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  • Yeast
  • For example, introns are extremely common within the nuclear genome of higher vertebrates (e.g. humans and mice), where protein-coding genes almost always contain multiple introns, while introns are rare within the nuclear genes of some eukaryotic microorganisms, for example baker's/brewer's yeast (Saccharomyces cerevisiae). (wikipedia.org)
  • Mining existing data from genomewide studies on yeast revealed that intron-containing genes produce more RNA and more protein and are more likely to be haplo-insufficient than nonintronic genes. (genetics.org)
  • These data provide evidence that introns improve transcriptional and translational yield and are required for competitive growth of yeast. (genetics.org)
  • We conclude from these observations that introns confer fitness to an organism by improving transcriptional and translational output and suggest that they are required for competitive growth of yeast in their natural environment. (genetics.org)
  • retention
  • In the absence of selection for intron retention, cycles of intron gain and loss ensue ( Goddard and Burt 1999 ), accompanied by recurrent endonuclease activity that predictably targets the very same recognition site. (genetics.org)
  • peginterferon
  • Peg-Intron (peginterferon alfa-2b) Powder for Injection has been approved by the FDA as a once-weekly monotherapy for the treatment of chronic hepatitis C. It is indicated for patients with compensated liver disease who were not previously treated with alpha interferon. (centerwatch.com)
  • Peginterferon (PEG-INTRON, Schering Corporation, Kenilworth, NJ) is a new formulation of interferon recently approved for the treatment of HCV. (pharmacytimes.com)
  • homologues
  • Intron position was defined at the nucleotide level making it possible to determine whether the intron is at an identical position (same codon and same phase) or not in the homologues. (gsf.de)
  • In the cases herein illustrated, some intron positions were found divergent in homologues sharing a high degree of sequence conservation, suggesting that these positions may result either from intron sliding or intron gain events [Bon et al. (gsf.de)
  • Nuclear
  • A sampling of the alternative transcripts with retained introns were confirmed by RT-PCR and were shown to co-purify with polyribosomes, indicating their nuclear export. (futura-sciences.com)
  • transcript
  • The preponderance of retained introns (65%) were either part of open reading frames, present in the UTR region or present as the last intron in the transcript, indicating that their occurrence would not participate in non-sense-mediated decay. (futura-sciences.com)
  • poly A ta
  • I am assuming that the question wants us to draw an organization that has not yet been spliced, so I included the introns and also the G-cap and poly A tail. (biology-online.org)
  • viral
  • For the interferon-based drug used in viral and cancer treatments, see Intron A . For the album by LCD Soundsystem , see Introns (album) . (wikipedia.org)
  • populate
  • On the basis of our observations we propose that introns confer an additional advantage: they improve the transcriptional and translational output of the genes they populate. (genetics.org)
  • insertion
  • This implies that most of these discordant intron positions should be attributed to independent intron insertion events rather than intron sliding events [Bon et al. (gsf.de)
  • transcription
  • Following transcription into RNA, group I and group II introns also make extensive internal interactions that allow them to fold into a specific, complex three-dimensional architecture. (wikipedia.org)
  • humans
  • Search algorithms of AS forms in a variety of Arabidopsis databases showed they contained an unusually high fraction of retained introns (above 30%), compared with 10%that was reported for humans. (futura-sciences.com)
  • Branch
  • Then the three complexes interact with each other to draw together the ends of the intron and position them near the branch site. (blogspot.com)
  • phenomenon
  • Although it is now admitted that intron sliding by one or two bases is a real phenomenon, it remains relatively rare and probably occurs in less than 5% of all introns [Stoltzfus et al. (gsf.de)
  • functional
  • Interestingly, the functional distribution of the transcripts with retained introns is skewed towards stress and external/internal stimuli-related functions. (futura-sciences.com)
  • album
  • Introns is a remix album by the American rock band LCD Soundsystem, released in March 2006 through DFA as a digital download. (wikipedia.org)
  • show
  • You could think of introns as long commercials, in a language you don't understand, interrupting your favorite television show right in the middle of the action. (panspermia.org)
  • events
  • The most common adverse events associated with Peg-Intron were 'flu-like' symptoms, which occurred in approximately 50% of subjects. (centerwatch.com)