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  • carbon
  • A large number of microbes capable of utilizing toxic chemicals as their sole sources of carbon and energy have been isolated, many of which break complex chemical compounds down to carbon dioxide and water through a series of chemical reactions catalyzed by microbial enzymes [ 5 - 8 ], such as monooxygenases, dioxygenases, reductases, deaminases, and dehalogenases. (biomedcentral.com)
  • genes
  • With respect to the initial step of biphenyl degradation, expression of all sets of ring hydroxylating dioxygenase genes (bphA, etbAl, etbA2) likewise is induced by biphenyl, and gene disruption experiments suggested that all these genes are involved in biphenyl degradation (Takeda et al. (alpfmedical.info)
  • ligand
  • Construction of a monoanionic S,N,S-pincer ligand with a pyrrole core by sequential [1,2] phospho-Fries rearrangement. (growkudos.com)
  • iron
  • Most mononculear iron dioxygenases are members of the cupin superfamily in which the overall domain structure is described as a six-stranded β-barrel fold (or jelly roll motif). (wikipedia.org)
  • At the center this barrel structure is a metal ion, most commonly ferrous iron, whose coordination environment is frequently provided by residues in two partially conserved structural motifs: G(X)5HXH(X)3-4E(X)6G and G(X)5-7PXG(X)2H(X)3N. (wikipedia.org)
  • Extradiol members utilize ferrous iron as the active redox state, and this center is commonly coordinated octahedrally through a 2-His-1-Glu motif with labile water ligands occupying empty positions. (wikipedia.org)
  • In the 2OG-dependent dioxygenases, ferrous iron (Fe(II)) is also coordinated by a (His)2(Glu/Asp)1 "facial triad" motif. (wikipedia.org)
  • As a signature pattern for these enzymes we selected a region that includes a tyrosine residue which, in 3,4-PCD, has been shown [ 2 ], to be implicated in the binding of the ferric iron atom. (expasy.org)
  • synthesis
  • 1,2-CTD degrades phenolic hydrocarbons key to the synthesis lipid membranes. (wikipedia.org)
  • suppressor gene can be implicated in the control of the cell routine, DNA MK-4827 synthesis, and DNA restoration aswell as apoptosis [2]. (cancer-colorectal.com)
  • form
  • 2006). Two cis-dihydrodiol dehydrogenases BphB1 and BphB2, which are encoded on pRHL1 and pRHL2, respectively, catalyze the second step in biphenyl catabolism, i.e., the rearomatization of the cis-dihydrodiol to form 2,3-dihydroxybiphenyl. (alpfmedical.info)
  • structure
  • Therefore, 1,2-CTD may bind to the cell lipid membrane via its terminal phospholipids and thus have greater access to the phenolic hydrocarbons vital in lipid membrane structure. (wikipedia.org)
  • family
  • A member of family index for individuals' sera was determined, relating to manufacturer's guidelines, the following: = .136) (Figure 3). (cancer-colorectal.com)
  • Structure
  • Therefore, 1,2-CTD may bind to the cell lipid membrane via its terminal phospholipids and thus have greater access to the phenolic hydrocarbons vital in lipid membrane structure. (wikipedia.org)