Intracellular membrane binds n ethylmaleimide sensitive proteins. Medical search. Frequent questions

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
They play a role in the intracellular transport of molecules contained within membrane vesicles. (uchicago.edu)

It is a central component of the cellular machinery in the transfer of membrane vesicles from one membrane compartment to another. (wikipedia.org)
Recent work indicates that the ATPase function of NSF does not function in recycling of vesicles but rather functions in the act of fusing vesicles with the plasma membrane. (wikipedia.org)
Because neuronal function depends on the release of neurotransmitters at a synapse - a process in which synaptic vesicles fuse with the presynaptic membrane - NSF is a key synaptic component. (wikipedia.org)
In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)
Extracellular vesicles (EVs) are a population of heterogeneous particles that originate from the endosomal system or plasma membrane. (bmrat.org)
Exocytosis of secretory or synaptic vesicles is executed by a mechanism including the SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor) proteins. (jneurosci.org)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (uchicago.edu)
In some cases, the exocytotic vesicles derive from the Golgi apparatus and consist of newly synthesized materials, while in others the vesicles derive from the plasma membrane and cycle locally. (sdbonline.org)
Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)

During this process, SNARE proteins on two joining membranes (usually a vesicle and a target membrane such as the plasma membrane) form a complex, with the α-helical domains of the SNAREs coiling around each other and forming a very stable four-helix bundle. (wikipedia.org)
NSF unravels SNARE complexes once membrane fusion has occurred, using the hydrolysis of ATP as an energy source, allowing the dissociated SNAREs to be recycled for reuse in further rounds of membrane fusion. (wikipedia.org)
STX6 is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein family and is involved in intracellular membrane trafficking and vesicle fusion events. (affigen.com)
It interacts with other SNARE proteins and vesicle-associated membrane proteins (VAMPs) to mediate membrane fusion events during intracellular transport processes. (affigen.com)
This inhibition reflects the binding of Munc18-1 to a closed conformation of the target-SNARE syntaxin1. (jneurosci.org)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
by binding to the N-terminus of respective Qa-SNARE. (molcells.org)
Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)
We identify the closed binding mode of neuronal SM (Munc18-1) and SNARE (syntaxin-1) as the key factor leading to mechanistic divergence of membrane fusion systems in yeast and neurons. (biomedcentral.com)
We applied the framework to study SM-SNARE-mediated exocytic membrane fusion processes in yeast and neurons. (biomedcentral.com)
Moreover, hydrosol obtained from the branch substantially inhibited a lipopolysaccharide (LPS) induced overproduction of intracellular active oxygen (ROS) and nitric oxide (NO). Consistently, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) proteins of SNAP23, syntaxin4, VAMP7, and VAMP8 were remarkably decreased through hydrosol treatment. (ncsu.edu)
Hydrosol suppressed the activation of SNARE proteins in DNP-BSA-stimulated RBL-2H3 cells and inhibited ROS and NO in LPS-stimulated RAW264.7 cells. (ncsu.edu)
Camphor and estragole are the main chemical components of hydrosol and downregulate the LPS-induced phosphorylation of the SNARE proteins. (ncsu.edu)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
The exocyst, like SNARE complexes, may be needed for all fusions at the plasma membrane both in developing and mature neurons, or it may be required only for particular forms of traffic (Murthy, 2003 and references therein). (sdbonline.org)

The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. (antibodies-online.com)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)

NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. (antibodies-online.com)
Another neuronal role for NSF is indicated by its direct binding to the GluR2 subunit of AMPA type glutamate receptors (which detect the neurotransmitter glutamate). (wikipedia.org)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)

ERAD enables ER processing to distinguish the properly and improperly folded proteins in the ER lumen and then extracts them through membrane channels (dislocation or retrotranslocation) in an energy-dependent manner for delivery to cytosolic proteasomes. (eu.org)
Tcell recognition of Ag-bearing cells is associated with cytoskeletal polarization and the redistribution of membrane and cytosolic molecules toward the cell-cell contact zone known as the immunological synapse ( 1 , 2 , 3 ). (aai.org)
By combining lipidomics and molecular dynamic simulations the authors show that oxidatively truncated (ox-tr) triacylglycerides accumulate in large lipid droplets of tumour-associated mouse DCs, and that these highly electrophilic species are predicted to preferentially occupy the droplet surface where they can directly access cytosolic proteins. (biomedcentral.com)

