Investigate hsp90 heat shock proteins. Medical search. Frequent questions

The contents of Cd in the testis, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) production, messenger RNA (m RNA) levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), protein expressions of heat shock proteins (HSPs) (HSP60, HSP70, and HSP90), and the histopathological changes of the testis were determined. (greenmedinfo.com)
The results indicated that ABP improved Cd-caused testicular tissue damageby increasing the SOD and GSH-Px activities: decreasing the Cd accumulation and MDA content, mRNA levels of TNF-α, IL-1β, and IL-6, and protein expressions of HSP60, HSP70, and HSP90. (greenmedinfo.com)
To examine whether exposure to a 2.45 GHz electromagnetic field modifies the level of the heat shock proteins Hsp70 and Hsp90 and damages the morphological structure in the thyroid gland as well as to investigate whether apoptosis occurs. (emf-portal.org)
In the present study, we investigated the potential role and association of HSP70-2 with breast cancer. (biomedcentral.com)
Further, we studied the effect of HSP70-2 protein ablation on signaling cascades involved in apoptosis, cell cycle and Epithelial-Mesenchymal-Transition both in culture as well as in-vivo human breast xenograft mouse model. (biomedcentral.com)
However, the clinical relevance and association of HSP70-2 expression in IDC specimens have not been investigated so far. (biomedcentral.com)
In the present study, we have investigated the possible association of HSP70-2 mRNA and protein expression with various stages, grades and histotypes of breast cancer patients. (biomedcentral.com)
This study aimed to investigate the expression and prognostic significance of highly stress-inducible HSP70 in OSCC. (biomedcentral.com)
Dietary Se, VE and Se + VE significantly enhanced the activities and mRNA levels of catalase as well as superoxide dismutase (SOD) but decreased the mRNA levels of HSP70 and HSP90 . (springeropen.com)
Stress inducible proteins like HSP70 work as molecular chaperons that safe guard cells and organisms as they keep cellular proteins in a competent folding condition to prevent the aggregation of irreversible proteins and help in the refolding of proteins damaged by the stress (Gabriel et al. (springeropen.com)
Aiming at identifying the mechanism of low salinity tolerance, quantitative real-time PCR was employed to investigate the expression profiles of 4 HSP genes ( HSP60 , HSP70 , HSP90-1 , HSP90-2 ) in the hepatopancreas of wild (WG) and screened (SG) groups of P. trituberculatus exposed to low salinity (4 ppt). (geneticsmr.com)
The results showed that 3 of the candidate genes ( HSP60 , HSP70 , HSP90 - 1 ) exhibited similarly downregulated expression profiles in the first 3 h (P HSP90-2 gene was upregulated during the first 6 h for the WG, and during the first 12 h for the SG, after which it became downregulated. (geneticsmr.com)
The steroids on the market etiology of AAS dependence is a matter of growing public health importance, since individuals action, in the absence of ligand, nuclear receptors are associated with the heat-shock proteins Hsp70 and Hsp90. (showyou.com)
Pertinent to AD pathophysiology, heat shock protein 90 (HSP90)/co-chaperone complex folds tau or hyperphosphorylated tau, whereas heat shock protein 70-carboxyl-terminus of HSP70 Interacting protein (HSP70-CHIP) complex mediates degradation 13 , 14 . (nature.com)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)

However, there are also special proteins, called Heat Shock Proteins (HSPs) that dampen the effect of hyperthermia. (shtc-erasmusmc.nl)
Heat shock family of proteins (HSPs) is proposed to play pivotal role in breast tumor development owing to their intrinsic molecular chaperone properties [ 5 ]. (biomedcentral.com)
Heat shock proteins (HSPs) play a role in tumor antigenicity. (biomedcentral.com)
Another approach in predicting prognosis in cancer is expression of heat shock proteins (HSPs). (biomedcentral.com)
Usually, HSPs are expressed at low levels, and under normal physiological conditions, many members of the HSP family are involved in protein synthesis. (biomedcentral.com)
2001 ). While the main role of HSPs is to prevent and reverse the damage to proteins, the antioxidant enzymes decrease oxidation and prevent oxidative damage. (springeropen.com)
Keywords: AUY922 Clinical trial HSP90 Japanese Phase I Intro Heat-shock proteins (HSPs) are molecular chaperones that assist in the structural formation folding and activation of a wide variety of oncogenic client proteins involved in varied cellular processes such as apoptosis proliferation transmission transduction and transcription control [1-4]. (pkc-inhibitor.com)
Heat shock proteins (HSPs) are highly conserved and immunogenic proteins that are shared among diverse groups of mammals and microbial agents. (eg.net)

