Intravenous dose of digoxin. Medical search. Frequent questions

In this setting, AV nodal blocking drugs such as adenosine, verapamil, digoxin and esmolol are contraindicated as their use will divert atrial impulses to the AP. (ccasociety.org)
2. Medications include intravenous adenosine (see figure 2), calcium- entry blockers, digoxin, beta-adrenergic blockers. (rjmatthewsmd.com)

3. Long term management include medications like digoxin, propranolol (inderal) or verapamil. (rjmatthewsmd.com)

If you are taking this medicine, your doctor may ask you to have regular blood tests to determine the amount of digoxin in the blood. (medicines.org.uk)
When a large amount of digoxin has been ingested, especially in patients with impaired renal function, hyperkalemia may be present due to release of potassium from skeletal muscle. (tasmanianairrescuetrust.org)

Chronic toxicity in patients on digoxin therapy may result from deteriorating renal function, dehydration, electrolyte disturbances, or drug interactions. (medscape.com)
High doses can cause fluid and electrolyte imbalances from loss of sodium and water. (universityhealthnews.com)
However, in deciding whether a patient's symptoms are due to digoxin, the clinical state together with serum electrolyte levels and thyroid function are important factors. (tasmanianairrescuetrust.org)
Unusual (more severe): Peripheral neuropathy (dose related), electrolyte abnormalities, and hyperuricemia. (cdc.gov)

For adults and pediatric patients if a loading dosage is to be given, administer half the total loading dose initially, then ¼ the loading dose every 6-8 hours twice, with careful assessment of clinical response and toxicity before each dose. (guidelinecentral.com)
The recommended starting maintenance dose in adults and pediatric patients over 10 years old with normal renal function is given in Table 2 . (guidelinecentral.com)
Table 3 provides the recommended (once daily) maintenance dose for adults and pediatric patients over 10 years old (to be given once daily) according to lean body weight and renal function. (guidelinecentral.com)
In 2-year study in SPRAGUE-DAWLEY (R) rats, albuterol sulfate caused dose-related increase in the incidence of benign leiomyomas of the mesovarium at the above dietary doses of mg/kg (approximately 15 times the maximum recommended daily inhalation dose for adults on mg/m basis and approximately times the maximum recommended daily inhalation dose for children on mg/m basis). (drugcentral.org)
In an 18-month study in CD-1 mice, albuterol sulfate showed no evidence of tumorigenicity at dietary doses of up to 500 mg/kg (approximately 1700 times the maximum recommended daily inhalation dose for adults on mg/m basis and approximately 800 times the maximum recommended daily inhalation dose for children on mg/m basis). (drugcentral.org)
Albuterol sulfate was not clastogenic in human peripheral lymphocyte assay or in an AH1 strain mouse micronucleus assay.Reproduction studies in rats demonstrated no evidence of impaired fertility at oral doses up to 50 mg/kg (approximately 340 times the maximum recommended daily inhalation dose for adults on mg/m basis). (drugcentral.org)
Children exposed to the same levels of mercury vapor as adults may receive larger doses because they have greater lung surface area:body weight ratios and increased minute volumes:weight ratios. (cdc.gov)
Uncommon: Pancreatitis (dose related, less common in children than adults), increased liver enzymes, and retinal depigmentation. (cdc.gov)

Low body weight, advanced age or impaired renal function, hypokalemia , hypercalcemia , or hypomagnesemia may predispose to digoxin toxicity. (wikidoc.org)

Nevertheless, cardiac glycoside toxicity continues to be a problem in the United States because of the wide use of digoxin (a preparation of digitalis) and its narrow therapeutic window. (medscape.com)
In selecting a LANOXIN dosing regimen, it is important to consider factors that affect digoxin blood levels (e.g., body weight, age, renal function, concomitant drugs) since toxic levels of digoxin are only slightly higher than therapeutic levels. (guidelinecentral.com)
Administration of doses ranging from five to ten times greater (on a mg/kg basis) than the daily recommended therapeutic dose has resulted in embryo and fetal lethality. (pillsync.com)

Correct hypokalemia by administering potassium so that serum potassium is maintained between 4.0 and 5.5 mmol/L. Potassium is usually administered orally, but when correction of the arrhythmia is urgent and serum potassium concentration is low, potassium may be administered by the intravenous route. (tasmanianairrescuetrust.org)

