Invasive pneumococcal disease among adults. Medical search. Frequent questions

Two types of pneumococcal vaccines are cur- polysaccharide vaccine (PPSV23) because its effective- rently available for adults: the 23-valent pneumo- ness differs according to serotype. (cdc.gov)
Neither indirect protection through use of 13-valent and 10-valent pneumococcal conjugate vaccines (PCV13 and PCV10) in pediatric National Immunization Programs (NIPs) nor direct vaccination with the 23-valent polysaccharide vaccine have eliminated vaccine serotype invasive pneumococcal disease (IPD) in older adults . (bvsalud.org)
Vaccinating older adults with higher-valency PCV15 and PCV20 could address remaining IPD due to pediatric PCV serotypes plus additional IPD due to serotypes included in these vaccines . (bvsalud.org)
Two pneumococcal vaccines (13-valent pneumococcal conjugate vaccine [PCV13] and 23-valent pneumococcal polysaccharide vaccine [PPSV23]) were recommended for use in adults, and the recommendations varied by age- and risk-groups. (cdc.gov)
The ACIP Pneumococcal Vaccines Work Group reviewed available data to inform the use of PCV20 in adults and identify policy options that maximize pneumococcal disease prevention among adults, reduce disparity, and simplify recommendations to improve vaccine uptake. (cdc.gov)
Recommendations for use of pneumococcal vaccines varied by conditions. (cdc.gov)
On October 20, 2021, the Advisory Committee on Immunization Practices (ACIP) simplified adult pneumococcal vaccination recommendations across age and risk groups, now including people 19-64 years who have any of a broader group of chronic medical conditions and incorporating use of either 20-valent (PCV20) or 15-valent (PCV15) pneumococcal conjugate vaccines (PCV). (ihs.gov)
However, because "there are more than 90 pneumococcal strains and current vaccines protect against only a minority, it is very important to continue monitoring trends in pneumococcal diseases," Dr Griffin said. (medscape.com)
Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. (biospace.com)
Vaxcyte, Inc. (Nasdaq: PCVX), a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, today announced financial results for the third quarter ended September 30, 2023 and provided a business update. (biospace.com)
Vaxcyte, Inc. (Nasdaq: PCVX), a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, today announced that Company management will participate in a fireside chat at the 2023 Cantor Fitzgerald Global Healthcare Conference in New York on Tuesday, September 26, 2023 at 11:40 a.m. (biospace.com)
Currently available PCVs are safe and efficacious and the increased number of serotypes present in these vaccines, compared to the first licensed PCV7, represent significant progress in the fight against pneumococcal morbidity and mortality, in particular from a developing country perspective. (who.int)
For more than 100 years, Merck has contributed to the discovery and development of novel medicines and vaccines to combat infectious diseases. (merck.com)
For over 130 years, Merck, known as MSD outside of the United States and Canada, has been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases in pursuit of our mission to save and improve lives. (merck.com)
Pneumococcal vaccines help protect against some of the more than 90 types of pneumococcal bacteria. (infectioncontroltoday.com)
For more than a century, Merck inventors have developed vaccines that help tackle some of society's biggest public health challenges, and that heritage is reflected today in our pneumococcal vaccine portfolio," said Dr. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories. (merck.com)
Pneumonia vaccines help prevent invasive pneumococcal diseases. (medicalnewstoday.com)
Our investigational vaccine, Prevenar 13, builds on the scientific foundation of Prevenar and is designed to provide more comprehensive protection against pneumococcal disease, says Emilio A. Emini, Ph.D., Executive Vice President, Vaccines Research and Development, Wyeth Pharmaceuticals. (science20.com)
Based on recent programs to control pneumococcal diseases, experts show that targeted action can assist in preventing ill health and in controlling antibiotic resistance at the same time, when associating the judicious use of antibiotics with prevention in the form of key vaccines. (euractiv.com)
Paolo Bonanni of the University of Florence (Italy) added, "Given the effectiveness of key pneumococcal conjugate vaccines, there is a need to enhance access to preventive medicine like these vaccines for all European citizens. (euractiv.com)
Whilst effective pneumococcal conjugate vaccines are not the only solution, when used in association with the judicious use of antibiotics, we have seen positive results. (euractiv.com)
Should pneumococcal vaccines be used to prevent LRTI? (ers-education.org)
Pneumococcal conjugate vaccines (PCVs), which were primarily developed for vaccination of infants under 2 years of age, have significantly decreased invasive pneumococcal diseases worldwide in all age groups by herd protection effects [ 5 , 6 ]. (ersjournals.com)
However, PCV10 held the smallest market share of only 8% of pneumococcal vaccines in Germany in 2018 [ 10 ]. (ersjournals.com)
Vaccines are directed against many of the serotypes that cause disease. (merckmanuals.com)
For a summary of changes to the 2023 adult immunization schedule, including new recommendations for the use of PCV15 and PCV20 in people who previously received pneumococcal vaccines, see the Advisory Committee on Immunization Practices Recommended Adult Immunization Schedule, United States, 2023: Changes to the 2023 Adult Immunization Schedule . (merckmanuals.com)
There are 2 types of pneumococcal vaccines: conjugate and polysaccharide. (merckmanuals.com)
Prior to the introduction of pneumococcal vaccines into the Australian immunization schedule, 83%-85% of IPD cases in children aged less than 14 years and 69% of IPD cases in adults aged more than 65 years in the state of New South Wales (NSW) could be attributed to the seven serotypes found in the 7-valent pneumococcal conjugate vaccine (7vPCV) ( Box 1 ). (who.int)
it is now included in the 13-, 15-, and 20-valent pneumococcal conjugate vaccines. (msdmanuals.com)
Additional infection-causing serotypes have been included in the updated 15- and 20-valent pneumococcal conjugate vaccines. (msdmanuals.com)
In Ontario, pneumococcal vaccines are given in infancy, in older adults and those at increased risk of the disease. (publichealthontario.ca)
Only 14 patients lived longer than their life expectancy, indicating the importance of immunization of adults with pneumococcal vaccines as well as the pernicious severity of IPD. (wvresearch.org)
3 The emergence of multi-drug resistant pneumococci has been an important reason for the development of new pneumococcal vaccines. (health.gov.au)
The rate of invasive pneumococcal disease (IPD) in children too old to be vaccinated (≈1.5 - 10 years old) fell by 33% over a five-year period following the introduction of PCV-10 vaccines in Finland. (immunizationevidence.org)
Vaccines are available to help protect against the strains that cause most disease. (immunisationcoalition.org.au)
Pneumonia vaccines are recommended for adults and children for a wide range of clinical conditions. (medgadget.com)
Unconjugated as well as conjugated pneumococcal polysaccharide vaccines have been used with success for reducing the rate of pneumococcal infections, especially in adults and children. (medgadget.com)
Over the past few years, several pharmaceutical and biopharmaceuticals have enrolled themselves in evaluating candidates of developing pneumococcal conjugate vaccines. (medgadget.com)
The high risk of mortality of invasive pneumococcal diseases has spurred research pertaining to this patient cohort, thereby unlocking new prospects in the pneumonia vaccines market. (medgadget.com)
This aside, increasing trend of antibiotic resistance has spurred research in pneumococcal vaccines that can cover against wide range of pneumococci antigens. (medgadget.com)
Particularly, progress made in development of vaccines for the development of invasive pneumococcal diseases has also reinforced lucrative avenues to vaccine manufacturers. (medgadget.com)
Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. (ox.ac.uk)
In some situations, pneumococcal vaccines should also be given to other children and adults. (askapollo.com)
GlobalData believes these latest developments will increase the already fierce competition between Pfizer and Merck as both companies attempt to reach the market first with their latest pneumococcal vaccines. (pharmaceutical-technology.com)
GlobalData expects that although Merck's V114 may beat Pfizer's 20vPnC to market, and currently looks posed to be a strong future player in the lucrative infant population based on its inclusion of the 22F and 33F serotypes, that broader overall serotype coverage of 20vPnC combined with Pfizer's extensive experience and strong reputation in the pneumococcal vaccines space will result in stiff competition. (pharmaceutical-technology.com)
World Pneumonia Day 2018: Pfizer's Future in the Pneumococcal Vaccines Space Looks Bright, November 2018, GDHC2111EI. (pharmaceutical-technology.com)
Which pneumococcal vaccines are recommended in Ireland? (hse.ie)
Pneumococcal conjugate vaccines reduce the rates of nasopharyngeal colonisation by vaccine serotypes, thus decreasing the potential for transmission from vaccinated to unvaccinated persons. (hse.ie)
Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. (mdpi.com)
These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice for pneumococcal diseases, especially for developing countries. (mdpi.com)
Most vaccines that are part of the Swedish child vaccination programme are given as combination vaccines, i.e. vaccines against several diseases are given in the same shot in order to minimize the number of injections. (folkhalsomyndigheten.se)

