IntramuscularPropofolDexmedetomidineAnesthesiaSurgical anesthetic and analgesicSedationHydrochlorideInjectionAgonistRapid intravenousKetamineAtipamezoleIsofluraneInfusionRacemicSufentanilCombinationAnestheticsAdministrationFormDEXMEDETOMIDINEAnaesthetized with propofol and sevofluraneXylazineSedativeButorphanolAnestheticInfusionsClinicalFluidsDoseImidazoleSubstanceRoutesEffectsDogsProcedures
Intramuscular4
- It can be given by intramuscular injection (IM), subcutaneous injection (SC) or intravenous injection (IV). (wikipedia.org)
- Epidural analgesia combined with inhalatory anesthesia may provide advantages over the conventional routes of analgesic administration (intravenous or intramuscular), including reduction of the doses of the inhalant agents required to produce anaesthesia and thus the side effects derived from higher doses 1 1. (scielo.br)
- Sedative and Cardiopulmonary effects of intramuscular combinations of hydromorphone, acepromazine, dexmedetomidine and glycopyrrolate followed by intravenous propofol and inhalant isoflurane anesthesia in healthy dogs. (colostate.edu)
- Einwaller J, Meyer LCR, Auer U, Raekallio M, Nowack J , Haw A, Vetter S, Painer J and G Stalder (2021) Cardiovascular effects of intravenous vatinoxan in wild boars ( Sus scrofa ) anaesthetised with intramuscular medetomidine-tiletamine-zolazepam . (julianowack.com)
Propofol3
- Propofol is a non-narcotic, non-barbiturate and rapid-acting intravenous anesthetic. (rrcus.org)
- Epidural anesthesia with bupivacaine, bupivacaine and fentanyl, or bupivacaine and sufentanil during intravenous administration of propofol for ovariohysterectomy in dogs. (scielo.br)
- Observation group were given target controlled infusion of sufentanil combined with propofol while control group received continuous intravenous infusion of sufentanil and propofol target controlled infusion for anesthesia maintenance in surgery. (biomedres.info)
Dexmedetomidine3
- DEXMEDETOMIDINE injection, for intravenous use. (nih.gov)
- Dexmedetomidine hydrochloride in 0.9% sodium chloride injection is indicated for short-term intravenous sedation. (pharmacyhq.com)
- DEXMEDETOMIDINE HYDROCHLORIDE in 0.9% sodium chloride injection, for intravenous use. (pharmacyhq.com)
Anesthesia4
- In veterinary anesthesia, medetomidine is often used in combinations with opioids (butorphanol, buprenorphine etc.) as premedication (before a general anesthetic) in healthy cats and dogs. (wikipedia.org)
- Premedicating the patient, pre-oxygenating prior to induction, and maintaining an intravenous catheter and administering IV fluids during general anesthesia can improve the relative safety of any drug or drug combination. (rrcus.org)
- Combination of continuous intravenous infusion using a mixture of guaifenesin-ketamine-medetomidine and sevoflurane anesthesia in horses. (lookformedical.com)
- The anesthetic and cardiovascular effects of a combination of continuous intravenous infusion using a mixture of 100 g/L guaifenesin-4 g/L ketamine-5 mg/L medetomidine (0.25 ml/kg/hr) and oxygen-sevoflurane (OS) anesthesia (GKM-OS anesthesia) in horses were evaluated. (lookformedical.com)
Surgical anesthetic and analgesic1
- Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. (wikipedia.org)
Sedation1
- This study assessed the effects of sedation using a combination of fentanyl, midazolam and medetomidine in comparison to ketamine. (biomedcentral.com)
Hydrochloride1
- It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. (wikipedia.org)
Injection1
- In additional studies, the biokinetics of ultrafine particles and soluble 192Ir was studied after administra- tion by either gavage or intratracheal instillation or intravenous injection. (cdc.gov)
Agonist1
- It is an α2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. (wikipedia.org)
Rapid intravenous1
- Bradycardia and Sinus Arrest: Have occurred in young healthy volunteers with high vagal tone or with different routes of administration, e.g., rapid intravenous or bolus administration. (nih.gov)
Ketamine10
- It is sometimes used in combination with butorphanol and ketamine (given IM) to produce general anaesthesia for short periods in healthy but fractious felines that will not allow an intravenous induction agent to be given. (wikipedia.org)
