Intrinsic factor deficiency. Medical search. Frequent questions

In pernicious anemia, which is usually an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B12, and subsequent megaloblastic anemia. (wikipedia.org)
Atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall. (wikipedia.org)
Other risk factors contributing to pernicious anemia are anything that damages or removes a portion of the stomach's parietal cells, including bariatric surgery, gastric tumors, gastric ulcers, and excessive consumption of alcohol. (wikipedia.org)
Babies with this type of anemia do not make enough intrinsic factor. (medlineplus.gov)
B12 [ vitamin b12 (liver-stomach concentrate with intrinsic factor)] is an anti- anemia preparation used to treat anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemia and also iron-deficiency anemia. (rxlist.com)
Hematinic concentrate with intrinsic factor is a multifactor preparation effective in the treatment of anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemias and also iron-deficiency anemia . (rxlist.com)
Folic acid alone is unwarranted in the treatment of proof vitamin B12 (liver-stomach concentrate with intrinsic factor) deficiency states, such as pernicious anemia. (rxlist.com)
Iron deficiency causes microcytic anemia. (medicalnewstoday.com)
It can present as fatigue, because B12 deficiency can cause anemia. (sharecare.com)
12231 Vitamin B12 deficiency causes pernicious anemia Describe the two roles of vitamin B12 in metabolism in humans. (brainmass.com)
Pernicious anemia is caused by a lack of intrinsic factor. (brainmass.com)
B12 deficiency can result in anemia . (brainmass.com)
Autoimmune AG can result in B12 deficiency, with symptoms such as anemia . (brainmass.com)
For example, depression and anemia together might suggest a vitamin B12 deficiency. (brainmass.com)
But beware: one can have Vitamin B12 deficiency without anemia. (journalpress.com)
Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. (nih.gov)
Anemia, particularly the iron deficiency kind, has been linked to mental health conditions like depression and anxiety. (psychcentral.com)
A Japanese study from 2018 with 11,876 participants identified a link between self-reported depression and self-reported iron-deficiency anemia. (psychcentral.com)
The most common form of this condition, iron deficiency anemia, has the added impact of insufficient iron. (psychcentral.com)
For example, iron-deficiency anemia results from inadequate amounts of iron in your body. (psychcentral.com)
Iron deficiency anemia (IDA) occurs when you don't have enough iron to make the blood hemoglobin you need to transport oxygen. (psychcentral.com)
This type of anemia is caused by a deficiency in vitamin B12, which is required to produce healthy red blood cells. (psychcentral.com)
People who have pernicious anemia sometimes lack intrinsic factor, which helps the body absorb B12. (psychcentral.com)
Severe B12 deficiency in conditions like pernicious anemia (an autoimmune condition where the body destroys intrinsic factor, a protein necessary for the absorption of B12) used to be fatal until scientists figured out death could be prevented by feeding patients raw liver (which contains high amounts of B12). (thehealthyskeptic.org)
But anemia is the final stage of B12 deficiency. (thehealthyskeptic.org)
Long before anemia sets in, B12 deficiency causes several other problems, including fatigue, lethargy, weakness, memory loss and neurological and psychiatric problems. (thehealthyskeptic.org)
B12 deficiency occurs in four stages, beginning with declining blood levels of the vitamin (stage I), progressing to low cellular concentrations of the vitamin (stage II), an increased blood level of homocysteine and a decreased rate of DNA synthesis (stage III), and finally, pernicious anemia (stage IV). (thehealthyskeptic.org)
Its clinical manifestationa are therefore the consequences of B12 deficiency and include anemia and neurological defect. (ima.org.il)
Pernicious anemia is when you lack intrinsic factor because your immune system dispatches antibodies to attack intrinsic factor, causing deficiency. (livestrong.com)
