i.e. activity dependent mechanisms, which are the bases of memory and learning processes. (biomedcentral.com)
While this compensatory plasticity in the auditory system relies on robust dendritic sprouting and novel synapse formation, the compensatory plasticity in the cercal escape circuitry shows little obvious dendritic sprouting and instead may rely on shifts in excitatory and inhibitory synaptic strength. (biomedcentral.com)
Crickets also show compensatory plasticity in escape responses after unilateral removal of one of the wind-sensitive appendages known as a cercus, though this compensation relies on synaptic strength alterations [ 9 ] instead of obvious anatomical reorganization. (biomedcentral.com)
Our simulations demonstrate how simultaneous, brief multimodal memory cues could build a temporary joint memory representation as an "index" in PFC by means of fast Hebbian synaptic plasticity. (eneuro.org)
A key question is how memories can be made stable over long periods of time despite the ongoing synaptic plasticity. (jesuscortes.info)
Society for Neuroscience Annual Meeting 2007 How short term plasticity (STP) affects synaptic transmission has been widely studied during the last decade (Zucker and Regehr, 2001). (jesuscortes.info)

In the olfactory bulb (OB), locally generated inhibitory synaptic interactions play a central role in shaping mitral and tufted cell responses to sensory stimuli ( Hamilton and Kauer, 1985 , 1989 ). (jneurosci.org)
Thus, AP initiation was favored by hyperpolarizing events, such as negative membrane oscillations or inhibitory synaptic input. (eneuro.org)

Instability of attractors in auto-associative networks with bio-inspired fast synaptic noise. (jesuscortes.info)

The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions. (jneurosci.org)
In this second of two companion papers, we present an ionic current network model composed of populations of Hodgkin-Huxley type excitatory and inhibitory neurons embedded within extracellular space and glia, in order to investigate the role of micro-environmental ionic dynamics on the stability of persistent activity. (yale.edu)
Network.f90 couples 100 inhibitory neurons and 100 excitatory neurons where the membrane potential dynamics of these neurons is taken from Gutkin et al. (yale.edu)
The results from Network.f90 are stored into data files (see comments in Network.f90) that include activity and raster plots for two network types, the membrane potentials, extracellular potassium and intracellular sodium of excitatory and inhibitory neurons. (yale.edu)
Thus, ACh modulates network dynamics in a biphasic fashion, probably by inhibiting excitatory synaptic transmission and facilitating neuronal excitability through muscarinic signaling pathways. (springer.com)
The inhibitory action of the AHP is generally attributed to the potassium channels that prevent excitatory currents to bring the membrane potential ( V m ) to the AP threshold ( Rubin and Cleland, 2006 ). (eneuro.org)
In addition to biochemical signaling cascades, the excitatory synapses of dendritic spines support electrical signaling via post-synaptic potentials. (frontiersin.org)
The focus of this study was on the effects of two particular properties of the synaptic input: correlations of synaptic input rates, and the balance between excitatory and inhibitory inputs (E-I balance). (kth.se)

However, relatively little is known about the synaptic mechanisms responsible for activating these interneurons in addition to the specialized dendrodendritic synapses located on distal dendrites. (jneurosci.org)
The structure of dendritic spines suggests a specialized function in compartmentalizing synaptic signals near active synapses. (frontiersin.org)
Most of these signals can be considered as superpositions of spike trains filtered by components of the neural system (synapses, membranes) and the measurement process. (mit.edu)
Motivated by the need to address some aspects of the functioning of neural synapses, we have developed one such model for synaptic processes in the calyx of Held , which is a glutamatergic synapse in the auditory pathway of the mammalia. (biomedcentral.com)
Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic Neurexin/Neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to Neurexin. (sdbonline.org)
Chemical synapses release synaptic vesicles (SVs) at specialized presynaptic membranes, so-called active zones (AZs), which are characterized by electron-dense structures, reflecting the presence of extended molecular protein scaffolds. (sdbonline.org)
However, how presynaptic scaffold assembly and maturation are controlled and coupled spatiotemporally to the postsynaptic assembly of neurotransmitter receptors remains largely unknown, although trans-synaptic signalling via Neurexin-1 (Nrx-1)-Neuroligin-1 (Nlg1) adhesion molecules is a strong candidate for a conserved 'master module' in this context, based on Nrx-Nlg signalling promoting synaptogenesis in vitro, synapses of rodents, Caenorhabditis elegans and Drosophila (Muhammad, 2015). (sdbonline.org)
The trans-synaptic dialogue between Nrx-1 and Nlg1 aids in the initial assembly, specification and maturation of synapses, and is a key component in the modification of neuronal networks. (sdbonline.org)

