Investigate structure activity relationship. Medical search. Frequent questions

Antibacterial activity was evaluated by the radial diffusion assay (RDA) and absorbance methods. (hindawi.com)
The rank order potency of these analogs was equivalent to that of the pharmacological activity of LTB4 agonists in the PMN chemotaxis assay. (aspetjournals.org)
Moreover, simulation docking of Cur with the HA structure revealed that Cur binds to the region constituting sialic acid anchoring residues, supporting the results obtained by the inhibition of HA activity assay. (greenmedinfo.com)
We used the Porsolt swim test to assess antidepressant-like activity and locomotor activity assay to test for psychostimulant effects. (erowid.org)

Thus, the present study reports nanoscale quantitative structure-activity relationship (nano-QSAR) models, which are based on an ensemble learning approach, for predicting the cytotoxicity of heavy metals adsorbed on nano-TiO 2 to human renal cortex proximal tubule epithelial (HK-2) cells. (beilstein-journals.org)
Of these areas, SAR/quantitative structure-activity relation- ship (QSAR) studies and their implication for contact allergy have been frequently reviewed over the years and will therefore not be scrutinized in detail. (cdc.gov)

The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target. (rcsb.org)

In this study, 22 phenolic compounds were investigated to inhibit the angiotensin-converting enzyme (ACE). (ugent.be)
QSAR analysis confirmed that the numbers of hydroxyl groups on the benzene ring play an important role for activity of phenolic compounds and that substitution of hydroxyl groups by methoxy groups decreased activity. (ugent.be)
Other compounds, such as resveratrol and pyrogallol, may inhibit ACE via interactions with amino acids at the active site, thereby blocking the catalytic activity of ACE. (ugent.be)
These structure function relationships are useful for designing new ACE inhibitors and potential blood-pressure-lowering compounds based on phenolic compounds. (ugent.be)
Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships," JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , vol. 61, no. 48, pp. 11832-11839, 2013. (ugent.be)
Those empirical descriptors are easily calculated from the molecular structure and can be quickly generated for large data sets of compounds. (int-conf-chem-structures.org)
5] After excluding inorganic and organometallic compounds, salts, duplicates, and structures not accepted by PETRA 3.11, [2] the remaining 548 structures were partitioned into a training and a test set with 445 and 103 objects respectively. (int-conf-chem-structures.org)
however, the antimitotic activity of these compounds does not always correlate with stabilization of MTs in cells. (cardiff.ac.uk)
To investigate how structural modifications to aminopropiophenones affect antidepressant or stimulant activity, we synthesized several analogs of bupropion and methcathinone and tested the new compounds for antidepressant-like or psychostimulant effects. (erowid.org)
Some compounds, including bupropion, increased locomotor activity at moderate-to-high doses. (erowid.org)
The effect of changing the metal in S-based dithiocarbamate compounds on biological activity was also investigated. (monash.edu)
To study the biological activity of ruthenium(II) p-cymene (pcy) complexes, seven new compounds with the general formula {[Ru(pcy)L]2} were successfully synthesised and the structure of four of these compounds were characterised by X-ray crystallography. (monash.edu)
Most of the investigated compounds are semisynthetic derivatives prepared by the condensation of the natural product damsin (1) with aldehydes. (lu.se)
This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)

The purpose of this study is to perform a structure-activity relationship study on both the mosquito biting deterrency and mosquito toxicity of synthetic analogs of callicarpenal. (usda.gov)
The agonist activities of several LTB4 analogs were employed to investigate the structure-activity relationships of LTB4 receptor-mediated activation of phosphatidylinositol hydrolysis. (aspetjournals.org)
To investigate the structure-activity relationship of L-755,807 for amyloid-β aggregation inhibitory activity, L-755,807 analogs were synthesized and biologically evaluated. (heterocycles.jp)
The binding of these analogs to thrombin was investigated at pH 8 by FRET and UV/Vis-absorption spectroscopy. (unipd.it)

Thereby, several important structure-activity relationships for high potency or selectivity were found. (logos-verlag.de)
10). Structure-activity relationships that may explain the observed differences in potency and selectivity are discussed. (lu.se)