LANOXIN dose is based on patient-specific factors (age, lean body weight, renal function, etc. (guidelinecentral.com)

Reduce the dose of LANOXIN in patients whose lean weight is an abnormally small fraction of their total body mass because of obesity or edema. (guidelinecentral.com)
Lanoxin (Digoxin) unscored tablets: 62.5 and 187.5 mcg. (tasmanianairrescuetrust.org)
Lanoxin (Digoxin) scored tablets 125 and 250 mcg. (tasmanianairrescuetrust.org)
In addition to cardiac monitoring, temporarily discontinue Digoxin (Lanoxin) until the adverse reaction resolves. (tasmanianairrescuetrust.org)
Once the adverse reaction has resolved, therapy with Lanoxin may be reinstituted following a careful reassessment of dose. (tasmanianairrescuetrust.org)
Avoid Digoxin (Lanoxin) in patients with myocarditis. (tasmanianairrescuetrust.org)

While standardised concentrations for intravenous infusion and drug concentrations that avoid measurement of small volumes would ameliorate problems, further work is needed to establish accurate methods for handling small volumes during the administration of medicines to children and risk minimisation strategies to support staff involved are also necessary. (bmj.com)

Use digoxin solution to obtain the appropriate dose in infants, young pediatric patients, or patients with very low body weight. (guidelinecentral.com)
Pediatric usual dose: In combination with other antiretrovirals: 90 mg per m2 of body surface area every 12 hours. (cdc.gov)
Pediatric dose: 4 mg per kg of body weight twice daily. (cdc.gov)
Neonatal dose: Under evaluation in Pediatric AIDS Clinical Trial Group protocol 332. (cdc.gov)
Pediatric dose: 1 mg per kg of body weight every 12 hours (up to weight of 30 kg). (cdc.gov)

Medications to treat the toxic effects include: intravenous fluids, calcium gluconate, glucagon, high dose insulin, vasopressors and lipid emulsion. (wikipedia.org)
The three most common types of heart medications that result in this outcome are calcium channel blockers along with beta blockers and digoxin. (wikipedia.org)
The half-life of routinely used medications and adjustment of the dose according to the perioperative schedule must be considered. (medscape.com)
Many medications must be continued through the perioperative period, with the last dose taken with a sip of clear liquid up to 2 hours prior to the procedure, and resumed during recovery. (medscape.com)

He would inject that into patients or add lethal doses of insulin and other drugs to their harmless intravenous saline pouches. (uromivoice.com)
Dicycloverine may affect the gastrointestinal absorption of various drugs, such as digoxin, metoclopramide. (medeasy.health)
SD 14.2) months, starting deferoxamine at 5 (SD 0.48) years and taking cardiotonic drugs for at least 1 month (all patients were on digoxin, 93.3% on captopril and 80.0% first evaluation (after 2 days of deferoxam- on furosemide). (who.int)

Acute digitalis toxicity can result from unintentional, suicidal, or homicidal overdose of the digitalis preparation digoxin, or accidental ingestion of plants that contain cardiac glycosides. (medscape.com)
Digoxin tablets contain the active substance digoxin, which belongs to a group of medicines called cardiac glycosides. (medicines.org.uk)
Are allergic to digoxin, other cardiac glycosides or any of the other ingredients of this medicine (listed in section 6). (medicines.org.uk)

After the 1st day of concomitant dosing, a 30-fold increase of bosentan trough plasma concentrations was observed compared with volunteers receiving bosentan alone. (aspetjournals.org)

Our goal in this study was to assess the efficacy of intravenous dofetilide, in five different dosing regimens, for treating patients with inducible atrioventricular re-entrant tachycardia, by determining its ability to prevent reinduction of the tachycardia. (bmj.com)
L1) [7-9] and ICL670 (Exjade) [4,10] was taken and they underwent a physi- and different intravenous (IV) regimens cal examination. (who.int)

High doses of intravenous insulin with glucose may be useful and are a first line treatment in overdoses. (wikipedia.org)

Known hypersensitivity to digoxin (reactions seen include unexplained rash, swelling of the mouth, lips or throat or a difficulty in breathing). (wikidoc.org)
A hypersensitivity reaction to other digitalis preparations usually constitutes a contraindication to digoxin. (wikidoc.org)
Known hypersensitivity to digoxin or other forms of digitalis. (tasmanianairrescuetrust.org)

