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Chlamydophila psittaciChlamydia trachomatisChlamydia InfectionsChlamydiaLymphogranuloma VenereumFemale Urogenital DiseasesBacteriaGenital Diseases, FemaleMale Urogenital DiseasesUterine CervicitisGonorrheaCervix UteriTrachomaPelvic Inflammatory DiseaseUrethraChlamydia muridarumSalpingitisUrethritisNeisseria gonorrhoeaeSexually Transmitted Diseases, BacterialAntibodies, BacterialBacterial Outer Membrane ProteinsUterine Cervical DiseasesDNA, BacterialFluorescent Antibody Technique, DirectUrineConjunctivitis, InclusionInclusion BodiesNucleic Acid Amplification TechniquesPorinsUrethral DiseasesPolymerase Chain ReactionBacteriological TechniquesSpecimen HandlingLigase Chain ReactionAzithromycinBacterial ProteinsArthritis, ReactiveVaginal DiseasesReagent Kits, DiagnosticMolecular Sequence DataAntigens, BacterialMycoplasma genitaliumReproductive Tract InfectionsSensitivity and SpecificityGenital Diseases, MaleSexually Transmitted DiseasesUrogenital SystemPsittacosisGram-Negative BacteriaGenitalia, FemaleDoxycyclineHeLa CellsVaginaChlamydophila InfectionsFallopian Tube DiseasesAnti-Bacterial AgentsGram-Positive BacteriaInfertility, FemalePrevalenceFallopian TubesMycoplasma InfectionsProctitisUreaplasmaTrichomonas vaginalisEvaluation Studies as TopicChaperonin 60Mass ScreeningConjunctivitisChlamydophila pneumoniaeChlamydiaceae InfectionsRNA, Ribosomal, 16SBacteria, AnaerobicConjunctivaBase SequenceGenes, BacterialPregnancy Complications, InfectiousChlamydiaceaeVaginal SmearsTrichomonas InfectionsImmunoenzyme TechniquesRNA, BacterialConjunctivitis, BacterialImmunoglobulin GTrichomonas VaginitisBacterial VaccinesPhylogenyFluorescent Antibody TechniqueSexual BehaviorMycoplasma hominisDEAE-DextranSequence Analysis, DNAEscherichia coliAmino Acid SequenceMycoplasmatales InfectionsSerotypingContact TracingSpecies SpecificityImmunoglobulin AGene Expression Regulation, Bacterial
InfectionPsittaciAsymptomaticPathogenInfectionsObligate intracellular gram-negativePneumoniaeSpeciesHumansGenusSexually TransmitBacterial pathogensTreatment for chlamydiaNeisseriaInstitut PasteurBiphasic developmental cycleCause abnormal vaginal dischargeGenital tractSymptoms of chlamydiaVacuoleTrachomaSyphilisPneumoniaEpithelialGram-negativePathogenic bacteriaVaginalGenomeInfectChlamydialConjunctivitisMechanismsInfectsSerovarsDiagnosisComplicationsInfectivityCure chlamydiaPrevalenceEukaryotic cellsSTIsBiologyDevelopmental cycleTractLegionellaOrganismMycobacteriumProteinsGenomesReplicateMolecularInflammationMammalian cellsHostRectalArchaea
Infection42
  • Rather, it was produced by a tiny intracellular bacterium known as Legionella pneumophila , the pathogen behind a serious lung infection called Legionnaire's disease. (the-scientist.com)
  • Infection with the obligate intracellular organism Chlamydia trachomatis (immunotypes D-K) frequently associates with other lower genitourinary (GU) tract infections. (medscape.com)
  • C trachomatis infection has also been linked to painful bladder syndrome (PBS). (medscape.com)
  • In men, the most common manifestation of C. trachomatis infection is inflammation of the urethra (about 50% of cases) [4]. (roboscreen.com)
  • Chlamydia trachomatis is the leading cause of both bacterial sexually transmitted infection and infection-derived blindness world-wide. (plos.org)
  • Between 2005 and 2010, Australian notification rates for chlamydia infection increased by 64% from 203 to 333 per 100 000 population. (who.int)
  • Chlamydia is a sexually transmitted infection caused by the intracellular bacterium Chlamydia trachomatis . (who.int)
  • 2 Chlamydia is a significant public health problem as a proportion of women with untreated infection may develop pelvic inflammatory disease, tubal infertility and ectopic pregnancies. (who.int)
  • 3-5 Chlamydia infection also facilitates the transmission of HIV. (who.int)
  • Chlamydia is a sexually transmitted infection caused by bacteria. (virtualpsychcentre.com)
  • There are three main species of Chlamydia causing human infection: Chlamydia trachomatis, Chlamydia pneumoniae (also known as Chlamydophila pneumoniae), and Chlamydia psittacci. (virtualpsychcentre.com)
  • Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. (virtualpsychcentre.com)