Here, we examined the electrophysiological properties of glutamatergic MS-DBB neurons and tested whether they provide a functional synaptic input to the hippocampus. (jneurosci.org)
We found that glutamatergic MS-DBB neurons as a population display a highly heterogeneous set of firing patterns including fast-, cluster-, burst-, and slow-firing. (jneurosci.org)
In this study, we aimed to characterize the intrinsic membrane properties of glutamatergic MS-DBB neurons and examine whether the glutamatergic septohippocampal pathway is functional. (jneurosci.org)
Specifically, a neuron pruning in temporal domain is proposed that prunes less important neurons and skips its future operations based on the layer-wise pruning thresholds of membrane voltages. (journaltocs.ac.uk)
In the following, we will apply this approach in order to investigate which of the two mechanisms is at work in primary motion-sensitive neurons of the fruit fly Drosophila . (elifesciences.org)
In a neural mass model, the activity of the population of neurons is described by a set of differential equations that capture the interactions between different neural populations. (neuroelectrics.com)
Together with Tomoyuki Takahashi, Sakmann developed a method to expose neurons in brain slices, so that patch clamp techniques could be applied to measure synaptic currents. (healing-waves.com)
In neurons, TASK channels carrying hyperpolarizing K + leak currents, and the pacemaker channel HCN2, carrying depolarizing I h , stabilize the membrane potential by a mutual functional interaction. (biomedcentral.com)
For thalamocortical relay neurons, it could be demonstrated that two ion channels, which are predominantly active at rest, strongly influence the resting membrane potential. (biomedcentral.com)
Many central nervous system (CNS) neurons have extensively pocampal pyramidal neurons, markedly reducing AP firing arborized dendrites on which they receive the majority of their when initiated from dendritic depolarization, but minimally synaptic contacts. (hmamedicalclinic.com)
The non- uniform distribution of voltage-gated channels affect signal Actions of anticonvulsants on dendritic excitability processing in the dendrites, altering the retrograde propaga- Using somatic and dendritic recordings in hippocampal CA1 tion (or 'back-propagation') of action potentials (APs), and pyramidal neurons, we tested the hypothesis that anticonvul- the integration of synaptic potentials. (hmamedicalclinic.com)
Triangles indicate the membrane potential dynamics then results in NMDAR-dependent release (or pro-conversion) of mBDNF that induces Hebbian synaptic strengthening in postsynaptic tectal neurons in vivo. (dannymillsfoundation.com)
Additionally, we reproduced in silico the obtained experimental results with a novel spiking neurons network model of mouse V1, by implementing in the model both the synaptic alterations characterizing the FHM1 genetic mouse model adopted. (biomedcentral.com)
They also provide general afferent neurons to the mucous membrane of the posterior third of the tongue. (medscape.com)

The synaptic currents here are modified from that given in Gutkin et al. (yale.edu)
We demonstrate that the structure of the connectivity matrix of such networks induces considerable correlations between synaptic currents as well as between subthreshold membrane potentials, provided Dale's principle is respected. (mit.edu)

To test this prediction, I compared subthreshold membrane potential fluctuations and spike-triggered average membrane potentials of the two MSN types. (kth.se)

