Intravenous or subcutaneous dose administration. Medical search. Frequent questions

IV injections are given either as a 1-to-2-min-bolus or an infusion with a longer duration to facilitate administering precise doses in a controlled manner or in providing a rapid response. (pharmtech.com)
Vials should be used only for subcutaneous administration and not intravenous infusion. (rxlist.com)
Recommended dose of ONIVYDE is 70 mg/m 2 intravenous infusion over 90 minutes every two weeks. (nih.gov)
A healthcare provider will give you Cinqair as an intravenous (IV) infusion in your doctor's office or a clinic. (medicalnewstoday.com)
The Day hospital (infusion suite) facilities at a reference hospital were considered for IV administrations and the first six SC injections . (bvsalud.org)
Besides the potential benefits of convenient administration and improving work-life balance , as suggested by the expert panel, natalizumab SC was associated with cost savings for the healthcare system by avoiding drug preparation , reducing administration time , and freeing up infusion suite capacity. (bvsalud.org)
BT-ON014 trade name] intravenous formulation is not intended for subcutaneous administration and should be administered via an intravenous infusion only. (who.int)
Your doctor will watch you carefully for 30 minutes after you receive your intravenous infusion and after your first subcutaneous injection of the medication. (medlineplus.gov)
Your doctor may slow or stop your intravenous infusion if you have an allergic reaction. (medlineplus.gov)

The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics. (pharmtech.com)
Although subcutaneous (SC) delivery is the preferred way to administer an injected therapeutic, SC injections are limited in the amount of drug substance that can be delivered. (pharmtech.com)
They also investigated the pharmacokinetics of multiple injections as well as subcutaneous dosing (which may be self-administered). (news-medical.net)
Provide proper training in subcutaneous injection technique to patients or their caregivers so they can receive once daily subcutaneous injections. (wikidoc.org)
On the next day following the loading dose, instruct patients or their caregivers to begin daily subcutaneous injections of 10 mg of SOMAVERT. (wikidoc.org)
IGF-I levels should also be monitored when a Somavert dose given in multiple injections is converted to a single daily injection. (wikidoc.org)
Will there be problems getting patients to accept weekly intravenous injections on a long-term basis? (medscape.com)

These effects were not seen in mice at approximately 2 times the maximum recommended daily intramuscular or subcutaneous dose. (drugs.com)
The dose can be repeated, as needed, at 1 hour intervals to a total dose of 3 mL for intramuscular or subcutaneous delivery or 2 mL for intravenous delivery in a 24 hour period. (rxlist.com)
We can treat this reaction with an intramuscular or subcutaneous injection of epinephrine - we can perform them with either a regular syringe, or with an automatic EpiPen . (omnicalculator.com)

After subcutaneous injection of insulin detemir in healthy subjects and in patients with diabetes, insulin detemir serum concentrations indicated a slower, more prolonged absorption over 24 hours in comparison to NPH human insulin. (globalrph.com)
On the second day of hospitalization, we switched from intravenous to subcutaneous injection of insulin. (cdc.gov)

A subcutaneous (SC) formulation of natalizumab has been recently authorised for multiple sclerosis patients . (bvsalud.org)
This study aimed to assess the implications of the new SC formulation, and to compare the annual treatment costs of SC versus intravenous (IV) natalizumab therapy from both the Spanish healthcare system (direct health cost ) and the patient (indirect cost ) perspectives. (bvsalud.org)