Pernicious anemia is an autoimmune disease that targets gastric parietal cells, resulting in gastritis, vitamin B12 (cyanocobalamin) deficiency, and a megaloblastic anemia. (logicalimages.com)
One form of vitamin B12 deficiency anemia is pernicious anemia. (healthylife.com)
People who don't have intrinsic factor eventually show symptoms of a vitamin B12 deficiency -- a condition called pernicious anemia. (howstuffworks.com)
While a B12 deficiency causes pernicious anemia , a lack of this metal causes the more well-known variety of the condition. (austinfitmagazine.com)
Cyanocobalamin is a vitamin B combination that is FDA approved for the treatment of cobalamin deficiency , malabsorption of cyanocobalamin and pernicious anemia , prophylaxis cobalamin deficiency , and diagnosis for Schilling test . (wikidoc.org)
Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency. (wikidoc.org)
What is the relationship of intrinsic factor and pernicious anemia? (healthtap.com)
a result consistent with intrinsic factor deficiency, is there any chance its not pernicious anemia? (healthtap.com)
Do you know what is the intrinsic factor and how it causes pernicious anemia? (healthtap.com)
Hematopoietic alterations vary, depending on the degree of cobalamin (B12) deficiency and metabolic causes leading to the anemia. (innvista.com)
However, a decreased gastric production of hydrochloric acid and a deficiency of IF, means that no matter how much B12 is eaten, it cannot be absorbed by the digestive tract and anemia occurs. (innvista.com)
Actually, as far as B12 is concerned and for those who have severe iron deficiency anemia, supplements are way better than whole foods. (theveganrd.com)
Eggs for treating iron deficiency anemia? (theveganrd.com)
They showed that even small amounts of this factor can be used to treat and to prevent pernicious anemia. (wikidoc.org)
Vitamin B12 deficiency manifests as anemia because hematopoetic stem cells in the bone marrow which are rapidly dividing need B12 for division and DNA production. (wikidoc.org)
Methylmalonic acid levels are elevated in the urine of people affected with pernicious anemia and other forms of B12 deficiency. (wikidoc.org)
Deficiency causes megaloblastic anemia, damage to the white matter of the spinal cord and brain, and peripheral neuropathy. (msdmanuals.com)
People often mistakenly think that a deficiency only occurs in sufferers of pernicious anemia or strict vegetarians. (stichtingb12tekort.nl)
Vitamin B12 deficiency is a cause of megaloblastic anemia, in which red blood cells are larger than normal and the ratio of nucleus size to cell cytoplasm is increased. (naturalmedicinejournal.com)
There are other potential causes of megaloblastic anemia, including folate deficiency or various inborn metabolic disorders. (naturalmedicinejournal.com)
Pernicious anemia is a type of megaloblastic anemia caused by vitamin B12 deficiency, and it should be treated with vitamin B12. (naturalmedicinejournal.com)
People at risk for vitamin B12 deficiency include strict vegetarians, elderly people, breastfed infants, and people with increased vitamin B12 requirements associated with pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, or liver or kidney disease. (naturalmedicinejournal.com)
Thirty-four patients were enrolled with vitamin B12 deficiency, non-regenerative macrocytic anemia, a positive anti-intrinsic factor antibody and anti-parietal cell antibody and a histological diagnosis of atrophic gastritis in the presence or not of Helicobacter pylori. (bvsalud.org)
Pernicious anemia is caused by an intrinsic factor deficiency or autoantibodies against intrinsic factor. (bvsalud.org)
Both lead to megaloblastic anemia caused by vitamin B12 deficiency. (bvsalud.org)
A chronic dietary deficiency of either folate or vitamin B12 causes macrocytic anemia, although strict dietary deficiencies are rare. (cdc.gov)
Untreated deficiencies will lead to megaloblastic anemia and vitamin B12 deficiency results in irreversible central nervous system degeneration. (cdc.gov)