Distribution of serotypes causing invasive pneumococcal disease in older adults from high-income countries and impact of pediatric and adult vaccination policies. (bvsalud.org)
This report contains updated information regarding a) antimicrobial resistance among pneumococci, b) vaccine effectiveness and cost-effectiveness, c) indications for vaccination, d) guidelines for revaccination, e) strategies for improving delivery of vaccine, and f) development of pneumococcal conjugate vaccine. (cdc.gov)
Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination? (unifi.it)
In order to reduce the burden of disease in adults, adults should be offered a specific vaccination program with highly immunogenic PCV. (unifi.it)
Adults aged 19-64 years with certain chronic diseases and immunocompromising conditions and adults aged ≥65 years who have not previously received any PCV or whose vaccination history is unknown should receive 1 dose of either PCV20 or PCV15. (ihs.gov)
Prevnar (PCV7) was approved for use in the United States in February 2000, and vaccination with Prevnar was recommended for all children younger than two years and for unvaccinated children between 24 and 59 months old who were at high risk for pneumococcal infections. (wikipedia.org)
People with work-related asthma are particularly vulnerable to pneumococcal pneumonia," said NIOSH director John Howard, MD. "Vaccination is the best way to prevent pneumococcal disease, including pneumonia, and CDC recommends that all adults with asthma, whether work-related or not, get the pneumococcal polysaccharide vaccine. (infectioncontroltoday.com)
The Advisory Committee on Immunization Practices recommends a pneumococcal polysaccharide vaccination for all adults 19 through 64 years old with asthma. (infectioncontroltoday.com)
Our study found that the vaccination coverage for pneumococcal disease among adults who have ever worked and have asthma falls short of achieving the coverage public health experts recommend," said Katelynn Dodd, MPH, lead author and an epidemiologist in the Respiratory Health Division, NIOSH. (infectioncontroltoday.com)
Vaccination is the safest, most effective way to protect yourself from getting pneumococcal disease. (infectioncontroltoday.com)
The present data contribute to pneumococcal vaccination public health policies for vulnerable patients, mainly those with comorbidity and the elderly. (bvsalud.org)
She continued by outlining how infant vaccination can limit the spread of disease causing pneumococci within a community - particularly for the antibiotic-resistant pneumococci -- by reducing the likelihood of S. pneumoniae transmission between vaccinated children and other unvaccinated members of the community, such as elderly adults. (euractiv.com)
Economic evaluations of childhood pneumococcal conjugate vaccination - a review (2002-2006) Vaccine 25 (2007) 1355-1367. (euractiv.com)
In adults, the German Standing Committee on Immunization (STIKO) recommends the 23-valent pneumococcal polysaccharide vaccine (PPV23) as routine pneumococcal vaccination for all adults of 60 years and above and for all patients with defined chronic comorbidities predisposing to pneumococcal disease, regardless of age. (ersjournals.com)
For more information, see Pneumococcal Advisory Committee on Immunization Practices Vaccine Recommendations and Centers for Disease Control and Prevention (CDC): Pneumococcal Vaccination . (merckmanuals.com)
For detailed information on administering the pneumococcal vaccine to children see CDC: Pneumococcal Vaccination: Summary of Who and When to Vaccinate and CDC: Child and Adolescent Immunization Schedule by Age ). (merckmanuals.com)
Vaccination can prevent disease for many of the current serotypes. (who.int)
with risk conditions who have not previously received a pneumococcal conjugate vaccine or whose previous vaccination history is unknown. (pharmashots.com)
The condition of adult vaccination is abysmal in the country primarily because of lack of awareness amongst people as well as the doctors. (india4u.com)
While we do not have any conclusive or comprehensive data on vaccination coverage amongst adults, we very often see adult patients coming with infections that could have been easily prevented with vaccination. (india4u.com)
Pneumococcal pneumonia and invasive pneumococcal disease, Influenza, Hepatitis A (and) B, Typhoid, Herpes Zoster, Diphtheria, Tetanus and Human Papillomavirus (HPV) infections are some of the diseases that adults can safeguard themselves against through vaccination. (india4u.com)
National and state surveys show large disparities in pneumococcal vaccination status among Whites, Blacks and Latinos aged ≥ 65. (biomedcentral.com)
The purpose of this study is to determine whether there is any difference in the validity of self-report for pneumococcal vaccination by race/ethnicity that might contribute to the substantial disparities observed in population-level coverage estimates. (biomedcentral.com)
The results of this study suggest that differential self-report error, i.e., summative effect of over-reporting and under-reporting within a race-ethnic group, may contribute to the size and direction of race-ethnic disparities in pneumococcal vaccination observed in surveys. (biomedcentral.com)
Healthy People 2010 Objectives call for ≥ 90% of adults aged ≥ 65 to have had a pneumococcal vaccination [ 3 ], and pneumococcal vaccination of adults in this age group has been made a performance measure for the 2004 Health Plan Employer Data and Information Set (HEDIS) sponsored by the National Committee for Quality Assurance (NCQA). (biomedcentral.com)
National surveys have found that while pneumococcal vaccination coverage has significantly increased over the years, vaccination rates of Black and Hispanic/Latino seniors are 17 to 30 percentage points lower than for Whites [ 4 - 6 ]. (biomedcentral.com)
Estimates of pneumococcal vaccination coverage are based on self-reported information from state (e.g. (biomedcentral.com)
The changing trend in the etiology of bacterial meningitis points to the need to study vaccination programme modifications, such as pneumococcal vaccine for the adult population, especially high-risk groups. (who.int)
Invasive pneumococcal disease in England and Wales: vaccination implications. (ox.ac.uk)
Pneumococcal vaccination is a significant preventive health care measure that reduces the burden of pneumococcal disease substantially in vaccinated people as well as the community. (askapollo.com)
While it is a routine part of childhood immunization schedules across the world, pneumococcal vaccination is also indicated for adults with risk factors for pneumococcal disease or those with severe adverse outcomes should the disease occur. (askapollo.com)
What are the benefits of Pneumococcal Vaccination? (askapollo.com)
Who can get Pneumococcal Vaccination? (askapollo.com)
The CDC advises pneumococcal vaccination for all children below 2 years of age and all adults 65 years or above. (askapollo.com)
Who cannot take Pneumococcal Vaccination? (askapollo.com)
Systematic childhood pneumococcal vaccination reduced the prevalence of community-acquired pneumococcal pneumonia, especially in 2-5 year group. (biomedcentral.com)
Universal vaccination with PCV7 also resulted in a 77% reduction in pneumococcal disease in children aged 1-5 and a 39% reduction in hospitalization of children age under age 2 [ 3 ]. (biomedcentral.com)
This change is being proposed because only 5% of pneumococcal infections in this population are caused by Prevnar 13 serotypes due to the herd immunity resulting from pediatric vaccination. (pharmaceutical-technology.com)
Prevention of disease through vaccination is now more important than ever. (hse.ie)
Direct vaccination of adults might be warranted if geographic regions or subpopulations exist where targeted serotypes persist at higher levels than expected. (amstat.org)
In Sweden, children are offered protection against eleven diseases through the national vaccination programme for children. (folkhalsomyndigheten.se)
In 2022, a vaccination programme against pneumococcal infections for risk groups started. (folkhalsomyndigheten.se)
The vaccination programmes are governed by the Communicable Diseases Act and regulations issued by the Public Health Agency of Sweden. (folkhalsomyndigheten.se)
Starting in 2022, persons with certain underlying diseases will be offered vaccination against invasive pneumococcal infections within a national vaccination programme. (folkhalsomyndigheten.se)