  • The research in the Division of Microbiology & Parasitology comprises a wide range of topics including: bacterial motility and flagellar biogenesis, mechanisms of entry of bacteria into mammalian cells, bacterial toxin export and multi-drug efflux, regulation of gene expression during host-pathogen interaction, transmission, cell-cycle dynamics and virulence mechanisms in malaria parasites, host modulation by parasitic organisms and dynamics of parasitic worm infection in human populations. (cam.ac.uk)
  • Chlamydia trachomatis is the most common bacterial cause of sexually transmitted infection. (pasteur.fr)
  • Chlamydia antigen production is scalable from 10 mL to several litres and is optimised by the multiplicity of infection and by harvesting time. (thenativeantigencompany.com)
  • However, 70-80% of women with C. trachomatis genital tract infection remain asymptomatic. (thenativeantigencompany.com)
  • It is often caused by an untreated STD infection, such as chlamydia, which moves upwards from the vagina/cervix into the reproductive organs. (genetrack.ca)
  • Untreated chlamydia during pregnancy is associated with a 50-70% risk of passing the infection to the newborn during childbirth. (genetrack.ca)
  • To determine the prevalence of rectal chlamydia infection in a cohort of men who have sex with men (MSM) and the proportion of infection that would be missed without routine screening. (bmj.com)
  • MSM presenting to four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust between 1 November 2005 and 29 September 2006 were offered testing for rectal chlamydia infection in addition to their routine screen for sexually transmitted infections (STIs). (bmj.com)
  • Our data show a high rate of rectal chlamydia infection, in the majority of cases it was asymptomatic. (bmj.com)
  • We recommend routine screening for rectal chlamydia in men at risk, as this may represent an important reservoir for the onward transmission of infection. (bmj.com)
  • 1 2 Currently, testing for urethral chlamydia infection is routinely offered to all men presenting to GUM clinics for sexual health screening. (bmj.com)
  • 12 13 Although there are currently no data to suggest rectal chlamydia infection has a similar effect on transmission of HIV, it is certainly feasible. (bmj.com)
  • As a direct result of the numbers diagnosed, we began offering routine screening for infection with rectal chlamydia in MSM in November 2005. (bmj.com)
  • The objectives of this study were to determine: (1) the prevalence of rectal chlamydia infection in an MSM cohort, (2) the proportion of asymptomatic infections, and (3) the number of infections that would be missed if routine rectal screening had not been performed. (bmj.com)
  • All MSM who presented to the directorate's four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust were screened for rectal chlamydia infection if they had a history of receptive anal intercourse. (bmj.com)
  • Differences in somatometric measurements and clinical variables in newborns with respiratory distress and infection between different Chlamydia trachomatis genotypes. (analesdepediatria.org)
  • We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. (analesdepediatria.org)
  • We have identified a previously uncharacterized protein, CT622, unique to the Chlamydiaceae, in the absence of which most bacteria failed to establish a successful infection. (hal.science)
  • Ocular prophylaxis at birth does not reliably prevent C. trachomatis conjunctivitis or extraocular infection, even if erythromycin ointment is used. (unboundmedicine.com)
  • C. trachomatis is responsible for neonatal conjunctivitis, trachoma, pneumonia in young infants, genital tract infection, and LGV. (unboundmedicine.com)
  • C. trachomatis infection can occur in infants delivered by cesarean section, even without rupture of amniotic membranes. (unboundmedicine.com)
  • Pediatrics Central , peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617493/all/Chlamydia_Trachomatis_Infection. (unboundmedicine.com)
  • This is the case also for bacteria such as Borrelia burgdorferi and Burkholderia pseudomallei (causative of Lyme disease and melioidosis , respectively) where there are reports that symptoms of infection have re-emerged months to years ( B.burgdorferi ), and even up to 60 years ( B.pseudomallei ), after the initial infection. (immunology.org)
  • 5) Which of the following antibiotics are the drug of choice or are the first line treatment for chlamydia infection? (medicalbiochemist.com)
  • 15) Which of the following bacteria is responsible for the infection 'psittacosis' that is transmitted from the parrots to humans? (medicalbiochemist.com)