IV dosing requires the skilled insertion of a needle or catheter directly into a vein, a process that can be challenging, especially in certain patient types such as obese, palliative-care, and neonate patients. (pharmtech.com)
In 1985 IL-2 administration produced durable tumor regressions in some patients with metastatic melanoma. (wikipedia.org)
Recommended starting dose of ONIVYDE in patients homozygous for UGT1A1*28 is 50 mg/m 2 every two weeks. (nih.gov)
There is no recommended dose of ONIVYDE for patients with serum bilirubin above the upper limit of normal. (nih.gov)
The US Food and Drug Administration has recently issued the emergency use authorization or EUA for monoclonal antibodies for both the treatment of COVID-19 and for post-exposure prophylaxis for certain patients, including patients with immunocompromising conditions. (cdc.gov)
The trial assessed the safety and efficacy of maintenance therapy with SC vedolizumab in adult patients with moderately to severely active UC who achieved clinical response at week 6 following two doses of vedolizumab IV. (medscape.com)
At week 6, a total of 162 patients were randomly allocated (2:1) to vedolizumab or placebo by subcutaneous injection every 2 weeks. (medscape.com)
Vedolizumab SC "can provide physicians with an additional administration option for achieving remission in their moderate to severe ulcerative colitis patients," Bruce Sands, MD, chief of gastroenterology at the Icahn School of Medicine at Mount Sinai in New York City, said in the news release. (medscape.com)
I appreciate now having a subcutaneous administration option that provides a clinical profile consistent with Entyvio IV while also giving me and my appropriate UC patients a choice of how they receive their maintenance therapy," Sands added. (medscape.com)
Ketamine sessions can be repeated (if necessary, at higher doses) to elicit response in patients who do not respond. (psychiatrist.com)
Ketamine is most commonly administered in the dose of 0.5 mg/kg, but some patients may respond to doses as low as 0.1 mg/kg, and others may require up to 0.75 mg/kg. (psychiatrist.com)
In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
Patients should be carefully monitored and doses of anti-diabetic drugs reduced as necessary to avoid hypoglycemia in patients with diabetes mellitus . (wikidoc.org)
P433 Intravenous ustekinumab as maintenance treatment is effective in patients with partial or loss of response to optimized ustekinumab sc. (ecco-ibd.eu)
With the usual sc doses (90 mg every 8-12 weeks) some patients will only partially respond or experience secondary loss of response. (ecco-ibd.eu)
Last dose used before the start of ustekinumab IV was 90 mg / 6 weeks in 31.6% and 90 mg / 4 weeks in 68.4% of the patients. (ecco-ibd.eu)
Patients who lose response to the intensified dose of ustekinumab sc could benefit from intravenous administration as maintenance treatment. (ecco-ibd.eu)
The Phase III study, conducted in Japanese patients who converted from intravenous immunoglobulin (IVIG) treatment, found that a dose-equivalent switch to Hizentra therapy maintained serum IgG (immunoglobulin) at a similar level of trough concentration than previous IVIG therapy. (salesandmarketingnetwork.com)
Our study is the first to investigate the safety and efficacy of a subcutaneous immunoglobulin product in Japanese patients," said Toshio Miyawaki, M.D., Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama in Japan, and Coordination Investigator of the study. (salesandmarketingnetwork.com)
Since the 1980s, the first-line therapy for most PID patients has been intravenous immunoglobulin (IVIg), which immunoglobulin is delivered through a needle into the vein. (salesandmarketingnetwork.com)
Some patients, however, cannot easily tolerate intravenous infusions due to serious side effects or poor venous access. (salesandmarketingnetwork.com)
Hizentra allows patients to use a small, portable pump to self-administer their infusions by injection under the skin (subcutaneous administrations). (salesandmarketingnetwork.com)
Patients were switched using 1:1 dose conversion. (salesandmarketingnetwork.com)
Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. (statpearls.com)
Pupils and heart rate are poor indications of appropriate dosing in these patients. (statpearls.com)
However, recent clinical studies reported that clinically approved doses of statins failed to improve clinical outcome in patients with PAH. (escardio.org)
Productivity time associated with travel (56 min to reference hospital , 24 min to regional hospital ) and waiting time pre- and post- treatment (SC 15 min, IV 25 min) were assessed for patients and caregivers (accompanying 20% of SC and 35% of IV administrations). (bvsalud.org)
Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)