Area B will provide information on the structure and function of the TSPO molecule in response to TSPO ligands and within its multimeric complex by biophysical methods in order to unravel further molecular mechanisms of TSPO signaling and to give further input for TSPO ligand drug development. (uni-regensburg.de)
The aim of this research was to extend structure-activity relationships of Cu2+-Phen complexes containing sterically functionalized pendant carboxylates and to investigate how synthetic extension of the ligated phenazine ligand within this complex model influences DNA recognition and oxidative degradation. (dcu.ie)
Therefore, NT may function as an energy acceptor in resonance energy transfer (FRET) studies for investigating ligand protein interactions. (unipd.it)
Our results indicate that the incorporation of NT can be effectively used to detect protein protein interactions with sensitivity in the low nanomolar range, to uncover subtle structural features at the ligand protein interface, and to obtain reliable Kd values for structure activity relationship studies. (unipd.it)

We investigated the mechanism of action (MOA) of selected candidates, and identified druglike EBOV inhibitors with good in vitro ADME properties. (sbir.gov)
We identified potent allosteric inhibitors of IRE1α endonuclease activity that bound to the kinase site on the enzyme. (rcsb.org)
Prisecaru, Andreea (2015) Metallodrugs as inducers and inhibitors of chemical nuclease activity. (dcu.ie)
In this study, a multiparameter optimization (MPO) approach, molecular modeling, and structure-activity relationships (SARs) were employed for the identification of new benzimidazole derivatives as potent competitive inhibitors of cruzain with trypanocidal activity and suitable pharmacokinetics. (bvsalud.org)

The antioxidant activities of the extracts were evaluated using Folin-Ciocalteau, oxygen radical absorbance capacity (ORAC), DPPH free radical scavenging, and total radical trapping antioxidant parameter (TRAP) assays. (nih.gov)
Characterization and quantification of polymer-protein binding relationships were established using fluorescence quenching assays. (umass.edu)
New assays to investigate competition of polymer-cargo complexes by intracellular proteins were introduced and revealed that competition of xii polymer-cargo is influenced by initial binding strength. (umass.edu)

The best drug loading (% entrapment efficiency = 90.2%), the fastest release rate (% release = 88.2%), and the best antibacterial activity were observed in ratio 10:30 of vancomycin:SPNs. (hindawi.com)

The synthesis of bismuth(III) sulfidocarboxylate complexes was investigated using a range of bismuth precursors. (monash.edu)

This study aimed to investigate the antimicrobial activity of vancomycin-loaded soy protein nanoparticles (vancomycin-SPNs). (hindawi.com)
In the present study, structural modifications were performed on callicarpenal in an effort to understand the functional groups necessary for maintaining and/or increasing its activity and to possibly lead to more effective insect control agents. (usda.gov)
In the present study, we adopted MO calculations to investigate interactions between FMs and eight DNA hexamers with sequences such as AAAAAA, TTTTTT, AAATTT, TTTAAA, ATATAT, TATATA, GGGGGG and CCCCCC. (int-conf-chem-structures.org)
For this purpose, this study enhances its empirical validity by collecting data from 214 respondents in South Korea and testing the hypothesis using structure equation modelling. (researchgate.net)
In this study, we investigate, for the first time, the use of pairwise-relationships between resting-state independent spatial maps to characterize individuals. (biorxiv.org)
In this study we further investigated the relationship between cochlear compound action potential threshold loss, cochlear outer and inner hair cell loss, and central hyperactivity in inferior colliculus of guinea pigs. (edu.au)
Modulatory effects of polycyclic aromatic hydrocarbons on the mutagenicity of 1-nitropyrene: a structure-activity relationship study. (cdc.gov)
This study of healthy and schizophrenic patients investigated the differential effects of childhood adversity on brain volume and structure, and its association with the ability to recognize emotions. (medscape.com)
This EEG study demonstrated that class activity and class time is reflected in adolescents' real-world brain state, suggesting that mid-morning may be the best time to learn. (medscape.com)
This fMRI study aimed to advance our understanding of the development of aggression in children by investigating the relevance of personality traits and their neural correlates. (medscape.com)
In the present study, we investigated the organization of microzones within the C3 zone and their activity during a skilled forelimb reaching task in cats. (lu.se)

Conclusion: Molecular and pharmacophore modelling methods allowed us to create a new group of substituted cinnamoyl derivatives of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1-(2H)-one oxime with anticonvulsant activity. (eurekaselect.com)
Multiparametric Structure-Activity Relationships were investigated using a set of 277 derivatives. (bvsalud.org)