5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)

They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)
Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. (biomedcentral.com)

1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)

Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)

NSF is a homohexameric AAA ATPase involved in membrane fusion. (wikipedia.org)

Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. (lookformedical.com)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)

In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4 + T cells. (aai.org)
In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. (aai.org)
The acrosome reaction is analogous to regulated exocytosis in somatic cells in that both are initiated by ligand acting at the plasma membrane, both require activation of signaling pathways and ion channels, both are Ca 2+ -dependent and both result in the fusion of the plasma membrane with the membrane of a docked secretory granule (acrosome) [2,9,10] . (ommegaonline.org)
In contrast to the sperm acrosome reaction, the secretory pathway of somatic cells has received detailed characterization in recent years and a great deal has been learned of the processes regulating vesicle docking and fusion with the plasma membrane. (ommegaonline.org)
The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)

Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)

Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1 . (sdbonline.org)
NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons, and it binds to the high-affinity tyrosine kinase receptor, TrkA, leading to its phosphorylation and the subsequent activation of PI3K/Akt/GSK3β pathways. (biomedcentral.com)
Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. (uchicago.edu)
Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)

The controversy would be solved if binding to closed syntaxin1 were shown to be stimulatory for vesicle fusion and/or additional essential interactions were identified between Munc18-1 and the fusion machinery. (jneurosci.org)
A mutation that diminished Munc18 binding to syntaxin1 in vitro attenuated the vesicle-docking step but rescued vesicle priming in excess of docking. (jneurosci.org)
Conversely, expressing the Munc18-2 isoform, which also displays binding to closed syntaxin1, rescued vesicle docking identical with Munc18-1 but impaired more downstream vesicle priming steps. (jneurosci.org)
In conclusion, binding of Munc18-1 to closed syntaxin1 stimulates vesicle docking and a distinct interaction mode regulates the consecutive priming step. (jneurosci.org)
This binding mode prompted the "negative regulator" hypothesis according to which Munc18-1 sequesters syntaxin1 and inhibits exocytosis. (jneurosci.org)
The results show that vesicle docking correlates with the ability of Munc18-1 to bind to closed syntaxin1. (jneurosci.org)
In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)

The N-terminal domain of VCP acts as a binding site for a group of adaptor proteins through their Arg/Lys-rich peptide motifs. (eu.org)
Zinc binding to the peptide replica and analogs to residues 93-115 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine structure analysis of the zinc ligands. (researchgate.net)
Proinsulin C-peptide is known to bind specifically to cell membranes and to exert intracellular effects, but whether it is internalized in target cells is unknown. (researchgate.net)

Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
They are involved in diverse physiological processes in plants by interacting with distinct plasma membrane (PM) syntaxins. (molcells.org)
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
Western blots of caput and cauda sperm lysates and plasma membrane fractions, stained with anti-syntaxin 2, revealed the presence of a 31kDa band in both sperm lysates and plasma membrane fractions, respectively. (ommegaonline.org)
Several biochemical analyses demonstrated that syntaxin 2 is an integral component of bovine cauda sperm plasma membranes. (ommegaonline.org)
The mammalian sperm acrosome reaction entails extensive fusion between the periacrosomal plasma membrane and the outer acrosomal membrane, with the release of hydrolases which function in sperm penetration through the zona pellucida [1-3] . (ommegaonline.org)
Following the acrosome reaction the fused hybrid membrane complex remains adherent to the zona surface, [4] and the newly exposed inner acrosomal membrane of the spermatozoon functions as the limiting membrane or plasma membrane equivalent [1] . (ommegaonline.org)
Gabrilovich's team begins to answer this with an astonishing observation that either inhibiting or depleting HSP70 leads to a re-routing of pMHC-I complexes, which rather than reaching the plasma membrane, are sent to lysosomes instead. (biomedcentral.com)

