• Last, adaptive and purifying selection can work together to keep the lengths of short introns around an optimum size . (plos.org)
  • The results with the new pegylated interferons (PEG-Intron) plus ribavirin are demonstrating even better results. (thebody.com)
  • We are proposing a randomized trial of Peg-Intron 0.5mcg per kg weekly versus colchicine 0.6mg bid in prior non-responders to Interferon, Rebetron, PegIntron, or PegIntron & Ribavirin or any third agent such as Pegasys, CellCept, Amantadine with advanced fibrosis/cirrhosis. (clinicaltrials.gov)
  • For the interferon-based drug used in viral and cancer treatments, see Intron A . For the album by LCD Soundsystem , see Introns (album) . (wikipedia.org)
  • Peg-Intron (peginterferon alfa-2b) Powder for Injection has been approved by the FDA as a once-weekly monotherapy for the treatment of chronic hepatitis C. It is indicated for patients with compensated liver disease who were not previously treated with alpha interferon. (centerwatch.com)
  • Peg-Intron is the first pegylated interferon to be approved in the United States, and therefore offers a new treatment option for hepatitis patients. (centerwatch.com)
  • Peg-Intron is a longer-acting formulation of Schering-Plough's Intron A, which is a recombinant version of a naturally occurring alpha interferon. (centerwatch.com)
  • Peg-Intron was evaluated in a randomized, controlled trial that included 1,219 adult subjects with chronic hepatitis C who were not previously treated with alpha interferon. (centerwatch.com)
  • The trial compared Peg-Intron (0.5, 1.0 or 1.5 mcg/kg) administered subcutaneously once weekly to Schering-Plough's Intron A (recombinant interferon alfa-2b) Injection (3 MIU) administered subcutaneously three times weekly. (centerwatch.com)
  • Peginterferon (PEG-INTRON, Schering Corporation, Kenilworth, NJ) is a new formulation of interferon recently approved for the treatment of HCV. (pharmacytimes.com)
  • At this time, there is currently no recommended maintenance treatment for patients who have failed to respond to Interferon/Rebetron/Peg Intron and have advanced fibrosis. (clinicaltrials.gov)
  • This study is being done to compare the safety and efficacy of PEG-Intron™ to that of PEGASYS™ in participants with chronic hepatitis B (hepatitis B envelope antigen [HBeAg] positive or negative) who have not previously been treated with interferon. (clinicaltrials.gov)
  • The secondary structure of the HAC1/XBP1 intron is very well conserved, and consists of two hairpins (H2 and H3) around the splice sites, and an extended hairpin (H1) that brings the splice sites together (see figure). (wikipedia.org)
  • The sequence of the intron is well conserved only around the splice sites. (wikipedia.org)
  • It could be interpreted that the introns in S. cerevisiae are nucleic acid relics that have yet to be removed by evolution ( F ink 1987 ). (genetics.org)
  • Watson-Crick tertiary interactions, base triples, and base-stacking contacts are shown only for the core of the intron and are represented as open circles, squares, and rectangles, respectively. (nih.gov)
  • A) Secondary structure of domain V. Interactions between domain V and other intron bases are indicated. (nih.gov)
  • Frilander MJ, Steitz JA (1999) Initial recognition of U12-dependent introns requires both U11/5′ splice-site and U12/branchpoint interactions. (springer.com)
  • The YFL037w scaffold gene contains 6 introns of which i2 position is absent in the S. pombe YFL037w gene, but present in C. albicans and P. sorbitophila . (gsf.de)
  • The gene contains 6 introns and 7 exons. (wikipedia.org)
  • To test this hypothesis, we examined the sizes of 14 introns in a nonflying relative of birds, the American alligator (Alligator mississippiensis), and in 19 flighted and flightless birds in 12 taxonomic orders. (harvard.edu)
  • Although these distances are computed in the context of the secondary structure of the entire intron, our hypothesis is still consistent with the original hypothesis that attributes the shortening of a long branchpoint distance to a single stem. (nih.gov)