The overall goal is to understand the structure-property relationship of these polymers and to develop practical industrial applications. (hofstra.edu)
These synthetic polymers non-covalently bind to cargo, offering a mechanism to deliver proteins in a way that does not alter protein secondary structure. (umass.edu)
These polymers were further investigated for their self-assembly properties. (umass.edu)

Density functional theory calculations and micro kinetic modeling are employed to elucidate structure-property-activity relationships for carbon dioxide and methane adsorption and activation on complex oxide catalysts with controlled structure, composition, and electronic properties. (aiche.org)
To further elucidate the structure-activity relationship (SAR) and to identify potentially improved MT-stabilizing candidates for neurodegenerative disease, a comprehensive set of 68 triazolopyrimidine congeners bearing structural modifications at C6 and/or C7 was designed, synthesized, and evaluated. (cardiff.ac.uk)

The described setup and experimental design enable real-time monitoring of substrate turnover in light-activated enzymes on a molecular scale, thus opening the pathway to a deeper understanding of enzyme activity and protein-protein interactions. (elifesciences.org)

Several analogues of TAN-2483B that are functionalised at the propenyl sidechain have previously been synthesised in the Harvey group and have shown promising biological activity. (figshare.com)
The aim of this thesis was to investigate the viability of a synthetic route toward lactam analogues of TAN-2483B. (figshare.com)
An alternative route toward lactam analogues of TAN-2483B, via intermediate amines accessed by the substitution of an activated alcohol, was briefly investigated with encouraging results. (figshare.com)
Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity. (greenmedinfo.com)
To search for a stable Cur analogue with potent anti-IAV activity and to investigate the structure contributing to its anti-IAV activity, a comparative analysis of structural and functional analogues of Cur, such as tetrahydrocurcumin (THC) and petasiphenol (Pet), was performed. (greenmedinfo.com)
It should be noted that the structure of Pet and THC differs from Cur with respect to the number of double bonds present in the central seven-carbon chain, and structure modelling of Cur analogues indicates that the conformations of THC and Pet are distinct from that of Cur. (greenmedinfo.com)
These studies expand upon prior understanding of triazolopyrimidine SAR and enabled the identification of novel analogues that, relative to the existing lead, exhibit improved physicochemical properties, MT-stabilizing activity, and pharmacokinetics. (cardiff.ac.uk)
Alteration of cytosine-guanine interactions due to N7 metal cation binding: a structure-activity relationship for cisplatin analogues. (aspetjournals.org)
From this observation a hypothesis is presented for a structure-activity relationship, which is supported by in vivo animal data, that may permit the design of less toxic analogues of the antitumor agent cisplatin. (aspetjournals.org)

The results suggest that a hydrophobic conjugate d carbon chain with a terminal hydrophilic functional group is essential for the potent activity. (heterocycles.jp)
Structure-activity relationship (SAR) studies led to 16 and 18, which were selective in kinase screens and were potent against recombinant IRE1α endonuclease as well as cellular IRE1α. (rcsb.org)

4U79: Crystal structure of human JNK3 in complex with a benzenesulfonamide inhibitor. (rcsb.org)
The first X-ray crystal structure of a kinase inhibitor (16) bound to hIRE1α was obtained. (rcsb.org)

Callicarpenal is currently being investigated by the United States Department of Agriculture's Agricultural Research Service (USDA-ARS) as a possible alternative to commercially available natural and synthetic based insect repellents. (usda.gov)
In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. (logos-verlag.de)

Metal cation binding to N7 of guanine (G) and the resulting altered interaction with cytosine (C) were investigated by ab initio quantum chemical calculations for the ions Li+, Na+, B+, Be2+, and Mg2+. (aspetjournals.org)

The relationship between patents as an intermediate output resulting from R&D inputs has been investigated extensively. (oecd.org)