During a second postdoctoral period, in the laboratory of Prof. Bert Sakmann at the Max Planck Institute for Medical Research in Heidelberg (1999-2003), he began working on the primary somatosensory barrel cortex, investigating cortical circuits and sensory processing. (wikipedia.org)
The current work determines how and where opioids modulate synaptic transmission between the thalamic, cortical and striatal regions that are important for the perception of affective pain. (elifesciences.org)
Here, we investigate these using a novel multiarea spiking neural network model of prefrontal cortex (PFC) and two parietotemporal cortical areas based on macaque data. (eneuro.org)
3. About 80% of the neurones with intact cortical connections were set into the slow oscillatory mode by bringing their membrane potential to between -68 and -90 mV. (researchgate.net)
4. Anatomical or functional disconnection from related cortical areas resulted in a membrane potential hyperpolarization of about 9 mV and in the occurrence of spontaneous slow oscillations in virtually all recorded neurones. (researchgate.net)
In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). (biomedcentral.com)
The computational model showed how these network effects may arise from a combination of changes in thalamocortical and intra-cortical synaptic transmission, with the former inducing a lower cortical activity and the latter inducing the higher frequencies ɣ oscillations. (biomedcentral.com)

Carl Petersen joined the Brain Mind Institute of the School of Life Sciences at the École Polytechnique Fédérale de Lausanne (EPFL) in 2003, setting up the Laboratory of Sensory Processing to investigate the functional operation of neural circuits in awake mice during quantified behavior. (wikipedia.org)
Correlated neural activity has been observed at various signal levels (e.g., spike count, membrane potential, local field potential, EEG, fMRI BOLD). (mit.edu)
Some of the sources of trial-by-trial variability include synaptic noise, neural refractory period, and ongoing neural activity. (kth.se)
Neural mass models provide a physiologically grounded description of the average synaptic activity and firing rate of neural populations. (neuroelectrics.com)
By simulating the effects of tDCS on neural networks affected by these disorders, researchers can identify potential targets for tDCS treatment and improve our understanding of the underlying pathophysiology of these disorders. (neuroelectrics.com)
Overall, the use of neural mass models in tDCS research provides a powerful tool for understanding the effects of tDCS on large-scale brain activity, optimizing stimulation parameters, and identifying potential targets for the treatment of brain disorders. (neuroelectrics.com)
It thereby bridges microscopic synaptic effects with macroscopic memory dynamics, and reproduces several key neural phenomena reported in WM experiments. (eneuro.org)
To address this gap and draw attention to the wider cognitive perspective of WM accounting for more than STM correlates in PFC, we present a large-scale multiarea spiking neural network model of WM and focus on investigating the neural mechanisms behind the fundamental STM-LTM interactions critical to WM function. (eneuro.org)
Switching between memories in neural automata with synaptic noise. (jesuscortes.info)
Neurocomputing 58-60: 67-71, 2004 [pdf] We present a stochastic neural automata in which activity fluctuations and synaptic intensities evolve at different temperature, the latter moving through a set of stored patterns. (jesuscortes.info)
2005, Neural chaos and synaptic noise. (jesuscortes.info)
Human neural progenitor cells (hNPC) are useful cell systems for high-throughput screening due lớn their homogeneity, along with little complexity & limited differentiation potential. (baoninhsunrise.com)
The development of such a Model offers an exciting new range of opportunities khổng lồ investigate the molecular responses of human neural tissue khổng lồ psychoactive substances. (baoninhsunrise.com)

Simulations showed that fine-tuning of pre- and post-synaptic parameters generated effective MF-GrC transmission channels, which could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage. (nature.com)
The compositionality of the approach has permitted us to independently focus on tuning the models of the pre- and post- synaptic traits, and then to naturally connect them, by dealing with "interface" issues. (biomedcentral.com)

The synaptic terminals of the transmitting neuron (the presynaptic element) send signals by releasing chemical molecules (neurotransmitters) to the dendritic, somatic or axonic, part of the receiving neuron (postsynaptic term) [ 3 ]. (biomedcentral.com)
The intrinsic nature of the phenomenon was supported by the lack of rhythmic postsynaptic potentials as the cells were prevented from oscillating by outward current injection. (researchgate.net)