It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs. (wikipedia.org)
Crystal structures are available for the N-terminal domain of yeast and human Hsp90, for complexes of the N-terminus with inhibitors and nucleotides, and for the middle domain of yeast Hsp90. (wikipedia.org)
inhibitors that block a protein called heat shock protein 90 (Hsp90). (ki.se)
We have developed an innovative method for finding substances that can prevent aging and we identify Hsp90 inhibitors as new and promising candidate substances," says Christian Riedel. (ki.se)
Hsp90 inhibitors are already being tested for other treatment purposes, and now further studies are needed to investigate their effect on human ageing. (ki.se)
We discovered that a novel, genetically definable mixed subgroup spanning both triple-negative breast cancer and ovarian cancer is vulnerable to treatment with heat shock protein 90 (HSP90) inhibitors. (turningthetideovarianretreat.com)
HSP90 inhibitors have been investigated as potential anti-cancer drugs for many years in clinical trials guided by organ site, but tumor response rates have been low. (turningthetideovarianretreat.com)
Future steps include a clinical study using the genetic signature to determine whether it predicts sensitivity to HSP90 inhibitors. (turningthetideovarianretreat.com)
Current research will investigate whether tumor cells in mice are indeed more sensitive to irradiation or chemotherapy during hyperthermia when HSP inhibitors are used. (shtc-erasmusmc.nl)
This research, using HSP inhibitors will investigate the effect and optimize the combination therapies. (shtc-erasmusmc.nl)
These processes are significantly affected by HSP90 inhibition and therefore HSP90 inhibitors are considered to have a strong restorative Delphinidin chloride potential in a wide variety of tumor types [5]. (pkc-inhibitor.com)
Indeed HSP90 inhibitors degrade a variety of oncogenic client Delphinidin chloride proteins [6-8]. (pkc-inhibitor.com)
In addition HSP90 inhibitors display synergy with numerous chemotherapeutic providers in murine tumor models and sensitize tumor cells to their cytotoxic effects [6-8]. (pkc-inhibitor.com)

Hu Y, Bobb D, He J, Hill DA and Dome JS: The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma. (spandidos-publications.com)
Overexpression of the most conserved region of the TM2D proteins acts as a potent inhibitor of Notch signaling at the Î³-secretase cleavage step. (bvsalud.org)
Moreover we examine the role of a monoclonal antibody (mAb) against HSP90, mAb 4C5, regarding these interactions and its value as a potential inhibitor of human breast cancer cell invasion and metastasis. (biomedcentral.com)
Here we investigate the biologic significance of Hsp90 inhibition in multiple myeloma (MM) and other hemato- logic tumors using an orally available novel small molecule inhibitor SNX-2112, which exhibits unique activities relative to 17- allyamino-17-demethoxy- geldanamycin (17- AAG). (kl.ac.at)
Mittels Echtzeit-Proliferations-Assays untersuchten wir die Wirkung von Triciribine, einem AKT-Inhibitor, und IPI504, ein Inhibitor von HSP90, auf drei verschiedene gastroenteropankreatische neuroendokrine Tumorzelllinien. (fu-berlin.de)
We therefore examined the potency of triciribine, an AKT inhibitor, and IPI504, a HSP90 inhibitor, in three distinct neuroendocrine gastrointestinal tumor cell lines, using real- time cell proliferation assays. (fu-berlin.de)
AUY922 is a potent non-geldanamycin inhibitor of heat-shock protein 90. (pkc-inhibitor.com)