Intrinsic factor is secreted by parietal cells within the stomach, and so is present in the gastric juice as well as in the gastric mucous membrane. (wikipedia.org)
Vitamin B12 is primarily absorbed by the small intestine, after being bound to intrinsic factor secreted by parietal cells of gastric mucosa. (wikidoc.org)
After cleavage, intrinsic factor, secreted by parietal cells in the gastric mucosa, binds with vitamin B12. (msdmanuals.com)
Absorption of ingested B12 is dependent on intrinsic factor, which is secreted by parietal cells within the stomach. (bvsalud.org)

citation needed] Mutations in the GIF gene are responsible for a rare inheritable disease called intrinsic factor deficiency which results in malabsorption of vitamin B12. (wikipedia.org)
Malabsorption of vitamin B 12 , resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B 12 absorption. (drugs.com)
The more extensive surgeries, such as biliary-pancreatic diversion surgery or more extended Roux-en-Y gastric bypass surgery, may result in more protein malabsorption . (medscape.com)

We describe a 51-year-old man with atrophic gastritis, severe B12 deficiency and hyperhomocystein-emia. (ima.org.il)
Vitamin B12 deficiency can result in both central and peripheral nervous system manifestations (eg, paresthesias, loss of proprioception, poor concentration, and depression) as well as anosmia and atrophic glossitis. (logicalimages.com)
When this process is disrupted by conditions like atrophic gastritis, celiac disease, small bowel resection etc, B12 deficiency ensues. (wikidoc.org)

In humans, the gastric intrinsic factor protein is encoded by the CBLIF gene. (wikipedia.org)
A special protein, called intrinsic factor (IF), binds vitamin B12 so that it can be absorbed in the intestines. (medlineplus.gov)
An autoimmune condition in which the body's immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it. (medlineplus.gov)
It then binds with a protein made by your stomach called intrinsic factor, allowing for absorption by your digestive system. (journalpress.com)
Intrinsic factor is a protein produced by cells in your stomach lining. (livestrong.com)
To absorb vitamin B12 effectively, your body requires an intact stomach and gut, a well-functioning pancreas, and sufficiently high levels of intrinsic factor, a protein that binds to vitamin B12 in the stomach ( 1 ). (healthline.com)
Yes, they're a good source of iron, but the protein in eggs inhibits iron absorption, so this isn't the first food that comes to mind for treating a severe deficiency. (theveganrd.com)
In the stomach, B12 is uncoupled from its carrier protein due to the presence of gastric acid, which is why vitamin B12 deficiency is so commonly seen among those on chronic antacid medication. (wikidoc.org)
In the duodenum, digestive enzymes free the vitamin B12 from haptocorrin, and this freed vitamin B12 combines with intrinsic factor, a transport and delivery binding protein secreted by the stomach's parietal cells. (nih.gov)
A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (bvsalud.org)

Contact your provider if you have symptoms of vitamin B12 deficiency. (medlineplus.gov)
One of the Tribedoce benefits is its potential to alleviate the symptoms of Vitamin B12 deficiency swiftly. (journalpress.com)
If caught early, most symptoms of Vitamin B12 deficiency can be eliminated with treatment. (journalpress.com)
If you are experiencing symptoms of Vitamin B12 deficiency or believe you are at risk, it is imperative to contact your healthcare provider. (journalpress.com)

Health Sneak says that Vitamin B12 deficiency can cause a range of physical, neurological, and psychological symptoms. (journalpress.com)
Yes, untreated Vitamin B12 deficiency can cause severe neurological damages, increasing the risk of mortality. (journalpress.com)
I have seen severe B12 deficiency, with a wide range of neurological, psychiatric and physical symptoms, in someone whose B12 level was 260 pg/mL. (1) So a level of 220 does not rule out deficiency by any means. (pernicious-anaemia-society.org)
In a prospective study of 57 patients with vitamin B-12 deficiency neurological syndrome, common presenting syndromes included myeloneuropathy (25), myelopathy (14), myeloneuroencephalopathy (13), myeloencephalopathy (4), and behavioral (1). (medscape.com)

In the duodenum and jejunum, the pancreatic enzymes digest the gastric R binder and cobalamin is bound to intrinsic factor (IF). (wikidoc.org)

Parietal cells are responsible for the secretion of hydrochloric acid and also produce intrinsic factor. (medscape.com)
Sometimes, though, the stomach doesn't produce intrinsic factor, leading to a Vitamin B12 deficiency. (journalpress.com)

This deficiency most frequently occurs in individuals with celiac disease. (austinfitmagazine.com)

Because vitamin B12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B12, and Vitamin B12 is acid-sensitive, when vitamin B12 binds to Haptocorrin it can safely pass through the acidic stomach to the duodenum, given time in the mouth. (wikipedia.org)

Intrinsic factor (IF), cobalamin binding intrinsic factor, also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. (wikipedia.org)
Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. (wikipedia.org)

In the less acidic environment of the small intestine, pancreatic enzymes digest the glycoprotein carrier and vitamin B12 can then bind to intrinsic factor. (wikipedia.org)
Pancreatic exocrine insufficiency can interfere with normal dissociation of vitamin B12 from its binding proteins in the small intestine, preventing its absorption via the intrinsic factor complex. (wikipedia.org)

Folic-acid deficiency can also lead to infertility and an increased risk of infection. (healthylife.com)
Blunted or impeded therapeutic response to vitamin B 12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency. (drugs.com)

