• Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
  • The adipocyte was reported as an antigen-presenting cell (APC) which expresses CD1d and MHC class I and II molecules. (frontiersin.org)
  • This invariant chain is expressed on invariant NK T cells, which are a small subset of T lymphocytes that also express other NK cell molecules such as CD161. (bdbiosciences.com)
  • Invariant natural killer T ( i NKT) cells, also known as type I or classical NKT cells, are a distinct population of T cells that express an invariant a β T-cell receptor (TCR) and a number of cell surface molecules in common with natural killer (NK) cells. (immunology.org)
  • Unlike conventional T cells, which mostly recognise peptide antigens presented by MHC molecules, i NKT cells recognise glycolipid antigens presented by the non-polymorphic MHC class I-like molecule, CD1d . (immunology.org)
  • iNKT cells can recognize endogenous lipids presented by CD1d molecules on tumor cells and release Perforin and Granzyme B to lyse tumor cells directly. (aacrjournals.org)
  • 2011 A unifying feature of αGC analogs that induce predominantly Th2 cell-associated cytokines is that they are more polar than KRN7000 and can load directly onto CD1d molecules on the cell surface (Im et?al. (biotech-angels.com)
  • 2012 However other studies yielded different conclusions identifying pharmacokinetic properties of the glycolipids or localization of CD1d molecules containing bound glycolipids to different membrane microdomains as major determinants of cytokine skewing in the response to iNKT cell activation (Im et?al. (biotech-angels.com)
  • Interaction of CD8α+ dendritic cells (DCs) with iNKT cells during presentation of Th1 cell-biasing versus Th2 cell-biasing glycolipid antigens led to markedly different changes in expression of costimulatory and coinhibitory molecules on these. (biotech-angels.com)
  • They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as obesity and atherosclerosis. (ox.ac.uk)
  • Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be loaded into MHC-class-I-related CD1d molecules by dendritic cells and has been shown to stimulate invariant natural killer T (iNKT) cells. (tmu.edu.tw)
  • Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer cells, and a series of adjuvants and co-stimulatory molecules have been proposed to enhance the immune response against weak self-antigens expressed on cancer cells. (biomedcentral.com)
  • NKT cells recognise and respond to glycolipid antigens presented on CD1d molecules. (sicollaborative.org)
  • I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
  • Data_Sheet_1.pdf (513K) GUID:?514B8128-1B6A-4BCF-ADFD-8945AF1CB772 Abstract The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. (clinical-research-informatics.com)
  • 2008 Multiple studies show that this transactivation is influenced by the precise structure of glycolipid antigens which has enabled manipulation of immune responses with structural analogs of αGC (Venkataswamy and Porcelli 2010 For example derivatives of αGC containing truncated or unsaturated N-acyl chains induce responses in which cytokines typically associated with T helper-2 (Th2) cells predominate KM 11060 and transactivation of NK cells is limited (Yu et?al. (biotech-angels.com)
  • 2011 In contrast glycolipids that induce responses that are biased toward Th1 cell cytokines are more hydrophobic and require intracellular loading onto CD1d for presentation (Arora et?al. (biotech-angels.com)
  • Third, external signals such as toll-like receptor ligands, adipokines, and cytokines modulate antigen presentation and subsequent iNKT cell responses. (ox.ac.uk)
  • Cytokines, antigen-specific antibodies and subtype antibodies of serum and nasal wash fluid will be analyzed in order to investigate the enhancement of the Th1/Th2 immune-modulatory pathway. (tmu.edu.tw)
  • This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
  • The invariant T cell receptor of the iNKT cell is able to bind the CD1d:glycolipid complex leading to iNKT cell activation in both mice and humans. (wikipedia.org)
  • Recent studies have highlighted a variety of classes of endogenous and pathogen-derived lipid antigens that can trigger iNKT cell activation under sterile and nonsterile conditions. (ox.ac.uk)
  • Here we report that endoplasmic reticulum (ER)-stressed myeloid cells, via signaling events modulated by the protein kinase RNA-like ER kinase (PERK) pathway, increase CD1d-mediated presentation of immunogenic endogenous lipid species, which results in enhanced iNKT cell activation both in vitro and in vivo. (ox.ac.uk)
  • In addition, we demonstrate that actin cytoskeletal reorganization during ER stress results in an altered distribution of CD1d on the cell surface, which contributes to enhanced iNKT cell activation. (ox.ac.uk)