About 14% of an orally-administered dose of losartan is converted to the active metabolite. (medlibrary.org)
After single doses of losartan administered orally, about 4% of the dose is excreted unchanged in the urine and about 6% is excreted in urine as active metabolite. (medlibrary.org)
Patients who have intentionally or accidently ingested massive doses of digoxin should receive activated charcoal orally or by nasogastric tube regardless of the time since ingestion since digoxin recirculates to the intestine by enterohepatic circulation. (tasmanianairrescuetrust.org)

therefore, administer high doses with caution, and closely observe patient response. (medscape.com)
Several small doses are best because high doses may induce tachycardia. (msdmanuals.com)

The recommended intramuscular dose is 80 mg daily (in 4 equally divided doses). (medeasy.health)
Dicycloverine HCl Injection is a sterile, pyrogen-free, aqueous solution for intramuscular injection (Not For Intravenous Use). (medeasy.health)

Neonatal drug delivery is particularly challenging, and doses are often immeasurable with the equipment currently available. (bmj.com)

Life threatening arrhythmias (ventricular tachycardia, ventricular fibrillation, high degree A-V block, bradyarrhythma, sinus arrest) or hyperkalemia requires administration of Digoxin Immune Fab. (tasmanianairrescuetrust.org)
OBJECTIVE To assess the efficacy and safety of intravenous dofetilide in preventing induction of atrioventricular re-entrant tachycardia. (bmj.com)
Fifty one patients with electrically inducible atrioventricular re-entrant tachycardia were allocated to one of five doses of dofetilide (1.5, 3, 6, 9, and 15 μg/kg), two thirds of the dofetilide dose being given over a 15 minute loading period and the remainder over a 45 minute maintenance period. (bmj.com)
RESULTS Intravenous dofetilide had no effect on tachycardia inducibility at the two lower doses (1.5 and 3 μg/kg) but prevented the reinduction of tachycardia at the three higher doses (6, 9, and 15 μg/kg) at a rate of 36% (11/31). (bmj.com)
14-16 However, to date there have been no studies on the dose dependent effects of dofetilide on atrioventricular re-entrant tachycardia. (bmj.com)

The best way to guide therapy is to follow the digoxin level and correlate it with serum potassium concentrations and the patient's clinical and ECG findings. (medscape.com)
Doses may be increased every 2 weeks according to clinical response, serum drug levels, and toxicity. (guidelinecentral.com)
Digoxin: May decrease serum digoxin levels. (drugcite.com)

Albuterol has been shown in most clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. (drugcentral.org)

The doses are based on studies in adult patients with heart failure. (guidelinecentral.com)
The recommended adult dose of Lexapro is 10 mg once daily. (rxlist.com)

Amiodarone: I.V. DOSE RECOMMENDATIONS -- FIRST 24 HOURS -- Loading infusions. (globalrph.com)

Plasma protein binding is constant over the concentration range achieved with recommended doses. (medlibrary.org)

Symptomatic arrhythmias may be treated with Digoxin Immune Fab. (tasmanianairrescuetrust.org)

Dosing can be either initiated with a loading dose followed by maintenance dosing if rapid titration is desired or initiated with maintenance dosing without a loading dose. (guidelinecentral.com)
The recommended loading dose is displayed in Table 1 . (guidelinecentral.com)
Total Maintenance Dose = Loading Dose (i.e. (guidelinecentral.com)
20-45 mcg/kg PO administer half the total loading dose initially, then ¼ the loading dose every 6 to 8 hours twice. (wikidoc.org)
Before admission to the clinic, the unresponsive patients had significantly more frequently received the loading clopidogrel dose of 300 mg while that latter was 600 mg in the responsive patients. (ter-arkhiv.ru)
Initiate treatment with a single 60-mg oral loading dose ( 2 ). (lilly.com)

Depending on how severe your hand-foot syndrome is, your doctor may give you something to reduce the symptoms, or decrease or delay your next dose of liposomal doxorubicin . (webmd.com)
If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor's instructions. (patientassistance.com)
Your doctor may increase or decrease your dose during your heparin treatment. (medlineplus.gov)

