Intracellular gene encodes a cytoplasmic protein tyrosine kinase 3 phosphoinositide dependent protein kinases. Medical search. Frequent questions

Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) phospholipase C γ protein kinase C (PKC) Signal transducer and activator of transcription (STAT) In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (wikipedia.org)
ATM is usually a member of phosphoinositide 3-kinase (PI3K)-related protein kinase family, which also includes ataxia telangiectasia and Rad3-related protein (ATR) and catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) [23]. (biomasswars.com)
To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
The class 1A phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), heterotrimeric guanine nucleotide-binding protein (G-protein)-coupled receptors (GPCRs), and Rho-family GTPases. (elifesciences.org)
Previous experiments have not been able to elucidate whether interactions with membrane-tethered proteins primarily control PI3Kβ localization versus directly modulate lipid kinase activity. (elifesciences.org)
To address this gap in our understanding of PI3Kβ regulation, we established an assay to directly visualize and decipher how three binding interactions regulate PI3Kβ when presented to the kinase in a biologically relevant configuration on supported lipid bilayers. (elifesciences.org)
Using single molecule Total Internal Reflection Fluorescence (TIRF) Microscopy, we determined the mechanism controlling membrane localization of PI3Kβ, prioritization of signaling inputs, and lipid kinase activation. (elifesciences.org)
We find that auto-inhibited PI3Kβ must first cooperatively engage a single RTK-derived tyrosine phosphorylated (pY) peptide before it can engage either GβGγ or Rac1(GTP). (elifesciences.org)
Although pY peptides strongly localize PI3Kβ to membranes, they only modestly stimulate lipid kinase activity. (elifesciences.org)
misregulation of the PI3K signaling pathway can result in constitutively high levels of PI(3,4,5)P 3 that are detrimental to cell health. (elifesciences.org)
While much work has been dedicated in determining the factors that participate in the PI3K signaling pathway, how these molecules collaborate to rapidly synthesize PI(3,4,5)P 3 remains an important open question. (elifesciences.org)
Phosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways, especially PI3K/Akt, playing important roles in the pathogenesis of multiple diseases, such as cancer, neurodevelopmental disorders, cardiovascular dysfunction and so on. (biomedcentral.com)
PTEN dephosphorylates phosphatidylinositol (3,4,5)-triphosphate (PIP3), therefore represses the activation of phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathway, Akt/ glycogen synthase kinase3(GSK-3)/Snail signaling pathway, or Akt/GSK-3/Wnt/ signaling pathway. (biomedcentral.com)

Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)

Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (wikipedia.org)
In tract, markup at cell H3 lysine-5( H3K4) and detailed( H3K36), forming glucose and potential at these receptors, is released synthesized to partially associated kinases( shown in Martin & Zhang 2005). (erik-mill.de)
To decipher how amplification of PI(3,4,5)P 3 arises from the relay of signals between cell surface receptors, lipids, and peripheral membrane proteins, we must understand how membrane localization and activity of PI3Ks is regulated by different signaling inputs. (elifesciences.org)
Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
The plasma membrane can be envisioned as a central compartment in the cellular adaptation to diverse stress conditions as it shapes the interactions between cells and their environment by harboring an elaborate complement of transmembrane proteins, e.g. transporters, channels, receptors, or adhesion proteins. (cell-stress.com)
In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)

Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)

Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. (pfmjournal.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Because ELR1-DE encodes a peptide of only 23 residues presumably, just ELR1-IN was analyzed further. (angiogenesis-blog.com)

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. (wikipedia.org)
HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. (wikipedia.org)
The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
Critical for cellular organization, phosphatidylinositol phosphate (PIP) lipids regulate the localization and activity of numerous proteins across intracellular membranes in eukaryotic cells ( Di Paolo and De Camilli 2006 ). (elifesciences.org)
RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)

We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
Serving a critical role in cell signaling, the class I family of phosphoinositide 3-kinases (PI3Ks) catalyze the phosphorylation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ] to generate PI(3,4,5) P 3 . (elifesciences.org)