Invasive disease from Streptococcus pneumoniae (pneumococcus) is a major cause of illness and death in the United States, with an estimated 43,500 cases and 5,000 deaths among persons of all ages in 2009 ( 1 ). (cdc.gov)
Streptococcus pneumoniae is a major cause of illness of PPSV23 differs by serotype ( 8 , 9 ), so overall VE and death among adults ( 1 ). (cdc.gov)
Streptococcus pneumoniae (pneumococcus) is a bacterial pathogen that affects children and adults worldwide. (cdc.gov)
Streptococcus pneumoniae (pneumococcus) is a major cause of meningitis, pneumonia, and bacteremia, especially among young children and older adults. (unboundmedicine.com)
Morbidity and mortality weekly report JO - MMWR Morb Mortal Wkly Rep VL - 57 IS - 6 N2 - Streptococcus pneumoniae (pneumococcus) is a major cause of meningitis, pneumonia, and bacteremia, especially among young children and older adults. (unboundmedicine.com)
Pneumococcal conjugate vaccine is a pneumococcal vaccine and a conjugate vaccine used to protect infants, young children, and adults against disease caused by the bacterium Streptococcus pneumoniae (pneumococcus). (wikipedia.org)
Our conversation is based on her investigation of a Streptococcus pneumoniae outbreak in a pediatric psychiatric unit, which appears in CDC's journal, Emerging Infectious Diseases . (cdc.gov)
Mike Miller] In spite of its name, Streptococcus pneumoniae, this organism actually causes a lot of diseases, not just pneumonia. (cdc.gov)
From the nose, Streptococcus pneumoniae can sometimes move into other parts of the body, including the lungs, ears, sinuses, or bloodstream to cause disease. (cdc.gov)
Infections with Streptococcus pneumoniae affect all people, but in particular young children, the elderly, and people with certain medical conditions, such as lung disease and immune system problems, are at higher risk of being infected. (cdc.gov)
Medical facilities prevent outbreaks of Streptococcus pneumoniae and many other diseases using infection control practices, like hand washing and what we call "cough etiquette. (cdc.gov)
Pfizer Inc. (NYSE:PFE) today announced that the U.S. Food and Drug Administration (FDA) accepted for priority review a Biologics License Application (BLA) for its 20-valent pneumococcal conjugate vaccine (20vPnC) candidate, as submitted for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults ages 18 years and older. (pfizer.com)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older. (merck.com)
The global prevalence of pneumococcal disease, an infection caused by bacteria called Streptococcus pneumoniae , is evolving. (merck.com)
Pneumococcal disease is an infection caused by Streptococcus pneumoniae, which can cause many types of illnesses including ear infections, meningitis, and pneumonia. (infectioncontroltoday.com)
Pneumococcal disease is complex and describes a group of illnesses, all caused by the bacterium Streptococcus pneumoniae. (euractiv.com)
Pneumococcal infections are globally the most frequent vaccine-preventable cause of death [ 1 ], and community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae is the main burden of pneumococcal disease in the elderly [ 2 ]. (ersjournals.com)
Invasive pneumococcal disease (IPD) is a serious bacterial infection caused by the bacteria Streptococcus pneumoniae and can result in bacteraemia, meningitis and pneumonia. (who.int)
The bacterium Streptococcus pneumoniae can cause a type of pneumonia called pneumococcal pneumonia. (nih.gov)
Invasive pneumococcal disease (IPD) is caused by the bacteria Streptococcus pneumoniae . (publichealthontario.ca)
This report published in Communicable Diseases Intelligence Volume 26, No 4, December 2002 discusses reported cases in 2001 of infection with Streptococcus pneumoniae, which are responsible for significant morbidity and mortality worldwide, especially in the very young, the elderly and those with predisposing risk factors. (health.gov.au)
Pneumococcal disease is an illness caused by infection with the bacterium ('germ') Streptococcus pneumoniae. (immunisationcoalition.org.au)
The bacteria Streptococcus pneumoniae is responsible for pneumococcal infections causing otitis media, bacteremia, pneumonia, and meningitis. (medgadget.com)
Pneumococcal infections are caused by Streptococcus pneumoniae, a gram-positive, catalase-negative organism commonly referred to as pneumococcus. (medscape.com)
Pneumococcal disease is a severe infection caused by Streptococcus pneumoniae bacteria that spreads from person-to-person through air. (askapollo.com)
Childhood community-acquired pneumonia is most often attributed to Streptococcus pneumoniae , and the greatest incidence of invasive pneumococcal infection (IPD) is observed in children younger than age 2 [ 4 ]. (biomedcentral.com)
Pneumococcal disease is a bacterial infection caused by streptococcus pneumoniae of which there are more than 90 serotypes. (hse.ie)
Over the years streptococcus pneumoniae has become resistant to many medications making the treatment of pneumococcal infections much more difficult. (hse.ie)
Streptococcus pneumoniae is a human pathogen that is responsible for causing pneumonia, otitis media, meningitis, and other infectious diseases. (mdpi.com)
Background: Antimicrobial resistance in Streptococcus pneumoniae has compromised the effectiveness of therapy for pneumococcal diseases and asymptomatic nasopharyngeal carriers play an important role in transmission of resistant strains. (bvsalud.org)