This project attempts to confirm and expand the preclinical feasibility data and potential for IRS954 to be a novel therapy for HF with the following Specific Aims: Aim 1: Evaluate the pharmacokinetics and tissue distribution of IRS954 innormal and HF animals by clinically relevant dosing routes of administration. (sbir.gov)
Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration. (cdc.gov)
The objective of this study was to compare CPF pharmacokinetics using oral, intravenous (IV), and subcutaneous (SC) routes as well as corn oil, saline, and dimethyl sulfoxide (DMSO) vehicles in the rat. (cdc.gov)
IV administration of CPF caused bimodal pharmacokinetics, probably due to CPF partitioning into fat once in the body. (cdc.gov)
These results will be useful for elucidating differences regarding potential uncertainty in CPF pharmacokinetics due to varying exposure routes and vehicles of administration. (cdc.gov)

Until definitive studies comparing different doses, rates of administration, routes of administration, and other considerations are conducted, firm recommendations are not possible. (psychiatrist.com)

The indications and dosing regimen for ONUREG differ from that of intravenous or subcutaneous azacitidine ( 2.1 , 5.1 ). (nih.gov)

Therapeutic agents can be introduced into the body by several routes of administration with each having specific advantages and disadvantages (see Table I). For many drugs, including biologics and anticancer agents, the traditional route of administration is intravenous (IV). (pharmtech.com)
Administration of IL-2 after cell transfer enhanced therapeutic potential. (wikipedia.org)
We may also strategize by initiating treatment with intrathecal dosing to rapidly achieve therapeutic concentrations, followed by intravenous or subcutaneous maintenance as needed. (news-medical.net)
1 Despite significant therapeutic advances for MM, autologous stem cell transplant (ASCT) following high-dose, single-agent melphalan conditioning remains a cornerstone of therapy. (haematologica.org)
Correction of enzymatic deficits in hepatocytes by systemic administration of a recombinant protein is a desired therapeutic goal for hepatic enzymopenic disorders such as acute intermittent porphyria ( AIP), an inherited porphobilinogen deaminase (PBGD) deficiency. (unav.edu)
A long-lasting therapeutic effect of rApoAI-PBGDms was observed after either intravenous or subcutaneous administration. (unav.edu)
The MAbs recognize the highly conserved HA1 region of H5N1 hemagglutinin and inhibit multiple strains of the H5N1 virus, as well as treated mice infected with a lethal dose of H5N1 viruses of two divergent strains, demonstrating their potential as therapeutic agents for multivalent prophylaxis and treatment of influenza. (justia.com)

In the phase 1b dose-finding HannaH trial, the appropriate dose of trastuzumab and hyluronidase-oysk (Herceptin Hylecta) was identified. (onclive.com)
3 The appropriate dose of subcutaneous pertuzumab was identified in a phase 1b dose-finding trial. (onclive.com)
This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up. (uchicagomedicine.org)

CONCLUSIONS: Whereas bictegravir plasma concentrations persist at least 4 days after a two-oral-dose HIV prophylaxis regimen, elvitegravir accumulates in mucosal tissues. (cdc.gov)

Bolus administration is safe and effective when the drug is administered intramuscularly or subcutaneously. (psychiatrist.com)
D.H.E. 45 Injection is administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. (rxlist.com)

If you're looking for everyday calculations instead, try our pediatric paracetamol dosage calculator and general pediatric dose calculator . (omnicalculator.com)
Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)

Using a recombinant DNA-derived hyaluronidase enzyme is an approach for possibly changing dosing regimens and bioavailability of several types of agents, including biologics. (pharmtech.com)