However, during aging and disease the Hsp90 chaperone network becomes highly imbalanced with some Hsp90/co-chaperone complexes increasing, while others are repressed. (usf.edu)
This imbalance in Hsp90/co-chaperone complexes could result in a worsening of tau pathology in Alzheimer's disease. (usf.edu)
Upon phosphorylation, R-SMADs recruit the co-SMAD SMAD-4 to form protein complexes that translocate into the nucleus and exhibit transcriptional activity. (springer.com)
Extracellular CLU-client protein complexes are susceptible to endocytic clearance by monocytes and hepatocytes, and this action is thought to form a central plank in the operation of a co-ordinated system to maintain extracellular protein homeostasis (proteostasis) [ 14 ]. (biomedcentral.com)

Heat-shock protein 90 (Hsp90) acts as a molecular chaperone required for maintain- ing the conformational stability of client proteins regulating cell proliferation, sur- vival, and apoptosis. (kl.ac.at)
The heat shock protein 90 kDa (Hsp90) chaperone network is highly involved in modulating client proteins, including tau. (usf.edu)
These client proteins include human being epidermal growth element receptor 2 (HER2) estrogen receptor epidermal growth element receptor platelet-derived growth element receptor vascular endothelial growth element AKT c-KIT and c-MET [1 2 HSP90 is the most abundant molecular chaperone and is essential for cell survival proliferation and apoptosis. (pkc-inhibitor.com)

The objective of this study was to investigate the mechanism of heat shock protein 90 alpha (Hsp90α) protection against heart damage resulting from heat stress by detecting Hsp90α mRNA, Hsp90α protein, protein localization, and cell damage in primary myocardial cells of neonatal rats in response to heat stress in vitro. (geneticsmr.org)
Hsp90α levels decreased between 10 and 60 min of heat stress and increased after 360 and 480 min, while Hsp90α mRNA decreased after 360 min. (geneticsmr.org)
The study was carried out to investigate the effect of dietary selenium (Se) and vitamin E (VE) supplementation on mRNA level of heat shock proteins, selenoproteins, and antioxidant enzyme activities in the breast meat of broilers under summer heat stress conditions. (springeropen.com)

As a molecular chaperone, HSP90 regulates the conformational maturation and functional stability of many signaling proteins in cells, serves important roles in cell growth, differentiation, apoptosis and tumor development and is an important antitumor target ( 8 , 9 ). (spandidos-publications.com)
Also, we investigated the induction of apoptosis and effects on a broad range of cancer-associated gene products. (fu-berlin.de)

MAb 4C5, while not affecting the secretion of inactive MMPs, inhibits their activation by disrupting their interaction extracellularly with both isoforms of HSP90. (biomedcentral.com)
Additionally, we have reported results showing that a monoclonal antibody (mAb) recognizing both the α and the β isoforms of HSP90, mAb 4C5, inhibits melanoma cell invasion and metastasis by binding selectively to the surface pool of HSP90 [ 13 ]. (biomedcentral.com)
Our results indicate that blockade of Hsp90 by SNX-2112 not only inhibits MM cell growth but also acts in the bone marrow microenvi- ronment to block angiogenesis and oste- oclastogenesis. (kl.ac.at)
A substance that inhibits that activity of the Hsp90 heat shock protein. (hsp90-inhibitors.com)

In this study we found that Aha1 enhanced Hsp90-mediated tau aggregation and increased insoluble tau accumulation in vitro. (usf.edu)
In their defense, bacteria activate a chaperone, Hsp33, which protects the proteins against bleach-induced protein unfolding and aggregation and helps bacteria survive. (asbmb.org)
We have examined in this study whether or not increased expression of clusterin is able to protect neuronal cells against intracellular protein aggregation and cytotoxicity, characteristics that are strongly implicated in a range of neurodegenerative diseases. (biomedcentral.com)
We used the amyotrophic lateral sclerosis-associated protein TDP-43 as a primary model to investigate the effects of clusterin on protein aggregation and neurotoxicity in complementary in vitro, neuronal cell and Drosophila systems. (biomedcentral.com)

Firstly, the expression of HSP90α in osteoclast differentiation was detected by western blotting in vitro, then the effect of HSP90α inhibition on the formation and differentiation of osteoclasts was examined. (spandidos-publications.com)
A series of tailored novobiocin-ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. (ru.ac.za)
Nck-associated protein 1 (NAP1/NCKAP1), a protein that associates with the Src homology 3 (SH3) domain of NCK protein both in vitro and in intact cells, was found to localize along the lamellipodia and to mediate contact-dependent cell migration [ 4 ]. (biomedcentral.com)