  • This type of chlamydia causes an eye infection that can lead to blindness. (drvikram.com)
  • LGV is a rare type of chlamydia that can cause a systemic infection, including swollen lymph nodes, ulcers, and abscesses. (drvikram.com)
  • Joint pain and swelling that can occur several weeks after a chlamydia infection. (drvikram.com)
  • Chlamydia trachomatis , the bacteria that causes chlamydia infection, cannot survive outside the human body . (chlamydiaexplained.com)
  • A typically gram-negative bacterium causes a sexually transmitted infection called gonorrhea . (bioexplorer.net)
Psittaci11
Asymptomatic2
Pathogen9
  • C trachomatis , which is almost exclusively a human pathogen, includes the agents of classic trachoma (ie, serotypes A, B, Ba, C). It also includes the agents of inclusion conjunctivitis or paratrachoma (ie, serotypes D-K). The latter organisms infect the epithelium of mucoid surfaces and were once identified as the trachoma-inclusion conjunctivitis agents (TRIC). (medscape.com)
  • She subsequently became an independent NIH-funded investigator and Assistant Professor at Harvard, continuing to investigate host-pathogen relationships in the genital tract, but primarily focusing on the unique obligate intracellular bacteria, Chlamydia trachomatis . (lsuhsc.edu)
  • Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
  • Thus, it is thought that the success of C . trachomatis as a human pathogen may lie in its ability to survive these immunological stress situations by slowing growth and development until conditions in the cell have improved. (plos.org)
  • We still need to understand the advantage that glycogen accumulation brings to Chlamydia trachomatis, a pathogen that develop exclusively in humans. (pasteur.fr)
  • Although the bacterial translocase has been characterized in other intercellular pathogens such as Chlamydia trachomatis and Rickettsia prowazeki, this is the first characterization of an ATP/ADP translocases in an obligate-intracellular plant pathogen and, given the conservation of the ATP uptake mechanism, may represent an evolutionary link between plant and animal pathogens. (usda.gov)
  • A putative ATP/ADP translocase was uncovered during the genomic sequencing of the intracellular plant pathogen, Candidatus Liberibacter asiaticus (Las), the causal agent of citrus huanglongbing. (usda.gov)
  • Here, we used the Acanthamoeba symbiont Protochlamydia amoebophila, a distant relative of the human pathogen Chlamydia trachomatis and representative of a large group of protist-associated environmental chlamydiae, as a model to study how obligate intracellular symbionts evolve and adapt to elevated temperature, a prerequisite for the pivotal evolutionary leap from protist to endothermic animal hosts. (univie.ac.at)
  • Examples of tetrad-forming bacteria are Aerococcus , a urinary tract pathogen, Pediococcus , and Tetragenococcus , both of which ferment foods. (bioexplorer.net)
Infections19
Obligate intracellular gram-negative1
Pneumoniae3
  • 8) What is the most sensitive laboratory diagnostic tests for Chlamydia pneumoniae ? (medicalbiochemist.com)
  • Chlamydia pneumoniae and, in recent studies, Chlamydia trachomatis , may not only induce asthma exacerbations but may also be involved in the pathogenesis of chronic asthma. (medscape.com)
  • [ 10 ] Other bacteria, although common in children's airways, such as Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarrhalis , seem to play no role in asthma exacerbations, although the available data are over 30 years old. (medscape.com)
Species9
  • Chlamydiae are obligate intracellular organisms from bacteria that now comprise 3 species. (medscape.com)
  • To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)
  • As some C. trachomatis isolates are reported not to carry cryptic plasmid or have deletion(s) in it [7], "RealLine Chlamydia trachomatis/ Neisseria gonorrhoeae" assay kit detects two DNA fragments from gyrA gene and cryptic plasmid, specific to C. trachomatis species. (roboscreen.com)
  • Neisseria gonorrhoeae is a species of Gram-negative diplococci non-motile bacteria from the genus Neisseria . (roboscreen.com)
  • Here we identify SNARE-like motifs in the inclusion protein IncA, which are conserved among most Chlamydia species. (pasteur.fr)
  • Chlamydia trachomatis, commonly known as chlamydia, is one of four bacterial species in the genus Chlamydia. (cupidshealth.com)