ACIP recommendations for prevention of pneumococcal disease among infants and youths aged ≤18 years using the 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 are published separately ( 3 ). (cdc.gov)
13-valent pneumococcal conjugate vaccine (PCV13). (cdc.gov)
adults with immunocompromising conditions, cochlear implant or CSF leak were recommended to receive a dose of 13-valent pneumococcal polysaccharide vaccine (PCV13) followed by PPSV23 at least 8 weeks later [3]. (cdc.gov)
Introduction of PCV13 in children in 2010 reduced the invasive pneumococcal disease (IPD) incidence due to PCV13-types in both adults with CMC and IC aged 19-64 years (ABCs unpublished data). (cdc.gov)
In the phase 2 study targeting adults aged 60-64 years and the phase 3 studies, geometric mean titer (GMT) was lower among adults receiving PCV20 vs. PCV13 in 12-13/13 shared serotypes. (cdc.gov)
Adults who previously received PCV13 should complete the previously recommended series with PPSV23 (with an interval of one year between doses for adults ≥65 years, or 8 weeks between doses for immunocompromised individuals), or one dose of PCV20 may be used if PPSV23 is not available. (ihs.gov)
Prevnar 13 (PCV13) is produced by the Wyeth subsidiary of Pfizer and it replaces Prevnar (PCV7), the pneumococcal 7-valent conjugate vaccine (PCV7). (wikipedia.org)
PCV10 reduces more disease than PCV7, and PCV13 reduces more disease than PCV10," she said. (medscape.com)
Both PCV7, PCV10 and PCV13 are licensed for active immunization for the prevention of invasive disease, pneumonia and acute otitis media caused by the respective vaccine serotypes of S. pneumoniae in infants and children from 6 weeks to 5 years of age. (who.int)
In addition, PCV13 is licensed for the prevention of pneumococcal disease in adults >50 years of age. (who.int)
Adults only need one dose of PCV13. (medicalnewstoday.com)
Impaired response to 13-valent pneumococcal conjugate vaccine (PCV13) in children with recurrent respiratory infections and chronic cough. (ers-education.org)
For Germany, we have described earlier the distribution of vaccine serotypes covered by the first but no longer available 7-valent pneumococcal conjugate vaccine (PCV7) and the 13-valent conjugate vaccine (PCV13) between 2002 and 2016 in adult patients with CAP enrolled into the prospective multicentre study CAPNETZ [ 8 , 9 ]. (ersjournals.com)
The newer PCV13 vaccine (13-valent pneumococcal conjugate vaccine), known by the brand name Prevnar 13, protects against bacterial pneumonia and other invasive pneumococcal illnesses in children, but the efficacy and most effective dosage in adults is unknown. (nih.gov)
Earlier studies suggest that PCV13 may not induce as strong an immune response in older adults who previously received the PPSV23 vaccine within the past 5 years as in those who have not. (nih.gov)
The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in the childhood immunization program in July 2006, and was replaced by the 13-valent vaccine (PCV13) in 2011. (biomedcentral.com)
GRADE was used to evaluate 13-valent Pneumococcal Conjugate Vaccine (PCV13) for routine use among adults aged ≥65 years. (bvsalud.org)
1] The primary policy question was "Should PCV13 be administered routinely to all adults aged ≥65 years? (bvsalud.org)
Evidence used to evaluate efficacy of PCV13 against IPD and pneumococcal pneumonia was from the randomized placebo-controlled trial (RCT) conducted among approximately 85,000 adults aged ≥65 years in Netherlands (CAPiTA). (bvsalud.org)
Safety of PCV13 was evaluated based on 6 RCTs in immunocompetent adults, compared to PPSV23. (bvsalud.org)
A decline of 50% in notifications of disease caused by the additional serotypes in PCV13 was also observed. (hse.ie)

Indirect vaccine effects (i.e., herd effects) have reduced pneumococcal infections among unvaccinated persons of all ages, including those aged ≥65 years, since introduction of the routine infant 7-valent pneumococcal conjugate vaccine (PCV7) immunization program in 2000 ( 4 ). (cdc.gov)
This vaccine protects against invasive bacteremic disease, although existing data suggest that it is less effective in protecting against other types of pneumococcal infections. (cdc.gov)
Severe pneumococcal infections result from dissemination of bacteria to the bloodstream and the central nervous system. (cdc.gov)
Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. (unifi.it)
Respiratory infections are well known triggers of asthma exacerbations, but their role in stable adult asthma remains unclear. (bmj.com)
Both clinical and experimental evidence suggest an important role for respiratory infections as triggers of asthma attacks in adults and in children. (bmj.com)
In fact, this strategy brings at least a 2-fold decrease in antimicrobial resistance even to bacteria commonly responsible for widespread infections in children and adults," she explained. (euractiv.com)
Pneumococcal disease affects both children and adults, and includes invasive infections such as bacteremia/sepsis and meningitis, as well as pneumonia and acute otitis media. (euractiv.com)
While this vaccine protects against pneumococcal meningitis and bloodstream infections, it is unclear how well it protects against bacterial pneumococcal pneumonia. (nih.gov)
These serotypes cause about 90% of invasive infections in children and 60% in adults. (msdmanuals.com)
Older adults, even those without other disease, tend to have a poor prognosis with pneumococcal infections. (msdmanuals.com)
Damage to the respiratory epithelium by chronic bronchitis or common respiratory viral infections, notably influenza, may predispose to pneumococcal invasion. (msdmanuals.com)
While viruses like the influenza and some bacteria change over time, the immune systems also tend to weaken over time, putting older adults at higher risk of some infections. (india4u.com)
Adults with certain chronic or immuno-compromising conditions are more likely to develop complications if they were to catch these infections. (india4u.com)
Epidemiology of pneumococcal infections in hospitalised adult patients in Lebanon with a highlight on non-invasive disease. (jidc.org)
Clinical signs and symptoms and physical examination findings alone cannot distinguish S pneumoniae disease from infections caused by other pathogens. (medscape.com)
Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. (biomedcentral.com)
The vaccinations that are offered to all children protect against eleven diseases: rotavirus infection, diphtheria, tetanus, whooping cough, polio, infections caused by Haemophilus influenzae type b, measles, mumps, rubella, serious diseases caused by pneumococcus and human papillomavirus (HPV). (folkhalsomyndigheten.se)