This antibody provides a valuable tool for investigating intracellular membrane trafficking, vesicle fusion, and the role of STX6 in cellular processes such as protein sorting, secretion, and endocytosis. (affigen.com)
New insights into protein secretion: TANGO1 runs rings around the COPII coat. (uchicago.edu)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Here, we show that DPP8/DPP9 inhibition in macrophages that express a Bacillus anthracis lethal toxin (LeTx)-sensitive Nlrp1b allele triggered significantly accelerated pyroptosis concomitant with caspase-1 maturation, ASC speck assembly, and secretion of mature IL-1beta and IL-18. (inra.fr)

The resulting molecules show superior functional properties for their respective applications and demonstrate the generalizable potential of the described protein design approach. (bvsalud.org)
Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)
Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (uchicago.edu)
The identification, therefore, of the molecules required for directed membrane traffic will be important for understanding organismal development and cell-cell signaling (Murthy, 2004). (sdbonline.org)

VCP complexes are involved in many cellular processes, particularly in the endoplasmic reticulum (ER)‐associated degradation (ERAD) process for protein quality control, membrane trafficking, and DNA damage response. (eu.org)
The ERAD (ER-Associated Degradation) mechanism acts as a protein quality control and removes these misfolded proteins. (eu.org)
Nearly all ERAD substrates are ubiquitinated prior to their degradation and these ubiquitin chains provide a binding site for VCP (Valosin-Containing Protein). (eu.org)
And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)

The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process. (antibodies-online.com)

The calpains ostensibly participate in a variety of cellular processes including remodelling of cytoskeletal/membrane attachments, different signal transduction pathways, and apoptosis. (embl.de)
Integrating the dynamics across species is particularly important in modeling cellular processes through protein interaction networks. (biomedcentral.com)
Many of the biological processes mediated by protein interaction networks are highly evolutionarily conserved or related across species. (biomedcentral.com)
By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)
As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)
The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
Directed membrane traffic is essential for many developmental processes, including cell growth, cytokinesis and signaling between cells. (sdbonline.org)
Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)

Ter94 in fly, CDC48 in yeast) is a hexameric multidomain protein belonging to the functionally highly diverse AAA+ (ATPases Associated with diverse cellular Activities) superfamily of proteins. (eu.org)
Thus, the exocyst complex in yeast may provide a model for the directed membrane traffic of developing cells in higher organisms (Murthy, 2004 and references therein). (sdbonline.org)

Thus, conditional temperature-sensitive mutations in the Drosophila melanogaster gene for NSF lead to a comatose behaviour at the restrictive temperature (and hence the gene is called comatose), presumably because neuronal functions are blocked. (wikipedia.org)

Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)
D: In the download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa phase of the module, the pattern-recognition: GTP plays the form, widely containing the region out of the A chaperone to spiral Loss and binds the Convention lipid: GDP. (evakoch.com)
Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)

Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)

A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)
Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)
The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)

This gene encodes soluble NSF attachment protein gamma. (antibodies-online.com)
N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene. (wikipedia.org)
Na(+) influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation. (nih.gov)
Mutations of a gene sequence can modify the interfaces or domains of its protein product and lead to the emergence of new or loss of existing protein interaction patterns [ 11 ]. (biomedcentral.com)

Vesicular Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Vesicular Transport Proteins" by people in this website by year, and whether "Vesicular Transport Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Vesicular Transport Proteins" by people in Profiles. (uchicago.edu)

Three motifs known to bind to the N-terminal domain of VCP are the SHP box, VIM (VCP-Interacting Motif), and VBM (VCP-Binding Motif) and they help direct VCP into different cellular pathways. (eu.org)
Within neurons, multiple pathways are known to transport proteins and transmitters to the cell surface. (sdbonline.org)

Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)

As SNAREs intertwine, they pull the vesicle towards the target membrane, excluding water and promoting fusion of the vesicle with the target membrane. (wikipedia.org)

ATP-sensitive potassium (K ATP ) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death. (biomedcentral.com)

N-ethylmaleimide sensitive fusion protein has been shown to interact with NAPA. (wikipedia.org)
STX6 is primarily localized to the trans-Golgi network (TGN) and endosomes, where it plays a role in regulating membrane fusion and cargo trafficking. (affigen.com)
These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
Presently, all membrane trafficking steps are thought to possess a similar underlying mechanism for membrane fusion, and yet clear distinctions in these trafficking steps must also occur. (sdbonline.org)

they identified NSF after observing that a cytoplasmic factor, required for membrane fusions, was inactivated by treatment with N-ethylmaleimide. (wikipedia.org)