  • Indeed, Chlamydia species that infect other hosts do not accumulate glycogen. (pasteur.fr)
  • The "Ca. Clavichlamydia salmonicola" genome harbors genes that so far have been exclusively found in Chlamydia species suggesting that basic mechanisms important for the interaction with chordate hosts have evolved stepwise in the history of chlamydiae. (univie.ac.at)
  • The field of Chlamydia genomics has seen a rampant development, from the very first release of the whole genome sequence of a C. trachomatis strain to the current availability of hundreds of genomes from multiple Chlamydia species. (caister.com)
Humans5
  • It is an obligate intracellular parasite, for which humans are the only host [1]. (roboscreen.com)
  • The origins of both sexually transmitted and ocular C. trachomatis are unclear, but it seems likely that they evolved with humans and shared a common ancestor with environmental chlamydiae some 700 million years ago. (virtualpsychcentre.com)
  • Infected birds shed the bacteria through feces and nasal discharges, and humans become infected from exposure to these materials. (cdc.gov)
  • Chlamydia trachomatis is a gram-negative, obligate intracellular bacterium that infects humans. (drvikram.com)
  • Chlamydia trachomatis is the etiological agent of several significant diseases of humans, including trachoma, the leading cause of infectious blindness worldwide. (nih.gov)
Genus3
Sexually Transmit5
Bacterial pathogens2
  • Whilst many bacterial pathogens are intracellular in nature, others do not need to invade the host cell, but instead use various secretion processes which effect the delivery of toxins and other virulence factors into the host cell. (immunology.org)
  • Our main research goal is to understand the mechanisms underlying the ability of intracellular bacterial pathogens to subvert processes in the host cell in order to survive and replicate, namely by using secreted effector proteins. (unl.pt)
Treatment for chlamydia1
  • The main Ayurvedic treatment for chlamydia involves balancing these doshas through a combination of diet, lifestyle changes, and herbal remedies. (drvikram.com)
Neisseria4
Institut Pasteur2
  • A publication in eLife from researchers of the Institut Pasteur, CNRS, University of Lille and Indiana University (USA) explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit. (pasteur.fr)
  • In this work, researchers from the Institut Pasteur, CNRS, University of Lille and Indiana University explain the mechanisms by which glycogen accumulates around the bacteria. (pasteur.fr)
Biphasic developmental cycle2
  • C. trachomatis is an intracellular Gram-negative bacterium with a biphasic developmental cycle in which extracellular, infectious elementary bodies (E. (mysciencework.com)
  • Chlamydiae are obligate intracellular bacteria with a biphasic developmental cycle that involves cell types adapted for extracellular survival and intracellular multiplication. (nih.gov)
Cause abnormal vaginal discharge1
Genital tract3
Symptoms of chlamydia1
Vacuole5
  • They share a unique hydrophobic motif thought to target them to the membrane of the large vacuole where Chlamydia resides intracellularly. (europa.eu)
  • The obligate intracellular bacteria Chlamydia replicate within an intracellular vacuole, termed an inclusion. (pasteur.fr)
  • In the case of Chlamydia trachomatis, it is known that the vacuole is rich in glycogen, an energy storage molecule made of sugar units. (pasteur.fr)
  • Firstly, the bacterium hijacks the glycogen stores synthesized by the host, which get trapped inside the vacuole. (pasteur.fr)
  • Chlamydiae undergo their developmental cycle entirely within a parasitophorous vacuole, termed an inclusion, that is isolated from established routes of endocytic vesicle trafficking. (nih.gov)
Trachoma1
Syphilis2
  • Syphilis, caused by the bacterium Treponema pallidum , is the second most common cause of genital ulcers in the U.S. 7 Among active component service members, the incidence rate of syphilis was 5.0 cases per 10,000 p-yrs from 2013 through 2021. (health.mil)
  • In addition, Easwara holds significant responsibility and experience in serological diagnostics, which includes STD Syphilis for Treponima Pallidum spirochete bacterium tests by Rapid Plasma Reagin (RPR), Venereal Disease Antigen Test (VDRL), Immuno florescence test FTA , Cr. (sivams.com)
Pneumonia3
Epithelial5