IV dosing is also typical when administering irritating agents such as cytotoxics that would otherwise cause tissue damage and pain if given by alternative routes. (pharmtech.com)
During SC administration, a needle is inserted through the epidermal and dermal layers of the skin and into the fatty subcutaneous tissue. (pharmtech.com)
TRESIBA forms multi-hexamers when injected into the subcutaneous tissue resulting in a subcutaneous insulin degludec depot. (globalrph.com)
The protracted time action profile of TRESIBA is predominantly due to delayed absorption of insulin degludec from the subcutaneous tissue to the systemic circulation and to a lesser extent due to binding of insulin-degludec to circulating albumin. (globalrph.com)
A wearable, single use device intended exclusively for use with the co-packaged prefilled drug product container to deliver a fixed dose into subcutaneous (SC) tissue of the thigh or abdomen, in a predetermined time. (westpharma.com)
Bictegravir and elvitegravir reached rectal tissues within 2 h after the first dose, and elvitegravir tissue concentrations [1.07 (0.38-13.51) ng/mg] were greater than bictegravir concentrations [0.27 (0.15-0.70) ng/mg]. (cdc.gov)

Although there are a large number of possible administration routes (limited only by the size and organs of the animal), most are not used regularly in research. (jove.com)
The goal of this article is to expose a viewer unfamiliar with these techniques to basic restraint and substance administration routes. (jove.com)
The study results demonstrated in an animal model that tegoprubart may be safely delivered subcutaneously and that similar blood levels of drug may be achieved by both routes of administration. (itbusinessnet.com)
For all exposure routes and vehicles, approximately 85% of the molar dose of CPF was excreted as some conjugated form of TCPy. (cdc.gov)
Drug administration is the giving of a drug by one of several means (routes). (msdmanuals.com)

Compare levels of IRS954 in the liver of normal animals dosed intraperitoneally with those of animals receiving more clinically relevant subcutaneous and intravenous dosing.b. (sbir.gov)

Large proteins are typically not suited for oral administration, as such drugs would be degraded in the digestive tract and poorly absorbed. (pharmtech.com)
Oral, subcutaneous, and intranasal delivery are perhaps the most practical methods. (psychiatrist.com)
From the point of view of clinical practicability, subcutaneous, intranasal, and oral ketamine warrant further study. (psychiatrist.com)
Oral CPF administration resulted in the highest peak concentration of TCPy (7-11 times higher), which also occurred most rapidly (1.5 hr prior to the next closest). (cdc.gov)
Specimens were collected up to 96 h after two oral doses of tenofovir alafenamide and emtricitabine with elvitegravir boosted by cobicistat or unboosted bictegravir given 24 h apart. (cdc.gov)
After several parenteral doses treatment can be switched over to the oral form. (janusinfo.se)
Calcium folinate can be administered either by the intravenous route at a dose of 20 mg/m2 for 5 to 10 minutes every 6 hours for a total daily dose of 80 mg/m2 or by oral route with four doses of 20 mg/m2 administered at equal time intervals. (janusinfo.se)

The pediatric epinephrine dose calculator allows you to estimate the amount of epinephrine required for a child, no matter the route of administration, be it Intravenous (IV), Intramuscular (IM), Subcutaneous (SC), Endotracheal (ET) or via a nebulizer. (omnicalculator.com)
For the convenience of use, our pediatric epinephrine (adrenaline) dose calculator will equip you with results in both mL and mg . (omnicalculator.com)
The maximum pediatric Epi dose depends on the route of administration, as well as the reason for use. (omnicalculator.com)
Maximum dose for pediatric use is 1 mg . (omnicalculator.com)

FLORENCE, Italy, Oct. 4, 2012 -- (Healthcare Sales & Marketing Network) -- A new study conducted in Japan supports the previously demonstrated safety and efficacy of Hizentra ( immune globulin Subcutaneous [Human]) for the treatment of primary immunodeficiency (PID). (salesandmarketingnetwork.com)
Will its efficacy decline with age or with repeated administration? (medscape.com)