Deoxycytidine kinase (dCK) is usually a rate-limiting enzyme in the dN salvage pathway, capable of phosphorylating deoxycytidine (dC), deoxyadenosine (dA) and deoxyguanosine (dG) [3], [4]. (biomasswars.com)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
We establish a pH dependant oligomerisation pathway forming tetrameric DEC-205 using solution-based techniques and ultimately solved the 4.9 Å cryo-EM structure of the DEC-205 tetramer to identify the unfurling of the second lectin ring which enables tetramer formation. (uci.edu)
Focal adhesion kinase (FAK) is dephosphorylated by PTEN directly, leading to the inactivation of FAK/p130Cas pathway. (biomedcentral.com)

STP, serine/threonine protein phosphatase. (rupress.org)
The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. (embl.de)
The PDZ-binding domain (post-synaptic density protein (PSD95), Drosophila discs large (Dlg) and the tight junction protein zonula occludens-1 (ZO-1)) associates with the phosphatase activity, membrane association and stability of PTEN. (biomedcentral.com)

Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)

Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Although the importance of kinases in this process has long been recognized, an appreciation for the complex and fundamental role of phosphatases is more recent. (rupress.org)
Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
Phosphoinositide phosphatases play an essential but as yet not well-understood role in lipid-based signal transduction. (embl.de)

Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing are poorly understood. (babraham.ac.uk)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
HER2 mutations drive the growth of a subset of breast cancers and are targeted with HER2 tyrosine kinase inhibitors (TKIs) such as neratinib. (meilerlab.org)

The C2 domain includes two tyrosine phosphorylation sites (Y240 and Y315). (biomedcentral.com)

Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)
These factors regulate gene expression, cell differentiation, and extracellular matrix synthesis. (pfmjournal.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)

Specifically, ATM phosphorylates and activates deoxycytidine kinase (dCK) at serine 74 in response to ionizing radiation (IR). (biomasswars.com)
Ataxia telangiectasia mutated (ATM) serine/threonine protein kinase is at the center of DNA double-strand break (DSB) repair [23]. (biomasswars.com)

Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). (babraham.ac.uk)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)

All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. (wikipedia.org)
Substitution of a valine for a glutamic acid or a glutamine in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (wikipedia.org)

Activation of dCK shifts its substrate specificity toward deoxycytidine, increases intracellular dCTP pools post IR, and enhances the rate of DNA repair. (biomasswars.com)

The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)

For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). (wikipedia.org)
Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. (wikipedia.org)
HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (wikipedia.org)

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1. (babraham.ac.uk)

In particular, prenatal cannabinoid treatment reduced the phosphorylated levels of ERK1/2 in selected subcellular compartments of hippocampus, frontal and prefrontal cortex, whereas no changes were observed in the total levels of these proteins. (researchgate.net)
This may be relevant to the suggestion of kinase-independent effects of ERK1/2 and the therapeutic use of ERKi. (babraham.ac.uk)
PTEN also dephosphorylates Src homology 2-containing protein (Shc) directly, and inhibits the activation of Shc/Raf/ERK1/2 (extracellular signal-regulated kinase) signaling cascade. (biomedcentral.com)

Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)

The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)

ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. (wikipedia.org)
CSL is an download Your Brain on Latino Comics: From Gus Arriola to Los Bros Hernandez of a possible DNA-binding histone cause that releases kinase of invalid genome interests in one decision, but hormone of the Canadian developments in another endocytosis. (evakoch.com)

ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)

One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)

On occasion, vacuolated cytoplasm and cytoplasmic pseudopods can be seen. (biomedcentral.com)

Plexins are widely expressed transmembrane proteins that mediate the effects of semaphorins. (rupress.org)

The signal source can be either extracellular, such as nitric oxide (NO) (114), or intracellular, such as bicarbonate (189). (pancreapedia.org)
The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. (cell-stress.com)

He designed computer hardware, software, and algorithms that accelerate molecular dynamics simulations by orders of magnitude, and applied these simulations to the study of protein function, protein folding, and protein-drug interactions. (stanford.edu)

Changes in the overall endocytic flux or in the endocytic regulation of select proteins conceivably can help to counteract adverse environmental conditions. (cell-stress.com)

In the cerebellar cortex, tenascin-C mRNA in Golgi epithelial cells was down-regulated 3 days after the lesion and returned to control values 80 days after the lesion. (researchgate.net)

The ErbB family consists of four individual plasma membrane-bound receptor tyrosine kinases. (wikipedia.org)

The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)

FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

lacks kinase domain), and erbB-4. (wikipedia.org)
In Library, lysine-10( H3K9) vision gene has required a green protein-protein for visual studies and lacks visually one of the unknown conditions known with acid( Peters et al. (erik-mill.de)

Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)

B) dCK kinase assay using CHOC6 nuclear ABT-888 (Veliparib) and cytoplasmic fraction lysates, [3H]-dC as substrate and performed 2 hours after exposure to 3 Gy (*, P? (biomasswars.com)
D) dCK kinase assay using L1210 nuclear and cytoplasmic fraction lysates, [3H]-dC as substrate and performed 2 hours after exposure to 3 Gy (*, P? (biomasswars.com)

Amplification, also known as the over-expression of the ERBB2 gene, occurs in approximately 15-30% of breast cancers. (wikipedia.org)

Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. (bjbms.org)
TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
The equine infectious anemia trojan (EIAV) is normally a member from the genus Lentivirus, family members Retroviridae, and its own structure may be the simplest of the many known lentiviruses [3]. (angiogenesis-blog.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

In addition, the double mutant (Y42A/L48Q) of the PX domain of Vam7p, reported to cause vacuolar trafficking defects in yeast, has a dramatically decreased level of binding to PtdIns-3-P. These data reveal that the membrane targeting function of the Vam7p PX domain is based on its ability to associate with PtdIns-3-P, analogous to the function of FYVE domains. (embl.de)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

Expression of one copy of wild type Gap1 under control of the sev enhancer/ promoter cassette ( sevGap1 ) rescues the complete loss-of-function eye phenotype, while creating no phenotypic defects when placed in a wild type background containing two copies of the endogenous Gap1 gene. (sdbonline.org)

A) Western blot of nuclear (N) and cytoplasmic (C) fractions of CHOC6 (WT LCL) before and 2 hours after 3 Gy exposure. (biomasswars.com)
Bone marrow aspirate studies show a preponderance of lymphoblasts with high nuclear to cytoplasmic (N:C) ratio, finely dispersed nuclear chromatin, and prominent nucleoli. (biomedcentral.com)
B . Touch preparation of core biopsy material showed lymphoblasts with high nuclear to cytoplasmic (N:C) ratio, finely dispersed nuclear chromatin, and prominent nucleoli. (biomedcentral.com)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

3).(TIF) pone.0104125.s003.tif (337K) GUID:?72E596CD-8491-42F1-8F9C-3C721423C727 Abstract Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. (biomasswars.com)

To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
In this case the impaired protein folding induced by heat stress is, at least partially, counteracted by an increased expression of chaperone proteins. (cell-stress.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Some of these stress programs such as the heat shock response are understood in great detail, while other aspects remain largely elusive including potential stress-dependent adaptations of the plasma membrane proteome. (cell-stress.com)

An inositol-1,3,4,5-tetrakisphosphate (IP4)-sensitive extended PH domain is essential for Gap1 activity, while Ca2+-sensitive C2 domains and a glutamine-rich region contribute equally to full activity in vivo. (sdbonline.org)

These assist with protein folding and, thereby, help to keep the cellular protein machinery functional in spite of adverse thermal conditions. (cell-stress.com)

Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)
The proteins of such MAPKs increased and were then repress UniProt differential download Sarkozy, Israël et whereby steps include to the spliced group before any further cell. (erik-mill.de)
14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
These cell surface proteins impinge on the vast majority of all cellular functions by mediating nutrient uptake, preserving ion homeostasis and initiating complex signaling cascades in response to extracellular cues. (cell-stress.com)

Anatomy21

Organisms9

Chemicals and Drugs167

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes41

Information Science3

PI3K13

Receptor tyrosi1

Receptors6

MAPK1

Pathways4

Residues2

Membranes5

Phosphatidylinositol4

Pathway5

Phosphatase3

Stimulates2

Phosphatases6

Mutations4

Phosphorylation sites1

Regulate5

Serine2

Inhibit3

Transmembrane domain2

Specificity1

Heterotrimeric2

Signaling molecules1

HER23

Inhibitors1

ERK13

Hypoxia1

Cytosolic1

Genome2

Inhibition1

Extracellular ligand1

Cytoplasm1

Mediate1

Signal2

Molecular1

Regulation1

Golgi1

Membrane-bound1

Binds1

Interactions1

Lacks2

Enzymes1

Substrate2

Cancers1

Family5

Lipid1

Associate2

Endogenous1

Nuclear4

Abstract1

Expression4

Plasma membrane1

Activity1

Cellular protein1

Proto-oncogene1

Cell7