This report provides updated recommendations from the Advisory Committee on Immunization Practices (ACIP) for prevention of invasive pneumococcal disease (IPD) (i.e., bacteremia, meningitis, or infection of other normally sterile sites [ 2 ]) through use of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) among all adults aged ≥65 years and those adults aged 19--64 years with underlying medical conditions that put them at greater risk for serious pneumococcal infection. (cdc.gov)
In many whereas invasive pneumococcal disease (IPD), in- countries, the proportion of PCV-covered serotypes cluding meningitis and bacteremia, has severe clinical among adult IPD patients has been decreasing since manifestations with a high case-fatality ratio ( 2 ). (cdc.gov)
Each year in the United States, pneumococcal disease accounts for an estimated 3,000 cases of meningitis, 50,000 cases of bacteremia, 500,000 cases of pneumonia, and 7 million cases of otitis media (1-4). (cdc.gov)
The focus of this report is the prevention of invasive pneumococcal disease (i.e., bacteremia, meningitis, or infection of other normally sterile sites) through the use of pneumococcal polysaccharide vaccine. (cdc.gov)
Black adults have a threefold to fivefold higher overall incidence of bacteremia (49-58 cases per 100,000 population) than whites (5-8). (cdc.gov)
Pneumococcal polysaccharide vaccine (PPV23): this contains containing 23 serotypes of the pneumococcus, which account for 88% of pneumococcal bacteremia disease and cross-react with other types that causes additional 8% of disease. (who.int)
PPSV23 reduces bacteremia by 56 to 81% in adults overall but is less effective in debilitated older people. (merckmanuals.com)

This trend suggests that adults with high-risk conditions might not have benefited as much from the indirect protective effects of childhood PCV7 immunization as persons who are relatively healthy ( 4 ). (cdc.gov)
In Japan, PCV7 was licensed in November 2010, ens Serum Institute, https://en.ssi.dk) after culturing included in the routine immunization program for overnight. (cdc.gov)
Corporate Authors(s) : Centers for Disease Control (U.S.). Immunization Practices Advisory Committee. (cdc.gov)
National Center for Immunization and Respiratory Diseases (U.S.). Division of Bacterial Disases. (cdc.gov)
This report updates the last recommendations by the Advisory Committee on Immunization Practices (ACIP) concerning pneumococcal polysaccharide vaccine (MMWR 1989;38:64-8,73-6). (cdc.gov)
VAXNEUVANCE is indicated in the U.S. for active immunization of adults 18 years of age and older for the prevention of invasive disease caused by the S. pneumoniae serotypes contained in the vaccine. (merck.com)
Hanna Nohynek of the University of Tampere (Finland) explained that there can be a synergy between national programmes to control unnecessary antibiotic use and immunization programs with an effective pneumococcal conjugate vaccine. (euractiv.com)
There have been some reports of the impact of the pneumococcal vaccine since its introduction into the Australian immunization schedule and the potential benefits that may be offered by the 13vPVC. (who.int)
CDC's Advisory Committee on Immunization Practices (ACIP) recommends a single dose of pneumococcal polysaccharide vaccine for all people 65 years and older [ 2 ]. (biomedcentral.com)
Immunization can help protect unimmunized children, adults and the elderly through herd effects. (immunizationevidence.org)
At the end of February 2019, the CDC's Advisory Committee on Immunization Practices (ACIP) plans to meet and has suggested that it may vote on changes following a re-evaluation of the recommendation for Prevnar 13 for all adults ages 65 years or older. (pharmaceutical-technology.com)

Adults who have previously received PPSV23 and have not received a pneumococcal conjugate vaccine may receive one dose of either PCV20 or PCV15 at least one year after their last PPSV23 dose. (ihs.gov)

In ad- Microbiological Testing dition, a few studies have suggested that VE is lower S. pneumoniae isolates were serotyped by using the among older adults, but evidence is limited ( 9 , 14 ). (cdc.gov)
We collected serotype -specific IPD data in older adults (≥65 years in most countries), from national or regional surveillance systems or hospital networks of 33 high- income countries. (bvsalud.org)
PPSV23 policies for older adults were not correlated with lower IPD percentages due to PPSV23 serotypes . (bvsalud.org)
Vaccinating older adults with higher-valency PCVs, especially PCV20, could substantially reduce the remaining IPD burden in high- income countries, regardless of current PCV use in pediatric NIPs and adult PPSV23 policies . (bvsalud.org)
While healthy adults can suffer from pneumococcal disease, patient populations particularly vulnerable to infection include older adults such as those 65 years of age and older, people with HIV, and those with certain chronic health conditions. (merck.com)
V114 consists of pneumococcal polysaccharides from 15 serotypes conjugated to a CRM197 carrier protein and includes serotypes 22F and 33F, which are commonly associated with invasive pneumococcal disease in older adults worldwide and are not contained in the pneumococcal conjugate vaccine currently licensed for use in adults. (merck.com)
Pneumonia is common among children and older adults, but according to the Centers for Disease Control and Prevention (CDC) , people over the age of 65 years are most at risk for serious illness or death. (medicalnewstoday.com)
PCSV23 protects older adults and others who need it against 23 different strains of bacterial pneumonia. (medicalnewstoday.com)
Higher rates of the disease are seen in children less than two years of age, in older adults and in people who are immunosuppressed or have a chronic illness. (who.int)
Researchers plan to see if a higher dose of a pneumococcal vaccine will create a stronger immune response in older adults who received an earlier generation vaccine against pneumonia and other pneumococcal diseases. (nih.gov)
There is also higher risk of transmission amongst older adults than young children. (india4u.com)

If our observations reflect the impact of herd protection, the benefits of the pneumococcal vaccine in the unvaccinated population certainly exceeds our expectations," Dr Jokinen told Medscape Medical News here at the 33rd Annual Meeting of the European Society for Paediatric Infectious Diseases. (medscape.com)
33rd Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID). (medscape.com)
To learn more about Merck's infectious diseases pipeline, visit www.merck.com . (merck.com)
Today, Merck continues to be at the forefront of research to prevent and treat diseases that threaten people and animals - including cancer, infectious diseases such as HIV and Ebola, and emerging animal diseases - as we aspire to be the premier research-intensive biopharmaceutical company in the world. (merck.com)
The Phase 3 data presented at the 27th Annual Meeting of the European Society for Pediatric Infectious Diseases (ESPID) come from seven core studies in the pediatric clinical trial program for Prevenar 13 which were conducted in France, Italy, Poland, Spain and the UK. (science20.com)
The study is funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH. (nih.gov)
The National Institutes of Health (NIH)/Infectious Diseases Society of America/Centers for Disease Control and Prevention (CDC) recommendations described here may differ from ACIP recommendations when the committees interpret data differently or when one guideline has been updated more recently than the other. (hiv.gov)