However, elderly patients are more likely to have age-related liver or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine. (drugs.com)
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. (nih.gov)
Treatment of these patients with digoxin leads to greater slowing of conduction in the atrioventricular node than in accessory pathways, and the risks of rapid ventricular response leading to ventricular fibrillation are thereby increased. (wikidoc.org)
Digoxin may cause severe sinus bradycardia or sino-atrial block particularly in patients with pre-existing sinus node disease and may cause advanced or complete heart block in patients with pre-existing incomplete AV block. (wikidoc.org)
There have been no clinical trials in patients with asthma to evaluate the relative efficacy of morning versus evening dosing. (medicatione.com)
Patients already taking Admont sodium daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. (medicatione.com)
She was approached by detectives Tim Braun and Danny Baldwin, who were investigating the deaths of a few patients who had high levels of a drug called digoxin, which affects the heart, in their systems. (uromivoice.com)
In general, patients are now treated with an ACE inhibitor or angiotensin receptor blocker (ARB), plus a diuretic and a beta-blocker, to which an aldosterone antagonist or digoxin can be added. (universityhealthnews.com)
Heart failure specialists prescribe diuretics for approximately 90 percent of patients, and strive to use the lowest effective dose. (universityhealthnews.com)
Spironolactone (Aldactone) is a potassium-sparing diuretic and neurohormonal modulator that improves survival in patients with severe heart failure when added to therapy with an ACE inhibitor, beta-blocker, digoxin, and diuretics. (universityhealthnews.com)
For patients with acute decompensated heart failure who no longer benefit from traditional diuretics, intravenous treatment with a synthetic natriuretic peptide such as ularitide may help. (universityhealthnews.com)
This phase I trial studies the side effects and best dose of ubidecarenone injectable nanosuspension (BPM31510) in treating patients with high-grade glioma (anaplastic astrocytoma or glioblastoma) that has come back and have been previously treated with bevacizumab. (stanford.edu)
Note: may need higher dose in patients with central nervous system disease. (cdc.gov)
Haemosiderosis, which plays a considerable function in thalassaemia patients before and role in early mortality, can be prevented or after treatment with high-dose deferoxam- postponed by iron-chelating agents which ine. (who.int)

Doses of less than 0.4 mg may be sufficient in less severe conditions while severe and life-threatening diseases may require up to 20 mg or more a day. (who.int)

Following oral and intravenous administration of 14C-labeled losartan potassium, circulating plasma radioactivity is primarily attributed to losartan and its active metabolite. (nih.gov)
Bosentan, sodium salt (lot 71102B1758) used for intravenous dosing and in vitro experiments, bosentan, micronized free sulfonamide (lot 704004) for oral pharmacokinetic experiments, and 14 C-radiolabeled bosentan, free sulfonamide (specific activity 40.9 μCi/mg, lot 12352B65) were obtained from Actelion Pharmaceuticals Ltd. (Allschwil, Switzerland) internal sources. (aspetjournals.org)
Digoxin psychoanalysis begins with a digitalizing quantity divided into disparate doses (oral or intravenous [IV]) to a 24-hour period to reach maximum cardiac effect. (adjantis.com)
The pharmacokinetics of losartan and its active metabolite are linear with oral losartan doses up to 200 mg and do not change over time. (medlibrary.org)

1. What Digoxin tablets is and what it is used for 2. (medicines.org.uk)
When administering chewable tablets, at least two tablets should be administered to ensure adequate buffering capacity (e.g., if the child's dose is 50 mg, administer two 25-mg tablets and not one 50-mg tablet). (cdc.gov)

The overall incidence of adverse reactions with digoxin has been reported as 5-20%, with 15-20% of adverse events considered serious. (tasmanianairrescuetrust.org)

Along with beta blockers and digoxin calcium channel blockers have one of the highest rates of death in overdose. (wikipedia.org)
Intravenous calcium gluconate or calcium chloride is considered a specific antidote. (wikipedia.org)
However, the use of large doses of supplemental calcium, together with absorbable alkali, increases the risk of hypercalcemia, especially in postmenopausal women. (oregonstate.edu)

There was an increased incidence of stillbirths at doses of 20 times the human dose or greater. (pillsync.com)

Toxicity is usually associated with digoxin levels greater than 2 ng/mL although symptoms may also occur at lower levels. (wikidoc.org)
Signs and symptoms of digoxin toxicity become more frequent with levels above 2 ng/mL. (tasmanianairrescuetrust.org)
Digoxin Immune Fab has been shown to be 80-90% effective in reversing signs and symptoms of digoxin toxicity. (tasmanianairrescuetrust.org)
For the treatment of cerebral oedema , [CV004 trade name] may be given intravenously in an initial dose of 8 mg, followed by 4 mg every 6 hours intramuscularly, until the cerebral oedema symptoms have remitted. (who.int)