- Medetomidine has also been used in combination with morphine (or methadone), lidocaine and ketamine in constant rate infusion analgesia in canines. (wikipedia.org)
- Objective: To assess the differences in the pharmacokinetic profiles of S-ketamine, R-ketamine and their metabolites, S-norketamine and R-norketamine, and to measure relevant physiologic variables after intravenous administration of racemic (RS) ketamine or S-ketamine alone in Beagle dogs sedated with medetomidine. (unibo.it)
- Methods: Medetomidine (450 μg m-2) was administered intramuscularly, followed by either S-ketamine (2 mg kg-1) or RS-ketamine (4 mg kg-1) 20 minutes later, both administered intravenously. (unibo.it)
- Blood samples were collected before medetomidine administration and at multiple time points 1-900 minutes following the ketamine administration. (unibo.it)
- Conclusions and clinical relevance: This study performed in dogs showed that RS-ketamine and S-ketamine combined with medetomidine showed enantioselective pharmacokinetics as S- and R-norketamine AUCs were different, but S-ketamine levels were identical. (unibo.it)
- This study compared the effects of a combination of fentanyl-midazolam-medetomidine (FMM), followed by reversal with naloxone and atipamezole, with ketamine (KET) in rhesus macaques. (biomedcentral.com)
- 2020. Postanaesthetic effects of ketamine-midazolam and ketamine-medetomidine on gastrointestinal transit time in rabbits anaesthetised with isoflurane. (awionline.org)
- The objective of this study was to assess the impact on gastrointestinal transit time of ketamine-midazolam (KMZ) versus ketamine-medetomidine (later antagonised by atipamezole) (KMT-A) in rabbits. (awionline.org)
- Induction was induced with medetomidine (medetomidine, Kyron Laboratories, 40 mg/ml) 25 mg and ketamine (ketamine, Kyron Laboratories, 200 mg/ml) 300 mg IM in the left neck using a carbon dioxide powered rifle (Daninject JM Special Rifle, Daninject). (vin.com)
Atipamezole1
- Although this can be achieved by the addition of medetomidine, as in other species, recovery is still relatively prolonged even after reversal of the medetomidine with atipamezole [ 11 ]. (biomedcentral.com)
Isoflurane1
Infusion1
- An imidazole antifungal agent that is used topically and by intravenous infusion. (drugcentral.org)
Racemic1
- It is closely-related to MEDETOMIDINE, which is the racemic form of this compound. (drugcentral.org)
Sufentanil1
- Sufentanil analgesia following cesarean section: epidural versus intravenous administration. (scielo.br)
Combination1
- Torske KE, Dyson DH, Pettifer G. End tidal halothane concentration and postoperative analgesia requirements in dogs: a comparison between intravenous oxymorphone and epidural bupivacaine alone and in combination with oxymorphone. (scielo.br)
Anesthetics1
- Therapy was continued with two more repeat anesthetics for assessment, intravenous fluid therapy, repeat biochemistry, and CBC, which showed deterioration in renal and hepatic parameters. (vin.com)
Administration1
- Compared with other modes of administration, intravenous medications generally have a quick onset, have a predictable drug absorption, and are titratable. (medscape.com)
Form1
- The free base form of medetomidine is sold as Selektope for use as an antifouling substance in marine paints. (wikipedia.org)
DEXMEDETOMIDINE11
- Dexmedetomidine is the S -enantiomer of medetomidine, a sedative and analgesic for veterinary use, and has structural similarity to clonidine. (medscape.com)
- Dissociative anaesthetics (ketamine, tiletamine) in combination with α -2 agonists (xylazine, medetomidine, dexmedetomidine) administered intramuscularly, and propofol or alfaxalone (3- α -hydroxy-5- α -pregnane-11,20-dione) administered intravenously have been reported as being used for effective sedation or anaesthesia in reptiles. (vin.com)
- 5. Effects of dexmedetomidine and xylazine on cardiovascular function during total intravenous anaesthesia with midazolam and ketamine and recovery quality and duration in horses. (nih.gov)
- 11. Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins. (nih.gov)