Inhibition of HSP90α could block the formation and differentiation of osteoclasts, and remit osteoporosis in mice. (spandidos-publications.com)
Regarding the underlying mechanism, inhibition of HSP90α could block the nuclear import of PPARγ to inhibit osteoclast differentiation and proliferation. (spandidos-publications.com)
In conclusion, these data indicated that the inhibition of HSP90α could block osteoclast formation and remit osteoporosis by reducing the nuclear import of PPARγ. (spandidos-publications.com)
Inhibition of HSP90β expression improved neurological deficits and alleviated brain injury by increasing EAAT2 expression. (spandidos-publications.com)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
Thus, our data show that inhibition of the AKT-pathway as well as inhibition of HSP90 potently reduces the growth of GEP- NET cells alone or in combination therapies. (fu-berlin.de)

The N-terminal domain shows homology not only among members of the Hsp90 chaperone family but also to members of the ATPase/kinase GHKL (Gyrase, Hsp90, Histidine Kinase, MutL) superfamily. (wikipedia.org)
One co-chaperone that has the potential to become a therapeutic target for tauopathies is the activator of Hsp90 ATPase homolog 1 (Aha1). (usf.edu)
Aha1 is the only known stimulator of the ATPase of Hsp90, so targeting this particular co-chaperone could potentially mimic the effects of Hsp90 inhibition with more specificity. (usf.edu)

In mammalian cells, there are two or more genes encoding cytosolic Hsp90 homologues, with the human Hsp90α showing 85% sequence identity to Hsp90β. (wikipedia.org)
The five functional human genes encoding Hsp90 protein isoforms are listed below: There are 12 human pseudogenes (non-functional genes) that encode additional Hsp90 isoforms that are not expressed as proteins. (wikipedia.org)
TM2 domain containing (TM2D) proteins are conserved in metazoans and encoded by three separate genes in each model organism species that has been sequenced. (bvsalud.org)
Using bioinformatics analyses, we predicted HNK protein targets from several databases and retrieved the genes differentially expressed in mBCSCs from the GEO database. (hindawi.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Among these, 17.5% had putative functions in signaling, 14.3% were assigned to cell cycle and gene expression, 8.7% were linked to the cytoskeleton or inner membrane complex, 7.9% were involved in proteostasis and 6.4% in metabolism, 12.7% were cell surface-associated proteins, 11.9% were assigned to other functions, and 20.6% represented genes of unknown function. (biomedcentral.com)
For 40% of the identified genes there has as yet not been any protein evidence. (biomedcentral.com)
For selected genes, a regulated expression during gametogenesis was confirmed on the protein level, using quantitative confocal microscopy. (biomedcentral.com)

Increasing data reveal an extracellular chaperoning activity for HSP90. (biomedcentral.com)
Finally, we have presented data indicating that surface HSP90 interacts specifically with the extracellular domain of HER-2 and that this interaction which is necessary for the receptor's activation leading to breast cancer cell invasion, is disrupted by mAb 4C5 [ 14 ]. (biomedcentral.com)
Although extracellular Hsp90 (eHsp90) action is not well defined, eHsp90 targeting attenuates tumor invasion and metastasis, supporting its unique role in tumor progression. (oncotarget.com)

Hsp90 co-chaperones are currently being investigated for as potential therapeutic targets for tauopathies, with the hope that targeting co-chaperones will lead to more specific targeting without toxicity. (usf.edu)
The ability of neurons to manage the burden of misfolded proteins and to resist their accumulation into insoluble protein deposits depends critically on the functioning of molecular chaperones. (biomedcentral.com)
HSP90) and induction of chaperones promoting tau degradation (e.g. (nature.com)
This 90 kDa heat-shock protein is a part of the highly conserved family of proteins that are well characterized for their function as chaperones. (bmglabtech.com)

The time scale of these dynamic modes depends on the conformational state of the Hsp90 dimer. (lu.se)
Altogether, this data is best described by fast molecule-spanning dynamics, which precede larger conformational changes in Hsp90 and might be the molecular basis for allostery. (lu.se)

Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells. (biomedcentral.com)

