• The remnant protein is processed by another protease, gamma-secretase. (thermofisher.com)
  • The gamma-secretase complex is an intramembrane aspartyl protease comprised of at least four known subunits: Presenilin (PS), Nicastrin (Nct), Aph, and Pen2. (biomedcentral.com)
  • γ-Secretase is an intramembrane aspartyl protease complex that cleaves the transmembrane domain of over 150 peptide substrates, including amyloid precursor protein (APP) and the Notch family of receptors, via two conserved aspartates D257 and D385 in the presenilin-1 (PS1) catalytic subunit. (bvsalud.org)
  • It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). (wikipedia.org)
  • Signal peptide peptidase‐like 3 (SPPL3) is an intramembrane‐cleaving aspartyl protease of the GxGD type. (uni-muenchen.de)
  • Secretase is normally a multi-subunit aspartyl protease using the presenilin (PSEN) protein, either PSEN1 or PSEN2, as its catalytic primary. (conferencedequebec.org)
  • In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role in transplant rejection The homologous proteases SPPL2A and SPPL2B promote the intramembrane cleavage of TNFα in activated dendritic cells and might play an immunomodulatory role. (wikipedia.org)
  • Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. (thermofisher.com)
  • The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. (cipsm.de)
  • The intramembrane-cleaving protease -secretase catalyzes the final part of the generation of toxic amyloid- (A) peptides and it is a principal therapeutic target in Alzheimer's disease. (conferencedequebec.org)
  • The intramembrane-cleaving protease -secretase is in charge of the last part of the proteolytic discharge of A42 peptides in the amyloid precursor proteins (APP), and it is a primary therapeutic focus on in Advertisement [3]. (conferencedequebec.org)
  • γ-Secretase is a pivotal intramembrane-cleaving protease complex and important drug target for Alzheimer's disease. (cipsm.de)
  • Presenelins are related to the signal peptide peptidase (SPP) family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides. (embl.de)
  • ß-secretase is a membrane-bound protease with motifs containing the highly conserved signature sequence of aspartic proteases, D(T/S)G(T/S), within which the aspartic acid residue is essential for proteolytic activity. (medscape.com)
  • β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. (harvard.edu)
  • SPP catalyses intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. (embl.de)
  • Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. (embl.de)
  • This study represents an example of a potential role for intramembrane proteolysis in the maturation of a viral protein. (embl.de)
  • 8. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. (nih.gov)
  • 17. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. (nih.gov)
  • It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). (wikipedia.org)
  • The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. (harvard.edu)
  • The progeny viruses expressed from the activated viral gene expression are assembled on and budded through the host cell membrane after being processed by the viral encoded enzyme protease [ 7 ]. (biomedcentral.com)
  • The active n-butanol fraction was evaluated for its inhibition against HIV-1 reverse transcriptase, integrase, protease, pro-viral genome integration and viral Tat protein mediated transactivation. (biomedcentral.com)
  • The n-butanol fraction demonstrates a potent inhibitory activity against the viral protease (IC 50 = 12.9 μg/ml), but not reverse transcriptase or integrase. (biomedcentral.com)