Flavonols and flavones constitute the main two classes of flavonoids, whose antioxidant properties and high biological activity have been proofed both in vitro and in vivo. (raysahelian.com)
I have been intrigued by the activity of antimicrobial peptides for a long time, due to my interest in biological membranes. (rsc.org)
Furthermore, the discovery of new molecular mechanisms by which small molecules modify DNA structure, reactivity, and biological repair contributes significantly to potential drug development. (dcu.ie)
In addition to the application of developmental metallodrugs as inducers of chemical nuclease activity, the effects of cytotoxic trinuclear platinum(II) complexes as high-affinity DNA binders that inhibit-or block-endonuclease enzyme recognition and excision are reported through a wide variety of biophysical and molecular biological methods. (dcu.ie)
The effect of metal on biological activity was explored against the Leishmania major promastigote and human fibroblasts. (monash.edu)
Although the reactivity of the α-methylene-γ-lactone moiety is important for these effects, the Michael addition is reversible and it can be assumed that also other parts of the molecules will moderate any given biological activity. (lu.se)

Tannic acid showed the highest activity (IC50 = 230 mu M). The IC50 values obtained for phenolic acids and flavonoids ranged between 0.41 and 9.3 mM. (ugent.be)

We then discussed the findings of previous studies that examined pain-related neural activity during meditation. (frontiersin.org)
By thoroughly overviewing previous findings, we hypothesized that meditation reduces pain-related neural activity in the ACC, insula, secondary somatosensory cortex, and thalamus. (frontiersin.org)
We suggest that the characteristics of the modulation of this activity may depend on the kind of meditation and/or number of years of experience of meditation, which were associated with paradoxical findings among previous studies that investigated pain-related neural activities during meditation. (frontiersin.org)
These studies provided evidence of modulation regarding pain-related neural activity during meditation. (frontiersin.org)
However, the characteristics of this modulation were not consistent among these studies, which will be introduced in Section "Neural Activity of Pain Perception during Meditation" in detail. (frontiersin.org)

This narrative review explores the relationship of functional brain network organization to obesity and to eating disorders such as binge eating. (medscape.com)

Dr. Rooney's research interests include investigating the structure-function relationships of metallopeptides and the interactions between peptides and lipid bilayers. (hofstra.edu)
Emotionally Focused Therapy for couples (EFT) is a short-term structured approach based on attachment theory that integrates a humanistic, experiential approach to restructuring emotional experience and a systemic structural approach to restructuring interactions. (unav.edu)
The role of polymer self-assembly was observed to impact not only initial binding interactions with protein cargo, but also internalization and intracellular activity. (umass.edu)

Two weeks after a 10-kHz pure tone acoustic trauma, a tight relationship was demonstrated between the frequency region of compound action potential threshold loss and frequency regions in the inferior colliculus showing hyperactivity. (edu.au)

The regulatory influence of the rhodopsin domain on the enzyme activity is only partially understood and holds the key for a deeper understanding of intra-molecular signaling pathways. (elifesciences.org)
PEPD gene mutations that cause prolidase deficiency result in the loss of prolidase enzyme activity. (medlineplus.gov)

The project takes its point of departure in the gap in the previous graffiti research in relation to the existence of plural structures of meaning through which subcultural action, spatiality, identities, and style are negotiated, thus enabling different subcultural authenticities and activities. (lu.se)
Neurons from individual microzones had characteristic patterns of activity during movement, indicating that function is organized in relation to microcomplexes. (lu.se)

The antibacterial activities were investigated against various Gram-negative and Gram-positive foodborne pathogens. (nih.gov)

Indeed, even though satisfaction is considered a significant predictor of loyalty in all marketing literature, the path was inconclusive, as the relationship between CSR and satisfaction was very weak, whereas the majority of researchers [28, 29, 81] found a direct relationship between CSR and customer satisfaction, which surprisingly contradicts those of previous studies. (researchgate.net)

We will begin with an overview of the history of Venetian medical practice and then move to an evaluation of the molecules of medicine at a molecular level with an activity I have already developed entitled "Organic Molecules and Medicine. (univiu.org)
After synthesising a range of mercaptocarboxylic acids, the chemistry and structure-activity relationship of these molecules with bismuth, ruthenium and rhenium was explored. (monash.edu)

abstract = "Acoustic trauma caused by exposure to a very loud sound increases spontaneous activity in central auditory structures such as the inferior colliculus. (edu.au)
Abstract: The cerebellum is the largest sensorimotor structure in the brain. (lu.se)

These results suggest that IRE1α activity is not essential for viability in most tumor cell lines, in vitro, and that interfering with the survival functions of the UPR may not be an effective strategy to block tumorigenesis. (rcsb.org)