As a result, in the process of osteoclast differentiation and proliferation, the expression of HSP90α was upregulated. (spandidos-publications.com)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
Lentivirus construction and injection were used to interfere with the expression of HSP90β. (spandidos-publications.com)
Immunofluorescence was used to detect HSP90β expression localization and the expression levels of HSP90β and EAAT2 were determined using western blotting and reverse transcription‑quantitative PCR. (spandidos-publications.com)
HSP90β expression coincided with astrocyte markers in the ischemic penumbra area, while no expression was observed in microglia. (spandidos-publications.com)
This is known to lead to the expression of so-called chaperone proteins that improve the animals' ability to keep their proteins correctly folded and thus in a functional state throughout their lifetime. (ki.se)
Auch hat die vermehrte Expression von HSP90 in Tumoren eine wichtige prognostische Bedeutung. (fu-berlin.de)
The effects of an imidazoline compound (BL11282) on protein expression in rat pancreatic islets were investigated with a proteomic approach. (researchgate.net)
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients. (biomedcentral.com)
In contrast, the expression profile of the HSP90-2 gene was upregulated during the first 6 h for the WG, and during the first 12 h for the SG, after which it became downregulated. (geneticsmr.com)
HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)
This is accomplished by increasing both the interaction strength and number of interactions among participant proteins, which is not necessarily accompanied by a change in expression levels. (nature.com)
Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOSSer1177) and AktSer473, and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice. (edu.hk)

It is one of the most abundant cytoplasmic proteins in unstressed cells, where it performs housekeeping functions, controlling the activity, intracellular disposition and proteolytic turnover of a variety of proteins. (biomedcentral.com)
Endoplasmic reticulum stress (ERS) is a state induced by increased synthesis of intracellular proteins, accumulation of mal-folded proteins, changes in cytosolic calcium levels, or imbalances in endoplasmic reticulum (ER) redox homeostasis [ 8 ]. (biomedcentral.com)
These result in imbalances in the connectivity of neuronal circuitry, and also negatively impact the intracellular connectivity of neuronal proteins and protein pathways, contributing to cognitive decline associated with AD 6 . (nature.com)

Aspirin blocks the effects of the COX enzymes, proteins involved in inflammation and found at unusually high levels in several types of cancer. (canceractive.com)

Here we investigate the interaction of the secreted isoforms of HSP90 with matrix metalloproteinases (MMP) MMP2 and MMP9. (biomedcentral.com)
Both isoforms of HSP90 are secreted by MDAMB453 cells and interact with MMP2 and MMP9. (biomedcentral.com)
The heat shock protein 90 (HSP90) is a molecular chaperone which exists in mammalian cells in two isoforms that share 86% aminoacid conservation (HSP90α and HSP90β). (biomedcentral.com)

Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. (wikipedia.org)
However, when cells are heated, the fraction of heat shock proteins increases to 4-6% of cellular proteins. (wikipedia.org)

We have just completed a study on the osmotic induction of stress proteins in nemertean, Paranemertes peregrina . (weber.edu)

Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90). (ru.ac.za)

A membrane-associated variant of cytosolic Hsp90, lacking an ATP-binding site, has recently been identified and was named Hsp90N. (wikipedia.org)

Hsp90 forms homodimers where the contact sites are localized within the C-terminus in the open conformation of the dimer. (wikipedia.org)
Heat shock protein (HSP) 90 is abundant in cells, mainly in the form of homodimers, including HSP90α and HSP90β. (spandidos-publications.com)

Finally, the inhibitory effect of HSP90α in vivo was explored, using a mouse model of osteoporosis. (spandidos-publications.com)
We also assessed the potency of AKT- and HSP90 inhibition to slow tumor growth in vivo, by using the chick chorioallantoic membrane assay. (fu-berlin.de)

Aspartate aminotransferase, lactate dehydrogenase, and creatine kinase enzyme levels were elevated during heat stress, and acute cellular lesions that were characterized by vacuolar degeneration and necrosis were observed. (geneticsmr.org)

In this study, conducted during 2013-2014, we investigated 21 mammalian Lagenidium strains and compared them with L. giganteum isolates used for mosquito control. (cdc.gov)

Recently structures for full length Hsp90 from E. coli (2IOP, 2IOQ), yeast (2CG9, 2CGE), and the dog endoplasmic reticulum (2O1U, 2O1V) were elucidated. (wikipedia.org)
Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)

