• We found that mRNA levels of HSP family members (HSP70B′, HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload. (elsevierpure.com)
  • For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70 and 90 kilodaltons in size, respectively. (wikipedia.org)
  • However, some studies suggest that an increase in damaged or abnormal proteins brings HSPs into action. (wikipedia.org)
  • Heat shock proteins (HSPs) are highly conserved and immunogenic proteins that are shared among diverse groups of mammals and microbial agents. (eg.net)
  • Heat shock proteins have been found in all species examined, from bacteria to humans, suggesting that they evolved very early and have an important function. (wikipedia.org)
  • The mechanism by which heat-shock (or other environmental stressors) activates the heat shock factor has been determined in bacteria. (wikipedia.org)
  • Ixodid ticks are responsible for the transmission of various intracellular bacteria, such as the Rickettsia species. (uibk.ac.at)
  • Ribosomal protein S20 [Interproscan]. (ntu.edu.sg)
  • Ribosomal protein L35 [Interproscan]. (ntu.edu.sg)
  • protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
  • The results demonstrated that the gene thb encoding the b subunit of the thermosome, as well as hsp14 and hsp20, play crucial roles in the majority of stress conditions. (jcbose.ac.in)
  • During heat stress, outer membrane proteins (OMPs) do not fold and cannot insert correctly into the outer membrane. (wikipedia.org)
  • An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
  • The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). (wikipedia.org)
  • As a consequence, the heat shock proteins are also referred to as stress proteins and their upregulation is sometimes described more generally as part of the stress response. (wikipedia.org)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
  • Some bacterial heat shock proteins are upregulated via a mechanism involving RNA thermometers such as the FourU thermometer, ROSE element and the Hsp90 cis-regulatory element. (wikipedia.org)
  • Among these factors, heat shock factor 1 (HSF1) cooperated with the MMP3 to activate the HSP70B′ gene promoter in reporter gene assays, while a dominant negative HSF1 blocked the role for MMP3 in the trans-activation. (elsevierpure.com)
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
  • Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. (wikipedia.org)
  • This discovery eventually led to the identification of the heat-shock proteins (HSP) or stress proteins whose expression this puffing represented. (wikipedia.org)
  • Heat shock proteins often function as chaperons in the refolding of proteins damaged by heat stress. (wikipedia.org)
  • Additionally, four common transcription factors: FadR, TFEb, CRISPR loci binding protein, and HTH family protein were consistently overexpressed across all stress conditions, indicating their significant role in managing stress. (jcbose.ac.in)
  • This potentiation involves PDE4D inhibition and cytoskeletal regulatory proteins. (nih.gov)
  • In addition, chromobox proteins CBX5/HP1α and CBX3/HP1γ cooperated with the PEX domain in induction of HSP70B′ mRNA. (elsevierpure.com)
  • In human ASM cells, these constituents decreased phosphorylation of 17-kD protein kinase C-potentiated inhibitory protein of type 1 protein phosphatase and 8-gingerol decreased myosin light chain phosphorylation. (nih.gov)
  • In this paper, we used transcriptomics analysis in order to examine novel transcriptional target genes regulated by intracellular MMP3. (elsevierpure.com)
  • Taken together, this study newly clarified that intracellular MMP3 cooperate with CBXs/HP1s in transcriptional promotion of HSP genes. (elsevierpure.com)
  • protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
  • sHSPs independently express not only in heat shock response but also have developmental roles in embryonic or juvenile stages of mammals, teleost fish and some lower vertebral genomes. (wikipedia.org)
  • This initial biochemical finding gave rise to a large number of studies on the induction of heat shock and its biological role. (wikipedia.org)
  • In the appropriate redox condition, a TG2 intermediate thioester is formed through the attack of an acyl donor (γ-carboxamide group of a protein glutamine residue) by the nucleophilic active thiolate (cysteine residue at the active site of TG2), with release of ammonia. (encyclopedia.pub)
  • They play an important role in protein-protein interactions such as folding and assisting in the establishment of proper protein conformation (shape) and prevention of unwanted protein aggregation. (wikipedia.org)
  • Petersen and Mitchell found that in D. melanogaster a mild heat shock pretreatment which induces heat shock gene expression (and greatly enhances survival after a subsequent higher temperature heat shock) primarily affects translation of messenger RNA rather than transcription of RNA. (wikipedia.org)
  • Expression of the hspb4 gene, which codes for alpha crystallin, increases considerably in the lens in response to heat shock. (wikipedia.org)
  • The presence of these proteins accounts for the transparency of the lens. (lookformedical.com)
  • They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. (wikipedia.org)
  • It is known that rapid heat hardening can be elicited by a brief exposure of cells to sub-lethal high temperature, which in turn provides protection from subsequent and more severe temperature. (wikipedia.org)
  • Heat shock proteins are also synthesized in D. melanogaster during recovery from prolonged exposure to cold in the absence of heat shock. (wikipedia.org)
  • A mild heat shock pretreatment of the same kind that protects against death from subsequent heat shock also prevents death from exposure to cold. (wikipedia.org)
  • Since its discovery, several aspects of the symbiosis between T. vaginalis and M. hominis have been characterized, demonstrating that the presence of the intracellular guest strongly influences the pathogenic characteristics of the protozoon, making it more aggressive towards host cells and capable of stimulating a stronger proinflammatory response. (uibk.ac.at)
  • Protein of unknown function (DUF1158) [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2526) [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF441) [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2511) [Interproscan]. (ntu.edu.sg)
  • The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
  • In 1974, Tissieres, Mitchell and Tracy discovered that heat-shock induces the production of a small number of proteins and inhibits the production of most others. (wikipedia.org)