Here, we investigated how ACh influences reverberatory activity in cultured neuronal networks. (springer.com)
Thus, an important indicator for neuronal survival seems to be the stability of the resting membrane potential. (biomedcentral.com)
FHM1 mutations result in gain-of-function of recombinant human Ca V 2.1 channels and native neuronal Ca V 2.1 channels in FHM1 knock-in mice, causing the enhancement of action potential evoked Ca 2+ influx [ 12 , 13 , 14 , 15 ]. (biomedcentral.com)

As a result, DOR activation in the ACC facilitated poly-synaptic (thalamo-cortico-striatal) excitation of MSNs by MThal inputs. (elifesciences.org)

In the olfactory bulb, mitral cells (MCs) display a spontaneous firing that is characterized by bursts of action potentials (APs) intermixed with silent periods. (eneuro.org)

We are particularly interested in the slower time-scale dynamics that determine overall excitability, and set the stage for transient episodes of persistent oscillations, working memory, or seizures. (yale.edu)
Moreover, input rate correlations and changes in the E-I balance by themselves also proved to have a marked impact on the response variability.Finally, I investigated the beta-band phase properties of the STN-GPe network, known for its exaggerated beta-band oscillations during Parkinson's disease (PD). (kth.se)
Calcium Oscillations driving an excitable membrane: Hysteresis and Bi-stability. (jesuscortes.info)

It is concluded that presynaptic Spinophilin fine-tunes Neurexin/Neuroligin signalling to control active zone number and functionality, thereby optimizing them for action potential-induced exocytosis (Muhammad, 2015). (sdbonline.org)

During his PhD studies under the supervision of Prof. Sir Michael Berridge at the University of Cambridge (1992-1996), he investigated cellular and molecular mechanisms of calcium signalling. (wikipedia.org)
The MC intrinsic dynamics generate a discharge of action potentials (APs) in burst patterns whose underlying mechanisms are not yet elucidated. (eneuro.org)
By employing mass spectrometry-based proteomics to analyze cerebral organoids, we managed to lớn investigate effects on a large scale & in an unbiased manner, and also gained insight into lớn its molecular mechanisms and biochemical pathways27. (baoninhsunrise.com)

Proteins, glycolipids, and phospholipids make up cellular membranes, which are crucial for protecting and limiting metabolic processes within cells while also preserving cellular integrity and homeostasis. (alliedacademies.org)
Most membrane proteins are less abundant and more hydrophobic than typical soluble proteins, which makes study of these proteins more challenging. (alliedacademies.org)
The sample preparation, which includes the enrichment and dissolution of the membrane proteins, is crucial for the successful identification of membrane proteins. (alliedacademies.org)
The enrichment of low-abundance membrane proteins at membrane and/or protein levels and the dissolution of hydrophobic membrane proteins have both been accomplished using a variety of established and recently developed techniques. (alliedacademies.org)
Transmembrane proteins are water insoluble, which makes them difficult to study using mass spectrometry and conventional biochemical methods, but not impossible (MS). In this review, we emphasise the importance of shotgun MS for hastening the discovery and investigation of membrane proteins. (alliedacademies.org)
Undoubtedly, the under-representation of membrane proteins in large-scale proteomic datasets is due to the relatively low abundance of these proteins in un-fractionated samples. (alliedacademies.org)
A significant rise in the representation of PM proteins in large-scale data sets has been attributed to a number of recent technological developments, including enhanced sample preparation, equipment, and liquid chromatographic (LC) performance [ 1 ]. (alliedacademies.org)
Even though the majority of membrane proteins cannot be accessed using conventional sample preparation methods, this is a subject that is very important to our discussion and has already been well reviewed. (alliedacademies.org)
This is necessary in order to completely characterise membrane proteins. (alliedacademies.org)
A significant advancement would be the identification of a comprehensive catalogue of membrane proteins, which might give a comprehensive overview of all the proteins at the PM [ 2 ]. (alliedacademies.org)
The hydrophobicity, intricate post-translational modifications (PTMs), and low quantity of membrane proteins make it difficult to analyse them. (alliedacademies.org)
The identification of membrane proteins is now more accurate than in earlier analyses due to improved instrument performance, making it possible to analyse complicated protein mixtures in greater detail. (alliedacademies.org)
With the commercial availability of column ovens, raising the temperature from degrees during micro LC has recently been demonstrated to increase the amount of membrane proteins detected in a typical analysis and should become standard practise. (alliedacademies.org)
however, neurotransmitters can also be released via reverse transport through membrane transport proteins. (cpsase-signal.com)
Notably, elamipretide not only provided protective effects against mitochondrial dysfunction and oxidative stress but also facilitated the regulation of brain-derived neurotrophic factor (BDNF) signaling, including the reversal of important synaptic-signaling proteins and increased synaptic structural complexity. (biomedcentral.com)