MAb 4C5 prevents MMP2 and MMP9 activation, by disrupting their interaction with HSP90. (biomedcentral.com)
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis. (biomedcentral.com)

What we figured out is that bleach works as a really potent protein-denaturing agent, essentially boiling bacterial proteins at room temperature. (asbmb.org)
Background We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). (bmj.com)

Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. (wikipedia.org)
PROTACs are small, readily designed molecules that target unwanted proteins to the cell's ubiquitin-proteasome system for degradation. (bmglabtech.com)

This protein was first isolated by extracting proteins from cells stressed by heating, dehydrating or by other means, all of which caused the cell's proteins to begin to denature. (wikipedia.org)

Whilst CLU is predominantly a secreted protein, multiple independent studies have now clearly established that during conditions of ER stress, CLU secretion is inhibited, and full-length CLU exits the secretory system to enter the cytosol. (biomedcentral.com)
The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)

Whereas cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions. (wikipedia.org)
These results indicate that heat stress might induce irreversible damage in certain myocardial cells. (geneticsmr.org)
The elevated Hsp90α level at the end of heat stress and its positive signal in the cytoplasm of myocardial cells after heat stress could be associated with its protective role. (geneticsmr.org)
Overall results showed that Se in combination with VE has maximal effects to mitigate heat stress. (springeropen.com)
Based on given results it can be recommended that Se + VE are a suitable dietary supplement for broilers to ameliorate the negative effects of summer heat stress conditions. (springeropen.com)
Heat stress affects the performance of the birds (Gregory 2010 ). (springeropen.com)
Previous studies showed that meat productivity decreased in chronic heat stress conditions (Hashizawa et al. (springeropen.com)
2014 ). The heat stress induced changes (biochemical as well as physiological) potentially enhances the formation of reactive oxygen species (ROS) (Mujahid et al. (springeropen.com)
2006 ). Broilers kept under acute heat stress manifested more than a twofold increase in malondialdehyde content of breast meat, which is a secondary product of lipid oxidation (Mujahid et al. (springeropen.com)
However, if the stress on the ER is chronic or severe and quality control of protein folding cannot be met, ER activates its stress receptor, the unfolded protein response, which triggers programmed cell death [ 9 ]. (biomedcentral.com)
Nitration of Hsp90 induces cell death " describes how nitration as a result of oxidative stress can turn a normally helpful protein into a toxic protein. (bmglabtech.com)

HSP90-1 and HSP90-2 were highly expressed at 12 h after low salinity challenge in the SG, but not the WG. (geneticsmr.com)

Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition. (ru.ac.za)

These mutations in receptors or protein kinases can stimulate a complex cascade of cross signalling pathways such as the RAS-RAF-MEK-ERK or MAPK, PI3K-AKT-mTOR or JAK-STAT pathways ( Figure 2 ) ( 3 , 4 , 7 , 18 , 20 ). (amegroups.org)

If this holds true for such heavily mined targets as Hsp90 (and kinases, as discussed previously ) it should be even more true for newer classes of targets. (blogspot.com)

Being a cytoplasmic protein requires that the protein be globular in structure, that is largely non-polar on the inside and polar on the outside, so as to be dissolved by water. (wikipedia.org)

Hsp90 is also found extracellularly, particularly in tumor models. (oncotarget.com)

In addition, Mg2+ and several water molecules form bridging electrostatic and hydrogen bonding interactions, respectively, between Hsp90 and ATP. (wikipedia.org)
Protein-protein interactions were determined by immunoprecipitation. (biomedcentral.com)
Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)

5 Since changes in de novo protein synthesis are the basis for glucocorticoid effectiveness, the lack of a modulatory effect on platelet functions is not surprising given that these cells have been regarded as incapable of synthetic activity. (ashpublications.org)

Both, AKT- and HSP90 inhibition significantly suppressed growth in different neuroendocrine cell lines. (fu-berlin.de)