Which dose of heparin is most effective in the prevention of thromboembolic disorders after elective gynecological or abdominal-thoracic surgery? (findmedarticle.com)
Heparin comes as a solution (liquid) to be injected intravenously (into a vein) or deeply under the skin and as a dilute (less concentrated) solution to be injected into intravenous catheters. (medlineplus.gov)
When heparin is used to prevent blood clots from forming in intravenous catheters, it is usually used when the catheter is first put in place, and every time that blood is drawn out of the catheter or medication is given through the catheter. (medlineplus.gov)

Minimal conversion of losartan to the active metabolite (less than 1% of the dose compared to 14% of the dose in normal subjects) was seen in about one percent of individuals studied. (nih.gov)
Following an intravenous dose of 14 C-labeled losartan, about 45% of radioactivity is recovered in the urine and 50% in the feces. (medlibrary.org)
Neither losartan nor its metabolite accumulate in plasma upon repeated once-daily dosing. (medlibrary.org)

The initial dose should be maintained or adjusted until the clinical response is satisfactory and, if no suitable clinical response is obtained after a reasonable period of time, [CV004 trade name] should be stopped and the patient's treatment changed. (who.int)

Consider monitoring digoxin levels. (drugcite.com)

Digoxin is a cardiac glycoside that is FDA approved for the treatment of atrial fibrillation , atrial flutter , and heart failure . (wikidoc.org)
Consider insertion of a pacemaker before treatment with digoxin. (wikidoc.org)
Need for more doses of PROAIR HFA than usual may be a sign of deterioration of asthma and requires reevaluation of treatment. (drugcite.com)
secundum en mujer oxygen was administrated and pharmacological treatment was started. (bvsalud.org)

In these cases, your doctor may want to change the dose, or other precautions may be necessary. (drugs.com)

Inaccuracies are described throughout the literature with dose administration errors attributed to technique, calculation, dilution and problems associated with equipment. (bmj.com)

The patient should be observed closely for signs that the dose may need to be altered, such as changes in clinical status resulting from disease remissions or exacerbations. (who.int)

Sometimes, a high dose of diuretics will be given intravenously or in bolus form (a large amount given at one time). (universityhealthnews.com)

Conclusions This review has revealed a paucity of information on the clinical outcomes from problems in measuring small volumes for children and highlighted the need for further work to eliminate this source of inaccurate dosing and potential for medication error. (bmj.com)
Once an initial favourable response has been obtained, the initial dose should be reduced in small amounts until the lowest dose that maintains a suitable clinical response is obtained. (who.int)

You will monitor your weight daily, and if you gain more than three pounds above your normal, baseline weight, you may increase the diuretic dose as instructed. (universityhealthnews.com)
Which daily dose of aspirin should be used for the prevention of myocardial infarction? (findmedarticle.com)
If the condition allows it, [CV004 trade name] should be given as a single daily dose (daytime) or a single dose every second day, to reduce suppression of the hypothalamic-pituitary-adrenal (HPA) axis. (who.int)

The lowest effective dose should be used for the minimum period and this should be reviewed frequently to appropriately titrate the dose against disease activity. (who.int)

Anatomy2

Organisms7

Diseases2

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes14

Health Care5

Adenosine2

Verapamil1

Amount of digoxin2

Electrolyte4

Adults8

Hypomagnesemia1

Therapeutic3

Hypokalemia1

Renal function1

LANOXIN6

Infusion1

Pediatric5

Medications4

Drugs3

Cardiac glycosides3

Concomitant1

Regimens2

Insulin1

Hypersensitivity3

Orally3

High doses2

Intramuscular2

Neonatal1

Tachycardia5

Serum3

Cardiovascular effects1

Adult2

Amiodarone1

Concentration1

Arrhythmias1

Loading6

Decrease3

Patients14

Severe1

Oral4

Tablets2

Reactions1

Calcium3

Incidence1

Symptoms4

Heparin3

Losartan3

Patient's1

Levels1

Treatment4

Precautions1

Administration1

Closely1

Given intravenously1

Clinical2

Daily3

Lowest effective dose1