The structure of spiking activity in cortical networks has important implications for how the brain ultimately codes sensory signals. (springeropen.com)

Dr. Lefurgy's research focuses on the problem of bacterial antibiotic resistance - a major public health threat - by examining the structure and function of beta-lactamases. (hofstra.edu)
All major research-funding agencies have geared substantial parts of their funds towards supporting activities under this concept. (lu.se)
In the research presented here, the social approach was used to investigate workers' representation of the risks they are exposed to in their professional activity. (bvsalud.org)
Some of our main research activities are driven by questions, such as the following: 1) Is it possible to reduce the uncertainties in our estimates of vegetation productivity and ecosystem respiration by combining in situ, EO and dynamic vegetation modelling methods? (lu.se)
EOF@Lund (Entrepreneurship, Ownership and Finance) is a research group financed by Tetra Laval (TetraPak) donation (15,000,000 SEK - 1,400,000 EUR) that explores the role of ownership in entrepreneurial firms and its impact on the way in which firms finance their activities. (lu.se)
Mr Kalyan Pasumarthy (PhD student - his research investigates the role of business angels groups in financing entrepreneurial firms). (lu.se)

It was verified that access to technical information (which depends on the position occupied by the worker in the company structure) and the way that the relationship between company and workers is established (which is directly linked to the work organization) were the more relevant aspects in the construction of representations. (bvsalud.org)

Our results support the hypothesis that the cerebellar C3 zone is organized and operates within a microzonal frame of reference, with a specific relationship between the sensory input to each microzone and its motor output. (lu.se)

that is, random forest, AdaBoost, Gradient Boost, and Extreme Gradient Boost were constructed and utilized to establish statistically significant relationships between the structural properties of NPs and the cause of cytotoxicity. (beilstein-journals.org)

The interaction between DNA and a fluorescent material has been investigated for a long time. (int-conf-chem-structures.org)
Collectively, structure-activity relationship analyses indicate that the presence of the double bonds in the central seven-carbon chain enhanced the Cur -dependent anti-IAV activity and also that Cur might interfere with IAV entry by its interaction with the receptor binding region of viral HA protein. (greenmedinfo.com)

Consistent with their genetic divergence, bat-associated influenza A surface proteins lack typical hemagglutination and neuraminidase activities ( 6 ), leading to the terminology HA-like (HL) and neuraminidase-like (NL) for bat-associated influenza surface proteins. (cdc.gov)
Marie Skepö (PI), has in collaboration with Lise Arleth and Kresten Lindorff-Larsen at University of Copenhagen, and Jens Preben Morth at University of Oslo, been awarded 6.8 MNOK for studying the structure of membrane proteins under solution conditions. (lu.se)
The aim is to understand how the lipid environment influences the activity of membrane proteins, using the active transporter MgtA as benchmark system, and to investigate the dynamic fluctuations between lipid and protein in solution, utilising neutron and X-ray scattering in combination with computer simulations. (lu.se)
To reveal static and dynamic properties of intrinsically disordered proteins (IDPs) to provide a deeper understanding of the mechanism of action and the static as well as dynamic structure-function relationship. (lu.se)
Expert systems containing information about the relationship between the chemical structure and the ability of chemicals to haptenate proteins are available. (cdc.gov)

The body's ability to differentiate between even subtle differences in molecular structure, such as the different actions in the human body of a pair of enantiomers, will be explored, and students will gain a basic understanding of functional groups. (univiu.org)

Structure activity relationships were investigated among the primary alcohols with carbon chain lengths from 1 to 10. (cdc.gov)

No prior knowledge of chemistry is required, as students will learn the basics of organic structure and stereochemistry through this and other inquiry-guided, team-based activities. (univiu.org)
In our scientific activity at the Division of Physical Chemistry 1 we find it essential to establish long-term goals and policies that are based on an unbiased analysis of the specific situation, rather than an uncritical following of the current trends. (lu.se)

Reduced brain activity and functional connectivity during creative idea generation in individuals with smartphone addiction. (medscape.com)

The IC50 values were found to depend strongly on the overall structure. (lu.se)