- 19. Evaluation of a ketamine-propofol drug combination with or without dexmedetomidine for intravenous anesthesia in cats undergoing ovariectomy. (nih.gov)
- Dexmedetomidine is a water-soluble imidazole compound and a pharmacologically active dextro-isomer of medetomidine, a potent alpha-2 agonist used in veterinary medicine. (mhmedical.com)
- Intravenous dexmedetomidine has a large volume of distribution of about 118 L and is 94% protein bound. (mhmedical.com)
- The mean elimination half-life of dexmedetomidine is one and a half to 3 hours for intravenous administration and 5 to 6 hours for intramuscular administration. (mhmedical.com)
- Dosing intravenous dexmedetomidine is dependent on the clinical setting. (mhmedical.com)
- In the ICU, intravenous dexmedetomidine is dosed based on the Richmond Agitation Sedation Scale (RASS) or clinical sedative effect. (mhmedical.com)
- Ramsay MA, Luterman DL (2004) Dexmedetomidine as a total intravenous anesthetic agent. (aimspress.com)
Anaesthetized with propofol and sevoflurane1
- Vasiljević M, Krstić V, Stanković S, Zrimšek P, Nemec Svete A, Seliškar A. Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction . (uni-lj.si)
Xylazine2
- 2021. Comparison of recovery quality following medetomidine versus xylazine balanced isoflurane anaesthesia in horses: A retrospective analysis. (awionline.org)
- 24 cats were randomized to either no surgery, or onychectomy with intravenous morphine, xylazine, or salicylate. (littlebigcat.com)
Sedative1
- 2023. Antinociceptive, sedative and excitatory effects of intravenous butorphanol administed alone or in combination with detomidine in calves: A prospective, randomized, blinded cross-over study. (awionline.org)
Butorphanol2
- Postoperative pain control in cats: clinical trials with medetomidine and butorphanol. (littlebigcat.com)
- Medetomidine and butorphanol provided equivalent pain relief up to 2 hours. (littlebigcat.com)
Anesthetic2
- Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. (wikipedia.org)
- The GI and renal adverse effects can be expected to occur most commonly in higher risk patients, e.g.: hypovolemia, hypotension (including anesthetic procedures especially those not supported by intravenous fluids), pre-existing GI or renal disease, overusage, and the inappropriate combination with other NSAID's or corticosteroids. (dvm360.com)
Infusions1
- Initially the muscle spasms, stiffness and tremors casued by tetanus were managed with constant rate infusions of medetomidine and midazolam, as well as boluses of ACP. (veterinary-practice.com)
Clinical1
- The article describes the intravenous inoculation methodology for each route, the clinical health status assessment and the histological evaluation of the inoculated veins. (usamv.ro)
Fluids1
- CiCi was immediately given intranvenous tetanus antitoxin without any side effects and was hospitalised to receive supportive treatment of intravenous fluids, sedation, muscle relaxants and antibiotics. (veterinary-practice.com)
Dose1
- In published studies conducted on the intravenous administration of alfaxalone in reptiles there is a variation in recommended dose rates and degree of anaesthetic monitoring. (vin.com)
Imidazole1
- An imidazole antifungal agent that is used topically and by intravenous infusion. (harvard.edu)
Substance2
- The free base form of medetomidine is sold as Selektope for use as an antifouling substance in marine paints. (wikipedia.org)
- Medetomidine can be used as an antifouling substance in marine paint. (wikipedia.org)
Routes1
- Bradycardia and Sinus Arrest: Have occurred in young healthy volunteers with high vagal tone or with different routes of administration, e.g., rapid intravenous or bolus administration. (nih.gov)
Effects1
- The results obtained show that the safenous vein represents a safe way of intravenous inoculation, both as a technique and as side effects and histopathological lesions, and can be an alternative to the current method. (usamv.ro)
Dogs1
- This group of dogs was the control group, as in these dogs medetomidine was not administered. (gov.rs)
Procedures1
- Intravenous inoculation is done, according to procedures, 2 times at 7 days in the intravenous penile vein, therefore only males are used. (usamv.ro)