Ketamine is commonly administered intravenously in the dose of 0.5 mg/kg. (psychiatrist.com)
Consequently, these drugs are often given in smaller doses when injected intravenously to produce the same effect. (msdmanuals.com)
The first dose of pozelimab-bbfg injection is usually infused (injected slowly) intravenously over a period of at least 1 hour. (medlineplus.gov)

A sixth Phase 1 study (bridging study) tested IV and subcutaneous doses (24 participants received active medication). (tevapharm.com)
WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. (wikidoc.org)
You can also visit the Food and Drug Administration (FDA) website ( http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide. (medlineplus.gov)

Systemic doses being higher, adverse effects such as mild decrease in platelets were expected,' says Nagata. (news-medical.net)
However, benefits and adverse effects are probably dose-dependent in the range of 0.10-0.75 mg/kg. (psychiatrist.com)

The recommended loading dose of SOMAVERT is 40 mg given subcutaneously, under healthcare provider supervision. (wikidoc.org)
Thereafter, it is usually given subcutaneously once a week, starting 8 days after the first intravenous dose. (medlineplus.gov)

The initial use of intramuscular immunoglobulin (IMIg) which was limited by volume and pain was followed by the development of intravenous immunoglobulin preparations (IVIg), with the advantage that much greater volumes could be given maintaining physiological blood levels of immunoglobulin using doses of around 0.4 g/kg/month. (bmj.com)

This article presents a qualitative review and summary about what is known about ketamine dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions. (psychiatrist.com)
There is likely to be a complex interaction between ketamine dose, session duration, route of administration, frequency of administration, and related practice. (psychiatrist.com)
3 The present article examines issues related to dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions when ketamine is used in subanesthetic doses for the treatment of depression, especially treatment-resistant depression. (psychiatrist.com)
Ketamine was administered by the intravenous (IV) route in the doses of 0.1 and 0.5 mg/kg when its psychotomimetic and other effects were formally studied. (psychiatrist.com)
The route of administration is by subcutaneous injection. (drugs.com)
If an alternate route of administration is required, other trastuzumab products offering such an option should be used. (who.int)
ACAM2000 should not be injected by the intradermal, subcutaneous, intramuscular, or intravenous route ( ACAM2000 package insert [873 KB, 11 pages] ). (cdc.gov)

Previously, achieving delivery of ASO with adequate concentrations in the central nervous system (CNS) with systemic dosing was difficult. (news-medical.net)
This results in more stable trough IgG concentrations which are more physiological than the peaks and troughs associated with intravenous administration. (bmj.com)
Antiretroviral drugs were measured by LC-MS. RESULTS: Mean bictegravir plasma concentrations remained above the 95% protein-adjusted effective concentration 96 h after dosing [273 (95% CI: 164-456) ng/mL] whereas elvitegravir plasma concentrations became undetectable 48 h after the second dose. (cdc.gov)

SC administration with a corn oil vehicle led to faster absorption/metabolism of CPF than did SC administration using DMSO as a vehicle (ka/f: 0.6 and 0.2 mu mol/hr, respectively). (cdc.gov)

Ingestions especially require higher doses (up to 20 mg). (statpearls.com)

Large doses and repeat doses may be required. (statpearls.com)
If there is no improvement in the clinical state after repeat doses of atropine, additional treatments with atropine are unlikely to be effective. (statpearls.com)

We will not be discussing vaccines, extra vaccine doses for persons with immunocompromising conditions. (cdc.gov)
When deciding whether to co-administer other vaccine(s) with ACAM2000, the reactogenicity of ACAM2000 must be considered in balancing the benefits and risks of multiple vaccine doses administered at the same time. (cdc.gov)

In addition immunoglobulin could be used at high dose (hdIVIg) for immunomodulation in a range of autoimmune and inflammatory settings. (bmj.com)
refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
In case of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts. (janusinfo.se)

Another unexplored option is intravenous (IV) administration at regular intervals when shortening sc dose is not effective enough. (ecco-ibd.eu)