We recorded extracellular field potentials from the primary visual cortex (V1) of head-fixed awake FHM1 knock-in ( n = 12) and wild type ( n = 12) mice in response to square-wave gratings with different visual contrasts. (biomedcentral.com)

Spectral analysis of the local field potentials revealed an increase in the β/low γ range of WT mice following the abrupt reversal of contrast gratings. (biomedcentral.com)

Here, we investigate the projection from the primary somatosensory cortex (S1), which encodes the sensory pain information, to the anterior cingulate cortex (ACC), a key area for processing pain affect, in freely behaving rats. (iasp-pain.org)

Although the dendritic arborization of granule cells is relatively small (50-200 μm) ( Shepherd and Greer, 1998 ), a single granule cell may receive synaptic inputs from mitral cells several millimeters away ( Shepherd and Greer, 1998 ), providing a theoretical basis for massive synaptic divergence. (jneurosci.org)

Although correlations are strongly attenuated when proceeding from membrane potentials to action potentials (spikes), the resulting weak correlations in the spike output can cause substantial fluctuations in the population activity, even in highly diluted networks. (mit.edu)
2021. Inhibitory noise decreases membrane potential fluctuations and may lead to increased firing regularity. (tomasbarta.cz)

Furthermore, a similar effect can be achieved by adjusting synaptic transmission delays between the two populations. (kth.se)
In order to investigate the elementary processes of synaptic signal transmission in close cooperation with molecular biologists, Sakmann moved his laboratory from Göttingen, where he had been collaborating with Erwin Neher for sixteen years, to Heidelberg, one of the best molecular biology centers in Germany. (healing-waves.com)
The expression and function of NRP-1 and its specific protective mechanism were investigated by Western Blot, immunofluorescence staining, flow cytometry, magnetic resonance imaging, transmission electron microscopy, etc. (biomedcentral.com)

Some potential benefits of tDCS include improved cognitive function, enhanced motor learning, and reduced symptoms of depression and chronic pain. (neuroelectrics.com)

In this study, we designed an experiment to characterize the effects of multiple pulse stimulation and proposed a computational model that considers electrostimulation of fibers and synaptic effects in a multiscale model. (frontiersin.org)
Therefore, the planned research group aims to characterize the role of TSPO as a diagnostic and therapeutic target from structural biology over neurology to psychiatry and to delineate the potential of TSPO ligands as a novel therapeutic approach within the nervous system. (uni-regensburg.de)

Correlations between the neck geometry and the amplitude of synaptic potentials and calcium transients evoked by 2-photon glutamate uncaging were also investigated. (frontiersin.org)

Intraburst firing frequency and duration are heterogeneous among MCs and increase with membrane depolarization. (eneuro.org)
Using dendritic and somatic whole-cell and cell-attached recordings in rat hippocampal slices, we found that the anticonvulsant lamotrigine selectively reduced action potential firing from dendritic depolarization, while minimally affecting firing at the soma. (hmamedicalclinic.com)