The aim of the present study was to investigate the role of HSP90α involved in the regulation of osteoclast formation and the process of osteoporosis. (spandidos-publications.com)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
An experimental mouse model was generated to investigate the gene regulation in tumor growth and metastasis. (biomedcentral.com)
The mechanism may be, at least partly, attributed to enhancement of PI3K/HSP90/eNOS/Akt cascade, reduction in plasma resistin level, down-regulation of PTEN and slight modification of oxidative state. (edu.hk)
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

This HSP90α-Δ-N transcript is a chimera, with the first 105 bp of the coding sequence derived from the CD47 gene on chromosome 3q13.2, and the remaining coding sequence derived from HSP90AA1. (wikipedia.org)

Overall, this work highlights Aha1 as an important regulator of tau pathology through Hsp90. (usf.edu)

pathogenic to mammals have been published ( 3 , 4 ), their taxonomic relationship to Lagenidium strains approved for biological control and the capacity of their zoospores to infect mosquitoes have yet to be investigated ( 5 , 6 ). (cdc.gov)
While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. (frontiersin.org)

In this blog post you will get an overview of the available protein assays. (bmglabtech.com)

The emergence of heat-tolerant strains of L. giganteum pathogenic to lower animals and humans is of environmental and public health concern. (cdc.gov)

We herein investigated the potential role of eHsp90 as a modulator of cancer stem-like cells (CSCs) in prostate cancer (PCa). (oncotarget.com)
The aim of this study was to investigate the protective role of Agaricus blazei polysaccharide (ABP) against Cd-induced damage in chicken testis through enhancing antioxidant activity and alleviating inflammatory response. (greenmedinfo.com)
In the past, our research group has investigated the role of hormones in the reproductive life history stages for crabs, ribbon worms, and the red backed salamanders. (weber.edu)
The tau protein plays a role in many neurological diseases and disorders. (bmglabtech.com)

Das Hitzeschockprotein 90 (HSP90) ist ein wichtiger Regulator von AKT. (fu-berlin.de)
The Heat shock protein 90 (Hsp90) is an important regulator of AKT-activity. (fu-berlin.de)
Our previous studies further demonstrated that NAP1 is required for the protein stability of WASF3 in breast cancer cells, implicating that NAP1 is a critical regulator in favor of breast cancer metastasis [ 5 ]. (biomedcentral.com)

The Hsp90/Aha1 complex could provide a novel therapeutic target for the treatment of tauopathies. (usf.edu)

The microtubule associated protein, tau, is involved in regulating microtubule stability and axonal transport. (usf.edu)

These included (i) temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis and (ii) post-transfusion disappearance of a subset of monocytes characterized by hyperactivated Interferon responses and decreased TNF-α signaling. (frontiersin.org)
We find that disease resolution was associated with temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis. (frontiersin.org)

thus, these species' evolutionary traits need to be investigated ( 1 - 7 ). (cdc.gov)

Hsp90 is found in bacteria and all branches of eukarya, but it is apparently absent in archaea. (wikipedia.org)
An MCAO model was successfully established and it was found that HSP90β, but not HSP90α, was upregulated after MCAO. (spandidos-publications.com)
We were wondering how bacteria defend themselves against bleach, and in 2008, we found that they produce a protein that gets specially activated in response to bleach and then protects the bacteria from it. (asbmb.org)

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Phenomena and Processes64

Disciplines and Occupations2

Information Science4

Health Care4

Hsp7015

HSPs8

Inhibitors13

Inhibitor7

Complexes4

Client proteins3

MRNA3

Apoptosis2

Inhibits4

Aggregation4

Vitro3

Inhibition of HSP906

ATPase3

Genes8

Extracellular3

Chaperones4

Conformational2

Invasion and metastasis1

Expression13

Intracellular3

Enzymes1

Isoforms3

Cellular proteins2

Induction1

Inhibitory effects1

Cytosolic1

Homodimers2

Vivo2

Necrosis1

Mammalian1

Endoplasmic reticulum2

Interaction2

Potent2

Functional1

Degradation2

Cell's1

Secretory2

Stress11

Highly expressed1

Anticancer1

Signalling pathways1

Kinases1

Cytoplasmic1

Extracellularly1

Interactions3

Synthesis1

Significantly1

Regulation6

Gene1

Pathology1

Biological2

Assays1

Strains1

Role4

Regulator3

Novel therapeutic target1

Stability1

Homeostasis2

Species1

Found3