Individuals can be characterized in a population according to their brain measurements and activity, given the inter-subject variability in brain anatomy, structure-function relationships, or life experience. (biorxiv.org)
In the 19th and 20th century, cases of individuals with brain injury, such as Phineas Gage or Henry Molaison, have advanced our understanding of the relationship between the anatomy of the brain and its function. (lifeboat.com)

It has been investigated for the treatment of age-related cognitive decline. (wikipedia.org)
Now, cognitive neuroscientists have some ability to visualize and measure activity of the whole brain at once, as well as the computational tools to investigate complex network-level relationships between brain structure, brain function, and behavior. (lifeboat.com)

The data indicate that phenyl ring substitution or branched alkylamines can shift the psychopharmacological profile of aminopropiophenones from stimulant activity to antidepressant-like activity. (erowid.org)

Then all the bonds of one molecule are submitted to the trained SOM, and the pattern of activated neurons is interpreted as a map of the reactivity features of that molecule (MOLMAP) a fingerprint of the bonds available in that structure. (int-conf-chem-structures.org)

Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. (springeropen.com)
Differences in the psychoactive effects of these two drugs result from small variations in their chemical structures, but the relationship between chemical structure and psychoactivity has not been characterized. (erowid.org)

Back then, methods were limited to investigate whole-brain structure and function. (lifeboat.com)
2019). Understanding the relationship between brain structure and function in health and disease is therefore essential to develop appropriate treatments. (lifeboat.com)

Our results suggest that the circle was defined by posts set in individual pits, and that a central pit, perhaps enclosed within a structure, was filled with burned soil. (ohiohistory.org)
The results suggest a major contribution of pranthocyanidins and flavan-3-ols to the antioxidative activities of the extracts. (nih.gov)
The results are expected to constitute a significant step towards deciphering the structure-function relationship of IDPs, which is vital for developing the next generations of pharmaceuticals, such as antibiotics, i.e., antimicrobial peptides. (lu.se)
The Office also made a mid-year report to the Director-General highlighting the results of its activities and calling attention to specific risks. (who.int)
It is unclear how absence of prolidase activity results in the other features of prolidase deficiency. (medlineplus.gov)
Taken together, these describe what the Ministry wants to do (or the results we want), how we will do it (or the activities we will implement), and how we will know if we have succeeded (or how we will monitor progress). (who.int)

The purpose of this project is to investigate the relationship between graffiti writing, participants' use of urban space, and their reactions to measures by the authorities to decrease illegal graffiti. (lu.se)

Reagents capable of cutting DNA are applied within these fields as probes for DNA structure and function, with the ultimate aim being the design of target-specific-customised endonucleases-capable of modifying genomic DNA. (dcu.ie)

Antimicrobial peptides have long been hailed as a solution to the antibiotic resistance crisis, because they target the bacterial membrane and can cause quick bactericidal activity in bacterial cells. (rsc.org)

The Strategic Plan emphasises the importance of relationships, partnerships and inter-sectoral coordination and collaboration to the effective delivery of the plan. (who.int)

The organizational structure and the corresponding business functions, together with a risk assessment process that includes both objective and subjective factors, continue to be the cornerstone of the Office's approach to its activities. (who.int)

However, correlations of the protein binding-delivery relationship or the role of polymer-protein complexation on intracellular activity of protein cargo are understudied. (umass.edu)

It is important to investigate and publicize sites like these before they totally disappear. (ohiohistory.org)

Organisms1

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes16

Disciplines and Occupations3

Information Science2

Assay4

Quantitative2

Anticancer1

Compounds14

Analogs4

Selectivity2

Ligand4

Inhibitors4

Assays3

Ratio 101

Synthesis1

Study11

Derivatives2

Polymers3

Elucidate2

Protein-protein inte1

Analogues9

Potent2

Inhibitor2

Synthetic2

Calculations1

Extensively1

Biological6

Phenolic1

Neural5

Explores the relationship1

Interactions3

Compound1

Enzyme activity2

Relation2

Antibacterial1

Studies1

Molecules2

Abstract2

Viability1

Cortical1

Research6

Organization1

Hypothesis1

Structural1

Interaction2

Proteins5

Molecular structure1

Carbon1

Chemistry2

Functional1

IC501

Anatomy2

Cognitive2

Substitution1

Molecule1

Chemical2

Brain structure2

Results6

Participants1

Function1

Membrane1

Effective1

Approach1

Role1

Important1