The rapid transfer of signals between nerve and muscle cells occurs through the alteration of the electrical potential of the cell membrane. (healing-waves.com)
The potential is altered by sodium, potassium, calcium or chloride ions, which establish a gradient across the cell membrane, passing through the membrane. (healing-waves.com)
After numerous futile experiments and constant improvements, Neher and Sakmann finally succeeded in 1976 to measure the ionic current of single channels in the cell membrane of a muscle fiber. (healing-waves.com)
A glass pipette with a tip diameter of only one thousandth millimeter is pressed gently on the cell membrane. (healing-waves.com)
Thereby, the acidified milieu after arterial occlusion most probably influences the activity of acid-sensing ion channels as well as the cell membrane potential. (biomedcentral.com)

S, 2007 In normal rat kidney (NRK) fibroblasts the excitable membrane exhibits action potentials caused by an intracellular, IP3-mediated calcium oscillation (CaO). (jesuscortes.info)

The determination of the plasma membrane (PM) proteome, resolution of membrane protein topology, establishment of numerous receptor protein complexes, identification of ligand-receptor pairs, and elucidation of signalling networks originating at the PM have all benefited from recent developments in proteomic mass spectrometry. (alliedacademies.org)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

The central nervous system receives somatosensory information from different receptors and peripheral nerve fibers, which are integrated by synaptic processes. (frontiersin.org)
Our model overcomes some limitations of the kinetic ones and, to our knowledge, represents the first model of synaptic processes based on process calculi. (biomedcentral.com)
We therefore set out where to buy eldepryl in charleston to test their hypotheses regarding how ecological processes drive network topology. (dannymillsfoundation.com)

In general, each neuron consists of a somatic cellular body, on which a variable number of thin elongated structures, called dendrites, converge and from which a long single structure, called axon, emerges, branching in several synaptic terminals. (biomedcentral.com)

2. A slow (0.5-4 Hz) membrane potential oscillation was observed in thalamocortical cells recorded in motor, sensory, associational and intralaminar thalamic nuclei. (researchgate.net)

We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)

As altered responsivity to visual stimuli and abnormal processing of visual sensory information are common hallmarks of migraine, herein we investigated the effects of FHM1-driven synaptic alterations in the visual cortex of awake mice. (biomedcentral.com)

Buzsaki G, Anastassiou CA, Koch C. Local Field Potentials Primarily Reflect Inhibitory Neuron Activity in Motor Learning. (dannymillsfoundation.com)

In mouse, RGC dendritic stratification in the ON and OFF layers of the inner plexiform layer matures after eye opening 5 and light-driven activity guides the refinement of synaptic connectivity 6 , 7 . (biorxiv.org)

The opening of ion channels located in the spine, local capacitive charging of the spine head, and the electrical resistance of the neck could potentially shape the amplitude, time course, and spatial spread of synaptic potentials. (frontiersin.org)
FHM1 mice displayed similar amplitude but slower temporal evolution of visual evoked potentials. (biomedcentral.com)

Our work suggests that the stability of persistent states to perturbation is set by glial activity, and that how the response to such perturbations decays or grows may be a critical factor in a variety of disparate transient phenomena such as working memory, burst firing in neonatal brain or spinal cord, up states, seizures, and perhaps spreading depression. (yale.edu)

It has been studied as a potential treatment for a range of neurological and psychiatric disorders, including depression, chronic pain, and stroke. (neuroelectrics.com)
Synaptic depression and multi-scale phenomena. (jesuscortes.info)

Within the cell, TSPO is predominantly located in mitochondria, specifically in the outer mitochondrial membrane. (uni-regensburg.de)
Consequently, alleviating mitochondrial oxidative stress and protecting mitochondrial function provides a potential method for the treatment of these diseases. (biomedcentral.com)

8. These results demonstrate that the majority of thalamocortical neurones are endowed with electrophysiological properties allowing them to oscillate at 0.5-4 Hz, if they have a membrane potential more negative than -65 mV and a high input resistance. (researchgate.net)

