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  • reaction with dioxygen
  • This then allows for reaction with dioxygen and subsequent intradiol cleavage to occur through a cyclic anhydride intermediate. (wikipedia.org)
  • 3-9 Although the reaction with dioxygen is thermodynamically favourable, the electronic configuration of the O 2 molecule creates a strong kinetic barrier that requires activation, which is useful to prevent any spontaneous reaction of O 2 with organic molecules. (rsc.org)
  • reactivity
  • FeIII(L4)(dtbc)(H2O)] (dtbc = 3,5-di-tert-butylcatechol) was studied with respect to its dioxygen reactivity, and oxidative cleavage of the substrate was observed. (uu.nl)
  • enzyme
  • The enzyme 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase uses 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and NAD+ to produce 3-methylcatechol, NADH and CO2. (wikipedia.org)
  • However, the enzyme preparations from Brevibacterium and Arthrobacter have only the intradiol cleavage activity. (wikipedia.org)
  • The structural and spectroscopic characterization of mononuclear iron(III)-catecholato complexes of ligand L4 (methyl bis(1-methylimidazol-2-yl)(2-hydroxyphenyl)methyl ether, HL4) are described, which closely mimic the enzyme-substrate complex of the intradiol-cleaving catechol dioxygenases. (uu.nl)
  • ligands
  • Extradiol members utilize ferrous iron as the active redox state, and this center is commonly coordinated octahedrally through a 2-His-1-Glu motif with labile water ligands occupying empty positions. (wikipedia.org)
  • ligand
  • HL = NN-bis(2-pyridylmethyl)-N-(2hydroxyethyl)amine] of the tripodal N3O ligand was prepared as a biomimetic model for the intradiol-cleaving dioxygenase enzymes. (diva-portal.org)
  • All heteroatoms (N3O) of the ligand are coordinated to the iron center in complex 1 with two pyridine nitrogen atoms on the axial bonds, while one of the pyridyl arms of the ligand is left uncoordinated in complex 2. (diva-portal.org)
  • phenol
  • Catechin /ˈkætɪtʃɪn/ is a flavan-3-ol, a type of natural phenol and antioxidant. (wikipedia.org)
  • catecholate
  • The reaction of 1 and catechol in the presence of excess triethylamine gave the catecholate (CAT) chelate b is(u -al koxo) -bridged dinuclear iron(Ill) complex [Fe(L)(CAT)12 (2). (diva-portal.org)
  • This complex catalyzes the ring opening of catecholate with exclusive formation of the intradiol cleaved product. (diva-portal.org)
  • complexes
  • The molecular structures of complexes 1 and 2 were determined by X-ray crystallography. (diva-portal.org)
  • Diiron complexes 1 and 2 contain the same bis(u-alkoxo)diiron diamond core. (diva-portal.org)
  • structural motif
  • The 3-methylcatechol structural motif is rare in natural products. (wikipedia.org)
  • This widespread structural motif is called the 2-His-1-carboxylate facial triad, and is found in many metalloproteins. (rsc.org)
  • methyl
  • For instance, the reaction of methyl carbonate 1 with methyl acrylate (2) leads to the coupling product 3. (docme.ru)
  • activity
  • The spectrop h oto metric titration experiment indicates the relatively low demand of the external base (0.8 equiv based on Fe3+) for attaining the highest dioxygenase activity of complex 1. (diva-portal.org)
  • Both enzymes have been characterized as 2-hydroxy-6-oxohepta-2,4-dienoate hydrolases with low activity toward 2-hydroxy-6-oxophenylhexa-2,4-dienoate (the substrate of BphD), but EtbD2 and EtbD1 convert the latter compound with 11 and 3.3% relative activity, respectively (Yamada et al. (alpfmedical.info)
  • iron
  • Iron-containing dioxygenases can be subdivided into three classes on the basis of how iron is incorporated into the active site: those employing a mononuclear iron center, those containing a Rieske [2Fe-2S] cluster, and those utilizing a heme prosthetic group. (wikipedia.org)
  • Most mononculear iron dioxygenases are members of the cupin superfamily in which the overall domain structure is described as a six-stranded β-barrel fold (or jelly roll motif). (wikipedia.org)
  • At the center this barrel structure is a metal ion, most commonly ferrous iron, whose coordination environment is frequently provided by residues in two partially conserved structural motifs: G(X)5HXH(X)3-4E(X)6G and G(X)5-7PXG(X)2H(X)3N. (wikipedia.org)
  • Two important groups of mononuclear, non-heme iron dioxygenases are catechol dioxygenases and 2-oxoglutarate (2OG)-dependent dioxygenases. (wikipedia.org)