  • 2003 Several models have been put forth to explain how variations in the structure of glycolipid antigens lead to different outcomes of iNKT cell activation. (biotech-angels.com)
  • In this review, we discuss the contribution of iNKT cell activation to immunometabolic disease, metabolic programming of lipid antigen presentation, and immunometabolic activation of iNKT cells. (ox.ac.uk)
  • This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. (beckman.com)
  • Invariant natural killer T (iNKT) cells are a specialised subset of T cells that are restricted to the MHC class I like molecule, CD1d. (ox.ac.uk)
  • Graphical Abstract Introduction Natural killer T?cells with invariant T?cell receptor α chains (iNKT cells) are a conserved population that recognizes KM 11060 glycolipid antigens bound to CD1d a lipid antigen-presenting molecule with structural similarities to major histocompatibility complex (MHC) class I proteins (Brennan et?al. (biotech-angels.com)
  • The iNKTCR recognizes lipid antigens on CD1d (an MHC class I like molecule, that is NOT polymorphic), so they can target multiple types of cancer (by recognizing tumor-derived glycolipids) using multiple mechanisms that are independent of protein tumor antigen and MHC restrictions. (molecule-world.com)
  • Dr. Cerundolo demonstrated how the length and saturation of lipid antigens contained within the CD1d binding site modulate their affinity of binding to invariant NKT cells (iNKT cells), hence explaining how lipid-specific lymphocytes are capable of recognizing both the group head and the length of lipid antigens, ensuring greater specificity of antigen recognition. (aacrjournals.org)
  • In addition to TLR ligands, CD1d-restricted invariant NKT (iNKT) cells have been shown to efficiently promote the transactivation of DCs through the CD40L-CD40 interaction upon recognition of the CD1d-glycolipid antigen complex by their semi-invariant TCR. (biomedcentral.com)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)
  • Recognition of lipid-based antigens presented by CD1d sets iNKT cells apart from conventional T cells. (guidetomalariapharmacology.org)
  • The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor. (uchicago.edu)
  • Invariant natural killer T (iNKT) cells are a unique population of T lymphocytes that lies at the interface between the innate and adaptive immune systems, and they are important mediators of immune responses and tumor surveillance. (aacrjournals.org)
  • In the absence of CD1d expression on tumor cells, iNKT cells may become activated in response to CD1d-expressing or Toll-like receptor (TLR)-activated antigen-presenting cells (APC). (aacrjournals.org)
  • Activation and tumor targeting of iNKT cells via recombinant α-galactosylceramide (αGC)-loaded CD1d-anti-HER2 fusion protein (CD1d-antitumor) is combined or not with OVA peptide/CpG vaccine. (biomedcentral.com)
  • Altogether, our study in mice demonstrates that αGC/CD1d-antitumor fusion protein greatly increases the efficacy of a therapeutic CpG-based cancer vaccine, first as an adjuvant during T cell priming and second, as a therapeutic agent to redirect immune responses to the tumor site. (biomedcentral.com)
  • However, except for virus-induced cancers, tumor antigens are mostly self or near-self protein epitopes that are often poorly immunogenic and submitted to central and peripheral tolerance. (biomedcentral.com)
  • CD1d-restricted invariant natural killer T (iNKT) cells actively participate in tumor immunosurveillance by restricting suppressive myeloid populations in the TME. (unimib.it)
  • Here, we showed that harnessing iNKT cells with a second TCR specific for a tumor-associated peptide generated bispecific effectors for CD1d- and major histocompatibility complex (MHC)-restricted antigens in vitro. (unimib.it)
  • Along these same lines, the lab uses innovative approaches to direct iNKT cells to the site of cancers in a tumor antigen-specific yet CD1d-independent manner. (msu.edu)
  • His seminal findings on the processing and presentation of peptide and lipid antigens made fundamental advances to the field of antigen presentation to MHC class I-restricted T cells and CD1d-restricted iNKT cells. (aacrjournals.org)
  • However, the context and mechanisms that drive the presentation of self-lipid antigens in sterile inflammation remain unclear. (ox.ac.uk)
  • GC leads to CD1d/glycolipid presentation and a coordinated dNKT and iNKT- driven mixed Th1/Th2 response against vaccine antigens. (grantome.com)