  • Chlamydiae are small gram-negative obligate intracellular microorganisms that preferentially infect squamocolumnar epithelial cells. (virtualpsychcentre.com)
  • Gonococci enter the body by attaching to nonciliated columnar mucosal epithelial cells using specialized surface structures on the bacteria known as pili (Fig. 46.1). (pediagenosis.com)
  • Chlamydiae access the body by invading the same epithelial cells of the endocervix, urethra, endometrium, fallopian tubes, rectum and conjunctivae that are host to the gonococcus. (pediagenosis.com)
  • Invasion of epithelial cells by the obligate intracellular bacterium Chlamydia trachomatis results in its enclosure inside a membrane-bound compartment termed an inclusion. (hal.science)
  • Lactobacilli and their antimicrobial and anti-inflammatory products along with components of the epithelial mucosal barrier provide an effective first line defense against invading pathogens including bacterial vaginosis, aerobic vaginitis-associated bacteria, viruses, fungi and protozoa. (frontiersin.org)
Gram-negative2
  • C. trachomatis is a weakly Gram-negative bacterium. (cupidshealth.com)
  • The gram-negative bacterium Haemophilus ducreyi causes chancroid, which is rarely diagnosed in the U.S., with less than 10 cases reported annually. (health.mil)
Pathogenic bacteria2
  • This article provides an overview of the most important human pathogenic bacteria. (amboss.com)
  • The following table provides an overview of the nomenclature of important human pathogenic bacteria, according to their form and Gram staining properties. (amboss.com)
Vaginal2
  • 50-75% of the neonates born to infected mothers via vaginal delivery will acquire C. trachomatis . (unboundmedicine.com)
  • You should not have oral, anal or vaginal sex during your course of chlamydia treatment or for seven days after a single dose of chlamydia treatment and also until your current partner completes their treatment and until both you and your partners symptoms have abated. (chlamydiaexplained.com)
Genome4
  • Then, we selected 48 genes that may encode uncharacterised effectors (e. g. no detectable amino acid identity to other proteins or with a particular putative biochemical activity) from the genome of C. trachomatis strain L2/434/Bu. (europa.eu)
  • Genome Dynamics and Temperature Adaptation During Experimental Evolution of Obligate Intracellular Bacteria. (univie.ac.at)
  • We then used infectivity assays and pooled whole-genome resequencing to identify any evolved phenotypes and the molecular basis of adaptation in these bacteria. (univie.ac.at)
  • Chlamydia Biology: From Genome to Disease (Edited by: Ming Tan, Johannes H. Hegemann and Christine Sütterlin). (caister.com)
Infect1
  • Chlamydia can infect both men and women and can affect various parts of the body, including the cervix, urethra, anus, throat, and eyes. (drvikram.com)
Chlamydial3
  • To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an important group of potential chlamydial virulence factors. (europa.eu)
  • Our results provide insights into the molecular evolution of intracellular bacteria under the constraints of strict host dependance and highly structured populations and suggest that for chlamydial symbionts of protists, temperature adaptation was facilitated through attenuation of symbiont infectivity as a tradeoff to reduce host cell burden. (univie.ac.at)
  • Understanding the initial events in chlamydial differentiation, including the transition in properties of the endocytic vesicle to one which intersects an exocytic pathway, remains a significant challenge in deciphering the pathogenic mechanisms of chlamydiae. (nih.gov)
Conjunctivitis3
  • Adult inclusion conjunctivitis results from C trachomatis serotypes D-K, causing chronic follicular conjunctivitis that can occur in adults or in the neonate. (medscape.com)
  • This image reveals a close view of a patient's left eye with the upper lid retracted in order to reveal the inflamed conjunctival membrane lining the inside of both the upper and lower lids, due to what was determined to be a case of inclusion conjunctivitis, a type of conjunctival inflammation caused by the bacterium, Chlamydia trachomatis. (medscape.com)
  • Chlamydia can also cause conjunctivitis (pink eye) if the eyes are infected during sexual contact. (drvikram.com)
Mechanisms4
  • The overall scientific objective of this project was to increase our fundamental understanding of mechanisms underlying C. trachomatis virulence. (europa.eu)