ACIP recommendations for revaccination with PPSV23 among the adult patient groups at greatest risk for IPD (i.e., persons with functional or anatomic asplenia and persons with immunocompromising conditions) remain unchanged ( 2 ). (cdc.gov)
The pediatric PCV program had limited impact ences in vaccine effectiveness (VE) by serotype and on PPSV23 effectiveness against IPD in adults. (cdc.gov)
Pneumococcal Polysaccharide Vaccine, Japan decline might have changed the effectiveness of microbiologic testing results were available were in- PPSV23 against PPSV23-serotype IPD. (cdc.gov)
effect of pediatric PCV programs on VE of PPSV23 among adults has not been fully established. (cdc.gov)
Title : Updated recommendations for prevention of invasive pneumococcal disease among adults using PPSV23 Personal Author(s) : Nuorti, J. Pekka. (cdc.gov)
Adults with immunocompromising conditions were recommended to receive a second dose of PPSV23 at least 5 years after the first dose [3]. (cdc.gov)
It also seems to confer greater protection against invasive pneumococcal disorders than PPSV23. (merckmanuals.com)
For both adult age groups, the dose of PPSV23 should follow the dose of PCV15 by at least 1 year. (merckmanuals.com)
A minimum interval of 8 weeks between PCV15 and PPSV23 can be considered for adults with an immunocompromising condition, cochlear implant, or cerebrospinal fluid (CSF) leak. (merckmanuals.com)
For the past 30 years, the PPSV23 vaccine (23-valent pneumococcal polysaccharide vaccine), known by the brand name Pneumovax 23, has been the standard protection from invasive pneumococcal disease in adults over 65 years of age. (nih.gov)

and meningitis (infection of the coverings of the brain and spinal cord), as well as non-invasive pneumonia (when pneumococcal disease is confined to the lungs). (merck.com)
Evidence shows this strategy has worked in at least one risk group - young children - in preventing pneumococcal diseases like pneumococcal meningitis, pneumonia or middle ear infection1. (euractiv.com)
IPD occurs when the pneumococcal bacterium invades a normally sterile site (e.g., blood) and can cause pneumonia, sepsis (blood poisoning) and meningitis. (publichealthontario.ca)
Pneumococcal meningitis and pneumococcal septicaemia are both forms of 'Invasive Pneumococcal Disease' (IPD). (immunisationcoalition.org.au)
Invasive pneumococcal disease - particularly septicaemia and meningitis - is a very serious illness. (immunisationcoalition.org.au)
Pneumococcal meningitis is extremely serious and has a high death rate. (immunisationcoalition.org.au)

According to US healthcare claims data, the risk of hospitalized pneumococcal pneumonia among adults aged 18-64 years with CMC was 4-5 times higher and among those with IC was 11-18 times higher than adults without these conditions [4]. (cdc.gov)
Among adults with work-related asthma, pneumococcal vaccine coverage was lowest among Hispanics (36 percent), those without health insurance (39 percent), and adults ages 18 to 44 years (42 percent). (infectioncontroltoday.com)
The overall response rate among adults aged ≥ 65 was 74% for both the 1999 and 2002 surveys, yielding approximately 7,100 respondents each year. (biomedcentral.com)

The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. (unifi.it)
Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. (unifi.it)
Before the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in the United States in 2000, the seven pneumococcal serotypes covered by the vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F) caused 80% of invasive pneumococcal disease (IPD) cases among young children, and the incidence of IPD was relatively stable. (unboundmedicine.com)
In February 2010, Prevnar 13 was approved in the United States to replace Prevnar (PCV7), the pneumococcal 7-valent conjugate vaccine (PCV7). (wikipedia.org)
The Prevnar (PCV7) seven-valent formulation (PCV7) contains serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F, and resulted in a 98% probability of protection against these strains, which caused 80% of the pneumococcal disease in infants in the U.S. PCV7 is no longer produced. (wikipedia.org)
The decrease in this age group can largely be attributed to a 98% decline in Invasive pneumococcal disease (IPD) due to serotypes covered by PCV7 between 2008 and 2016. (hse.ie)

The company is developing its pneumococcal vaccine for treating invasive diseases and otitis media in healthy infant populations. (medgadget.com)

Although the pneumonia shots will not prevent a person from ever getting pneumonia, they may help in reducing cases of invasive pneumococcal diseases. (medicalnewstoday.com)

Chronic lower respiratory disease, primarily COPD, is the third leading cause of death in the United States and the fourth leading cause of death worldwide, although it may become the fourth global cause of death in 2020. (medscape.com)

Vaxcyte, Inc. today announced that the first participants were dosed in a Phase 1/2 clinical study for VAX-31, a 31-valent pneumococcal conjugate vaccine (PCV) candidate designed to prevent invasive pneumococcal disease (IPD), in adults. (biospace.com)
Vaxcyte, Inc. (Nasdaq: PCVX) announced today that the U.S. Food and Drug Administration (FDA) has cleared the Company's adult Investigational New Drug (IND) application for VAX-31, a 31-valent pneumococcal conjugate vaccine (PCV) candidate designed to prevent invasive pneumococcal disease (IPD). (biospace.com)

Invasive pneumococcal disease (IPD) and sepsis are responsible for substantial morbidity and mortality worldwide with about 2 million deaths each year [ 4 ]. (biomedcentral.com)
Pneumococcal disease is the primary cause of childhood morbidity and mortality worldwide, resulting in 0.7 to 1.0 million deaths each year in children younger than age 5 years [ 3 ]. (biomedcentral.com)
Pneumococcal disease can lead to significant morbidity and mortality, particularly amongst the very young, the very old, those with impaired immunity and those with anatomic or functional asplenia. (hse.ie)

The pneumococcal conjugate vaccine, given primarily to children, covers 13 strains, while the adult vaccine covers 23 strains. (cdc.gov)
Serotype 3 strains, which are more heavily encapsulated and tend to form more mucoid colonies than other serotypes, are common causes of invasive pneumococcal disease in adults. (msdmanuals.com)
Immunisation against these strains greatly reduces the risk of disease. (immunisationcoalition.org.au)
201 strains from 115 adults and 86 children were included in the study. (bvsalud.org)

In India, the burden of pneumococcal disease is a major health concern. (askapollo.com)

Invasive pneumococcal disease (IPD) is defined as a clinical condition in which S. pneumoniae is isolated from a normally sterile site, e.g. blood, cerebrospinal fluid or pleural fluid. (health.gov.au)
S pneumoniae can cause a wide variety of clinical symptoms owing to its ability to cause disease by either direct extension from the nasopharynx into surrounding anatomic structures or vascular invasion with hematogenous spread. (medscape.com)
Taiwan began an IPD surveillance program in October 2007, requiring every hospital to report IPD cases of all ages and to send S. pneumoniae isolates to the Taiwan Centers for Disease Control (Taiwan CDC) [ 10 ]. (biomedcentral.com)

5,6,7 Adopting the newest ACIP PCV recommendations may further prevent an additional 30% of invasive pneumococcal disease cases. (ihs.gov)
The ACIP has recommended one dose of Prevnar 20 for adults aged ≥65 & for ≥19yrs. (pharmashots.com)

The benefits considered critical outcomes in GRADE included prevention of invasive pneumococcal disease (IPD), pneumococcal community-acquired pneumonia, and hospitalizations due to pneumococcal disease. (bvsalud.org)

Chronic diseases microbial-non-susceptibility of pneumococcus. (bvsalud.org)
In some people (particularly those at increased risk), the Pneumococcus bacteria invades the body or blood stream causing pneumococcal disease. (immunisationcoalition.org.au)