  • In Specific Aim 1, we will perform a series of in vitro studies in primary murine and human cells to determine how the adjuvant combination affects CD1d Ag presentation and activation and functional differentiation of NKT cells into different effector subsets. (grantome.com)
  • We will also examine the effect of adjuvant combination on class I and class II presentation of co-administered protein antigens. (grantome.com)
  • 1997 it has been proposed that selective presentation by different cell types could account for variation in functional outcomes with different glycolipid antigens (Bezbradica et?al. (biotech-angels.com)
  • 2005 This possibility was supported by a recent study using lineage-specific conditional deletion of gene expression which identified presentation by different types of antigen-presenting cells (APCs) as a major factor underlying the cytokine biasing properties of different αGC variants (Bai et?al. (biotech-angels.com)
  • 2010 In the current study we reassessed the presentation of various forms DUSP2 of αGC in?vivo to identify the predominant APCs involved in presentation of diverse glycolipid antigens. (biotech-angels.com)
  • By visualizing glycolipid antigen presentation directly with monoclonal antibodies specific for complexes of αGC bound to CD1d we showed that the CD8α+DEC-205+ subset of dendritic cells was the major APC in the spleen for a range of αGC analogs irrespective of their chemical structures and cytokine biasing activities. (biotech-angels.com)
  • Second, we discuss the effects of cellular metabolism on lipid antigen processing and presentation to iNKT cells. (ox.ac.uk)
  • Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. (proquest.com)
  • The inability of -GalCer to promote anti-parasitic immunity did not result from inefficient antigen presentation caused by contamination because -GalCerCloaded bone marrowCderived dendritic cells were also unable to improve disease resolution. (sicollaborative.org)
  • Data_Sheet_1.pdf (513K) GUID:?514B8128-1B6A-4BCF-ADFD-8945AF1CB772 Supplementary Physique 3: Statistical analysis of CD1b-restricted lipid antigen presentation by Mo-DCs. (clinical-research-informatics.com)
  • While defects in lipid antigen presentation hN-CoR and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. (clinical-research-informatics.com)
  • Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. (uchicago.edu)
  • GC adjuvant stimulates semi-invariant TCR-expressing Type I NKT cells (iNKT) and results in a mixed Th1/Th2 response. (grantome.com)
  • Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. (ox.ac.uk)
  • iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
  • We feel the project is significant because it will illuminate potential avenues for inclusion of CD1d-binding glycolipids in mixed adjuvant platforms. (grantome.com)
  • The synthesis and processing of glycolipids and other potential endogenous lipid antigens depends on metabolic demand and may steer iNKT cells toward adopting a Th1 or Th2 signature. (ox.ac.uk)
  • A. Representative spleen sections from 3 mo old B6.TC (left) and B6 (right) mice stained with Moma-1-FITC, CD1d-PE and B220-PB. (bio-rad-antibodies.com)
  • Representative spleen sections from 10 mo old B6.TC (left) and B6 (right) mice stained with CD4-FITC, CD1d-PE and B220-PB. (bio-rad-antibodies.com)
  • We demonstrate here that the absence of invariant NKT (iNKT) cells in mice during IAV infection resulted in the expansion of myeloid-derived suppressor cells (MDSCs), which suppressed IAV-specific immune responses through the expression of both arginase and NOS, resulting in high IAV titer and increased mortality. (ox.ac.uk)
  • 2008). Anomalies in conventional T and invariant natural killer T-cell populations in Fabry mice but not in Fabry patients . (up.pt)
  • Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. (uchicago.edu)
  • In addi-tion, antigen-presenting cells derived from NPC1 patients are functionally competent to present several different CD1d/iNKT-cell ligands. (ox.ac.uk)
  • Alternatively, the adjuvant activity of CD1d-restricted invariant NKT cells (iNKT) on the innate and adaptive immunity is well demonstrated, and several CD1d glycolipid ligands are under pre-clinical and clinical evaluation. (biomedcentral.com)
  • Importantly, additive or even synergistic effects have been shown upon combined CD1d/NKT agonists and TLR ligands. (biomedcentral.com)
  • Rat anti Mouse CD1d antibody, clone 1B1 ( MCA4700 ) used for immunofluorescence staining of mouse tissues. (bio-rad-antibodies.com)
  • In combination with a peptide antigen, α-GalCer is able to stimulate a strong immune response against the epitope. (wikipedia.org)
  • 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