  • When a pathogenic microorganism ( bacterium , viru s or protozoal parasite ) infects the human body, a battle ensues between the host's innate & adaptive immune systems and the pathogen's assorted virulence mechanisms and factors . (immunology.org)
  • To sustain their virulence mechanisms, many bacteria can sequester free iron in the mammalian host, through the elaboration of iron-binding siderophores. (immunology.org)
  • While this scientific advance has revealed fascinating patterns of adaptation to the intracellular environment, it has also disclosed the main genetic mechanisms driving Chlamydia evolution as well as many genes of unknown function that lack orthologs in the microbial world. (caister.com)
Infects1
Serovars3
Diagnosis3
  • hence why prompt diagnosis and treatment of chlamydia is very important. (genetrack.ca)
  • The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. (analesdepediatria.org)
  • Early diagnosis and treatment of chlamydia can prevent serious health problems. (drvikram.com)
Complications2
Infectivity1
  • Our report characterizes a complete signaling module, the Rsb network, that is capable of controlling the growth rate or infectivity of Chlamydia . (plos.org)
Cure chlamydia2
Prevalence1
  • Notification data provide no evidence for a general increase in the prevalence of chlamydia in the NSW community for this period. (who.int)
Eukaryotic cells2
  • C. trachomatis is an obligate, aerobic, intracellular parasite of eukaryotic cells. (virtualpsychcentre.com)
  • General Information: Bacteria belonging to the Chlamydiales group are obligate intracellular parasites of eukaryotic cells. (up.ac.za)
STIs1
  • Like other STIs that cause a breach in the genital mucosa, 9 - 11 genital chlamydia facilitates the acquisition and transmission of HIV. (bmj.com)
Biology6
  • For Mukherjee, the paper was a revelation: not only did it identify the fastest way yet to target Golgi biology, it suggested that scientists could use intracellular bacteria "as a lens to understand basic processes inside the cell. (the-scientist.com)
  • Research on how intracellular bacteria take control of their hosts is not only informing scientists about how these microbes cause disease, but revealing secrets of mammalian biology, says Mukherjee, who now heads up a lab at the University of California (UC), San Francisco. (the-scientist.com)
  • Studying the intracellular biology of the obligate intracellular bacterium Chlamydia trachomatis . (cam.ac.uk)
  • Chlamydia cell biology and pathogenesis. (thenativeantigencompany.com)
  • It has allowed advances not only in the understanding of fundamental aspects of the epidemiology and biology of these unique intracellular bacteria but also in deciphering the molecular basis of phenotypic differences, such as host and tissue tropism, invasiveness and ecological success. (caister.com)
  • The Host-Parasite Interactions Section studies the basic molecular and cellular biology of chlamydiae and other obligate intracellular parasites. (nih.gov)
Developmental cycle1
  • We show that CT622 is translocated into the host cytoplasm via type three secretion throughout the developmental cycle of the bacteria. (hal.science)
Tract1
  • The surface damage caused by the gonococcus allows other pathogens, such as chlamydia, to gain access to the upper reproductive tract and cause multiorganism PID. (pediagenosis.com)
Legionella3
  • Scientists studying pathogens such as Chlamydia , Legionella , and Listeria get a master class in how to control the internal workings of mammalian cells. (the-scientist.com)
  • So-called facultative intracellular bacteria such as Listeria monocytogenes and Legionella pneumophila do not need to be inside a host cell to reproduce. (the-scientist.com)
  • Legionella pneumophila and Chlamydia trachomatis are the two pathogens that, once inside the host cell, reside inside a compartment that is continuously modified by the action of effector proteins to escape killing and allow the creation of a replicative niche for the bacteria. (unl.pt)
Organism2
Mycobacterium1
Proteins6
  • we tested if these 22 C. trachomatis proteins with an N-terminal T3S signal were also secreted as full-length proteins after PyopE-dependent expression in Y. enterocolitica. (europa.eu)
  • Thirteen proteins showed a statistically significant higher level of secretion than full-length C. trachomatis RplJ. (europa.eu)