  • In the 2OG-dependent dioxygenases, ferrous iron (Fe(II)) is also coordinated by a (His)2(Glu/Asp)1 "facial triad" motif. (wikipedia.org)
  • a non-heme iron dioxygenase with broad substrate tolerance. (cbrc.jp)
  • As a signature pattern for these enzymes we selected a region that includes a tyrosine residue which, in 3,4-PCD, has been shown [ 2 ], to be implicated in the binding of the ferric iron atom. (expasy.org)
  • further
  • Chalcone is then isomerized to naringenin by chalcone isomerase which is oxidized to eriodictyol by flavonoid 3'- hydroxylase and further oxidized to taxifolin by flavanone 3-hydroxylase. (wikipedia.org)
  • gene
  • Catechol 1,2-dioxygenase (EC 1.13.11.1 ) (gene catA or clcA). (expasy.org)
  • Chlorocatechol 1,2-dioxygenase (EC 1.13.11.1 ) (gene tfdC). (expasy.org)
  • With respect to the initial step of biphenyl degradation, expression of all sets of ring hydroxylating dioxygenase genes (bphA, etbAl, etbA2) likewise is induced by biphenyl, and gene disruption experiments suggested that all these genes are involved in biphenyl degradation (Takeda et al. (alpfmedical.info)
  • suppressor gene can be implicated in the control of the cell routine, DNA MK-4827 synthesis, and DNA restoration aswell as apoptosis [2]. (cancer-colorectal.com)
  • Antibodies against p53 could be recognized in sera from tumor individuals, and a correlation between your expression of anti-p53 mutations and antibodies inside the gene continues to be founded [3]. (cancer-colorectal.com)
  • Anti-p53 antibodies have already been extensively studied since it has been proven that anti-p53 antibodies correlate towards the mutational position from the gene [3]. (cancer-colorectal.com)
  • synthesis
  • The way the program operates is demonstrated for the development of suggestions for the synthesis of the calicheamicin precursors, ( + )-a-bisabolene, and ( + )-7,8-epoxy-2-basmen-2-one. (docme.ru)
  • Since the amino group in 3 can be substituted readily, this approach enables the simple regioselective functionalization of ketones-an important goal in synthesis. (docme.ru)
  • patterns
  • Apart from their contrasting decay patterns, both P. chrysosporium and P. placenta belong to order Polyporales and are classified under Phlebia clade [ 3 ]. (ijbs.com)
  • molecular
  • belen.albela@ens-lyon.fr b Instituto de Ciencia Molecular, Universitat de València, C/Catedrático José Beltrán 2, 46980 Paterna, València, Spain. (rsc.org)
  • model
  • I\ /I I1 II 1 International Edition in English A Journal __ of the Gesellschaft Deutscher Chemiker 1995134 2-3/24 Pages 2571 -2796 COVER PICTURE The cover picture shows a ball-and-stick model of a multicyclophane described by an achiral K 3 , stereoelement. (docme.ru)
  • complex
  • The interaction of the diiron complex 1 and 3,5-di-tert-butylcatechol (H2DBC) was investigated by electronic and mass spectroscopy. (diva-portal.org)
  • Therefore
  • Therefore, 1,2-CTD may bind to the cell lipid membrane via its terminal phospholipids and thus have greater access to the phenolic hydrocarbons vital in lipid membrane structure. (wikipedia.org)
  • genes
  • With respect to the initial step of biphenyl degradation, expression of all sets of ring hydroxylating dioxygenase genes (bphA, etbAl, etbA2) likewise is induced by biphenyl, and gene disruption experiments suggested that all these genes are involved in biphenyl degradation (Takeda et al. (alpfmedical.info)
  • sequential
  • Construction of a monoanionic S,N,S-pincer ligand with a pyrrole core by sequential [1,2] phospho-Fries rearrangement. (growkudos.com)
  • Further
  • Chalcone is then isomerized to naringenin by chalcone isomerase which is oxidized to eriodictyol by flavonoid 3'- hydroxylase and further oxidized to taxifolin by flavanone 3-hydroxylase. (wikipedia.org)
  • Molecular
  • belen.albela@ens-lyon.fr b Instituto de Ciencia Molecular, Universitat de València, C/Catedrático José Beltrán 2, 46980 Paterna, València, Spain. (rsc.org)
  • Synthesis
  • The way the program operates is demonstrated for the development of suggestions for the synthesis of the calicheamicin precursors, ( + )-a-bisabolene, and ( + )-7,8-epoxy-2-basmen-2-one. (docme.ru)
  • Since the amino group in 3 can be substituted readily, this approach enables the simple regioselective functionalization of ketones-an important goal in synthesis. (docme.ru)