Chavez M, Besserve M, Verschure PF, Logothetis NK, Panzeri S. Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave-Ripples. (dannymillsfoundation.com)

We show that GrCs in fact generate diverse response patterns to current injection and synaptic activation, ranging from adaptation to acceleration of firing. (nature.com)
These findings raise the possibility that the pattern of interneuronal activation, and thus lateral inhibition onto principal cells, is not regulated predominately by dendrodendritic synaptic inputs but instead may reflect the temporal coincidence of several types of synaptic inputs to granule cells. (jneurosci.org)
This study further characterized the activation of small fibers and clarified the synaptic effects, demonstrating the importance of waveform selection. (frontiersin.org)
HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)

The model demonstrates that dopamine is in general a significant diminisher of trial-by-trial variability, but that its efficacy depends on the properties of synaptic input. (kth.se)

Importantly, at individual AZs, scaffold size is found to scale with the propensity to engage in action potential-evoked release. (sdbonline.org)
The oscillation did not depend upon the occurrence of fast action potentials and did not outlast the imposed hyperpolarization. (researchgate.net)

These allow both the phenomena investigated to be precisely modeled and virtual experiments to be performed in silico . (biomedcentral.com)

Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)

Area A will delineate the diagnostic potential of TSPO imaging by means of positron emission tomography (PET) in brain tumors in vivo and will enable the complementary characterization of brain tissue in vitro to delineate the neurobiological characteristics underlying TSPO PET labeling in the human brain. (uni-regensburg.de)

With this method, the ionic current is measured on a tiny membrane patch to which a predetermined voltage-clamp is applied. (healing-waves.com)
Patch clamp apparatus with which Sakmann and Neher were able to measure the ionic current through single membrane channels in 1976. (healing-waves.com)

Consequently, elamipretide may have a therapeutic potential in preventing damage from the oxidative stress and neuroinflammation that contribute to perioperative neurocognitive disorders (PND), which makes mitochondria a potential target for treatment strategies for PND. (biomedcentral.com)
We review in-depth important medicinal plants that have been already investigated for therapeutic uses against AD, focusing on a diversity of pharmacological actions. (j-alz.com)

The method can be used for automated detection of chemical/post- translational modifications, quality control of experiments and labelling approaches, and to control the modification settings of protein identification tools. (lu.se)

Quantifying the difference between human recordings and network simulations, I provide the set of parameters for which the model produces the greatest correspondence with experimental results. (kth.se)

To better understand membrane protein structure, protein-protein interactions, and signalling networks that emerge from the membrane surface, we briefly discuss recent MS developments to determine the entire membrane proteome. (alliedacademies.org)
Utilizing our previous interactome perturbation predictor, we identify a set of missense variants that are likely disruptive to protein-protein interactions. (springer.com)
Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)

Anatomy49

Organisms19

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes57

Disciplines and Occupations4

Technology, Industry, Agriculture5

Information Science4

Health Care1

Plasticity15

Inhibitory synaptic2

Fast synaptic1

Excitatory8

Synapses8

Neurons14

Currents2

Subthreshold membrane1

Cortical7

Neural13

Post-synaptic2

Postsynaptic2

Neuronal3

Excitation1

Olfactory bulb1

Oscillations3

Presynaptic1

Mechanisms3

Proteins15

Extracellular1

Contrast1

Primary somato1

Mitral cells1

Fluctuations2

Transmission3

Cognitive1

Characterize2

Correlations1

Depolarization2

Cell membrane5

Intracellular1

Plasma membrane2

Processes3

Cellular1

Thalamic1

Functional1

Alterations1

Neuron1

Dendritic1

Amplitude2

Activity1

Depression2

Mitochondrial2

Thalamocortical1

Hippocampal1

Activation4

Efficacy1

Action2

Phenomena1

Patterns1

Vivo1

Ionic2

Therapeutic2

Modification1

Parameters1

Interactions3