  • We enumerated invariant natural killer T cells by flow cytometry with the use of CD1d tetramers loaded with alpha-galactosylceramide and antibodies specific to the invariant natural killer T-cell receptor in samples of bronchoalveolar-lavage fluid, induced sputum, and bronchial-biopsy specimens obtained from subjects with mild or moderately severe asthma, subjects with COPD, and healthy control subjects. (nih.gov)
  • These cells are part of a lymphocyte population with selectivity for lipid antigens that are recognized by their potent immunoregulatory properties. (fapesp.br)
  • Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C. (ox.ac.uk)
  • In the NPC1 mouse model, iNKT cells are virtually undetectable, which is likely due to the inability of CD1d to be loaded with the selecting ligand due to defective lysosomal function and/or CD1d trafficking. (ox.ac.uk)
  • Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
  • Invariant NKT (iNKT) cells have the unique ability to shape immunity during antitumor immune responses and other forms of sterile and nonsterile inflammation. (ox.ac.uk)
  • The combined CD1d/iNKT antitumor therapy and CpG/peptide-based immunization leads to optimized expansion of NK and OVA-specific CD8 T cells (CTLs), likely resulting from the maturation of highly pro-inflammatory DCs as seen by a synergistic increase in serum IL-12. (biomedcentral.com)
  • The CD1d:glycolipid:TCR interaction activates the iNKT cell which can then activate the dendritic cell. (wikipedia.org)
  • An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonal expanded CD4- CD8- T cells, reactive to bacterial antigens. (beckman.com)
  • Krovi SH, Gapin L: Invariant natural killer T cell subsets - more than just developmental intermediates. (exbio.cz)
  • His demonstration that iNKT cells enhance both antigen-specific antibody and T-cell responses has had a major influence on the development of new vaccines and has opened up new therapeutic strategies to enhance immune responses against cancer and infectious pathogens. (aacrjournals.org)
  • We feel this project is innovative because it will provide the vaccine community with mechanistic information when CD1d-binding adjuvants are combined with Alum adjuvant and give careful consideration to NKT cell- driven components of the immune response. (grantome.com)
  • Many hematopoietic cell types express CD1d and so are with the capacity of presenting glycolipid antigens to invariant natural killer T?cells (iNKT cells). (biotech-angels.com)
  • Thus, α-GalCer-incorporated liposome is capable of improving the delivery of antigen to antigen-presenting-cell and inducing effective immune responses via various routes. (tmu.edu.tw)
  • Traficet-EN), a new picky Hepatic stellate cell villain in the CC chemokine receptor (CCR9), will be produced by GlaxoSmithKline plc beneath licenses coming from ChemoCentryx Inc for that probable treating inflammatory bowel condition, including Crohn's illness and also coeliac disease. (peroxidasessignaling.com)
  • The invariant in iNKT cells is because they also contain a specific T cell receptor (TCR) rearrangement (Vα24Jα18). (molecule-world.com)
  • mediated enhancement of keratinocyte antigen processing and T-cell lysis. (edu.au)
  • Real-time polymerase-chain-reaction analysis was performed on bronchoalveolar-lavage cells for evidence of gene expression of the invariant natural killer T-cell receptor. (nih.gov)
  • No expression of messenger RNA for the invariant natural killer T-cell-receptor domains Valpha24 and Vbeta11 was detected in bronchoalveolar-lavage cells from subjects with asthma. (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Squamous Cell Carcinoma Antigen 2 (SCCA2) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (pharmas-eu.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Squamous Cell Carcinoma Antigen 2 (SCCA2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (pharmas-eu.org)
  • Description: A sandwich ELISA kit for detection of Squamous Cell Carcinoma Antigen 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (pharmas-eu.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Squamous Cell Carcinoma Antigen 2 (SCCA2) in samples from tissue homogenates, cell lysates or other biological fluids. (pharmas-eu.org)
  • Expression of CD1c enhances human invariant NKT cell activation by a-GalCer. (uchicago.edu)
  • Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
  • Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells. (ox.ac.uk)
  • Immunometabolic Activation of Invariant Natural Killer T Cells. (ox.ac.uk)
  • Furthermore, attempts at therapeutic activation of invariant NKT (iNKT) cells with -galactosylceramide (-GalCer) during contamination exacerbated, rather than ameliorated, experimental visceral leishmaniasis. (sicollaborative.org)