We will also provide you with essential information on the epinephrine dose for anaphylaxis in pediatrics , as well as the dose of an EpiPen for kids . (omnicalculator.com)

Responses were often of short duration and faded days after administration. (wikipedia.org)
Sessions that are 40 minutes in duration are conventional, especially with intravenous dosing. (psychiatrist.com)
Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
If a patient continues to experience febrile neutropenia after dose reduction, reduce the treatment duration by 7 days. (guidelinecentral.com)
3. HEALTH EFFECTS the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)

To better understand INSTI distribution and inform dosing selection we compared the pharmacology of two-dose boosted elvitegravir and unboosted bictegravir regimens in MSM. (cdc.gov)

1982, studies demonstrated that intravenous immune lymphocytes could treat bulky subcutaneous FBL3 lymphomas. (wikipedia.org)
Hizentra is the first and only 20 percent subcutaneous immunoglobulin (SCIg) therapy in the world for the treatment of PID, a rare and serious group of diseases of the immune system. (salesandmarketingnetwork.com)
d) Intravenous immune globulin (IGIV): A product derived from blood plasma from a donor pool similar to the IG pool, but prepared so it is suitable for intravenous use. (cdc.gov)
For a list of intravenous immune globulins, see Table 2 . (cdc.gov)
Active immunization is the production of antibody or other immune responses through the administration of a vaccine or toxoid. (cdc.gov)

The FDA is currently reviewing Takeda's biologics license application for SC administration of vedolizumab in the treatment of adults with moderately to severely active Crohn's disease. (medscape.com)
The fixed-dose subcutaneous combination would allow for administration by a healthcare professional in a treatment center or at home. (onclive.com)
However, transient improvements with repeat dosing are an indication to continue treatment with atropine (which may exceed standard cumulative dosing maximums). (statpearls.com)
BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
If you have received this vaccine in the past, you may need to receive a booster dose before you begin your treatment. (medlineplus.gov)
In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)
Prevention: Calcium folinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate. (janusinfo.se)

We found that cholesterol conjugated HDO (Chol-HDO), unlike cholesterol-ASO, efficiently reached the CNS following subcutaneous or intravenous administration in experimental animals. (news-medical.net)
Practice restraint before attempting compound administration, and practice administering substances to control animals before experimental animals. (jove.com)

Successfully completed a preclinical, non-human primate study comparing subcutaneous and intravenous tegoprubart formulations. (itbusinessnet.com)

Ketamine may be administered as rapidly as in a bolus dose to as slowly as across 100 minutes. (psychiatrist.com)

The usual subcutaneous dose of Terbutaline Sulfate injection is 0.25 mg. (rxlist.com)
The usual subcutaneous dose of terbutaline sulfate injection is 0.25 mg injected into the lateral deltoid area. (rxlist.com)
If significant clinical improvement does not occur within 15 to 30 minutes, a second dose of 0.25 mg may be administered. (rxlist.com)
Lower doses have been trialed, such as 0.25 mg/kg with S -ketamine 3 and even 0.2 mg/kg with the racemate. (psychiatrist.com)

High doses of IL-2 could inhibit tumor growth in mice. (wikipedia.org)
Compare the levels of IRS954 in the liver of normal and HF mice with the optimal dosing conditions from part a. (sbir.gov)
Often, another part of the research or testing use of animals is the effective administration of compounds to mice and rats. (jove.com)

Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range. (medicines.org.uk)
Animal reproduction studies of subcutaneous administration of this during organogenesis resulted in adverse developmental effects (including gastroschisis, embryonic lethality, and delayed skeletal ossification) at doses approximately 2 times the maximum recommended daily intramuscular, subcutaneous, or intravenous dose. (drugs.com)
Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)