If you don't, you could develop a vitamin A deficiency. (austinfitmagazine.com)

In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs). (nih.gov)
In fact, the main groups of people at risk for B12 deficiency are vegans (strict vegetarians) and people whose stomachs produce less acid as they age. (howstuffworks.com)
Vegans and vegetarians are also prone to deficiencies because they don't consume animal products, the primary source of B12. (austinfitmagazine.com)
Like B12 deficiencies, though, this problem typically occurs in vegetarians and vegans. (austinfitmagazine.com)
Dietary deficiency of Vitamin B 12 , occurring in strict vegetarians and in their breast-fed infants. (drugs.com)
HIV-infected persons and vegetarians who are not taking in proper amounts of B12 are also prone to deficiency. (naturalmedicinejournal.com)

A lack of vitamin B12 usually results from the body's inability to absorb it, not from a dietary deficiency. (howstuffworks.com)
Vitamin B12 is widely available in non-vegan foods, so a dietary deficiency of this vitamin is rare. (labtestsonline.org.uk)

Hemophilia is divided into severe, moderate, and mild diseases depending on the level of functional factor VIII or factor IX. (pediatriconcall.com)
In severe vitamin B12 deficiency, a more serious nerve damage may occur known as subacute combined degeneration of the cord or SACD, where severe weakness and incoordination may occur. (labtestsonline.org.uk)
Folate deficiency in these patients is usually more severe than vitamin B 12 deficiency. (drugs.com)

People most at risk of deficiency include older adults, vegans, and those with specific medical conditions or taking certain medications. (healthline.com)
Dietary vitamin B12 deficiency usually results from inadequate absorption, but deficiency can develop in vegans who do not take vitamin supplements. (msdmanuals.com)

Folate deficiency in early pregnancy can cause neural tube defects such as spina bifida in a growing foetus. (labtestsonline.org.uk)

Diagnosing Vitamin B12 deficiency can be tricky, as the symptoms can resemble other nutritional deficiencies. (journalpress.com)
If you live in the United States, you might not spend much time worrying about nutritional deficiencies. (austinfitmagazine.com)
Nutritional deficiencies contribute strongly to the symptoms of ADHD. (progressivehealth.com)

Intrinsic factor is a substance normally secreted by the parietal cells of the stomach lining and is essential for vitamin B12 absorption. (innvista.com)
Impaired absorption occurs because of deficiency of intrinsic factor which is produced by the parietal cells of the stomach. (wikidoc.org)

If resistance occurs, parenteral therapy, or oral therapy with so-called massive doses of VITAMIN B12 (liver-stomach concentrate with intrinsic factor) may be necessary for adequate treatment of the patient. (rxlist.com)
Recent studies have shown that a vitamin B deficiency in children occurs more often than previously assumed. (stichtingb12tekort.nl)
B12 deficiency occurs much more frequently than generally assumed. (stichtingb12tekort.nl)

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). (drugs.com)

The coagulation cascade consists of two pathways - the intrinsic and extrinsic pathways. (pediatriconcall.com)
In other cases, the initiation of the condition may depend on extrinsic local factors and/or intrinsic predisposing factors. (medscape.com)
Risk factors for nosocomial gastroenteritis can be classified by intrinsic and extrinsic factors. (isid.org)
Extrinsic factors include nasogastric tube feeding while receiving cimetidine or proton pump inhibitors, which allow intestinal colonization of bacteria. (isid.org)

You might lack intrinsic factor, which is a glycoprotein that helps you absorb this vitamin in the gut. (austinfitmagazine.com)
Vitamin B12 and a glycoprotein called intrinsic factor (IF), combine to form the erythrocyte maturation factor, which is required for maturation of red cells in the marrow. (innvista.com)

After B-12 is released by hydrochloric acid and pepsin, pancreatic enzymes bind to B-12 for further digestion, then release B-12 for intrinsic factor to bind to it, which then transports it to your bloodstream. (livestrong.com)

Factors most frequently blamed for the development of idiopathic leukoplakia include tobacco use, alcohol consumption, chronic irritation, candidiasis, vitamin deficiency, endocrine disturbances, and possibly a virus. (medscape.com)
Characterized by chronic inflammation and atrophy (thinning or shrivelling) of the mucous membrane of the stomach and the diminished amount, or total lack, of parietal cells and intrinsic factor. (stichtingb12tekort.nl)