  • We have raised rabbit polyclonal antibodies against 5 of these proteins and we are currently analysing their subcellular localisation in C. trachomatis infected cells. (europa.eu)
  • The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins, which are essential for membrane fusion, are possible targets. (pasteur.fr)
  • These transport proteins appear to be unique to mitochondria, plant plastids, and obligate-intracellular bacteria. (usda.gov)
  • Currently, ongoing projects include the elucidation of the functions of L. pneumophila effector proteins that are involved in actin dynamics or are targeted to the nucleus, as well as a C. trachomatis Golgi associated protein. (unl.pt)
Genomes1
  • Obligate intracellular pathogens will often have reduced genomes compared to the facultative variety, a genetic tendency that is reflective of their more limited lifestyle. (the-scientist.com)
Replicate1
  • Microscopy analyses indicate that cholesterol regulates a step in L. pneumophila intracellular lifecycle that occurs after bacteria begin to replicate within an established intracellular niche. (microbialcell.com)
Molecular1
  • A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
Inflammation2
  • Chlamydia trachomatis is also able to colonize the eye, and the resulting inflammation is the leading cause of blindness by an infectious agent in several developing countries. (pasteur.fr)
  • Inflammation associated with chlamydia increases the risk of ectopic pregnancy, which is when the fertilized egg implants and grows outside the main cavity of the uterus (14). (genetrack.ca)
Mammalian cells1
  • One membrane component that is often subverted by vacuolar bacteria is cholesterol - an abundant lipid that mammalian cells produce de novo at the endoplasmic reticulum (ER) or acquire exogenously from serum-derived lipoprotein carriers. (microbialcell.com)
Host12
  • Dr. Quayle has been funded by NIH for 22 years, and her LSU career has focused on elucidating the complex relationship between Chlamydia and the host immune response in the human genital milieu. (lsuhsc.edu)
  • Quantitative polymerase chain reaction validation of three complete vMAGs revealed their independence from host bacterium abundance. (microbial-ecology.net)
  • In particular, we investigate how the obligate intracellular bacteria Chlamydia trachomatis manipulates the host and establishes an intracellular niche favorable for bacterial survival and replication, resulting in disease. (virginia.edu)
  • C . trachomatis only replicates from inside a host cell, and has evolved to acquire a variety of nutrients directly from its host. (plos.org)
  • Our results suggest a mechanism by which Chlamydia can tailor its growth rate to the conditions within the host cell. (plos.org)
  • Many intracellular pathogens rely on host cell membrane compartments for their survival. (pasteur.fr)
  • This dual strategy fulfills the nutritional needs of the bacteria while weakening the host, which loses access to its own energy stores. (pasteur.fr)
  • This discovery answers a 50-year old question: how do the bacteria manage to accumulate glycogen in a space that is separated from the host? (pasteur.fr)
  • Yet there is a paucity of such research focusing on strictly host-associated bacteria, even though they are widespread in nature. (univie.ac.at)
  • The bacterium quickly begins manipulating interactions between host intracellular trafficking and the inclusion interface, diverging from the endocytic pathway and escaping lysosomal fusion. (hal.science)
  • Mammalian host cells have also evolved an array of pattern recognition receptors for microbes or microbial factors, such as the Toll-like receptors (TLRs), which when bound, trigger intracellular signalling cascade(s) with antimicrobial effects. (immunology.org)
  • therefore, host lipids and their biosynthesis pathways have emerged as critical regulators of intracellular replication for vacuolar pathogens both as organelle membrane building blocks as well as nutrients [8] [9] . (microbialcell.com)
Rectal1
  • Rectal chlamydia testing in men who have sex with men (MSM) is not routinely offered in the majority of clinics, 3 neither is it recommended in the British Association for Sexual Health and HIV (BASHH) guidelines for STI screening. (bmj.com)
Archaea1
  • The classification of bacteria , including the archaea, into phyla is somewhat less established due to the complexities of bacterial diversity and the ongoing refinement of bacterial taxonomy . (microbiologynote.com)