Therefore, Prevnar 13 currently dominates the large market for the primary pediatric series of pneumococcal vaccinations included in the US routine immunisation schedule. (pharmaceutical-technology.com)
Additional vaccinations are recommended for children and adults at risk. (folkhalsomyndigheten.se)

However, Pfizer also has a late-stage, 20-valent conjugate pneumococcal vaccine, 20vPnC, which has also received FDA breakthrough therapy designation in adults. (pharmaceutical-technology.com)

NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. (nih.gov)

LEIPZIG, Germany - The introduction of the 10-valent pneumococcal conjugate vaccine, PCV10, decreases the rates of clinical pneumonia even in unvaccinated children, according to new research. (medscape.com)
If approved, 20vPnC will cover more serotypes responsible for the majority of pneumococcal disease than any other pneumococcal conjugate vaccine currently licensed or currently in late-stage clinical development. (pfizer.com)
The CHMP opinion was based on data from seven randomized, double-blind clinical studies evaluating VAXNEUVANCE in 7,438 individuals from a variety of adult populations and clinical circumstances. (merck.com)
The regulatory applications for licensure of V114 include results from Phase 2 and Phase 3 clinical studies in a variety of adult populations, including healthy adults and those at increased risk, such as adults with chronic medical conditions, adults with HIV, and those 65 years of age and older. (merck.com)
New data from Phase 3 European clinical trials reinforce that Wyeth's (NYSE: WYE) investigational pneumococcal vaccine, Prevenar 13* (Pneumococcal Polysaccharide Conjugate Vaccine, 13-valent [Adsorbed]), has the potential to provide coverage against the 13 most prevalent serotypes associated with pneumococcal disease (PD), the leading cause of vaccine-preventable death in children younger than five worldwide. (science20.com)
Clinical presentations and serotypes causing invasive pneumococcal disease in adults vaccinated with the 23-valent polysaccharide pneumococcal vaccine (PPV23) in Spain. (ers-education.org)
Researchers will conduct a Phase IIb randomized clinical trial, involving two groups of adults ages 55 to 74. (nih.gov)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norway from 1993 to 2011 to study the clinical variables and disease outcome. (biomedcentral.com)
Inclisiran is indicated as an adjunct to diet and maximally tolerated statin therapy for adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who require additional LDL-C lowering. (medscape.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)

V114 is Merck's investigational 15-valent pneumococcal conjugate vaccine candidate for the prevention of pneumococcal disease in adults and children. (merck.com)

It has been estimated that carriage of the bacteria may range from 10% of adults to 50% of children attending day care facilities. (hse.ie)

Question: Should PCV20 be recommended for U.S. adults aged 19-64 years with chronic medical conditions or immunocompromising conditions? (cdc.gov)
On June 8, 2021, a 20-valent pneumococcal conjugate vaccine (PCV20, Pfizer) was licensed for use in adults aged ≥18 years. (cdc.gov)
Unlike previous conjugate vaccine formulations, PCV20 was licensed for adults before submission for licensure in children. (cdc.gov)
Both PCV15 and PCV20 were licensed in 2021 for adults aged ≥18 years and expanded pneumococcal serogroup coverage for adults. (ihs.gov)
When PCV20 is used, no additional pneumococcal vaccine doses are recommended. (ihs.gov)
Note that PCV20 protects against serotype 12F, which has been identified as a contributor to invasive pneumococcal disease among AI/AN, typically impacting children with subsequent transmission to elders. (ihs.gov)
In June 2021, the U.S. Food and Drug Administration (FDA) approved the pneumococcal 20-valent conjugate vaccine, sold under the brand name Prevnar 20 (PCV20), for adults 18 years of age and older. (wikipedia.org)

We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations between breakthrough pneumonia and pneumococcal serotypes in Taiwan. (biomedcentral.com)

The decline in the proportion of pneumococcal conjugate vaccine (PCV)-covered serotypes among adult invasive adults, it is a public health concern, particularly in pneumococcal disease (IPD) patients might change the countries with aging populations, such as Japan ( 3 , 4 ). (cdc.gov)
The proportion of pneumococcal pneumonia decreased each year in age-stratified groups, especially in 2-5 year group. (biomedcentral.com)

Serotype 19A was the major serotype for all vaccine types in patients with pneumococcal pneumonia and severity of acute inflammatory response was reduced in vaccinated patients. (biomedcentral.com)

Rates of pneumococcal infection in the United States vary among demographic groups, with higher rates among infants, young children, and older persons. (cdc.gov)
The World Health Organization (WHO) states that pneumococcal disease is the world's number 1 vaccine-preventable cause of death among infants and children younger than 5 years of age. (immunisationcoalition.org.au)
On 30 January, Merck & Co's V114 (15-valent pneumococcal conjugate vaccine) received breakthrough therapy designation by the US Food and Drug Administration (FDA), for the prevention of invasive pneumococcal disease in infants, children and adolescents. (pharmaceutical-technology.com)
This, in addition to V114's breakthrough therapy designation for infants, means that Pfizer' Prevnar 13 could stand to lose its grip on the lucrative pneumococcal vaccine market in infants. (pharmaceutical-technology.com)

Invasive pneumococcal disease (IPD) is a serious bacterial disease. (who.int)
This stimulated us coding for inpatients admitted to Sal- meningitidis are the main pathogens of to conduct this study to assess the trend maniya Medical Complex, which is the community-acquired bacterial menin- and the temporal relationship between only government tertiary care hospital gitis in adults. (who.int)

Some serotypes are carried in the upper respiratory tract and others are more associated with the invasive disease. (who.int)

As the PUAT does not allow serotype discrimination, data on serotype distribution in adult non-bacteraemic pneumococcal CAP patients are sparse [ 4 ]. (ersjournals.com)

Researchers say the findings underscore the recommendations from the Centers for Disease Control and Prevention that all adults over 65 years old should be immunized with pneumococcal vaccine and that younger adults with chronic disease should be vaccinated. (wvresearch.org)

Since the 1970s, large outbreaks of severe pneumococcal disease caused by penicillin resistant organisms occurred in South Africa and Papua New Guinea and subsequently increased rates of penicillin resistance in pneumococci have been documented worldwide. (health.gov.au)

From 1998--1999 to 2006--2007, the percentage of adult IPD patients with underlying medical conditions increased from 52% to 59% among those aged 18--64 years and from 69% to 81% among those aged ≥65 years. (cdc.gov)
The 23-valent pneumococcal polysaccharide vaccine (PPV23) has been recommended to risk-groups and adults aged ≥65 years since 1996. (biomedcentral.com)
This vaccine is recommended for those aged 65 years and older and "at-risk" adults and children over 2 years of age. (hse.ie)