  • Monoclonal antibody 6B11 reacts with a unique determinant in the CDR3 region of the invariant (Vα24-JαQ) TCR chain. (bdbiosciences.com)
  • The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT). (exbio.cz)
  • 2012 Studies of the prototypical glycolipid antigen of iNKT cells an α-galactosylceramide (αGC) known as KRN7000 show the potential for iNKT cells to KM 11060 activate a range of immune effector functions in?vivo. (biotech-angels.com)
  • Upon in vivo transfer, TCR-engineered iNKT (TCR-iNKT) cells showed the highest efficacy in restraining the progression of multiple tumors that expressed the cognate antigen compared with nontransduced iNKT cells or CD8+ T cells engineered with the same TCR. (unimib.it)
  • In tumors, antigen-specific functional ICOS + CD4 + cells were increased, and both ICOS + CD4 + and CD8 + T cells were increased in the blood of patients. (acir.org)
  • There are many shreds of evidence that suggest that the extrinsic antigens, environmental conditions, and genetic factors play a crucial role in the development of sarcoidosis through an exaggerated immune response. (ijpsr.com)
  • Introduction Natural killer T (NKT) cells are a unique subset of CD1d-restricted T cells that provide a link between innate and adaptive immune responses. (sicollaborative.org)
  • Although immunotherapy is an alternative to a large number of diseases mediated by the immune system, the use of specific agonists to the invariant Natural Killer T (iNKT) lymphocytes remains neglected.One of these antagonists, the alfa-Galactosylceramide (a-GalCer), has been used in clinical trials, however, despite positive results, its efficiency is underwhelming. (fapesp.br)
  • Dr. Cerundolo described the first human antigen processing-deficient cells, leading to the cloning and characterization of the transporter associated with antigen-processing 1 and 2 (TAP1, TAP2) genes and the identification of several families of TAP1/2-deficient patients with necrotizing granulomatous skin lesions and small vessel vasculitis. (aacrjournals.org)
  • A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression. (proquest.com)
  • There are no known differences in the structure of the human MHC Class I antigen a chains encoded by the HLA-A locus compared to those encoded by the HLA-B or the HLA-C loci, or in the structure of the murine MHC Class I antigen a chains encoded by the H-2K locus compared to those encoded by the H-2D or H-2L loci. (microbenotes.com)
  • The function of the adaptive immune system is to recognize, remember and destroy invading pathogens through their antigens, and relieve pathogen-associated toxicities. (frontiersin.org)
  • GC) and delineate the mechanisms of action with a particular emphasis on CD1d-restricted Natural Killer T (NKT) cells and humoral immunity. (grantome.com)
  • The main cause of sarcoidosis is immune irregularities in genetically predisposed individuals which manifests antigen(s) like microorganism or their products, due to an ex-aggregated immune response. (ijpsr.com)
  • The immune irregularities have been found to be the main cause of sarcoidosis in genetically predisposed individuals, elicited by the antigen(s) like microorganisms or their products, pollens, viruses, bacteria, and borrelia, due to an ex-aggregated immune response. (ijpsr.com)
  • This class retains control of immune responsiveness and the different allelic forms of these genes confer differences in the ability to mount an immune response against a given antigen. (microbenotes.com)
  • 2017). Psychosine variants as antigens for natural killer T cells . (up.pt)
  • Recently my team has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. (cardiff.ac.uk)
  • Whether the majority of these cells are class II major-histocompatibility-complex-restricted cells or are among the recently identified CD1d-restricted invariant natural killer T cells is a matter of controversy. (nih.gov)
  • Their major function is to present antigen-processed peptides to the T-cytotoxic cells by the cytosolic pathway. (microbenotes.com)
  • Although a growing body of evidence supports the notion that the sympathetic nervous system (SNS) influences the immune system (IS), the relationship between the SNS and the invariant Natural Killer T lymphocytes remains underestimated. (fapesp.br)
  • Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells. (elifesciences.org)
  • 2023. CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms . (cardiff.ac.uk)
  • Her research focuses on how invariant natural killer T (iNKT) cells recognize and respond to malignant or infected cells. (msu.edu)
  • However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
  • Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)