A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
Neurons generate their polarity by directing membrane traffic to growing neurites and growth cones, and by sorting proteins differentially between the axon and dendrites. (sdbonline.org)

They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
K ATP channels, widely represented in metabolically active tissues, are hetero-octamers composed of four regulatory SUR subunits (SUR1, SUR2A, or SUR2B) and four ATP-sensitive pore-forming inwardly rectifying potassium channel (Kir6.x) subunits (Kir6.1 or Kir6.2) [ 20 ]. (biomedcentral.com)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

Orthologous to human NAPA (NSF attachment protein alpha). (nih.gov)

Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)
Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro , small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. (biomedcentral.com)

In Dictyostelium discoideum amoebae, similar mutations lead to a cessation of cell movement at the restrictive temperature, indicating a role for intracellular membrane transport in migration. (wikipedia.org)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
Lysosomes play a crucial role in intracellular transport. (biomedcentral.com)
We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)
We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)

Lysosomes are an important component of the inner membrane system. (biomedcentral.com)
Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)

The Endoplasmic Reticulum (ER) is an important eukaryotic cell organelle that has various functions, including the synthesis of proteins for export and quality control of nascent proteins. (eu.org)
Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)

However, support for the third model is missing at the physiological level, and it is unclear which role the two suggested binding modes play in the exocytotic cascade. (jneurosci.org)
The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)

sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
This protein is required for many aspects of membrane traffic within neurons, including the elaboration of neurites, but the release of neurotransmitter at the synapse is independent of this exocyst component (Murthy, 2003). (sdbonline.org)

The SHP box forms a short, antiparallel β-strand that interacts by β-augmentation with the β-sheet of the C-terminal part of the NTD subdomain of VCP at a site distinct from that to which other VCP ligands bind. (eu.org)
The N-terminal loop region of the SHP motif interacts with the first pocket, while the central β strand of the motif makes key interactions with the second binding pocket. (eu.org)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)

The AffiAB® Goat Anti-STX6 Polyclonal IgG Antibody is an antibody derived from goats that specifically targets and binds to STX6, also known as Syntaxin 6. (affigen.com)
Enables syntaxin binding activity. (nih.gov)

MIPβ1KO islets displayed a significant increase in protein levels of the apoptotic marker cleaved-Poly (ADP-ribose) polymerase and a reduction of the cell cycle marker cyclin D1. (oncotarget.com)
While the bud is growing, there is almost no increase in the surface area of the mother cell, indicating that all membrane addition occurs at the bud tip. (sdbonline.org)
The exocyst complex marks these areas of membrane addition, localizing to the bud tip of a growing daughter cell and the bud neck at the time of cytokinesis. (sdbonline.org)
Since water comes to diffusion equilibrium across cell membranes, the intracellular lt has an osmolarity equal to that aforex ltd the aforex ltd fluid. (tradingsignalsforex.com)

Anatomy3

Chemicals and Drugs2

Role in the intracellular transport2

Vesicles9

SNARE16

Soluble NSF attachment proteins2

Receptors10

Cytosolic3

Mediate membrane1

HETEROTRIMERIC G-PROTEI2

Recycled to the plasma membrane1

Vesicle membrane1

ATPase1

Extracellular4

Secretory5

Cytoskeletal proteins2

Pathway5

Phosphorylation4

Munc187

Peptide3

Plasma9

Secretion4

Molecules4

Degradation4

Exocytosis1

Processes8

Yeast2

Neuronal1

Lipid3

Kinase3

Genes3

Gene4

Vesicular3

Pathways2

Antigen2

Localization1

Vivo1

Target membrane1

Neurotransmitter release1

Fusion4

Fusions1

Differentially2

Regulatory2

Cytokines1

Attachment protein alpha1

Molecule2

Transport5

Lysosomes2

Synthesis2

Exocytotic2

Neurons2

Interacts2

Distinct1

Syntaxin2

Cell4