CatalysisCatalytic DomainModels, MolecularRNA, CatalyticBinding SitesHydrogen-Ion ConcentrationHistidineCrystallography, X-RayKineticsSubstrate SpecificityMutagenesis, Site-DirectedBiocatalysisHydrogen BondingModels, ChemicalProtonsHydrolysisMolecular Sequence DataAmino Acid SequenceProtein ConformationGlycoside HydrolasesProtein Tyrosine PhosphatasesAspartic AcidAmino Acid SubstitutionStructure-Activity RelationshipMolecular StructureRecombinant ProteinsProtein Structure, TertiaryEscherichia coliBacterial ProteinsBase SequenceMutationSequence Homology, Amino AcidProtein Binding