A deficiency in either vitamin B12 or folate can lead to macrocytic anaemia, where red cells are reduced but macrocytic (abnormally large). (labtestsonline.org.uk)

Therefore, a deficiency in this nutrient can have debilitating health effects. (healthline.com)
If you've heard any controversy about fluoride in your city's water supply, you'll discover this is actually an attempt to correct this nutrient deficiency. (austinfitmagazine.com)
I do think, though, that a desire to eat meat coupled with sickness due to nutrient deficiencies could make anyone more susceptible to a message about the alleged dangers of a vegan diet. (theveganrd.com)

When the stomach does not make enough intrinsic factor, the intestine cannot properly absorb vitamin B12. (medlineplus.gov)

It can result from a lack of digestive acids and a substance called the intrinsic factor. (healthylife.com)
A substance called intrinsic factor, made in the stomach, must be present in the intestinal tract in significant amounts to allow for the absorption of vitamin B12. (howstuffworks.com)
Once released, B12 combines with a substance called intrinsic factor (IF) before it is absorbed into the bloodstream. (naturalmedicinejournal.com)

The blind-loop syndrome may produce deficiency of Vitamin B 12 or folate. (drugs.com)

Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N. and Jeffery Stewart D.O., suggest treating all patients that are symptomatic and have B12 levels less than 450 pg/mL. (thehealthyskeptic.org)
It is usually unnecessary for a bone marrow test to be performed for diagnosis of vitamin B12 deficiency. (labtestsonline.org.uk)
Experts suggest that if a patient's serum vitamin B12 level is less than 150 pg/ml (111 pmol/L), the patient's serum MMA levels should be checked to confirm a diagnosis of vitamin B12 deficiency [ 7 , 9 ]. (nih.gov)

Gastrointestinal absorption of Vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions. (nih.gov)
If your grandmother seemed to shrink as she got older, she might have had osteoporosis resulting from a calcium deficiency. (austinfitmagazine.com)

They also recommend treating patients with normal B12, but elevated urinary methylmalonic acid (MMA), homocysteine and/or holotranscobalamin (other markers of B12 deficiency). (thehealthyskeptic.org)
B12 deficiency should therefore be considered in patients being investigated for hypercoagulability. (ima.org.il)
Patients with Addison's disease have a deficiency in the production of glucocorticoid hormones which are manufactured by the adrenal gland. (rarediseases.org)
Stage in response to medical attention immediately if seropositive, she is obese, with a deficiency in the newborn should never be subjected to a degree, volume should be obtained and treatment of patients suffering an episode of acute anaphylaxis. (elastizell.com)
Neonates with undeveloped immunity or patients with an immune deficiency state, such as those on immuno-suppressive drugs or with HIV infection and AIDS, are at increased risk to develop nosocomial gastroenteritis. (isid.org)
If these recommendations had been followed, three (from the seven) patients with a vitamin B12 deficiency (based on serum values) would have been missed. (stichtingb12tekort.nl)
In 1986, Schilling described 2 patients with unrecognized vitamin B-12 deficiency who developed paresthesias and poor manual dexterity 1-3 months after brief N 2 O exposure. (medscape.com)
During January-March 2014, we reviewed risk factors CMRs were lower, but still substantial, for patients receiv- for dissemination and summarized all coccidioidomycosis ing steroids (https://www.niaid.nih.gov/sites/default/files/ cases in patients with primary immunodeficiency (PID). (cdc.gov)
Patients with exogenous immunosuppres- consideration of underlying host genetic factors. (cdc.gov)
Oral cancer development in patients with leukoplakia--clinicopathological factors affecting outcome. (medscape.com)

A lack of B12 changes the blood in the same way as a deficiency of folate, affecting both erythrocyte and leukocyte precursors in the bone marrow. (innvista.com)

You can develop a nutritional deficiency from an inadequate diet, even if you consume ample calories. (austinfitmagazine.com)

Studies have shown that a deficiency of vitamin B12 can lead to abnormal neurologic and psychiatric symptoms. (naturalmedicinejournal.com)
Hematologic signs, however, are not always present in vitamin B12 deficiency and hematologic signs and neurologic abnormalities can be inversely correlated (Baik, et al. (cdc.gov)