In vivo experiments showed that, after intravenous injection, rhApoAI-PBGD circulates in blood incorporated into high-density lipoprotein (HDL), penetrates into hepatocytes, and crosses the blood-brain barrier, increasing PBGD activity in both the liver and brain. (unav.edu)
In addition, the feasibility of imaging of DAbR1-positive T cells in vivo after intravenous injection of 86 Y/ 177 Lu-AABD was studied and radiation doses determined. (snmjournals.org)

In an animal embryofetal development study with dosing during organogenesis (on days 3 to 5, 6 to 7, or 7 to 9 of gestation), epinephrine caused teratogenic effects (including gastroschisis) at doses approximately 15 times the maximum recommended intramuscular, subcutaneous, or intravenous dose (on a mg/m2 basis at a maternal subcutaneous dose of 1.2 mg/kg/day for 2 to 3 days). (drugs.com)
In an embryofetal development study subcutaneous administration on gestation days 6 to 15 showed teratogenicity, embryonic lethality, and delays in skeletal ossification at approximately 3 times the maximum recommended intramuscular, subcutaneous, or intravenous dose. (drugs.com)
In an embryofetal development study with subcutaneous administration during organogenesis (from gestation days 7 to 10) litter size was reduced and delayed skeletal ossification was seen at doses approximately 2 times the maximum recommended intramuscular, subcutaneous, or intravenous dose. (drugs.com)
This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic Leukemia. (uchicagomedicine.org)
The study will consist of a dose-escalation stage and an expansion. (uchicagomedicine.org)
The purpose of this study is to determine the safety and tolerability of intravenous (IV) and subcutaneous (SC) administration of XmAb13676 and to determine the maximally tolerated dose (MTD) and/or recommended dose (RD). (uchicagomedicine.org)
In the first study, CPF and isotopically labeled CPF (L-CPF) were co-administered, at doses of 5 mg/kg each, orally and IV in a saline with 5% Tween 20 vehicle. (cdc.gov)
In the second study, the same doses of CPF and L-CPF were co-administered SC using corn oil and DMSO. (cdc.gov)

Blood glucose decreased in response to continuous intravenous administration of insulin and saline. (cdc.gov)

An IM Epi dose for pediatrics using a regular syringe is 0.01 mg/kg of a 1:1,000 solution (0.01 ml/kg). (omnicalculator.com)
Benralizumab is indicated for administration once every 8 weeks in a fixed-dose subcutaneous injection via prefilled syringe. (medscape.com)

This suggests that CPF administered systemically could result in a greater body burden of CPF than would an equivalent dose administered orally, potentially leading to a higher CPF concentration at target tissues. (cdc.gov)

The weight-of evidence evaluations are qualitative in nature, although ATSDR recognizes that observations of toxicological interactions depend greatly on exposure doses and that some interactions appear to have thresholds. (cdc.gov)
however, longstanding ACIP guidance includes a recommendation for revaccination of laboratory and health care personnel designated to be at risk for ongoing occupational exposure to mpox virus and replication-competent vaccinia virus with a booster dose every 3 years or at least every 10 years, respectively. (cdc.gov)
The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (rxlist.com)
LBR-101 has successfully completed five Phase I trials with 94 healthy volunteers dosed with active drug. (tevapharm.com)
The US Food and Drug Administration (FDA) has approved the subcutaneous (SC) administration of vedolizumab (Entyvio SC, Takeda) for maintenance therapy in adults with moderately to severely active ulcerative colitis (UC) following induction therapy with intravenous administration of vedolizumab. (medscape.com)
Ustekinumab is an effective drug in Crohn´s Disease (CD) and most frequently used dose is subcutaneous (sc) 90 mg / 8 weeks. (ecco-ibd.eu)
The first combination product that incorporates the SmartDose ® 3.5 on-body delivery system (OBDS) has been approved by the U.S. Food and Drug Administration (FDA).The SmartDose ® 3.5 OBDS is a drug delivery system consisting of a battery-powered, wearable on-body injector with a separate, pre-fillable, polymer based cartridge that is filled with the drug product. (westpharma.com)
Considering the patient care pathway and according to natalizumab experience (IV) or estimation (SC), a national expert panel involving neurologists , pharmacists , and nurses provided information/data regarding resource consumption for drug and patient preparation, administration , and documentation . (bvsalud.org)
ACAM2000 is licensed by the U.S. Food and Drug Administration for immunization against smallpox for people determined to be at high risk for smallpox infection. (cdc.gov)
Introduction to Administration and Kinetics of Drugs See Nanomedicine for an overview of all the ways in which nanotechnology has improved drug delivery. (msdmanuals.com)
Benralizumab was approved by the US Food and Drug Administration (FDA) after several phase 3 trials. (medscape.com)