50 years of age demiologic information and pneumococcal isolates were was 54% ( 5 ). (cdc.gov)
This recommendation does not affect the pneumococcal vaccine schedule for children ≤18 years. (ihs.gov)
TY - JOUR T1 - Invasive pneumococcal disease in children 5 years after conjugate vaccine introduction--eight states, 1998-2005. (unboundmedicine.com)
Surveillance data in the coming years will shed more light on the full potential of PCV10 in reducing pneumonia and other pneumococcal disease in the unvaccinated population," Dr Jokinen added. (medscape.com)
The survey used a nationally representative sample of 1020 US adults 18 years of age and over, of whom 79 completed the survey by phone and 941 completed it online. (pharmacytimes.com)
CDC recommends all adults 19 through 64 years old with asthma get the pneumococcal polysaccharide vaccine. (infectioncontroltoday.com)
Nearly 10,000 adults ages 18-64 years with asthma from 29 states who have ever held a job, representing an estimated 12 million people, were included in the analysis. (infectioncontroltoday.com)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the company has submitted applications to the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) for licensure of V114, Merck's investigational 15-valent pneumococcal conjugate vaccine, for use in adults 18 years of age and older. (merck.com)
V114 previously received Breakthrough Therapy Designation from the FDA for the prevention of invasive pneumococcal disease in pediatric patients 6 weeks to 18 years of age and adults 18 years of age and older. (merck.com)
According to the World Health Organization (WHO), pneumococcal disease is the leading cause of vaccine-preventable death worldwide in children younger than 5 years and is estimated to cause up to 1 million deaths worldwide in children each year. (euractiv.com)
A vaccine programme has been in place in Australia for pneumococcal disease since 1999 when the 23-valent polysaccharide pneumococcal vaccine (23vPPV) was introduced for Aboriginal and Torres Strait Islander adults aged 50 years and over ( Box 2 ). (who.int)
The study supported by the National Institutes of Health will compare two dosages of a pneumococcal vaccine approved for children ages 6 weeks to 5 years, and adults 50 and older. (nih.gov)
Every three years since 1993, Kaiser Permanente in Northern California has conducted an adult Member Health Survey, a self-administered mailed survey which covers demographic characteristics, health status, health conditions, behavioral health risks, and receipt of preventive and patient education services. (biomedcentral.com)
A Marshall University Joan C. Edwards School of Medicine research team has published findings that show patients who recover from invasive pneumococcal pneumonia, on average, live 10 years less when measured against life expectancy tables for the state of West Virginia as well as two other techniques. (wvresearch.org)
Pneumococcal disease was reported most frequently in children aged less than 5 years (47.3 cases per 100,000 population). (health.gov.au)
In developed countries, the incidence rate of IPD is bimodal, with a peak in children under 2 years and another peak in adults over 65 years. (health.gov.au)
Pneumococcal is the leading cause of serious illness among Australian children under two years of age and people over the age of 70. (immunisationcoalition.org.au)
Pneumococcal disease is also an important cause of pneumonia in adults 70 years of age or over. (immunisationcoalition.org.au)
Evinacumab is indicated as an adjunct to other LDL-C-lowering therapies for homozygous familial hypercholesterolemia in adults and adolescents aged 12 years and older. (medscape.com)

Almost all people with IPD (children and adults) will be obviously sick, and in need of urgent medical care. (immunisationcoalition.org.au)

The presence of certain underlying medical conditions increases the risk for pneumococcal disease and its complications ( 2 ). (cdc.gov)
The risk for IPD is greatest among persons who have congenital or acquired immunodeficiency, abnormal innate immune response, human immunodeficiency virus (HIV) infection, or functional or anatomic asplenia (e.g., sickle cell disease or congenital or surgical asplenia) ( Table ). (cdc.gov)
Among Alaska Native and American Indian adults, the majority of IPD cases occur in persons with underlying medical conditions or other risk factors (e.g., heavy alcohol use or smoking) that are associated with increased risk for IPD in the general population ( 5 ). (cdc.gov)
Adults with certain underlying conditions are at increased risk of pneumococcal disease[1, 2]. (cdc.gov)
Adults with asthma are at increased risk for pneumococcal disease, yet according to a new Centers for Disease Control and Prevention (CDC) study published today in the American Journal of Preventive Medicine , just 54 percent of adults with work-related asthma-asthma triggered by an exposure at work-have been vaccinated against the infection. (infectioncontroltoday.com)
Adults with asthma who get pneumococcal pneumonia are at risk for additional complications including asthma exacerbation and invasive pneumococcal disease. (infectioncontroltoday.com)
Background: Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). (bvsalud.org)
Presence of 1 risk condition was reported in 34.8% of adults. (bvsalud.org)
Among high-risk comorbidity (n = 211), cancer (28%), HIV/AIDS (25.7%) and hematological diseases (24.5%) were the most frequent. (bvsalud.org)
Certain medical conditions (eg, chronic disorders, immunocompromising conditions, cerebrospinal fluid leaks, cochlear implants) increase the risk of pneumococcal disease. (merckmanuals.com)
Older age and higher severity of disease were important risk factors for death in IPD. (biomedcentral.com)
65 year age groups and in the older population, chronic comorbid disease is a risk factor for acquiring IPD [ 2 ]. (biomedcentral.com)
The team reported that the presence of two comorbid diseases-cancer and neurologic diseases-as well as the total number of comorbid diseases suffered by each patient with invasive pneumococcal disease were significantly associated with increased risk of mortality. (wvresearch.org)
The risk of disease is highest among people who are immunocompromised (e.g. due to HIV, asplenia) or have a chronic illness (e.g. chronic cardiovascular, pulmonary, renal or liver disease or diabetes). (health.gov.au)
Older people are especially at risk of death from this disease. (immunisationcoalition.org.au)
At-risk populations include individuals with diabetes, asthma, chronic obstructive pulmonary disease, human immunodeficiency virus (HIV), sickle cell disease, and cardiovascular diseases. (medgadget.com)
Finerenone is indicated to reduce risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes mellitus. (medscape.com)
Jardiance (empagliflozin) - Indicated to reduce the risk of cardiovascular death plus hospitalization for heart failure in adults with heart failure and reduced ejection fraction. (medscape.com)
200 cells/mm 3 ) was associated with a higher risk for the composite endpoint of intensive care unit admission, invasive mechanical ventilation, or death. (hiv.gov)
Who is most at risk of pneumococcal disease? (hse.ie)

Anatomy4

Organisms4

Diseases13

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes8

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

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Geographicals15

Vaccines51

Vaccination44

Streptococcus30

PCV1321

Infections18

Bacteremia7

Immunization11

Received a pneumococcal conjuga1

Older adults11

Infectious Diseases7

PPSV2310

Meningitis6

Among Adults3

PCV76

Otitis media1

Cases of invasive pneumococcal1

20201

Prevent invasive pneumococcal2

Morbidity and morta3

Strains4

Burden of pneumococcal disease1

Pneumoniae3

ACIP2

Community-acquired1

Pneumococcus2

Vaccinations2

Conjugate pneumococcal vaccine1

Illnesses1

Clinical11

Prevention of pneumococcal1

Bacteria1

PCV207

Prevalence of pneumococcal1

Proportion of pneumococcal2

Patients with pneumococcal1

Infants4

Bacterial2

Respiratory1

Serotype distribution1

Recommendations1

Pneumococci1

Aged 65 years3

Years19

Children and adults1

Risk20