There are two types of hemophilia - Hemophilia A and Hemophilia B. Hemophilia A results from deficiency or abnormality of factor VIII. (pediatriconcall.com)
Hemophilia B results from deficiency or abnormality of factor IX. (pediatriconcall.com)
Intrinsic factors include an abnormality in the mucosal defense, such as achlorhydria, impairment of intestinal motility, and alteration of normal enteric flora. (isid.org)

Some people are also born without the intrinsic factor needed to absorb B12. (howstuffworks.com)

Treatments for Vitamin B12 deficiency include oral medications, intramuscular injections, nasal gel, and nasal spray. (journalpress.com)
People most at risk of developing a deficiency include older adults, as well as those who smoke, abuse alcohol, or follow a vegetarian or vegan diet . (healthline.com)
Prebiopsy evaluation should also include a history for any bleeding disorders, medications that might affect hemostasis through their anticoagulative effects, or prior history of bleeding problems after a surgery or procedure, which may indicate an intrinsic clotting factor deficiency. (medscape.com)
Structural lesions leading to vitamin B 12 deficiency include regional ileitis, ileal resections, malignancies, etc. (drugs.com)
The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS. (bvsalud.org)

This explains why B12 deficiency can occur even in people eating large amounts of B12-containing animal products. (thehealthyskeptic.org)
Some individuals do not produce enough acid, pepsin or intrinsic factor to digest sufficient amounts of B-12 from their diet. (livestrong.com)

Because of this and the small daily requirements, it can take a year or longer of insufficient vitamin B12 intake to develop an overt deficiency ( 1 ). (healthline.com)

Cyanocobalamin is the most widely used form of Vitamin B 12 , and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract. (nih.gov)
Isolated vitamin B 12 deficiency is very rare). (drugs.com)
Total gastrectomy always produces vitamin B 12 deficiency. (drugs.com)
Vitamin B 12 deficiency may suppress the signs of polycythemia vera. (drugs.com)
Clinical manifestations due to vitamin B-12 deficiency are unrelated to etiology. (medscape.com)
Although the clinical features of vitamin B-12 deficiency may consist of a classic triad of weakness, sore tongue, and paresthesias, these are not usually the chief symptoms. (medscape.com)
The Elecsys Vitamin B 12 assay employs a competitive test principle using intrinsic factor specific for vitamin B 12 . (cdc.gov)
During the 3rd incubation, streptavidin-coated microparticles and vitamin B 12 labeled with biotin are added and the still-vacant sites of the ruthenium labeled intrinsic factor become occupied. (cdc.gov)
This forms a ruthenium labeled intrinsic factor-vitamin B 12 biotin complex. (cdc.gov)

Intrinsic factor is required for absorption of vitamin B12, which takes place in the terminal ileum. (msdmanuals.com)

Gut surgery, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders are considered additional risk factors. (healthline.com)

In recent years, there has been increasing evidence suggesting that hyperhomocysteinemia is a risk factor for thrombo-embolic disease. (ima.org.il)
Hyperhomocysteinemia is implicated as a risk factor in cardiovascular disease. (wikidoc.org)

Most people who develop a vitamin B12 deficiency have an underlying stomach or intestinal disorder that limits the absorption of vitamin B12. (cdc.gov)

How often does B12 deficiency occur? (stichtingb12tekort.nl)

Anatomy2

Diseases8

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Information Science1

Anemia56

Secreted by parietal cells4

Malabsorption3

Atrophic3

Protein10

Symptoms of vitamin B12 defici4

Neurological4

Bound to intrinsic factor1

Produce intrinsic factor2

Celiac disease1

Binds1

Cobalamin2

Small intestine2

Folic acid defic2

Develop a vitamin A deficien1

Vegetarians6

Dietary deficiency2

Severe3

Vegans2

Folate deficiency1

Nutritional deficiencies3

Parietal cells of the stomach2

Occurs3

Gastric mucosa1

Extrinsic4

Glycoprotein2

Hydrochloric acid1

Chronic2

Macrocytic1

Nutrient3

Absorb vitamin1

Substance3

Syndrome1

Diagnosis3

Calcium2

Patients10

Lack1

Inadequate1

Neurologic2

Abnormality3

Needed to absorb1

Include5

Amounts2

Insufficient1

Vitamin B9

Ileum1

Autoimmune1

Hyperhomocysteinemia2

Absorption of vitamin1

Occur1