One month after a single intravenous dose of rApoAI-PBGDms, the protein was still detectable in the liver, and hepatic PBGD activity remained increased above control values. (unav.edu)

The company expects vedolizumab SC to be available in the United States as a single-dose pre-filled pen (Entyvio Pen) by the end of October. (medscape.com)
Single dose: 3 mL / 60 kg (7.5 mg / kg). (abbeyveterinarysupply.com)
ACAM2000 vaccine is licensed as a single dose. (cdc.gov)

Resume at the same dose once platelets return to 50 Gi/L or higher. (guidelinecentral.com)
After platelets return to 50 Gi/L or higher, resume at reduced dose of 200 mg. (guidelinecentral.com)

However, divided or subcutaneous dosing can rescue these. (news-medical.net)
Calcium folinate rescue is necessary when methotrexate is given at doses exceeding 500 mg/m2 body surface and should be considered with doses of 100 mg - 500 mg/m2 body surface. (janusinfo.se)

The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)

Conventional dose: 1 ml / 60 kg (2.5 mg / kg). (abbeyveterinarysupply.com)

Terbutaline sulfate injection, USP is a beta-adrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. (rxlist.com)

Administer an antiemetic before each dose for at least the first 2 cycles ( 2.2 ). (nih.gov)
Administer an antiemetic 30 minutes prior to each dose of ONUREG for the first 2 cycles. (nih.gov)
We can administer epinephrine (adrenaline) dose in pediatrics with two different solutions , namely 1:1,000 and 1:10,000. (omnicalculator.com)

The total dose within 4 hours should not exceed 0.5 mg. (rxlist.com)

However, they do not enter the CNS effectively following systemic administration and require direct intrathecal injection. (news-medical.net)

Cite this: FDA OKs Subcutaneous Vedolizumab (Entyvio) for UC Maintenance Therapy - Medscape - Sep 28, 2023. (medscape.com)

How to calculate epinephrine dose in pediatrics? (omnicalculator.com)
What's the maximum dose of epinephrine for a child? (omnicalculator.com)

Anatomy2

Organisms2

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes6

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care4

Infusion9

Injections7

Intramuscular or subcutaneous3

Injection of insulin2

Formulation2

Patients28

Pharmacokinetics5

Considerations1

Indications1

Therapeutic7

Phase 1b3

Prophylaxis1

Intramuscularly or subcutaneously2

Dosage2

Bioavailability1

Tissue6

Routes5

Clinically1

Oral7

Pediatric4

Efficacy2

Intravenously3

Medication3

Adverse effects2

Subcutaneously2

IVIg1

Route7

Concentrations3

Absorption1

Higher doses1

Repeat doses2

Vaccine doses2

High-dose3

Intervals1

Anaphylaxis1

Duration5

Regimens1

Immune5

Treatment7

Experimental animals2

Formulations1

Rapidly1

0.25 mg4

Mice3

Daily3

Vivo2

Study8

Saline1

Syringe2

Orally1

Exposure3

Drug9

Protein1

Single3

Platelets2

Rescue2

Chemotherapy1

Conventional1

Sterile1

Administer3

Total dose1

Systemic administration1

Therapy1

Epinephrine2